Human papillomavirus 157

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 12

Average proteome isoelectric point is 5.9

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A166FK68|A0A166FK68_9PAPI Major capsid protein L1 OS=Human papillomavirus 157 OX=2259331 GN=L1 PE=3 SV=1
MM1 pKa = 7.07EE2 pKa = 5.43AKK4 pKa = 9.35TRR6 pKa = 11.84RR7 pKa = 11.84KK8 pKa = 9.5RR9 pKa = 11.84AAPDD13 pKa = 2.91QLYY16 pKa = 9.56RR17 pKa = 11.84HH18 pKa = 6.65CLQGGDD24 pKa = 5.15CIPDD28 pKa = 3.33VQNKK32 pKa = 9.5YY33 pKa = 7.08EE34 pKa = 4.1QKK36 pKa = 8.24TWADD40 pKa = 3.39VLLKK44 pKa = 10.51IFGSLLYY51 pKa = 10.37FGNLGIGTGRR61 pKa = 11.84GSGGSLGYY69 pKa = 10.22RR70 pKa = 11.84PLGTTRR76 pKa = 11.84VGEE79 pKa = 4.19VAPITPARR87 pKa = 11.84PSILIDD93 pKa = 3.34AVGPTDD99 pKa = 4.03VVPIDD104 pKa = 3.76ASTPAIVPLAEE115 pKa = 4.29GTLDD119 pKa = 3.39TGFIAPDD126 pKa = 3.64AGPGVGVEE134 pKa = 4.06EE135 pKa = 4.93LEE137 pKa = 4.95LYY139 pKa = 9.16TINDD143 pKa = 3.5PTTDD147 pKa = 3.2VGGVQPTPTVVSTEE161 pKa = 3.95EE162 pKa = 3.94GAVAIIDD169 pKa = 3.8AQPVPEE175 pKa = 4.45RR176 pKa = 11.84PVQVFYY182 pKa = 11.26DD183 pKa = 4.21PNPVTDD189 pKa = 3.39SSVNIFPAYY198 pKa = 6.87PTTSTDD204 pKa = 2.67VSIFVDD210 pKa = 3.74SFSSDD215 pKa = 3.5VIGGFDD221 pKa = 4.42EE222 pKa = 5.7IPLQRR227 pKa = 11.84LDD229 pKa = 4.02FSEE232 pKa = 5.67LDD234 pKa = 3.58IEE236 pKa = 5.38DD237 pKa = 3.82IPAASTPVQKK247 pKa = 10.92VEE249 pKa = 4.04AALSRR254 pKa = 11.84AKK256 pKa = 10.29SLYY259 pKa = 9.9SRR261 pKa = 11.84YY262 pKa = 9.34FKK264 pKa = 10.36QVPVRR269 pKa = 11.84SSRR272 pKa = 11.84FLTQPSSLVQFEE284 pKa = 4.64FEE286 pKa = 4.14NPAFEE291 pKa = 4.52SEE293 pKa = 3.71ISIQVEE299 pKa = 3.48RR300 pKa = 11.84DD301 pKa = 3.18LAQVTAAPDD310 pKa = 3.23AEE312 pKa = 4.26FADD315 pKa = 4.9VITLHH320 pKa = 6.76RR321 pKa = 11.84PQLSSVEE328 pKa = 3.98GTVRR332 pKa = 11.84VSRR335 pKa = 11.84LGEE338 pKa = 3.99TGTMSTRR345 pKa = 11.84SGLIIGQRR353 pKa = 11.84VHH355 pKa = 7.27FYY357 pKa = 10.82HH358 pKa = 7.41DD359 pKa = 3.55LSEE362 pKa = 4.25IQPAEE367 pKa = 4.27NIEE370 pKa = 3.95MAILGEE376 pKa = 4.03HH377 pKa = 6.37SGLNTVVDD385 pKa = 5.58DD386 pKa = 4.17ILSSTVVDD394 pKa = 3.75PTNATNIQYY403 pKa = 10.4PEE405 pKa = 4.06DD406 pKa = 5.35AILDD410 pKa = 4.13DD411 pKa = 5.13LDD413 pKa = 4.28EE414 pKa = 5.68DD415 pKa = 4.08FTNTHH420 pKa = 6.26LVVTNTAEE428 pKa = 4.1NEE430 pKa = 4.11EE431 pKa = 4.37SDD433 pKa = 4.18LVPTIVLRR441 pKa = 11.84NSSTTVTADD450 pKa = 2.9INNGVYY456 pKa = 10.22VSYY459 pKa = 10.93PNTLNNVFTPQIISPASILPQYY481 pKa = 10.47VIEE484 pKa = 4.27TFHH487 pKa = 7.75DD488 pKa = 4.76FFLTPDD494 pKa = 4.04LYY496 pKa = 9.76PRR498 pKa = 11.84KK499 pKa = 9.51RR500 pKa = 11.84RR501 pKa = 11.84RR502 pKa = 11.84IDD504 pKa = 3.29FFF506 pKa = 5.79

Molecular weight: 55.11 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A166FK53|A0A166FK53_9PAPI Minor capsid protein L2 OS=Human papillomavirus 157 OX=2259331 GN=L2 PE=3 SV=1
MM1 pKa = 7.32EE2 pKa = 4.51TQQTLAEE9 pKa = 4.16RR10 pKa = 11.84FAAQQEE16 pKa = 4.55TQMTLIEE23 pKa = 4.15QEE25 pKa = 4.28STNLRR30 pKa = 11.84DD31 pKa = 4.91HH32 pKa = 5.8ITYY35 pKa = 9.13WDD37 pKa = 3.62SVRR40 pKa = 11.84QEE42 pKa = 3.96NLLAFYY48 pKa = 10.33AKK50 pKa = 10.41KK51 pKa = 10.28EE52 pKa = 4.4GYY54 pKa = 7.23THH56 pKa = 7.86LGLQPLAALAVSEE69 pKa = 4.36YY70 pKa = 10.15RR71 pKa = 11.84CKK73 pKa = 10.71EE74 pKa = 3.72AMKK77 pKa = 10.15MKK79 pKa = 9.73MLLISLSKK87 pKa = 10.08SAYY90 pKa = 9.94GNEE93 pKa = 3.88PWTLSDD99 pKa = 4.6VSAEE103 pKa = 4.84LINTSPKK110 pKa = 10.65NCFKK114 pKa = 11.08KK115 pKa = 10.49NAFTVTVYY123 pKa = 10.67FDD125 pKa = 3.46NDD127 pKa = 3.3DD128 pKa = 4.11RR129 pKa = 11.84NTFPYY134 pKa = 10.05VCWEE138 pKa = 3.98SIYY141 pKa = 10.87YY142 pKa = 9.67QDD144 pKa = 5.72EE145 pKa = 3.79NSEE148 pKa = 3.91WHH150 pKa = 6.04KK151 pKa = 11.02VAGEE155 pKa = 3.89VDD157 pKa = 3.77VNGLYY162 pKa = 10.49FKK164 pKa = 10.57EE165 pKa = 3.91ITGDD169 pKa = 2.81ISYY172 pKa = 9.87FQLFQPDD179 pKa = 3.5AEE181 pKa = 4.77KK182 pKa = 10.95YY183 pKa = 8.49GHH185 pKa = 6.14SGHH188 pKa = 6.59WSVRR192 pKa = 11.84YY193 pKa = 9.74KK194 pKa = 10.93NQILSTSVTSSSRR207 pKa = 11.84AAAEE211 pKa = 4.0PEE213 pKa = 4.15SRR215 pKa = 11.84TEE217 pKa = 3.98RR218 pKa = 11.84PPTHH222 pKa = 7.22PISVPKK228 pKa = 9.87TPRR231 pKa = 11.84KK232 pKa = 9.55RR233 pKa = 11.84RR234 pKa = 11.84RR235 pKa = 11.84QTDD238 pKa = 2.87EE239 pKa = 3.69DD240 pKa = 4.38TNRR243 pKa = 11.84EE244 pKa = 4.36SPTSTSSGLRR254 pKa = 11.84LRR256 pKa = 11.84RR257 pKa = 11.84RR258 pKa = 11.84GSEE261 pKa = 3.75QGEE264 pKa = 4.55SSTDD268 pKa = 3.09GATTRR273 pKa = 11.84RR274 pKa = 11.84RR275 pKa = 11.84RR276 pKa = 11.84SRR278 pKa = 11.84TRR280 pKa = 11.84RR281 pKa = 11.84ISDD284 pKa = 3.76GSAVSPEE291 pKa = 4.07QVGSRR296 pKa = 11.84TEE298 pKa = 3.93SVPRR302 pKa = 11.84EE303 pKa = 3.62GLGRR307 pKa = 11.84IEE309 pKa = 4.25RR310 pKa = 11.84LQEE313 pKa = 3.72EE314 pKa = 4.49ARR316 pKa = 11.84DD317 pKa = 3.77PPVILIQGCANNLKK331 pKa = 10.35CFRR334 pKa = 11.84NRR336 pKa = 11.84NHH338 pKa = 6.61HH339 pKa = 5.06RR340 pKa = 11.84HH341 pKa = 4.62KK342 pKa = 10.32HH343 pKa = 5.08LYY345 pKa = 9.19LAASTVFTWVYY356 pKa = 10.65SNNDD360 pKa = 3.17RR361 pKa = 11.84TPQGRR366 pKa = 11.84MLVSFTSNSQRR377 pKa = 11.84DD378 pKa = 3.66LFLRR382 pKa = 11.84TVTIPKK388 pKa = 8.92GCRR391 pKa = 11.84YY392 pKa = 10.29CFGTLDD398 pKa = 3.85CLL400 pKa = 4.18

Molecular weight: 45.9 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2248

93

601

374.7

42.36

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.139 ± 0.317

2.491 ± 0.784

6.717 ± 0.512

6.228 ± 0.408

4.982 ± 0.467

5.071 ± 0.761

1.957 ± 0.273

5.205 ± 0.468

5.071 ± 0.868

8.541 ± 0.403

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.646 ± 0.36

5.16 ± 0.607

5.427 ± 0.86

4.226 ± 0.132

5.649 ± 0.927

7.518 ± 0.689

6.895 ± 0.605

6.361 ± 0.648

1.201 ± 0.224

3.514 ± 0.227
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski