Amino acid dipepetide frequency for Nora virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.633AlaAla: 2.633 ± 0.877
0.527AlaCys: 0.527 ± 0.325
3.949AlaAsp: 3.949 ± 1.719
3.686AlaGlu: 3.686 ± 0.849
2.633AlaPhe: 2.633 ± 0.71
2.106AlaGly: 2.106 ± 0.835
1.053AlaHis: 1.053 ± 0.418
5.529AlaIle: 5.529 ± 1.416
5.003AlaLys: 5.003 ± 1.205
5.266AlaLeu: 5.266 ± 1.472
1.053AlaMet: 1.053 ± 0.234
3.16AlaAsn: 3.16 ± 1.852
3.686AlaPro: 3.686 ± 1.437
1.843AlaGln: 1.843 ± 0.488
1.316AlaArg: 1.316 ± 0.69
3.423AlaSer: 3.423 ± 0.687
5.529AlaThr: 5.529 ± 1.227
3.949AlaVal: 3.949 ± 0.824
1.316AlaTrp: 1.316 ± 0.396
1.053AlaTyr: 1.053 ± 0.552
0.0AlaXaa: 0.0 ± 0.0
Cys
0.79CysAla: 0.79 ± 0.488
0.263CysCys: 0.263 ± 0.304
0.0CysAsp: 0.0 ± 0.0
1.053CysGlu: 1.053 ± 0.65
0.0CysPhe: 0.0 ± 0.0
0.79CysGly: 0.79 ± 0.488
0.0CysHis: 0.0 ± 0.0
0.527CysIle: 0.527 ± 0.325
0.0CysLys: 0.0 ± 0.0
1.316CysLeu: 1.316 ± 0.251
0.527CysMet: 0.527 ± 0.439
0.527CysAsn: 0.527 ± 0.325
0.263CysPro: 0.263 ± 0.163
0.527CysGln: 0.527 ± 0.325
0.263CysArg: 0.263 ± 0.163
0.263CysSer: 0.263 ± 0.304
0.527CysThr: 0.527 ± 0.325
1.053CysVal: 1.053 ± 0.324
0.263CysTrp: 0.263 ± 0.163
0.263CysTyr: 0.263 ± 0.163
0.0CysXaa: 0.0 ± 0.0
Asp
1.843AspAla: 1.843 ± 0.487
0.527AspCys: 0.527 ± 0.209
1.843AspAsp: 1.843 ± 0.488
5.529AspGlu: 5.529 ± 1.772
2.633AspPhe: 2.633 ± 1.044
1.843AspGly: 1.843 ± 0.372
1.316AspHis: 1.316 ± 0.463
4.476AspIle: 4.476 ± 0.723
3.423AspLys: 3.423 ± 1.267
5.003AspLeu: 5.003 ± 1.372
0.527AspMet: 0.527 ± 0.209
3.686AspAsn: 3.686 ± 0.73
1.58AspPro: 1.58 ± 0.706
2.896AspGln: 2.896 ± 1.709
1.58AspArg: 1.58 ± 0.371
3.686AspSer: 3.686 ± 0.888
2.896AspThr: 2.896 ± 0.904
3.949AspVal: 3.949 ± 2.157
1.316AspTrp: 1.316 ± 0.574
1.843AspTyr: 1.843 ± 1.138
0.0AspXaa: 0.0 ± 0.0
Glu
3.423GluAla: 3.423 ± 0.14
0.527GluCys: 0.527 ± 0.325
3.16GluAsp: 3.16 ± 0.89
6.846GluGlu: 6.846 ± 1.092
2.633GluPhe: 2.633 ± 0.859
2.106GluGly: 2.106 ± 0.928
1.843GluHis: 1.843 ± 0.721
4.739GluIle: 4.739 ± 2.672
5.003GluLys: 5.003 ± 2.049
6.319GluLeu: 6.319 ± 1.051
2.106GluMet: 2.106 ± 0.511
4.739GluAsn: 4.739 ± 1.014
1.053GluPro: 1.053 ± 0.418
4.739GluGln: 4.739 ± 0.839
2.896GluArg: 2.896 ± 1.111
3.16GluSer: 3.16 ± 0.418
4.213GluThr: 4.213 ± 1.194
5.266GluVal: 5.266 ± 0.303
0.79GluTrp: 0.79 ± 0.488
2.896GluTyr: 2.896 ± 1.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.949PheAla: 3.949 ± 1.733
0.263PheCys: 0.263 ± 0.163
2.896PheAsp: 2.896 ± 0.312
1.316PheGlu: 1.316 ± 0.463
0.79PhePhe: 0.79 ± 0.576
1.843PheGly: 1.843 ± 0.999
1.316PheHis: 1.316 ± 0.463
3.686PheIle: 3.686 ± 0.643
2.633PheLys: 2.633 ± 0.615
2.896PheLeu: 2.896 ± 0.563
0.79PheMet: 0.79 ± 0.608
1.843PheAsn: 1.843 ± 0.369
1.843PhePro: 1.843 ± 0.594
2.106PheGln: 2.106 ± 0.835
1.053PheArg: 1.053 ± 0.65
3.423PheSer: 3.423 ± 0.682
1.843PheThr: 1.843 ± 0.77
2.37PheVal: 2.37 ± 0.793
0.0PheTrp: 0.0 ± 0.0
1.053PheTyr: 1.053 ± 0.234
0.0PheXaa: 0.0 ± 0.0
Gly
2.633GlyAla: 2.633 ± 1.248
0.0GlyCys: 0.0 ± 0.0
3.686GlyAsp: 3.686 ± 1.245
4.739GlyGlu: 4.739 ± 1.399
1.316GlyPhe: 1.316 ± 0.251
2.37GlyGly: 2.37 ± 1.891
1.053GlyHis: 1.053 ± 0.324
4.213GlyIle: 4.213 ± 0.949
2.633GlyLys: 2.633 ± 0.502
5.003GlyLeu: 5.003 ± 1.087
1.58GlyMet: 1.58 ± 0.614
3.16GlyAsn: 3.16 ± 0.568
2.633GlyPro: 2.633 ± 0.26
1.053GlyGln: 1.053 ± 0.234
2.896GlyArg: 2.896 ± 0.848
2.633GlySer: 2.633 ± 0.274
4.213GlyThr: 4.213 ± 0.501
3.949GlyVal: 3.949 ± 0.639
0.79GlyTrp: 0.79 ± 0.488
2.106GlyTyr: 2.106 ± 0.571
0.0GlyXaa: 0.0 ± 0.0
His
2.106HisAla: 2.106 ± 0.517
0.527HisCys: 0.527 ± 0.325
0.0HisAsp: 0.0 ± 0.0
0.79HisGlu: 0.79 ± 0.219
1.316HisPhe: 1.316 ± 0.515
0.79HisGly: 0.79 ± 0.488
0.0HisHis: 0.0 ± 0.0
1.316HisIle: 1.316 ± 0.43
1.316HisLys: 1.316 ± 0.593
1.58HisLeu: 1.58 ± 0.437
0.527HisMet: 0.527 ± 0.209
0.263HisAsn: 0.263 ± 0.304
0.79HisPro: 0.79 ± 0.219
0.79HisGln: 0.79 ± 0.957
0.79HisArg: 0.79 ± 0.219
1.053HisSer: 1.053 ± 0.416
1.053HisThr: 1.053 ± 0.439
1.316HisVal: 1.316 ± 0.41
0.263HisTrp: 0.263 ± 0.163
1.053HisTyr: 1.053 ± 0.418
0.0HisXaa: 0.0 ± 0.0
Ile
4.213IleAla: 4.213 ± 0.78
0.79IleCys: 0.79 ± 0.488
4.476IleAsp: 4.476 ± 0.852
5.529IleGlu: 5.529 ± 0.639
1.316IlePhe: 1.316 ± 0.672
3.949IleGly: 3.949 ± 0.946
0.263IleHis: 0.263 ± 0.319
3.949IleIle: 3.949 ± 1.698
6.056IleLys: 6.056 ± 1.891
5.793IleLeu: 5.793 ± 1.735
0.527IleMet: 0.527 ± 0.325
3.686IleAsn: 3.686 ± 1.234
4.213IlePro: 4.213 ± 2.593
2.896IleGln: 2.896 ± 1.069
4.739IleArg: 4.739 ± 0.391
6.056IleSer: 6.056 ± 1.177
7.109IleThr: 7.109 ± 0.817
4.213IleVal: 4.213 ± 0.885
0.263IleTrp: 0.263 ± 0.163
3.16IleTyr: 3.16 ± 1.414
0.0IleXaa: 0.0 ± 0.0
Lys
3.16LysAla: 3.16 ± 1.265
0.527LysCys: 0.527 ± 0.325
3.949LysAsp: 3.949 ± 1.613
6.056LysGlu: 6.056 ± 2.619
2.896LysPhe: 2.896 ± 0.741
2.37LysGly: 2.37 ± 0.436
1.58LysHis: 1.58 ± 0.614
4.739LysIle: 4.739 ± 1.148
5.003LysLys: 5.003 ± 3.441
6.846LysLeu: 6.846 ± 2.106
1.58LysMet: 1.58 ± 0.845
2.896LysAsn: 2.896 ± 0.759
4.213LysPro: 4.213 ± 2.5
3.686LysGln: 3.686 ± 2.182
3.423LysArg: 3.423 ± 0.787
5.003LysSer: 5.003 ± 0.738
5.003LysThr: 5.003 ± 1.17
7.109LysVal: 7.109 ± 1.017
1.58LysTrp: 1.58 ± 0.474
2.106LysTyr: 2.106 ± 0.636
0.0LysXaa: 0.0 ± 0.0
Leu
6.056LeuAla: 6.056 ± 0.716
1.053LeuCys: 1.053 ± 0.65
5.793LeuAsp: 5.793 ± 2.267
5.003LeuGlu: 5.003 ± 1.373
2.633LeuPhe: 2.633 ± 0.886
4.739LeuGly: 4.739 ± 1.067
1.58LeuHis: 1.58 ± 0.464
5.529LeuIle: 5.529 ± 2.441
7.636LeuLys: 7.636 ± 1.539
4.739LeuLeu: 4.739 ± 1.312
1.316LeuMet: 1.316 ± 0.251
5.793LeuAsn: 5.793 ± 0.774
4.739LeuPro: 4.739 ± 1.594
5.003LeuGln: 5.003 ± 1.982
3.949LeuArg: 3.949 ± 0.593
6.056LeuSer: 6.056 ± 1.889
4.476LeuThr: 4.476 ± 1.714
7.372LeuVal: 7.372 ± 1.003
0.79LeuTrp: 0.79 ± 0.488
2.37LeuTyr: 2.37 ± 0.79
0.0LeuXaa: 0.0 ± 0.0
Met
1.053MetAla: 1.053 ± 0.547
0.527MetCys: 0.527 ± 0.325
1.316MetAsp: 1.316 ± 0.574
0.79MetGlu: 0.79 ± 0.331
0.0MetPhe: 0.0 ± 0.0
0.79MetGly: 0.79 ± 0.488
0.527MetHis: 0.527 ± 0.209
1.316MetIle: 1.316 ± 0.593
1.58MetLys: 1.58 ± 0.644
2.633MetLeu: 2.633 ± 1.248
1.053MetMet: 1.053 ± 0.517
1.316MetAsn: 1.316 ± 0.833
1.316MetPro: 1.316 ± 0.251
0.527MetGln: 0.527 ± 0.209
0.79MetArg: 0.79 ± 0.495
1.316MetSer: 1.316 ± 0.566
1.053MetThr: 1.053 ± 0.234
1.58MetVal: 1.58 ± 0.631
0.263MetTrp: 0.263 ± 0.163
0.79MetTyr: 0.79 ± 0.495
0.0MetXaa: 0.0 ± 0.0
Asn
2.633AsnAla: 2.633 ± 1.119
0.79AsnCys: 0.79 ± 0.219
2.896AsnAsp: 2.896 ± 0.563
2.896AsnGlu: 2.896 ± 1.297
1.843AsnPhe: 1.843 ± 0.322
3.949AsnGly: 3.949 ± 1.43
1.053AsnHis: 1.053 ± 0.552
4.739AsnIle: 4.739 ± 0.983
5.529AsnLys: 5.529 ± 1.312
6.056AsnLeu: 6.056 ± 2.001
1.316AsnMet: 1.316 ± 0.43
2.896AsnAsn: 2.896 ± 0.725
3.16AsnPro: 3.16 ± 0.911
1.316AsnGln: 1.316 ± 0.566
1.843AsnArg: 1.843 ± 0.77
4.213AsnSer: 4.213 ± 0.525
4.476AsnThr: 4.476 ± 2.554
3.949AsnVal: 3.949 ± 2.362
0.527AsnTrp: 0.527 ± 0.444
1.843AsnTyr: 1.843 ± 0.594
0.0AsnXaa: 0.0 ± 0.0
Pro
2.37ProAla: 2.37 ± 1.178
0.0ProCys: 0.0 ± 0.0
1.053ProAsp: 1.053 ± 0.418
1.58ProGlu: 1.58 ± 0.627
2.37ProPhe: 2.37 ± 0.79
1.053ProGly: 1.053 ± 0.418
0.263ProHis: 0.263 ± 0.163
4.213ProIle: 4.213 ± 1.043
3.686ProLys: 3.686 ± 1.42
3.423ProLeu: 3.423 ± 0.865
0.527ProMet: 0.527 ± 0.209
2.633ProAsn: 2.633 ± 0.343
1.58ProPro: 1.58 ± 0.706
2.633ProGln: 2.633 ± 0.859
1.58ProArg: 1.58 ± 1.126
2.37ProSer: 2.37 ± 0.946
2.896ProThr: 2.896 ± 1.412
4.739ProVal: 4.739 ± 2.551
1.843ProTrp: 1.843 ± 0.592
2.106ProTyr: 2.106 ± 0.511
0.0ProXaa: 0.0 ± 0.0
Gln
3.423GlnAla: 3.423 ± 1.231
0.79GlnCys: 0.79 ± 0.579
0.527GlnAsp: 0.527 ± 0.586
2.106GlnGlu: 2.106 ± 0.549
2.37GlnPhe: 2.37 ± 0.417
1.316GlnGly: 1.316 ± 0.813
1.316GlnHis: 1.316 ± 1.208
3.16GlnIle: 3.16 ± 0.361
4.476GlnLys: 4.476 ± 1.273
5.266GlnLeu: 5.266 ± 1.242
0.527GlnMet: 0.527 ± 0.268
3.16GlnAsn: 3.16 ± 0.837
1.843GlnPro: 1.843 ± 0.531
3.16GlnGln: 3.16 ± 1.259
1.843GlnArg: 1.843 ± 0.597
2.37GlnSer: 2.37 ± 0.481
3.16GlnThr: 3.16 ± 0.766
2.106GlnVal: 2.106 ± 0.433
0.263GlnTrp: 0.263 ± 0.163
0.527GlnTyr: 0.527 ± 0.209
0.0GlnXaa: 0.0 ± 0.0
Arg
2.896ArgAla: 2.896 ± 0.17
0.263ArgCys: 0.263 ± 0.163
2.633ArgAsp: 2.633 ± 0.737
3.16ArgGlu: 3.16 ± 1.325
2.633ArgPhe: 2.633 ± 0.791
3.423ArgGly: 3.423 ± 0.835
1.053ArgHis: 1.053 ± 0.795
3.423ArgIle: 3.423 ± 0.764
1.58ArgLys: 1.58 ± 0.627
1.58ArgLeu: 1.58 ± 0.437
1.053ArgMet: 1.053 ± 0.65
3.16ArgAsn: 3.16 ± 0.617
1.58ArgPro: 1.58 ± 0.437
2.37ArgGln: 2.37 ± 0.648
2.633ArgArg: 2.633 ± 0.549
2.896ArgSer: 2.896 ± 1.502
3.686ArgThr: 3.686 ± 1.871
3.423ArgVal: 3.423 ± 0.14
0.263ArgTrp: 0.263 ± 0.163
1.58ArgTyr: 1.58 ± 0.644
0.0ArgXaa: 0.0 ± 0.0
Ser
3.949SerAla: 3.949 ± 2.566
0.527SerCys: 0.527 ± 0.209
2.633SerAsp: 2.633 ± 0.947
2.633SerGlu: 2.633 ± 0.502
2.633SerPhe: 2.633 ± 1.626
4.476SerGly: 4.476 ± 0.723
0.263SerHis: 0.263 ± 0.163
5.003SerIle: 5.003 ± 2.11
4.213SerLys: 4.213 ± 0.921
8.425SerLeu: 8.425 ± 2.103
1.58SerMet: 1.58 ± 0.371
3.423SerAsn: 3.423 ± 1.182
2.106SerPro: 2.106 ± 0.928
1.58SerGln: 1.58 ± 0.888
3.686SerArg: 3.686 ± 1.056
3.423SerSer: 3.423 ± 0.784
3.686SerThr: 3.686 ± 0.747
5.003SerVal: 5.003 ± 1.152
0.527SerTrp: 0.527 ± 0.282
2.633SerTyr: 2.633 ± 1.371
0.0SerXaa: 0.0 ± 0.0
Thr
4.476ThrAla: 4.476 ± 2.002
0.263ThrCys: 0.263 ± 0.163
1.843ThrAsp: 1.843 ± 0.369
3.686ThrGlu: 3.686 ± 0.616
2.896ThrPhe: 2.896 ± 1.069
6.582ThrGly: 6.582 ± 0.732
0.527ThrHis: 0.527 ± 0.444
5.266ThrIle: 5.266 ± 0.548
5.529ThrLys: 5.529 ± 1.252
5.266ThrLeu: 5.266 ± 1.131
1.843ThrMet: 1.843 ± 0.372
3.16ThrAsn: 3.16 ± 0.766
1.843ThrPro: 1.843 ± 1.239
3.686ThrGln: 3.686 ± 0.847
4.213ThrArg: 4.213 ± 1.197
5.003ThrSer: 5.003 ± 2.216
8.952ThrThr: 8.952 ± 5.015
5.266ThrVal: 5.266 ± 1.803
1.58ThrTrp: 1.58 ± 0.663
1.843ThrTyr: 1.843 ± 0.488
0.0ThrXaa: 0.0 ± 0.0
Val
5.003ValAla: 5.003 ± 0.928
0.0ValCys: 0.0 ± 0.0
5.529ValAsp: 5.529 ± 0.922
7.899ValGlu: 7.899 ± 0.639
2.37ValPhe: 2.37 ± 1.108
5.529ValGly: 5.529 ± 0.554
1.053ValHis: 1.053 ± 0.552
3.686ValIle: 3.686 ± 0.888
5.266ValLys: 5.266 ± 0.329
6.582ValLeu: 6.582 ± 1.931
0.79ValMet: 0.79 ± 0.315
5.003ValAsn: 5.003 ± 1.624
3.686ValPro: 3.686 ± 2.083
1.843ValGln: 1.843 ± 0.768
2.896ValArg: 2.896 ± 0.653
4.213ValSer: 4.213 ± 0.891
5.793ValThr: 5.793 ± 0.905
4.476ValVal: 4.476 ± 0.995
1.58ValTrp: 1.58 ± 0.631
1.58ValTyr: 1.58 ± 0.408
0.0ValXaa: 0.0 ± 0.0
Trp
0.263TrpAla: 0.263 ± 0.163
0.263TrpCys: 0.263 ± 0.304
0.79TrpAsp: 0.79 ± 0.219
1.316TrpGlu: 1.316 ± 0.593
0.527TrpPhe: 0.527 ± 0.325
0.263TrpGly: 0.263 ± 0.163
0.263TrpHis: 0.263 ± 0.163
1.843TrpIle: 1.843 ± 0.77
0.263TrpLys: 0.263 ± 0.163
0.79TrpLeu: 0.79 ± 0.488
0.79TrpMet: 0.79 ± 0.219
1.316TrpAsn: 1.316 ± 0.593
0.0TrpPro: 0.0 ± 0.0
0.263TrpGln: 0.263 ± 0.163
0.527TrpArg: 0.527 ± 0.444
1.053TrpSer: 1.053 ± 0.324
1.316TrpThr: 1.316 ± 0.396
1.58TrpVal: 1.58 ± 0.701
0.263TrpTrp: 0.263 ± 0.319
1.053TrpTyr: 1.053 ± 0.599
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.843TyrAla: 1.843 ± 0.77
0.79TyrCys: 0.79 ± 0.488
3.423TyrAsp: 3.423 ± 0.758
1.843TyrGlu: 1.843 ± 1.47
2.106TyrPhe: 2.106 ± 0.833
2.37TyrGly: 2.37 ± 0.79
1.316TyrHis: 1.316 ± 0.251
1.843TyrIle: 1.843 ± 0.594
2.896TyrLys: 2.896 ± 1.175
1.843TyrLeu: 1.843 ± 0.531
0.263TyrMet: 0.263 ± 0.163
2.106TyrAsn: 2.106 ± 0.883
0.79TyrPro: 0.79 ± 0.488
1.053TyrGln: 1.053 ± 0.795
2.37TyrArg: 2.37 ± 0.197
0.79TyrSer: 0.79 ± 1.056
1.843TyrThr: 1.843 ± 0.369
2.106TyrVal: 2.106 ± 0.377
0.263TyrTrp: 0.263 ± 0.163
1.58TyrTyr: 1.58 ± 0.464
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski