Amino acid dipepetide frequency for Circovirus-like genome CB-B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.345AlaAla: 6.345 ± 4.641
0.0AlaCys: 0.0 ± 0.0
3.807AlaAsp: 3.807 ± 2.158
1.269AlaGlu: 1.269 ± 1.803
6.345AlaPhe: 6.345 ± 0.289
6.345AlaGly: 6.345 ± 4.641
1.269AlaHis: 1.269 ± 1.715
7.614AlaIle: 7.614 ± 2.532
5.076AlaLys: 5.076 ± 1.904
5.076AlaLeu: 5.076 ± 0.881
0.0AlaMet: 0.0 ± 0.0
3.807AlaAsn: 3.807 ± 2.158
2.538AlaPro: 2.538 ± 1.347
10.152AlaGln: 10.152 ± 1.754
0.0AlaArg: 0.0 ± 0.0
5.076AlaSer: 5.076 ± 1.904
7.614AlaThr: 7.614 ± 0.652
10.152AlaVal: 10.152 ± 3.587
1.269AlaTrp: 1.269 ± 1.803
1.269AlaTyr: 1.269 ± 1.715
0.0AlaXaa: 0.0 ± 0.0
Cys
1.269CysAla: 1.269 ± 0.719
0.0CysCys: 0.0 ± 0.0
1.269CysAsp: 1.269 ± 0.719
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.538CysGly: 2.538 ± 2.295
0.0CysHis: 0.0 ± 0.0
1.269CysIle: 1.269 ± 0.719
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
1.269CysAsn: 1.269 ± 0.719
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.269CysSer: 1.269 ± 1.803
1.269CysThr: 1.269 ± 0.719
3.807CysVal: 3.807 ± 1.188
1.269CysTrp: 1.269 ± 1.803
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
1.269AspCys: 1.269 ± 0.719
3.807AspAsp: 3.807 ± 2.158
2.538AspGlu: 2.538 ± 1.461
1.269AspPhe: 1.269 ± 1.715
0.0AspGly: 0.0 ± 0.0
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
0.0AspLys: 0.0 ± 0.0
5.076AspLeu: 5.076 ± 0.881
1.269AspMet: 1.269 ± 0.719
3.807AspAsn: 3.807 ± 1.537
2.538AspPro: 2.538 ± 3.431
1.269AspGln: 1.269 ± 1.803
0.0AspArg: 0.0 ± 0.0
3.807AspSer: 3.807 ± 3.104
2.538AspThr: 2.538 ± 1.461
5.076AspVal: 5.076 ± 1.904
2.538AspTrp: 2.538 ± 1.347
1.269AspTyr: 1.269 ± 1.803
0.0AspXaa: 0.0 ± 0.0
Glu
5.076GluAla: 5.076 ± 2.877
1.269GluCys: 1.269 ± 0.719
0.0GluAsp: 0.0 ± 0.0
2.538GluGlu: 2.538 ± 2.295
0.0GluPhe: 0.0 ± 0.0
6.345GluGly: 6.345 ± 6.503
0.0GluHis: 0.0 ± 0.0
3.807GluIle: 3.807 ± 3.1
0.0GluLys: 0.0 ± 0.0
2.538GluLeu: 2.538 ± 1.461
1.269GluMet: 1.269 ± 1.715
2.538GluAsn: 2.538 ± 1.439
5.076GluPro: 5.076 ± 1.429
3.807GluGln: 3.807 ± 3.628
3.807GluArg: 3.807 ± 2.158
1.269GluSer: 1.269 ± 1.715
2.538GluThr: 2.538 ± 3.606
1.269GluVal: 1.269 ± 0.719
0.0GluTrp: 0.0 ± 0.0
1.269GluTyr: 1.269 ± 0.719
0.0GluXaa: 0.0 ± 0.0
Phe
2.538PheAla: 2.538 ± 1.439
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
1.269PheGlu: 1.269 ± 0.719
1.269PhePhe: 1.269 ± 1.803
1.269PheGly: 1.269 ± 0.719
1.269PheHis: 1.269 ± 1.803
1.269PheIle: 1.269 ± 0.719
1.269PheLys: 1.269 ± 0.719
0.0PheLeu: 0.0 ± 0.0
0.0PheMet: 0.0 ± 0.0
0.0PheAsn: 0.0 ± 0.0
6.345PhePro: 6.345 ± 2.386
1.269PheGln: 1.269 ± 1.803
3.807PheArg: 3.807 ± 1.537
1.269PheSer: 1.269 ± 1.803
1.269PheThr: 1.269 ± 0.719
0.0PheVal: 0.0 ± 0.0
1.269PheTrp: 1.269 ± 1.715
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
5.076GlyAla: 5.076 ± 1.904
1.269GlyCys: 1.269 ± 0.719
6.345GlyAsp: 6.345 ± 8.576
5.076GlyGlu: 5.076 ± 2.922
0.0GlyPhe: 0.0 ± 0.0
5.076GlyGly: 5.076 ± 1.904
2.538GlyHis: 2.538 ± 1.439
1.269GlyIle: 1.269 ± 0.719
5.076GlyLys: 5.076 ± 2.693
3.807GlyLeu: 3.807 ± 3.628
2.538GlyMet: 2.538 ± 1.569
2.538GlyAsn: 2.538 ± 1.439
7.614GlyPro: 7.614 ± 6.209
5.076GlyGln: 5.076 ± 2.693
6.345GlyArg: 6.345 ± 0.289
3.807GlySer: 3.807 ± 1.537
6.345GlyThr: 6.345 ± 2.435
5.076GlyVal: 5.076 ± 1.904
0.0GlyTrp: 0.0 ± 0.0
3.807GlyTyr: 3.807 ± 1.188
0.0GlyXaa: 0.0 ± 0.0
His
5.076HisAla: 5.076 ± 3.062
0.0HisCys: 0.0 ± 0.0
1.269HisAsp: 1.269 ± 0.719
1.269HisGlu: 1.269 ± 0.719
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.269HisIle: 1.269 ± 0.719
0.0HisLys: 0.0 ± 0.0
1.269HisLeu: 1.269 ± 0.719
2.538HisMet: 2.538 ± 1.167
1.269HisAsn: 1.269 ± 0.719
0.0HisPro: 0.0 ± 0.0
1.269HisGln: 1.269 ± 1.715
1.269HisArg: 1.269 ± 1.715
2.538HisSer: 2.538 ± 1.347
0.0HisThr: 0.0 ± 0.0
1.269HisVal: 1.269 ± 0.719
1.269HisTrp: 1.269 ± 1.803
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.538IleAla: 2.538 ± 1.347
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
0.0IleGlu: 0.0 ± 0.0
2.538IlePhe: 2.538 ± 1.439
5.076IleGly: 5.076 ± 2.877
0.0IleHis: 0.0 ± 0.0
1.269IleIle: 1.269 ± 0.719
3.807IleLys: 3.807 ± 1.188
2.538IleLeu: 2.538 ± 1.347
2.538IleMet: 2.538 ± 1.439
3.807IleAsn: 3.807 ± 2.158
6.345IlePro: 6.345 ± 2.435
1.269IleGln: 1.269 ± 0.719
1.269IleArg: 1.269 ± 0.719
7.614IleSer: 7.614 ± 4.316
1.269IleThr: 1.269 ± 0.719
5.076IleVal: 5.076 ± 2.877
0.0IleTrp: 0.0 ± 0.0
1.269IleTyr: 1.269 ± 0.719
0.0IleXaa: 0.0 ± 0.0
Lys
6.345LysAla: 6.345 ± 4.427
0.0LysCys: 0.0 ± 0.0
1.269LysAsp: 1.269 ± 1.803
2.538LysGlu: 2.538 ± 1.347
0.0LysPhe: 0.0 ± 0.0
3.807LysGly: 3.807 ± 3.1
0.0LysHis: 0.0 ± 0.0
6.345LysIle: 6.345 ± 3.596
7.614LysLys: 7.614 ± 4.316
5.076LysLeu: 5.076 ± 1.429
1.269LysMet: 1.269 ± 0.719
5.076LysAsn: 5.076 ± 1.429
1.269LysPro: 1.269 ± 1.803
3.807LysGln: 3.807 ± 1.582
7.614LysArg: 7.614 ± 4.316
5.076LysSer: 5.076 ± 1.429
1.269LysThr: 1.269 ± 0.719
1.269LysVal: 1.269 ± 1.803
0.0LysTrp: 0.0 ± 0.0
1.269LysTyr: 1.269 ± 0.719
0.0LysXaa: 0.0 ± 0.0
Leu
6.345LeuAla: 6.345 ± 2.455
1.269LeuCys: 1.269 ± 1.715
2.538LeuAsp: 2.538 ± 1.439
3.807LeuGlu: 3.807 ± 1.188
3.807LeuPhe: 3.807 ± 1.188
7.614LeuGly: 7.614 ± 4.143
1.269LeuHis: 1.269 ± 0.719
2.538LeuIle: 2.538 ± 1.439
5.076LeuLys: 5.076 ± 2.693
3.807LeuLeu: 3.807 ± 1.188
3.807LeuMet: 3.807 ± 1.188
5.076LeuAsn: 5.076 ± 1.429
5.076LeuPro: 5.076 ± 0.881
0.0LeuGln: 0.0 ± 0.0
2.538LeuArg: 2.538 ± 1.347
5.076LeuSer: 5.076 ± 1.429
3.807LeuThr: 3.807 ± 3.1
2.538LeuVal: 2.538 ± 1.439
3.807LeuTrp: 3.807 ± 3.104
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
2.538MetAla: 2.538 ± 1.439
2.538MetCys: 2.538 ± 1.439
1.269MetAsp: 1.269 ± 1.715
3.807MetGlu: 3.807 ± 2.158
0.0MetPhe: 0.0 ± 0.0
1.269MetGly: 1.269 ± 0.719
1.269MetHis: 1.269 ± 1.803
1.269MetIle: 1.269 ± 0.719
0.0MetLys: 0.0 ± 0.0
2.538MetLeu: 2.538 ± 1.461
1.269MetMet: 1.269 ± 0.719
0.0MetAsn: 0.0 ± 0.0
1.269MetPro: 1.269 ± 1.803
1.269MetGln: 1.269 ± 0.719
2.538MetArg: 2.538 ± 1.439
0.0MetSer: 0.0 ± 0.0
2.538MetThr: 2.538 ± 1.461
1.269MetVal: 1.269 ± 0.719
1.269MetTrp: 1.269 ± 1.715
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
2.538AsnCys: 2.538 ± 1.439
0.0AsnAsp: 0.0 ± 0.0
0.0AsnGlu: 0.0 ± 0.0
0.0AsnPhe: 0.0 ± 0.0
2.538AsnGly: 2.538 ± 1.461
3.807AsnHis: 3.807 ± 2.158
6.345AsnIle: 6.345 ± 3.596
5.076AsnLys: 5.076 ± 1.429
2.538AsnLeu: 2.538 ± 1.347
0.0AsnMet: 0.0 ± 0.0
2.538AsnAsn: 2.538 ± 1.439
1.269AsnPro: 1.269 ± 1.803
1.269AsnGln: 1.269 ± 0.719
2.538AsnArg: 2.538 ± 1.439
3.807AsnSer: 3.807 ± 1.537
6.345AsnThr: 6.345 ± 1.926
7.614AsnVal: 7.614 ± 2.532
1.269AsnTrp: 1.269 ± 0.719
1.269AsnTyr: 1.269 ± 0.719
0.0AsnXaa: 0.0 ± 0.0
Pro
8.883ProAla: 8.883 ± 5.986
0.0ProCys: 0.0 ± 0.0
1.269ProAsp: 1.269 ± 1.715
5.076ProGlu: 5.076 ± 2.693
0.0ProPhe: 0.0 ± 0.0
3.807ProGly: 3.807 ± 2.158
0.0ProHis: 0.0 ± 0.0
0.0ProIle: 0.0 ± 0.0
0.0ProLys: 0.0 ± 0.0
3.807ProLeu: 3.807 ± 2.158
1.269ProMet: 1.269 ± 0.719
3.807ProAsn: 3.807 ± 3.754
10.152ProPro: 10.152 ± 7.71
1.269ProGln: 1.269 ± 1.803
2.538ProArg: 2.538 ± 1.461
11.421ProSer: 11.421 ± 5.442
5.076ProThr: 5.076 ± 5.424
2.538ProVal: 2.538 ± 1.461
0.0ProTrp: 0.0 ± 0.0
3.807ProTyr: 3.807 ± 1.188
0.0ProXaa: 0.0 ± 0.0
Gln
7.614GlnAla: 7.614 ± 4.383
1.269GlnCys: 1.269 ± 1.803
2.538GlnAsp: 2.538 ± 1.439
1.269GlnGlu: 1.269 ± 1.715
1.269GlnPhe: 1.269 ± 1.803
5.076GlnGly: 5.076 ± 2.922
0.0GlnHis: 0.0 ± 0.0
1.269GlnIle: 1.269 ± 0.719
0.0GlnLys: 0.0 ± 0.0
5.076GlnLeu: 5.076 ± 2.693
0.0GlnMet: 0.0 ± 0.0
2.538GlnAsn: 2.538 ± 1.347
2.538GlnPro: 2.538 ± 1.347
1.269GlnGln: 1.269 ± 0.719
2.538GlnArg: 2.538 ± 2.295
1.269GlnSer: 1.269 ± 0.719
3.807GlnThr: 3.807 ± 1.188
6.345GlnVal: 6.345 ± 2.386
0.0GlnTrp: 0.0 ± 0.0
1.269GlnTyr: 1.269 ± 0.719
0.0GlnXaa: 0.0 ± 0.0
Arg
3.807ArgAla: 3.807 ± 1.537
1.269ArgCys: 1.269 ± 1.803
0.0ArgAsp: 0.0 ± 0.0
0.0ArgGlu: 0.0 ± 0.0
1.269ArgPhe: 1.269 ± 0.719
2.538ArgGly: 2.538 ± 1.439
3.807ArgHis: 3.807 ± 3.628
1.269ArgIle: 1.269 ± 0.719
5.076ArgLys: 5.076 ± 2.877
6.345ArgLeu: 6.345 ± 0.289
3.807ArgMet: 3.807 ± 1.504
1.269ArgAsn: 1.269 ± 0.719
0.0ArgPro: 0.0 ± 0.0
1.269ArgGln: 1.269 ± 1.715
11.421ArgArg: 11.421 ± 4.611
3.807ArgSer: 3.807 ± 1.537
3.807ArgThr: 3.807 ± 2.158
3.807ArgVal: 3.807 ± 2.158
1.269ArgTrp: 1.269 ± 1.715
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
5.076SerAla: 5.076 ± 1.429
1.269SerCys: 1.269 ± 1.803
2.538SerAsp: 2.538 ± 1.439
3.807SerGlu: 3.807 ± 3.628
3.807SerPhe: 3.807 ± 1.582
6.345SerGly: 6.345 ± 3.876
1.269SerHis: 1.269 ± 0.719
2.538SerIle: 2.538 ± 1.439
7.614SerLys: 7.614 ± 2.375
2.538SerLeu: 2.538 ± 1.461
1.269SerMet: 1.269 ± 0.719
6.345SerAsn: 6.345 ± 3.596
3.807SerPro: 3.807 ± 3.104
1.269SerGln: 1.269 ± 0.719
2.538SerArg: 2.538 ± 1.439
8.883SerSer: 8.883 ± 1.739
6.345SerThr: 6.345 ± 1.926
6.345SerVal: 6.345 ± 0.289
2.538SerTrp: 2.538 ± 1.347
1.269SerTyr: 1.269 ± 0.719
0.0SerXaa: 0.0 ± 0.0
Thr
8.883ThrAla: 8.883 ± 3.185
0.0ThrCys: 0.0 ± 0.0
3.807ThrAsp: 3.807 ± 3.104
1.269ThrGlu: 1.269 ± 0.719
2.538ThrPhe: 2.538 ± 1.347
6.345ThrGly: 6.345 ± 1.926
1.269ThrHis: 1.269 ± 1.803
5.076ThrIle: 5.076 ± 1.429
1.269ThrLys: 1.269 ± 1.803
8.883ThrLeu: 8.883 ± 3.752
1.269ThrMet: 1.269 ± 0.719
2.538ThrAsn: 2.538 ± 1.439
2.538ThrPro: 2.538 ± 2.295
3.807ThrGln: 3.807 ± 2.158
0.0ThrArg: 0.0 ± 0.0
3.807ThrSer: 3.807 ± 3.1
2.538ThrThr: 2.538 ± 1.347
3.807ThrVal: 3.807 ± 1.537
1.269ThrTrp: 1.269 ± 0.719
2.538ThrTyr: 2.538 ± 1.347
0.0ThrXaa: 0.0 ± 0.0
Val
6.345ValAla: 6.345 ± 2.435
1.269ValCys: 1.269 ± 1.803
2.538ValAsp: 2.538 ± 1.347
3.807ValGlu: 3.807 ± 1.537
0.0ValPhe: 0.0 ± 0.0
10.152ValGly: 10.152 ± 2.053
1.269ValHis: 1.269 ± 0.719
0.0ValIle: 0.0 ± 0.0
8.883ValLys: 8.883 ± 3.752
6.345ValLeu: 6.345 ± 0.289
2.538ValMet: 2.538 ± 1.461
2.538ValAsn: 2.538 ± 1.439
5.076ValPro: 5.076 ± 1.429
2.538ValGln: 2.538 ± 1.461
5.076ValArg: 5.076 ± 2.922
5.076ValSer: 5.076 ± 2.877
3.807ValThr: 3.807 ± 2.158
3.807ValVal: 3.807 ± 1.188
1.269ValTrp: 1.269 ± 0.719
3.807ValTyr: 3.807 ± 2.158
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
3.807TrpAsp: 3.807 ± 3.754
2.538TrpGlu: 2.538 ± 1.461
1.269TrpPhe: 1.269 ± 0.719
1.269TrpGly: 1.269 ± 1.715
1.269TrpHis: 1.269 ± 1.715
1.269TrpIle: 1.269 ± 1.803
1.269TrpLys: 1.269 ± 0.719
1.269TrpLeu: 1.269 ± 0.719
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.269TrpPro: 1.269 ± 0.719
3.807TrpGln: 3.807 ± 3.1
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
1.269TrpVal: 1.269 ± 1.715
0.0TrpTrp: 0.0 ± 0.0
1.269TrpTyr: 1.269 ± 1.803
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.269TyrAla: 1.269 ± 1.803
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
2.538TyrGlu: 2.538 ± 1.461
0.0TyrPhe: 0.0 ± 0.0
1.269TyrGly: 1.269 ± 0.719
1.269TyrHis: 1.269 ± 0.719
2.538TyrIle: 2.538 ± 1.439
3.807TyrLys: 3.807 ± 1.188
1.269TyrLeu: 1.269 ± 0.719
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
0.0TyrPro: 0.0 ± 0.0
1.269TyrGln: 1.269 ± 0.719
1.269TyrArg: 1.269 ± 1.803
2.538TyrSer: 2.538 ± 1.439
1.269TyrThr: 1.269 ± 0.719
3.807TyrVal: 3.807 ± 1.188
1.269TyrTrp: 1.269 ± 1.803
2.538TyrTyr: 2.538 ± 1.439
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (789 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski