Amino acid dipepetide frequency for Gramella jeungdoensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.174AlaAla: 4.174 ± 0.073	0.525AlaCys: 0.525 ± 0.023	2.897AlaAsp: 2.897 ± 0.057	3.717AlaGlu: 3.717 ± 0.059	3.107AlaPhe: 3.107 ± 0.064	3.818AlaGly: 3.818 ± 0.073	0.972AlaHis: 0.972 ± 0.028	6.005AlaIle: 6.005 ± 0.082	4.564AlaLys: 4.564 ± 0.068	5.776AlaLeu: 5.776 ± 0.101	1.441AlaMet: 1.441 ± 0.041	3.306AlaAsn: 3.306 ± 0.064	1.841AlaPro: 1.841 ± 0.044	2.143AlaGln: 2.143 ± 0.048	1.75AlaArg: 1.75 ± 0.045	4.097AlaSer: 4.097 ± 0.073	3.914AlaThr: 3.914 ± 0.072	4.002AlaVal: 4.002 ± 0.076	0.597AlaTrp: 0.597 ± 0.027	2.292AlaTyr: 2.292 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.417CysAla: 0.417 ± 0.021	0.1CysCys: 0.1 ± 0.01	0.445CysAsp: 0.445 ± 0.027	0.479CysGlu: 0.479 ± 0.022	0.395CysPhe: 0.395 ± 0.017	0.588CysGly: 0.588 ± 0.025	0.172CysHis: 0.172 ± 0.02	0.611CysIle: 0.611 ± 0.028	0.564CysLys: 0.564 ± 0.022	0.586CysLeu: 0.586 ± 0.026	0.144CysMet: 0.144 ± 0.013	0.476CysAsn: 0.476 ± 0.02	0.362CysPro: 0.362 ± 0.022	0.184CysGln: 0.184 ± 0.013	0.187CysArg: 0.187 ± 0.012	0.493CysSer: 0.493 ± 0.022	0.414CysThr: 0.414 ± 0.02	0.41CysVal: 0.41 ± 0.02	0.073CysTrp: 0.073 ± 0.009	0.297CysTyr: 0.297 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.523AspAla: 3.523 ± 0.062	0.423AspCys: 0.423 ± 0.022	2.471AspAsp: 2.471 ± 0.065	3.556AspGlu: 3.556 ± 0.065	3.566AspPhe: 3.566 ± 0.07	3.397AspGly: 3.397 ± 0.076	0.689AspHis: 0.689 ± 0.027	4.376AspIle: 4.376 ± 0.065	3.992AspLys: 3.992 ± 0.065	4.95AspLeu: 4.95 ± 0.077	0.964AspMet: 0.964 ± 0.032	3.105AspAsn: 3.105 ± 0.057	1.524AspPro: 1.524 ± 0.044	1.156AspGln: 1.156 ± 0.037	1.631AspArg: 1.631 ± 0.037	3.012AspSer: 3.012 ± 0.059	2.746AspThr: 2.746 ± 0.06	3.388AspVal: 3.388 ± 0.064	0.704AspTrp: 0.704 ± 0.028	2.536AspTyr: 2.536 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.137GluAla: 4.137 ± 0.075	0.34GluCys: 0.34 ± 0.019	3.41GluAsp: 3.41 ± 0.061	4.623GluGlu: 4.623 ± 0.077	3.113GluPhe: 3.113 ± 0.056	3.658GluGly: 3.658 ± 0.069	1.082GluHis: 1.082 ± 0.036	6.42GluIle: 6.42 ± 0.084	6.213GluLys: 6.213 ± 0.079	6.419GluLeu: 6.419 ± 0.091	1.535GluMet: 1.535 ± 0.04	5.333GluAsn: 5.333 ± 0.074	1.424GluPro: 1.424 ± 0.037	2.222GluGln: 2.222 ± 0.045	2.24GluArg: 2.24 ± 0.054	3.235GluSer: 3.235 ± 0.062	3.84GluThr: 3.84 ± 0.069	4.373GluVal: 4.373 ± 0.066	0.584GluTrp: 0.584 ± 0.022	2.334GluTyr: 2.334 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.817PheAla: 2.817 ± 0.059	0.413PheCys: 0.413 ± 0.022	3.097PheAsp: 3.097 ± 0.065	3.627PheGlu: 3.627 ± 0.057	2.74PhePhe: 2.74 ± 0.052	3.631PheGly: 3.631 ± 0.064	0.764PheHis: 0.764 ± 0.028	4.451PheIle: 4.451 ± 0.074	4.598PheLys: 4.598 ± 0.07	4.829PheLeu: 4.829 ± 0.078	1.096PheMet: 1.096 ± 0.033	3.832PheAsn: 3.832 ± 0.073	1.748PhePro: 1.748 ± 0.044	1.436PheGln: 1.436 ± 0.038	1.474PheArg: 1.474 ± 0.041	4.16PheSer: 4.16 ± 0.062	3.064PheThr: 3.064 ± 0.06	3.026PheVal: 3.026 ± 0.058	0.618PheTrp: 0.618 ± 0.021	2.209PheTyr: 2.209 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.107GlyAla: 4.107 ± 0.078	0.574GlyCys: 0.574 ± 0.027	3.163GlyAsp: 3.163 ± 0.072	3.617GlyGlu: 3.617 ± 0.062	3.722GlyPhe: 3.722 ± 0.063	4.473GlyGly: 4.473 ± 0.083	1.047GlyHis: 1.047 ± 0.032	5.627GlyIle: 5.627 ± 0.073	4.908GlyLys: 4.908 ± 0.068	5.439GlyLeu: 5.439 ± 0.071	1.522GlyMet: 1.522 ± 0.042	3.573GlyAsn: 3.573 ± 0.071	1.225GlyPro: 1.225 ± 0.036	1.534GlyGln: 1.534 ± 0.035	1.916GlyArg: 1.916 ± 0.047	3.908GlySer: 3.908 ± 0.068	3.973GlyThr: 3.973 ± 0.073	4.338GlyVal: 4.338 ± 0.078	0.763GlyTrp: 0.763 ± 0.031	2.779GlyTyr: 2.779 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.797HisAla: 0.797 ± 0.029	0.156HisCys: 0.156 ± 0.012	0.671HisAsp: 0.671 ± 0.024	0.832HisGlu: 0.832 ± 0.027	1.1HisPhe: 1.1 ± 0.03	0.983HisGly: 0.983 ± 0.034	0.406HisHis: 0.406 ± 0.02	1.428HisIle: 1.428 ± 0.041	1.325HisLys: 1.325 ± 0.034	1.727HisLeu: 1.727 ± 0.04	0.249HisMet: 0.249 ± 0.014	1.042HisAsn: 1.042 ± 0.028	0.849HisPro: 0.849 ± 0.025	0.684HisGln: 0.684 ± 0.025	0.578HisArg: 0.578 ± 0.024	1.052HisSer: 1.052 ± 0.03	0.928HisThr: 0.928 ± 0.03	0.832HisVal: 0.832 ± 0.028	0.226HisTrp: 0.226 ± 0.015	0.802HisTyr: 0.802 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.884IleAla: 5.884 ± 0.083	0.659IleCys: 0.659 ± 0.028	5.11IleAsp: 5.11 ± 0.065	6.449IleGlu: 6.449 ± 0.08	4.036IlePhe: 4.036 ± 0.08	5.354IleGly: 5.354 ± 0.086	1.398IleHis: 1.398 ± 0.034	7.248IleIle: 7.248 ± 0.107	7.078IleLys: 7.078 ± 0.109	7.823IleLeu: 7.823 ± 0.114	1.494IleMet: 1.494 ± 0.039	5.409IleAsn: 5.409 ± 0.083	3.461IlePro: 3.461 ± 0.064	2.582IleGln: 2.582 ± 0.048	2.455IleArg: 2.455 ± 0.049	6.42IleSer: 6.42 ± 0.076	5.144IleThr: 5.144 ± 0.08	5.169IleVal: 5.169 ± 0.074	0.731IleTrp: 0.731 ± 0.031	3.059IleTyr: 3.059 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.781LysAla: 4.781 ± 0.076	0.386LysCys: 0.386 ± 0.019	4.561LysAsp: 4.561 ± 0.073	6.659LysGlu: 6.659 ± 0.094	3.507LysPhe: 3.507 ± 0.057	4.923LysGly: 4.923 ± 0.079	1.486LysHis: 1.486 ± 0.039	7.404LysIle: 7.404 ± 0.091	7.798LysLys: 7.798 ± 0.106	7.307LysLeu: 7.307 ± 0.098	2.023LysMet: 2.023 ± 0.049	6.733LysAsn: 6.733 ± 0.098	2.564LysPro: 2.564 ± 0.052	2.812LysGln: 2.812 ± 0.057	2.871LysArg: 2.871 ± 0.057	4.934LysSer: 4.934 ± 0.064	5.015LysThr: 5.015 ± 0.067	5.058LysVal: 5.058 ± 0.069	0.795LysTrp: 0.795 ± 0.027	3.448LysTyr: 3.448 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.536LeuAla: 5.536 ± 0.079	0.638LeuCys: 0.638 ± 0.024	4.669LeuAsp: 4.669 ± 0.074	6.217LeuGlu: 6.217 ± 0.08	5.136LeuPhe: 5.136 ± 0.084	5.653LeuGly: 5.653 ± 0.081	1.494LeuHis: 1.494 ± 0.037	7.95LeuIle: 7.95 ± 0.101	8.913LeuLys: 8.913 ± 0.117	8.652LeuLeu: 8.652 ± 0.123	1.888LeuMet: 1.888 ± 0.051	6.553LeuAsn: 6.553 ± 0.09	3.323LeuPro: 3.323 ± 0.058	2.985LeuGln: 2.985 ± 0.051	2.752LeuArg: 2.752 ± 0.054	5.972LeuSer: 5.972 ± 0.081	5.2LeuThr: 5.2 ± 0.069	5.263LeuVal: 5.263 ± 0.076	0.772LeuTrp: 0.772 ± 0.03	3.081LeuTyr: 3.081 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.421MetAla: 1.421 ± 0.046	0.145MetCys: 0.145 ± 0.012	1.033MetAsp: 1.033 ± 0.031	1.239MetGlu: 1.239 ± 0.03	0.875MetPhe: 0.875 ± 0.031	1.324MetGly: 1.324 ± 0.039	0.389MetHis: 0.389 ± 0.018	1.45MetIle: 1.45 ± 0.037	2.091MetLys: 2.091 ± 0.044	1.976MetLeu: 1.976 ± 0.042	0.491MetMet: 0.491 ± 0.021	1.285MetAsn: 1.285 ± 0.033	0.78MetPro: 0.78 ± 0.026	0.751MetGln: 0.751 ± 0.029	0.768MetArg: 0.768 ± 0.027	1.345MetSer: 1.345 ± 0.035	1.032MetThr: 1.032 ± 0.031	1.303MetVal: 1.303 ± 0.036	0.168MetTrp: 0.168 ± 0.011	0.696MetTyr: 0.696 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.859AsnAla: 3.859 ± 0.065	0.511AsnCys: 0.511 ± 0.025	3.09AsnAsp: 3.09 ± 0.062	4.281AsnGlu: 4.281 ± 0.07	3.597AsnPhe: 3.597 ± 0.07	3.988AsnGly: 3.988 ± 0.08	1.091AsnHis: 1.091 ± 0.029	5.602AsnIle: 5.602 ± 0.076	5.477AsnLys: 5.477 ± 0.089	6.191AsnLeu: 6.191 ± 0.085	1.313AsnMet: 1.313 ± 0.036	4.93AsnAsn: 4.93 ± 0.093	2.766AsnPro: 2.766 ± 0.056	2.164AsnGln: 2.164 ± 0.046	2.04AsnArg: 2.04 ± 0.041	4.53AsnSer: 4.53 ± 0.075	4.046AsnThr: 4.046 ± 0.074	3.595AsnVal: 3.595 ± 0.061	0.893AsnTrp: 0.893 ± 0.035	3.364AsnTyr: 3.364 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.725ProAla: 1.725 ± 0.042	0.194ProCys: 0.194 ± 0.014	1.731ProAsp: 1.731 ± 0.044	2.618ProGlu: 2.618 ± 0.056	1.898ProPhe: 1.898 ± 0.045	1.694ProGly: 1.694 ± 0.043	0.587ProHis: 0.587 ± 0.023	3.015ProIle: 3.015 ± 0.053	2.733ProLys: 2.733 ± 0.051	2.811ProLeu: 2.811 ± 0.053	0.672ProMet: 0.672 ± 0.025	2.286ProAsn: 2.286 ± 0.049	0.743ProPro: 0.743 ± 0.029	0.96ProGln: 0.96 ± 0.033	0.844ProArg: 0.844 ± 0.028	2.027ProSer: 2.027 ± 0.051	2.115ProThr: 2.115 ± 0.055	2.08ProVal: 2.08 ± 0.049	0.36ProTrp: 0.36 ± 0.022	1.332ProTyr: 1.332 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.715GlnAla: 1.715 ± 0.047	0.186GlnCys: 0.186 ± 0.012	1.409GlnAsp: 1.409 ± 0.034	2.148GlnGlu: 2.148 ± 0.047	1.73GlnPhe: 1.73 ± 0.042	1.663GlnGly: 1.663 ± 0.04	0.58GlnHis: 0.58 ± 0.024	2.557GlnIle: 2.557 ± 0.052	2.831GlnLys: 2.831 ± 0.058	3.469GlnLeu: 3.469 ± 0.065	0.699GlnMet: 0.699 ± 0.025	2.039GlnAsn: 2.039 ± 0.046	0.954GlnPro: 0.954 ± 0.027	1.5GlnGln: 1.5 ± 0.04	1.035GlnArg: 1.035 ± 0.032	1.63GlnSer: 1.63 ± 0.041	1.649GlnThr: 1.649 ± 0.041	1.716GlnVal: 1.716 ± 0.046	0.291GlnTrp: 0.291 ± 0.016	1.194GlnTyr: 1.194 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.946ArgAla: 1.946 ± 0.04	0.193ArgCys: 0.193 ± 0.013	1.557ArgAsp: 1.557 ± 0.037	1.884ArgGlu: 1.884 ± 0.048	1.708ArgPhe: 1.708 ± 0.039	1.795ArgGly: 1.795 ± 0.048	0.546ArgHis: 0.546 ± 0.023	2.718ArgIle: 2.718 ± 0.047	2.674ArgLys: 2.674 ± 0.052	2.89ArgLeu: 2.89 ± 0.057	0.764ArgMet: 0.764 ± 0.025	2.016ArgAsn: 2.016 ± 0.051	0.95ArgPro: 0.95 ± 0.03	0.872ArgGln: 0.872 ± 0.031	1.12ArgArg: 1.12 ± 0.037	1.733ArgSer: 1.733 ± 0.04	1.795ArgThr: 1.795 ± 0.044	1.827ArgVal: 1.827 ± 0.043	0.369ArgTrp: 0.369 ± 0.018	1.32ArgTyr: 1.32 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.496SerAla: 3.496 ± 0.053	0.684SerCys: 0.684 ± 0.027	3.331SerAsp: 3.331 ± 0.057	4.397SerGlu: 4.397 ± 0.065	3.786SerPhe: 3.786 ± 0.056	4.276SerGly: 4.276 ± 0.074	1.071SerHis: 1.071 ± 0.033	5.722SerIle: 5.722 ± 0.085	5.882SerLys: 5.882 ± 0.075	5.748SerLeu: 5.748 ± 0.071	1.211SerMet: 1.211 ± 0.031	4.314SerAsn: 4.314 ± 0.075	1.892SerPro: 1.892 ± 0.045	1.864SerGln: 1.864 ± 0.043	1.926SerArg: 1.926 ± 0.044	4.131SerSer: 4.131 ± 0.072	3.475SerThr: 3.475 ± 0.061	3.765SerVal: 3.765 ± 0.059	0.747SerTrp: 0.747 ± 0.028	2.725SerTyr: 2.725 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.685ThrAla: 3.685 ± 0.077	0.394ThrCys: 0.394 ± 0.022	3.086ThrAsp: 3.086 ± 0.057	3.515ThrGlu: 3.515 ± 0.054	3.052ThrPhe: 3.052 ± 0.053	3.894ThrGly: 3.894 ± 0.076	0.964ThrHis: 0.964 ± 0.031	5.652ThrIle: 5.652 ± 0.083	4.391ThrLys: 4.391 ± 0.069	5.26ThrLeu: 5.26 ± 0.076	0.964ThrMet: 0.964 ± 0.028	3.729ThrAsn: 3.729 ± 0.073	2.321ThrPro: 2.321 ± 0.049	1.671ThrGln: 1.671 ± 0.043	1.531ThrArg: 1.531 ± 0.04	4.044ThrSer: 4.044 ± 0.068	3.642ThrThr: 3.642 ± 0.07	3.683ThrVal: 3.683 ± 0.08	0.575ThrTrp: 0.575 ± 0.03	2.359ThrTyr: 2.359 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	3.928ValAla: 3.928 ± 0.072	0.484ValCys: 0.484 ± 0.02	3.368ValAsp: 3.368 ± 0.067	3.957ValGlu: 3.957 ± 0.061	3.338ValPhe: 3.338 ± 0.053	3.785ValGly: 3.785 ± 0.073	1.0ValHis: 1.0 ± 0.03	5.076ValIle: 5.076 ± 0.07	4.665ValLys: 4.665 ± 0.066	5.953ValLeu: 5.953 ± 0.073	1.102ValMet: 1.102 ± 0.031	3.71ValAsn: 3.71 ± 0.064	1.978ValPro: 1.978 ± 0.05	1.715ValGln: 1.715 ± 0.039	1.846ValArg: 1.846 ± 0.042	4.339ValSer: 4.339 ± 0.06	3.498ValThr: 3.498 ± 0.081	3.981ValVal: 3.981 ± 0.077	0.596ValTrp: 0.596 ± 0.025	2.194ValTyr: 2.194 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.629TrpAla: 0.629 ± 0.027	0.101TrpCys: 0.101 ± 0.01	0.6TrpAsp: 0.6 ± 0.024	0.672TrpGlu: 0.672 ± 0.027	0.608TrpPhe: 0.608 ± 0.026	0.715TrpGly: 0.715 ± 0.031	0.208TrpHis: 0.208 ± 0.012	0.763TrpIle: 0.763 ± 0.029	0.847TrpLys: 0.847 ± 0.026	0.942TrpLeu: 0.942 ± 0.034	0.307TrpMet: 0.307 ± 0.017	0.743TrpAsn: 0.743 ± 0.026	0.24TrpPro: 0.24 ± 0.016	0.362TrpGln: 0.362 ± 0.017	0.408TrpArg: 0.408 ± 0.019	0.655TrpSer: 0.655 ± 0.026	0.525TrpThr: 0.525 ± 0.024	0.602TrpVal: 0.602 ± 0.024	0.15TrpTrp: 0.15 ± 0.013	0.448TrpTyr: 0.448 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.038	0.294TyrCys: 0.294 ± 0.015	2.011TyrAsp: 2.011 ± 0.043	2.05TyrGlu: 2.05 ± 0.042	2.615TyrPhe: 2.615 ± 0.059	2.594TyrGly: 2.594 ± 0.055	0.72TyrHis: 0.72 ± 0.027	2.886TyrIle: 2.886 ± 0.047	3.519TyrLys: 3.519 ± 0.056	3.902TyrLeu: 3.902 ± 0.07	0.68TyrMet: 0.68 ± 0.026	2.913TyrAsn: 2.913 ± 0.056	1.481TyrPro: 1.481 ± 0.041	1.399TyrGln: 1.399 ± 0.035	1.302TyrArg: 1.302 ± 0.034	2.728TyrSer: 2.728 ± 0.056	2.396TyrThr: 2.396 ± 0.053	2.103TyrVal: 2.103 ± 0.041	0.514TyrTrp: 0.514 ± 0.024	1.885TyrTyr: 1.885 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3093 proteins (1079700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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