Amino acid dipepetide frequency for Streptococcus satellite phage Javan15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.264AlaAla: 0.264 ± 0.312
1.055AlaCys: 1.055 ± 0.388
4.749AlaAsp: 4.749 ± 1.389
4.749AlaGlu: 4.749 ± 1.285
2.375AlaPhe: 2.375 ± 0.793
1.583AlaGly: 1.583 ± 0.754
0.264AlaHis: 0.264 ± 0.217
7.388AlaIle: 7.388 ± 0.906
3.694AlaLys: 3.694 ± 1.122
4.222AlaLeu: 4.222 ± 0.886
1.055AlaMet: 1.055 ± 0.468
4.485AlaAsn: 4.485 ± 1.077
1.583AlaPro: 1.583 ± 0.502
1.847AlaGln: 1.847 ± 0.793
1.583AlaArg: 1.583 ± 0.449
2.902AlaSer: 2.902 ± 0.87
3.958AlaThr: 3.958 ± 0.858
2.902AlaVal: 2.902 ± 0.865
0.792AlaTrp: 0.792 ± 0.427
2.111AlaTyr: 2.111 ± 0.608
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.528CysAsp: 0.528 ± 0.326
0.264CysGlu: 0.264 ± 0.245
0.0CysPhe: 0.0 ± 0.0
0.528CysGly: 0.528 ± 0.346
0.528CysHis: 0.528 ± 0.324
0.264CysIle: 0.264 ± 0.295
0.264CysLys: 0.264 ± 0.204
0.792CysLeu: 0.792 ± 0.357
0.0CysMet: 0.0 ± 0.0
0.792CysAsn: 0.792 ± 0.448
0.264CysPro: 0.264 ± 0.245
0.528CysGln: 0.528 ± 0.49
0.528CysArg: 0.528 ± 0.318
0.264CysSer: 0.264 ± 0.268
0.0CysThr: 0.0 ± 0.0
0.264CysVal: 0.264 ± 0.244
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.528AspAla: 0.528 ± 0.342
1.055AspCys: 1.055 ± 0.548
2.902AspAsp: 2.902 ± 0.783
4.749AspGlu: 4.749 ± 0.918
4.222AspPhe: 4.222 ± 0.955
1.319AspGly: 1.319 ± 0.482
0.792AspHis: 0.792 ± 0.411
3.694AspIle: 3.694 ± 0.969
7.388AspLys: 7.388 ± 1.448
6.596AspLeu: 6.596 ± 1.112
2.375AspMet: 2.375 ± 0.701
2.902AspAsn: 2.902 ± 0.709
1.055AspPro: 1.055 ± 0.543
0.792AspGln: 0.792 ± 0.41
4.485AspArg: 4.485 ± 0.727
2.111AspSer: 2.111 ± 0.563
2.902AspThr: 2.902 ± 0.91
1.847AspVal: 1.847 ± 0.718
0.792AspTrp: 0.792 ± 0.38
3.694AspTyr: 3.694 ± 0.977
0.0AspXaa: 0.0 ± 0.0
Glu
5.805GluAla: 5.805 ± 0.781
0.264GluCys: 0.264 ± 0.245
5.277GluAsp: 5.277 ± 1.242
3.694GluGlu: 3.694 ± 0.856
2.111GluPhe: 2.111 ± 0.489
3.694GluGly: 3.694 ± 0.909
2.111GluHis: 2.111 ± 0.645
6.596GluIle: 6.596 ± 1.034
7.652GluLys: 7.652 ± 1.12
11.609GluLeu: 11.609 ± 1.54
1.847GluMet: 1.847 ± 0.617
3.166GluAsn: 3.166 ± 0.673
0.792GluPro: 0.792 ± 0.351
5.277GluGln: 5.277 ± 1.448
4.222GluArg: 4.222 ± 0.833
4.485GluSer: 4.485 ± 0.982
6.86GluThr: 6.86 ± 1.216
3.43GluVal: 3.43 ± 1.039
0.792GluTrp: 0.792 ± 0.398
3.694GluTyr: 3.694 ± 1.026
0.0GluXaa: 0.0 ± 0.0
Phe
1.319PheAla: 1.319 ± 0.547
0.264PheCys: 0.264 ± 0.204
2.902PheAsp: 2.902 ± 0.83
3.43PheGlu: 3.43 ± 0.796
1.319PhePhe: 1.319 ± 0.58
1.319PheGly: 1.319 ± 0.484
1.055PheHis: 1.055 ± 0.414
4.485PheIle: 4.485 ± 1.233
5.013PheLys: 5.013 ± 0.759
3.166PheLeu: 3.166 ± 0.598
0.264PheMet: 0.264 ± 0.251
4.749PheAsn: 4.749 ± 0.766
1.319PhePro: 1.319 ± 0.599
1.583PheGln: 1.583 ± 0.56
2.639PheArg: 2.639 ± 0.937
3.694PheSer: 3.694 ± 0.684
1.847PheThr: 1.847 ± 0.704
2.111PheVal: 2.111 ± 0.661
0.528PheTrp: 0.528 ± 0.305
2.639PheTyr: 2.639 ± 0.581
0.0PheXaa: 0.0 ± 0.0
Gly
2.375GlyAla: 2.375 ± 0.908
0.264GlyCys: 0.264 ± 0.234
2.902GlyAsp: 2.902 ± 0.945
3.694GlyGlu: 3.694 ± 1.094
2.902GlyPhe: 2.902 ± 0.711
1.319GlyGly: 1.319 ± 0.509
0.528GlyHis: 0.528 ± 0.332
2.902GlyIle: 2.902 ± 0.627
3.166GlyLys: 3.166 ± 0.856
5.541GlyLeu: 5.541 ± 1.533
0.792GlyMet: 0.792 ± 0.369
1.847GlyAsn: 1.847 ± 0.824
0.0GlyPro: 0.0 ± 0.0
1.055GlyGln: 1.055 ± 0.408
2.375GlyArg: 2.375 ± 0.728
1.055GlySer: 1.055 ± 0.469
2.639GlyThr: 2.639 ± 0.878
2.639GlyVal: 2.639 ± 0.839
0.528GlyTrp: 0.528 ± 0.408
3.694GlyTyr: 3.694 ± 1.213
0.0GlyXaa: 0.0 ± 0.0
His
2.375HisAla: 2.375 ± 0.651
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.528HisGlu: 0.528 ± 0.408
1.847HisPhe: 1.847 ± 0.48
1.055HisGly: 1.055 ± 0.524
0.0HisHis: 0.0 ± 0.0
0.792HisIle: 0.792 ± 0.425
1.319HisLys: 1.319 ± 0.55
1.319HisLeu: 1.319 ± 0.471
0.0HisMet: 0.0 ± 0.0
1.583HisAsn: 1.583 ± 0.657
0.264HisPro: 0.264 ± 0.243
0.792HisGln: 0.792 ± 0.564
0.264HisArg: 0.264 ± 0.268
1.055HisSer: 1.055 ± 0.643
1.847HisThr: 1.847 ± 0.613
1.055HisVal: 1.055 ± 0.545
0.264HisTrp: 0.264 ± 0.245
2.639HisTyr: 2.639 ± 0.749
0.0HisXaa: 0.0 ± 0.0
Ile
4.222IleAla: 4.222 ± 1.121
0.528IleCys: 0.528 ± 0.324
5.013IleAsp: 5.013 ± 0.828
6.069IleGlu: 6.069 ± 1.3
3.43IlePhe: 3.43 ± 0.841
2.639IleGly: 2.639 ± 0.558
1.319IleHis: 1.319 ± 0.606
5.013IleIle: 5.013 ± 1.088
10.026IleLys: 10.026 ± 1.944
4.485IleLeu: 4.485 ± 1.117
1.319IleMet: 1.319 ± 0.686
3.694IleAsn: 3.694 ± 1.084
2.902IlePro: 2.902 ± 0.83
1.847IleGln: 1.847 ± 0.68
1.583IleArg: 1.583 ± 0.504
3.694IleSer: 3.694 ± 1.109
5.013IleThr: 5.013 ± 1.05
3.43IleVal: 3.43 ± 0.764
0.0IleTrp: 0.0 ± 0.0
4.749IleTyr: 4.749 ± 0.865
0.0IleXaa: 0.0 ± 0.0
Lys
8.707LysAla: 8.707 ± 1.655
0.264LysCys: 0.264 ± 0.236
3.694LysAsp: 3.694 ± 1.271
8.443LysGlu: 8.443 ± 1.482
2.639LysPhe: 2.639 ± 0.741
2.639LysGly: 2.639 ± 0.811
3.166LysHis: 3.166 ± 0.736
5.013LysIle: 5.013 ± 1.229
9.235LysLys: 9.235 ± 1.402
8.971LysLeu: 8.971 ± 1.438
3.166LysMet: 3.166 ± 0.998
4.222LysAsn: 4.222 ± 0.996
4.222LysPro: 4.222 ± 1.102
4.485LysGln: 4.485 ± 1.259
5.277LysArg: 5.277 ± 1.269
6.069LysSer: 6.069 ± 1.465
4.749LysThr: 4.749 ± 1.048
4.222LysVal: 4.222 ± 0.813
0.528LysTrp: 0.528 ± 0.387
5.013LysTyr: 5.013 ± 1.29
0.0LysXaa: 0.0 ± 0.0
Leu
5.013LeuAla: 5.013 ± 1.367
0.264LeuCys: 0.264 ± 0.245
6.86LeuAsp: 6.86 ± 1.142
11.873LeuGlu: 11.873 ± 2.376
5.541LeuPhe: 5.541 ± 0.945
5.805LeuGly: 5.805 ± 1.428
1.319LeuHis: 1.319 ± 0.54
5.805LeuIle: 5.805 ± 1.497
7.916LeuLys: 7.916 ± 1.414
7.388LeuLeu: 7.388 ± 1.401
2.375LeuMet: 2.375 ± 0.611
6.069LeuAsn: 6.069 ± 1.344
3.166LeuPro: 3.166 ± 1.152
2.902LeuGln: 2.902 ± 0.733
3.166LeuArg: 3.166 ± 0.858
7.388LeuSer: 7.388 ± 1.126
4.749LeuThr: 4.749 ± 0.8
4.749LeuVal: 4.749 ± 1.029
0.792LeuTrp: 0.792 ± 0.336
3.43LeuTyr: 3.43 ± 0.652
0.0LeuXaa: 0.0 ± 0.0
Met
1.319MetAla: 1.319 ± 0.689
0.0MetCys: 0.0 ± 0.0
1.319MetAsp: 1.319 ± 0.579
1.319MetGlu: 1.319 ± 0.477
0.792MetPhe: 0.792 ± 0.468
0.792MetGly: 0.792 ± 0.37
0.264MetHis: 0.264 ± 0.312
1.583MetIle: 1.583 ± 0.479
1.847MetLys: 1.847 ± 0.594
3.43MetLeu: 3.43 ± 0.696
0.264MetMet: 0.264 ± 0.262
1.847MetAsn: 1.847 ± 0.699
0.528MetPro: 0.528 ± 0.317
0.528MetGln: 0.528 ± 0.371
1.319MetArg: 1.319 ± 0.443
1.319MetSer: 1.319 ± 0.597
2.639MetThr: 2.639 ± 0.869
0.792MetVal: 0.792 ± 0.428
0.0MetTrp: 0.0 ± 0.0
0.264MetTyr: 0.264 ± 0.236
0.0MetXaa: 0.0 ± 0.0
Asn
4.749AsnAla: 4.749 ± 0.9
0.0AsnCys: 0.0 ± 0.0
3.43AsnAsp: 3.43 ± 0.861
2.902AsnGlu: 2.902 ± 0.744
1.055AsnPhe: 1.055 ± 0.439
3.43AsnGly: 3.43 ± 0.853
1.319AsnHis: 1.319 ± 0.57
3.43AsnIle: 3.43 ± 0.993
4.749AsnLys: 4.749 ± 0.626
5.277AsnLeu: 5.277 ± 1.267
1.319AsnMet: 1.319 ± 0.768
2.375AsnAsn: 2.375 ± 0.559
2.639AsnPro: 2.639 ± 0.6
3.958AsnGln: 3.958 ± 1.029
3.43AsnArg: 3.43 ± 0.519
2.375AsnSer: 2.375 ± 0.651
3.694AsnThr: 3.694 ± 1.163
3.166AsnVal: 3.166 ± 0.827
0.792AsnTrp: 0.792 ± 0.419
3.166AsnTyr: 3.166 ± 0.86
0.0AsnXaa: 0.0 ± 0.0
Pro
1.319ProAla: 1.319 ± 0.357
0.264ProCys: 0.264 ± 0.268
1.583ProAsp: 1.583 ± 0.583
2.375ProGlu: 2.375 ± 0.988
1.847ProPhe: 1.847 ± 0.593
0.528ProGly: 0.528 ± 0.401
0.264ProHis: 0.264 ± 0.295
1.583ProIle: 1.583 ± 0.667
4.485ProLys: 4.485 ± 1.226
2.902ProLeu: 2.902 ± 0.725
0.264ProMet: 0.264 ± 0.245
2.639ProAsn: 2.639 ± 0.922
1.055ProPro: 1.055 ± 0.438
1.319ProGln: 1.319 ± 0.647
2.111ProArg: 2.111 ± 0.693
1.847ProSer: 1.847 ± 0.6
1.319ProThr: 1.319 ± 0.507
1.847ProVal: 1.847 ± 0.717
0.264ProTrp: 0.264 ± 0.204
1.055ProTyr: 1.055 ± 0.475
0.0ProXaa: 0.0 ± 0.0
Gln
3.43GlnAla: 3.43 ± 0.629
0.0GlnCys: 0.0 ± 0.0
1.055GlnAsp: 1.055 ± 0.611
5.805GlnGlu: 5.805 ± 1.414
1.055GlnPhe: 1.055 ± 0.481
2.639GlnGly: 2.639 ± 0.971
0.528GlnHis: 0.528 ± 0.365
2.111GlnIle: 2.111 ± 0.475
2.902GlnLys: 2.902 ± 0.835
4.222GlnLeu: 4.222 ± 0.836
0.792GlnMet: 0.792 ± 0.416
2.902GlnAsn: 2.902 ± 0.938
1.847GlnPro: 1.847 ± 0.845
1.847GlnGln: 1.847 ± 0.572
1.847GlnArg: 1.847 ± 0.602
2.375GlnSer: 2.375 ± 0.669
1.847GlnThr: 1.847 ± 0.714
2.902GlnVal: 2.902 ± 0.69
0.792GlnTrp: 0.792 ± 0.487
1.583GlnTyr: 1.583 ± 0.728
0.0GlnXaa: 0.0 ± 0.0
Arg
2.111ArgAla: 2.111 ± 1.063
0.528ArgCys: 0.528 ± 0.385
1.583ArgAsp: 1.583 ± 0.5
4.222ArgGlu: 4.222 ± 1.083
1.847ArgPhe: 1.847 ± 0.484
2.111ArgGly: 2.111 ± 0.779
1.055ArgHis: 1.055 ± 0.395
3.694ArgIle: 3.694 ± 1.12
3.166ArgLys: 3.166 ± 0.812
6.069ArgLeu: 6.069 ± 1.242
0.792ArgMet: 0.792 ± 0.434
3.166ArgAsn: 3.166 ± 0.849
1.583ArgPro: 1.583 ± 0.583
2.639ArgGln: 2.639 ± 0.806
1.847ArgArg: 1.847 ± 0.544
2.375ArgSer: 2.375 ± 0.876
3.166ArgThr: 3.166 ± 0.92
4.485ArgVal: 4.485 ± 0.872
0.528ArgTrp: 0.528 ± 0.391
2.111ArgTyr: 2.111 ± 0.574
0.0ArgXaa: 0.0 ± 0.0
Ser
1.847SerAla: 1.847 ± 0.746
0.0SerCys: 0.0 ± 0.0
4.222SerAsp: 4.222 ± 0.845
6.86SerGlu: 6.86 ± 1.475
2.902SerPhe: 2.902 ± 0.707
1.847SerGly: 1.847 ± 0.75
0.528SerHis: 0.528 ± 0.318
4.485SerIle: 4.485 ± 1.091
5.805SerLys: 5.805 ± 1.156
4.485SerLeu: 4.485 ± 0.953
1.583SerMet: 1.583 ± 0.74
2.111SerAsn: 2.111 ± 0.587
1.055SerPro: 1.055 ± 0.409
2.639SerGln: 2.639 ± 0.969
2.111SerArg: 2.111 ± 0.726
1.319SerSer: 1.319 ± 0.387
3.166SerThr: 3.166 ± 0.777
3.694SerVal: 3.694 ± 1.003
0.792SerTrp: 0.792 ± 0.391
4.485SerTyr: 4.485 ± 1.026
0.0SerXaa: 0.0 ± 0.0
Thr
3.958ThrAla: 3.958 ± 1.042
0.264ThrCys: 0.264 ± 0.245
3.166ThrAsp: 3.166 ± 1.031
4.222ThrGlu: 4.222 ± 0.633
3.958ThrPhe: 3.958 ± 1.382
3.694ThrGly: 3.694 ± 0.933
1.583ThrHis: 1.583 ± 0.656
5.013ThrIle: 5.013 ± 1.615
5.013ThrLys: 5.013 ± 1.112
5.277ThrLeu: 5.277 ± 1.117
1.319ThrMet: 1.319 ± 0.482
1.583ThrAsn: 1.583 ± 0.686
2.375ThrPro: 2.375 ± 0.824
3.958ThrGln: 3.958 ± 1.009
4.222ThrArg: 4.222 ± 0.723
1.847ThrSer: 1.847 ± 0.677
4.222ThrThr: 4.222 ± 1.565
2.902ThrVal: 2.902 ± 1.209
0.528ThrTrp: 0.528 ± 0.305
2.902ThrTyr: 2.902 ± 0.894
0.0ThrXaa: 0.0 ± 0.0
Val
2.375ValAla: 2.375 ± 0.662
0.264ValCys: 0.264 ± 0.204
1.847ValAsp: 1.847 ± 0.622
2.639ValGlu: 2.639 ± 0.787
2.375ValPhe: 2.375 ± 0.788
2.111ValGly: 2.111 ± 0.557
0.792ValHis: 0.792 ± 0.501
3.694ValIle: 3.694 ± 1.088
4.749ValLys: 4.749 ± 1.035
6.332ValLeu: 6.332 ± 1.406
1.055ValMet: 1.055 ± 0.524
2.902ValAsn: 2.902 ± 0.811
2.111ValPro: 2.111 ± 0.821
2.111ValGln: 2.111 ± 0.822
1.583ValArg: 1.583 ± 0.627
5.805ValSer: 5.805 ± 1.574
5.013ValThr: 5.013 ± 1.445
2.902ValVal: 2.902 ± 0.756
0.0ValTrp: 0.0 ± 0.0
1.055ValTyr: 1.055 ± 0.45
0.0ValXaa: 0.0 ± 0.0
Trp
0.264TrpAla: 0.264 ± 0.26
0.0TrpCys: 0.0 ± 0.0
0.792TrpAsp: 0.792 ± 0.36
1.583TrpGlu: 1.583 ± 0.487
0.528TrpPhe: 0.528 ± 0.348
0.264TrpGly: 0.264 ± 0.268
0.264TrpHis: 0.264 ± 0.204
0.792TrpIle: 0.792 ± 0.433
0.528TrpLys: 0.528 ± 0.318
0.792TrpLeu: 0.792 ± 0.365
0.0TrpMet: 0.0 ± 0.0
0.264TrpAsn: 0.264 ± 0.26
0.264TrpPro: 0.264 ± 0.204
0.528TrpGln: 0.528 ± 0.301
0.264TrpArg: 0.264 ± 0.204
0.792TrpSer: 0.792 ± 0.335
0.0TrpThr: 0.0 ± 0.0
1.055TrpVal: 1.055 ± 0.467
0.528TrpTrp: 0.528 ± 0.313
0.264TrpTyr: 0.264 ± 0.204
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.583TyrAla: 1.583 ± 0.625
0.528TyrCys: 0.528 ± 0.336
2.375TyrAsp: 2.375 ± 0.571
3.958TyrGlu: 3.958 ± 0.775
2.902TyrPhe: 2.902 ± 0.747
2.902TyrGly: 2.902 ± 0.812
1.319TyrHis: 1.319 ± 0.562
2.902TyrIle: 2.902 ± 1.019
5.805TyrLys: 5.805 ± 1.205
3.694TyrLeu: 3.694 ± 0.722
1.319TyrMet: 1.319 ± 0.573
3.958TyrAsn: 3.958 ± 1.012
1.847TyrPro: 1.847 ± 0.656
1.847TyrGln: 1.847 ± 0.599
4.222TyrArg: 4.222 ± 1.339
3.166TyrSer: 3.166 ± 1.392
2.375TyrThr: 2.375 ± 0.73
1.319TyrVal: 1.319 ± 0.569
0.528TyrTrp: 0.528 ± 0.49
2.111TyrTyr: 2.111 ± 0.95
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 26 proteins (3791 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski