Amino acid dipepetide frequency for Paenibacillus sp. FSL H7-0737

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.543AlaAla: 7.543 ± 0.098	0.643AlaCys: 0.643 ± 0.022	3.86AlaAsp: 3.86 ± 0.052	5.327AlaGlu: 5.327 ± 0.068	3.178AlaPhe: 3.178 ± 0.042	6.13AlaGly: 6.13 ± 0.074	1.283AlaHis: 1.283 ± 0.029	5.414AlaIle: 5.414 ± 0.061	4.113AlaLys: 4.113 ± 0.056	8.089AlaLeu: 8.089 ± 0.075	2.111AlaMet: 2.111 ± 0.037	2.628AlaAsn: 2.628 ± 0.043	2.529AlaPro: 2.529 ± 0.044	2.499AlaGln: 2.499 ± 0.039	2.969AlaArg: 2.969 ± 0.043	4.845AlaSer: 4.845 ± 0.059	3.826AlaThr: 3.826 ± 0.063	6.008AlaVal: 6.008 ± 0.06	0.86AlaTrp: 0.86 ± 0.023	2.534AlaTyr: 2.534 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.51CysAla: 0.51 ± 0.016	0.105CysCys: 0.105 ± 0.007	0.391CysAsp: 0.391 ± 0.016	0.432CysGlu: 0.432 ± 0.018	0.336CysPhe: 0.336 ± 0.013	0.733CysGly: 0.733 ± 0.025	0.191CysHis: 0.191 ± 0.011	0.558CysIle: 0.558 ± 0.016	0.347CysLys: 0.347 ± 0.014	0.729CysLeu: 0.729 ± 0.021	0.202CysMet: 0.202 ± 0.011	0.325CysAsn: 0.325 ± 0.013	0.323CysPro: 0.323 ± 0.013	0.234CysGln: 0.234 ± 0.012	0.393CysArg: 0.393 ± 0.015	0.558CysSer: 0.558 ± 0.019	0.386CysThr: 0.386 ± 0.015	0.452CysVal: 0.452 ± 0.016	0.081CysTrp: 0.081 ± 0.007	0.267CysTyr: 0.267 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.528AspAla: 3.528 ± 0.051	0.368AspCys: 0.368 ± 0.015	2.386AspAsp: 2.386 ± 0.039	3.808AspGlu: 3.808 ± 0.049	2.258AspPhe: 2.258 ± 0.041	3.819AspGly: 3.819 ± 0.056	1.162AspHis: 1.162 ± 0.029	3.825AspIle: 3.825 ± 0.048	2.947AspLys: 2.947 ± 0.046	5.04AspLeu: 5.04 ± 0.051	1.369AspMet: 1.369 ± 0.03	2.045AspAsn: 2.045 ± 0.037	2.239AspPro: 2.239 ± 0.036	1.811AspGln: 1.811 ± 0.03	2.368AspArg: 2.368 ± 0.035	3.013AspSer: 3.013 ± 0.038	2.588AspThr: 2.588 ± 0.04	3.429AspVal: 3.429 ± 0.052	0.784AspTrp: 0.784 ± 0.026	2.184AspTyr: 2.184 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.619GluAla: 5.619 ± 0.065	0.413GluCys: 0.413 ± 0.016	3.344GluAsp: 3.344 ± 0.048	5.417GluGlu: 5.417 ± 0.075	2.244GluPhe: 2.244 ± 0.032	4.536GluGly: 4.536 ± 0.055	1.515GluHis: 1.515 ± 0.032	4.757GluIle: 4.757 ± 0.065	4.068GluLys: 4.068 ± 0.059	7.27GluLeu: 7.27 ± 0.087	2.129GluMet: 2.129 ± 0.037	2.683GluAsn: 2.683 ± 0.039	2.089GluPro: 2.089 ± 0.035	3.468GluGln: 3.468 ± 0.054	3.587GluArg: 3.587 ± 0.053	3.695GluSer: 3.695 ± 0.043	3.204GluThr: 3.204 ± 0.05	4.599GluVal: 4.599 ± 0.052	0.903GluTrp: 0.903 ± 0.023	2.068GluTyr: 2.068 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.111PheAla: 3.111 ± 0.041	0.393PheCys: 0.393 ± 0.015	2.219PheAsp: 2.219 ± 0.034	2.43PheGlu: 2.43 ± 0.038	1.975PhePhe: 1.975 ± 0.036	3.311PheGly: 3.311 ± 0.046	0.854PheHis: 0.854 ± 0.022	3.347PheIle: 3.347 ± 0.049	2.185PheLys: 2.185 ± 0.039	3.965PheLeu: 3.965 ± 0.054	1.258PheMet: 1.258 ± 0.027	1.835PheAsn: 1.835 ± 0.031	1.576PhePro: 1.576 ± 0.035	1.387PheGln: 1.387 ± 0.027	1.86PheArg: 1.86 ± 0.037	3.164PheSer: 3.164 ± 0.044	2.636PheThr: 2.636 ± 0.037	2.926PheVal: 2.926 ± 0.042	0.592PheTrp: 0.592 ± 0.018	1.553PheTyr: 1.553 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.295GlyAla: 5.295 ± 0.074	0.652GlyCys: 0.652 ± 0.021	3.488GlyAsp: 3.488 ± 0.046	4.472GlyGlu: 4.472 ± 0.056	3.295GlyPhe: 3.295 ± 0.043	5.454GlyGly: 5.454 ± 0.07	1.395GlyHis: 1.395 ± 0.027	5.971GlyIle: 5.971 ± 0.062	4.497GlyLys: 4.497 ± 0.059	7.335GlyLeu: 7.335 ± 0.07	2.318GlyMet: 2.318 ± 0.036	3.017GlyAsn: 3.017 ± 0.048	1.819GlyPro: 1.819 ± 0.035	2.467GlyGln: 2.467 ± 0.037	3.078GlyArg: 3.078 ± 0.046	4.811GlySer: 4.811 ± 0.07	4.412GlyThr: 4.412 ± 0.063	5.331GlyVal: 5.331 ± 0.061	0.98GlyTrp: 0.98 ± 0.027	2.972GlyTyr: 2.972 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.327HisAla: 1.327 ± 0.029	0.191HisCys: 0.191 ± 0.011	0.938HisAsp: 0.938 ± 0.024	1.279HisGlu: 1.279 ± 0.031	0.974HisPhe: 0.974 ± 0.026	1.432HisGly: 1.432 ± 0.026	0.538HisHis: 0.538 ± 0.018	1.349HisIle: 1.349 ± 0.027	0.936HisLys: 0.936 ± 0.022	2.098HisLeu: 2.098 ± 0.041	0.559HisMet: 0.559 ± 0.018	0.768HisAsn: 0.768 ± 0.021	1.123HisPro: 1.123 ± 0.024	0.742HisGln: 0.742 ± 0.022	1.008HisArg: 1.008 ± 0.026	1.284HisSer: 1.284 ± 0.03	1.133HisThr: 1.133 ± 0.026	1.271HisVal: 1.271 ± 0.026	0.313HisTrp: 0.313 ± 0.015	0.882HisTyr: 0.882 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.972IleAla: 5.972 ± 0.067	0.654IleCys: 0.654 ± 0.022	3.773IleAsp: 3.773 ± 0.052	4.473IleGlu: 4.473 ± 0.06	2.808IlePhe: 2.808 ± 0.053	5.552IleGly: 5.552 ± 0.057	1.544IleHis: 1.544 ± 0.037	5.127IleIle: 5.127 ± 0.072	3.396IleLys: 3.396 ± 0.045	6.659IleLeu: 6.659 ± 0.087	1.903IleMet: 1.903 ± 0.035	2.822IleAsn: 2.822 ± 0.04	3.344IlePro: 3.344 ± 0.042	2.575IleGln: 2.575 ± 0.045	3.46IleArg: 3.46 ± 0.053	5.325IleSer: 5.325 ± 0.058	4.44IleThr: 4.44 ± 0.061	5.36IleVal: 5.36 ± 0.067	0.735IleTrp: 0.735 ± 0.02	2.32IleTyr: 2.32 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.204LysAla: 4.204 ± 0.051	0.263LysCys: 0.263 ± 0.011	3.231LysAsp: 3.231 ± 0.051	4.61LysGlu: 4.61 ± 0.055	1.697LysPhe: 1.697 ± 0.034	3.891LysGly: 3.891 ± 0.051	1.038LysHis: 1.038 ± 0.026	3.551LysIle: 3.551 ± 0.049	3.511LysLys: 3.511 ± 0.058	5.74LysLeu: 5.74 ± 0.061	1.743LysMet: 1.743 ± 0.034	2.355LysAsn: 2.355 ± 0.042	2.138LysPro: 2.138 ± 0.039	2.475LysGln: 2.475 ± 0.043	2.68LysArg: 2.68 ± 0.042	3.278LysSer: 3.278 ± 0.041	2.818LysThr: 2.818 ± 0.047	3.938LysVal: 3.938 ± 0.056	0.718LysTrp: 0.718 ± 0.022	1.997LysTyr: 1.997 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	7.683LeuAla: 7.683 ± 0.075	0.835LeuCys: 0.835 ± 0.022	5.068LeuAsp: 5.068 ± 0.056	6.465LeuGlu: 6.465 ± 0.083	4.724LeuPhe: 4.724 ± 0.07	6.915LeuGly: 6.915 ± 0.071	2.088LeuHis: 2.088 ± 0.042	7.105LeuIle: 7.105 ± 0.08	5.715LeuLys: 5.715 ± 0.057	11.305LeuLeu: 11.305 ± 0.123	2.811LeuMet: 2.811 ± 0.04	4.347LeuAsn: 4.347 ± 0.049	4.479LeuPro: 4.479 ± 0.059	4.076LeuGln: 4.076 ± 0.06	4.687LeuArg: 4.687 ± 0.062	7.648LeuSer: 7.648 ± 0.08	5.901LeuThr: 5.901 ± 0.058	6.261LeuVal: 6.261 ± 0.067	1.104LeuTrp: 1.104 ± 0.028	3.277LeuTyr: 3.277 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.11MetAla: 2.11 ± 0.037	0.169MetCys: 0.169 ± 0.01	1.607MetAsp: 1.607 ± 0.03	1.868MetGlu: 1.868 ± 0.035	1.146MetPhe: 1.146 ± 0.026	1.882MetGly: 1.882 ± 0.032	0.483MetHis: 0.483 ± 0.018	2.124MetIle: 2.124 ± 0.036	2.072MetLys: 2.072 ± 0.04	3.024MetLeu: 3.024 ± 0.039	0.92MetMet: 0.92 ± 0.024	1.651MetAsn: 1.651 ± 0.032	1.096MetPro: 1.096 ± 0.028	0.963MetGln: 0.963 ± 0.023	1.23MetArg: 1.23 ± 0.028	1.923MetSer: 1.923 ± 0.031	1.639MetThr: 1.639 ± 0.033	1.818MetVal: 1.818 ± 0.028	0.234MetTrp: 0.234 ± 0.012	0.807MetTyr: 0.807 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.9AsnAla: 2.9 ± 0.041	0.296AsnCys: 0.296 ± 0.013	2.127AsnAsp: 2.127 ± 0.039	2.817AsnGlu: 2.817 ± 0.041	1.568AsnPhe: 1.568 ± 0.033	3.323AsnGly: 3.323 ± 0.057	0.925AsnHis: 0.925 ± 0.023	2.984AsnIle: 2.984 ± 0.05	2.405AsnLys: 2.405 ± 0.04	3.753AsnLeu: 3.753 ± 0.05	1.076AsnMet: 1.076 ± 0.025	2.05AsnAsn: 2.05 ± 0.041	2.053AsnPro: 2.053 ± 0.036	1.525AsnGln: 1.525 ± 0.029	1.947AsnArg: 1.947 ± 0.035	2.549AsnSer: 2.549 ± 0.042	2.385AsnThr: 2.385 ± 0.046	2.873AsnVal: 2.873 ± 0.041	0.564AsnTrp: 0.564 ± 0.02	1.607AsnTyr: 1.607 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	2.933ProAla: 2.933 ± 0.048	0.249ProCys: 0.249 ± 0.013	2.406ProAsp: 2.406 ± 0.037	3.29ProGlu: 3.29 ± 0.046	1.84ProPhe: 1.84 ± 0.036	2.673ProGly: 2.673 ± 0.04	0.782ProHis: 0.782 ± 0.023	2.511ProIle: 2.511 ± 0.037	1.874ProLys: 1.874 ± 0.033	3.976ProLeu: 3.976 ± 0.05	0.946ProMet: 0.946 ± 0.025	1.552ProAsn: 1.552 ± 0.034	1.11ProPro: 1.11 ± 0.028	1.361ProGln: 1.361 ± 0.027	1.256ProArg: 1.256 ± 0.032	2.51ProSer: 2.51 ± 0.043	2.135ProThr: 2.135 ± 0.066	3.107ProVal: 3.107 ± 0.047	0.477ProTrp: 0.477 ± 0.018	1.486ProTyr: 1.486 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.883GlnAla: 2.883 ± 0.044	0.212GlnCys: 0.212 ± 0.012	1.687GlnAsp: 1.687 ± 0.033	2.669GlnGlu: 2.669 ± 0.045	1.548GlnPhe: 1.548 ± 0.03	2.505GlnGly: 2.505 ± 0.037	0.755GlnHis: 0.755 ± 0.022	2.588GlnIle: 2.588 ± 0.045	2.112GlnLys: 2.112 ± 0.036	4.04GlnLeu: 4.04 ± 0.056	1.161GlnMet: 1.161 ± 0.024	1.464GlnAsn: 1.464 ± 0.031	1.377GlnPro: 1.377 ± 0.029	1.74GlnGln: 1.74 ± 0.039	1.714GlnArg: 1.714 ± 0.037	2.279GlnSer: 2.279 ± 0.037	1.861GlnThr: 1.861 ± 0.03	2.395GlnVal: 2.395 ± 0.039	0.515GlnTrp: 0.515 ± 0.019	1.403GlnTyr: 1.403 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.843ArgAla: 2.843 ± 0.049	0.309ArgCys: 0.309 ± 0.014	2.196ArgAsp: 2.196 ± 0.037	3.365ArgGlu: 3.365 ± 0.054	1.955ArgPhe: 1.955 ± 0.037	2.781ArgGly: 2.781 ± 0.049	0.936ArgHis: 0.936 ± 0.022	3.387ArgIle: 3.387 ± 0.051	2.883ArgLys: 2.883 ± 0.039	4.728ArgLeu: 4.728 ± 0.07	1.489ArgMet: 1.489 ± 0.031	2.028ArgAsn: 2.028 ± 0.033	1.503ArgPro: 1.503 ± 0.035	1.75ArgGln: 1.75 ± 0.033	2.404ArgArg: 2.404 ± 0.043	2.902ArgSer: 2.902 ± 0.041	2.475ArgThr: 2.475 ± 0.036	2.827ArgVal: 2.827 ± 0.043	0.595ArgTrp: 0.595 ± 0.019	1.761ArgTyr: 1.761 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.883SerAla: 4.883 ± 0.058	0.445SerCys: 0.445 ± 0.016	3.221SerAsp: 3.221 ± 0.044	4.059SerGlu: 4.059 ± 0.052	3.265SerPhe: 3.265 ± 0.042	5.483SerGly: 5.483 ± 0.068	1.241SerHis: 1.241 ± 0.027	4.933SerIle: 4.933 ± 0.059	3.627SerLys: 3.627 ± 0.044	6.908SerLeu: 6.908 ± 0.07	1.928SerMet: 1.928 ± 0.035	2.689SerAsn: 2.689 ± 0.042	2.46SerPro: 2.46 ± 0.037	2.119SerGln: 2.119 ± 0.035	2.887SerArg: 2.887 ± 0.053	4.881SerSer: 4.881 ± 0.062	3.567SerThr: 3.567 ± 0.053	4.693SerVal: 4.693 ± 0.053	0.817SerTrp: 0.817 ± 0.021	2.413SerTyr: 2.413 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.675ThrAla: 4.675 ± 0.065	0.363ThrCys: 0.363 ± 0.015	2.851ThrAsp: 2.851 ± 0.04	3.335ThrGlu: 3.335 ± 0.041	2.482ThrPhe: 2.482 ± 0.043	4.533ThrGly: 4.533 ± 0.065	1.057ThrHis: 1.057 ± 0.027	4.094ThrIle: 4.094 ± 0.06	2.653ThrLys: 2.653 ± 0.045	5.851ThrLeu: 5.851 ± 0.068	1.36ThrMet: 1.36 ± 0.031	2.109ThrAsn: 2.109 ± 0.047	2.695ThrPro: 2.695 ± 0.064	1.603ThrGln: 1.603 ± 0.03	2.158ThrArg: 2.158 ± 0.036	3.643ThrSer: 3.643 ± 0.054	3.269ThrThr: 3.269 ± 0.058	4.476ThrVal: 4.476 ± 0.071	0.632ThrTrp: 0.632 ± 0.022	1.903ThrTyr: 1.903 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.107ValAla: 5.107 ± 0.066	0.583ValCys: 0.583 ± 0.018	3.588ValAsp: 3.588 ± 0.056	4.465ValGlu: 4.465 ± 0.051	2.978ValPhe: 2.978 ± 0.043	4.572ValGly: 4.572 ± 0.066	1.365ValHis: 1.365 ± 0.032	5.324ValIle: 5.324 ± 0.054	3.94ValLys: 3.94 ± 0.042	7.206ValLeu: 7.206 ± 0.068	2.064ValMet: 2.064 ± 0.038	3.022ValAsn: 3.022 ± 0.047	2.735ValPro: 2.735 ± 0.037	2.397ValGln: 2.397 ± 0.04	2.96ValArg: 2.96 ± 0.04	4.941ValSer: 4.941 ± 0.061	4.475ValThr: 4.475 ± 0.071	5.018ValVal: 5.018 ± 0.064	0.82ValTrp: 0.82 ± 0.023	2.321ValTyr: 2.321 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.745TrpAla: 0.745 ± 0.019	0.091TrpCys: 0.091 ± 0.007	0.693TrpAsp: 0.693 ± 0.019	0.777TrpGlu: 0.777 ± 0.021	0.559TrpPhe: 0.559 ± 0.018	0.861TrpGly: 0.861 ± 0.026	0.24TrpHis: 0.24 ± 0.012	0.943TrpIle: 0.943 ± 0.022	0.735TrpLys: 0.735 ± 0.024	1.308TrpLeu: 1.308 ± 0.032	0.428TrpMet: 0.428 ± 0.018	0.738TrpAsn: 0.738 ± 0.02	0.335TrpPro: 0.335 ± 0.013	0.469TrpGln: 0.469 ± 0.016	0.568TrpArg: 0.568 ± 0.02	0.859TrpSer: 0.859 ± 0.023	0.648TrpThr: 0.648 ± 0.021	0.777TrpVal: 0.777 ± 0.021	0.174TrpTrp: 0.174 ± 0.01	0.402TrpTyr: 0.402 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.52TyrAla: 2.52 ± 0.041	0.321TyrCys: 0.321 ± 0.014	1.895TyrAsp: 1.895 ± 0.036	2.249TyrGlu: 2.249 ± 0.037	1.744TyrPhe: 1.744 ± 0.032	2.674TyrGly: 2.674 ± 0.038	0.755TyrHis: 0.755 ± 0.021	2.347TyrIle: 2.347 ± 0.038	1.859TyrLys: 1.859 ± 0.035	3.469TyrLeu: 3.469 ± 0.047	0.989TyrMet: 0.989 ± 0.021	1.601TyrAsn: 1.601 ± 0.031	1.45TyrPro: 1.45 ± 0.03	1.248TyrGln: 1.248 ± 0.025	1.906TyrArg: 1.906 ± 0.032	2.413TyrSer: 2.413 ± 0.037	1.946TyrThr: 1.946 ± 0.036	2.318TyrVal: 2.318 ± 0.037	0.453TyrTrp: 0.453 ± 0.015	1.451TyrTyr: 1.451 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5383 proteins (1768007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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