Amino acid dipepetide frequency for Podoviridae sp. ctg2L5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.814AlaAla: 4.814 ± 0.728
0.558AlaCys: 0.558 ± 0.157
3.489AlaAsp: 3.489 ± 0.518
4.117AlaGlu: 4.117 ± 0.721
2.093AlaPhe: 2.093 ± 0.425
3.907AlaGly: 3.907 ± 0.589
1.326AlaHis: 1.326 ± 0.322
4.535AlaIle: 4.535 ± 0.697
5.024AlaLys: 5.024 ± 0.621
6.14AlaLeu: 6.14 ± 0.568
1.047AlaMet: 1.047 ± 0.265
3.07AlaAsn: 3.07 ± 0.468
2.163AlaPro: 2.163 ± 0.459
4.047AlaGln: 4.047 ± 0.582
4.814AlaArg: 4.814 ± 0.742
3.768AlaSer: 3.768 ± 0.648
3.419AlaThr: 3.419 ± 0.52
3.907AlaVal: 3.907 ± 0.474
1.256AlaTrp: 1.256 ± 0.326
3.349AlaTyr: 3.349 ± 0.349
0.0AlaXaa: 0.0 ± 0.0
Cys
0.488CysAla: 0.488 ± 0.185
0.0CysCys: 0.0 ± 0.0
0.628CysAsp: 0.628 ± 0.217
0.488CysGlu: 0.488 ± 0.198
0.209CysPhe: 0.209 ± 0.116
0.628CysGly: 0.628 ± 0.175
0.279CysHis: 0.279 ± 0.136
0.14CysIle: 0.14 ± 0.093
0.698CysLys: 0.698 ± 0.234
0.558CysLeu: 0.558 ± 0.258
0.07CysMet: 0.07 ± 0.072
0.279CysAsn: 0.279 ± 0.133
0.558CysPro: 0.558 ± 0.176
0.279CysGln: 0.279 ± 0.12
0.628CysArg: 0.628 ± 0.256
0.419CysSer: 0.419 ± 0.18
0.558CysThr: 0.558 ± 0.179
0.419CysVal: 0.419 ± 0.192
0.14CysTrp: 0.14 ± 0.107
0.279CysTyr: 0.279 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
3.419AspAla: 3.419 ± 0.562
0.419AspCys: 0.419 ± 0.192
4.117AspAsp: 4.117 ± 0.618
5.373AspGlu: 5.373 ± 0.603
3.07AspPhe: 3.07 ± 0.47
3.419AspGly: 3.419 ± 0.623
1.326AspHis: 1.326 ± 0.298
4.884AspIle: 4.884 ± 0.598
3.907AspLys: 3.907 ± 0.533
4.326AspLeu: 4.326 ± 0.711
1.047AspMet: 1.047 ± 0.252
2.791AspAsn: 2.791 ± 0.454
3.21AspPro: 3.21 ± 0.55
2.303AspGln: 2.303 ± 0.383
2.233AspArg: 2.233 ± 0.419
3.768AspSer: 3.768 ± 0.602
2.442AspThr: 2.442 ± 0.324
3.907AspVal: 3.907 ± 0.547
1.744AspTrp: 1.744 ± 0.341
2.512AspTyr: 2.512 ± 0.461
0.0AspXaa: 0.0 ± 0.0
Glu
6.001GluAla: 6.001 ± 0.634
0.279GluCys: 0.279 ± 0.13
3.628GluAsp: 3.628 ± 0.626
7.047GluGlu: 7.047 ± 0.834
3.838GluPhe: 3.838 ± 0.46
4.745GluGly: 4.745 ± 0.565
0.628GluHis: 0.628 ± 0.182
4.884GluIle: 4.884 ± 0.512
6.349GluLys: 6.349 ± 0.902
6.28GluLeu: 6.28 ± 0.914
2.303GluMet: 2.303 ± 0.441
3.419GluAsn: 3.419 ± 0.501
2.303GluPro: 2.303 ± 0.535
2.372GluGln: 2.372 ± 0.43
3.977GluArg: 3.977 ± 0.608
2.861GluSer: 2.861 ± 0.417
2.861GluThr: 2.861 ± 0.462
5.163GluVal: 5.163 ± 0.69
0.907GluTrp: 0.907 ± 0.265
2.721GluTyr: 2.721 ± 0.42
0.0GluXaa: 0.0 ± 0.0
Phe
2.791PheAla: 2.791 ± 0.445
0.558PheCys: 0.558 ± 0.181
2.721PheAsp: 2.721 ± 0.431
1.884PheGlu: 1.884 ± 0.349
2.163PhePhe: 2.163 ± 0.365
2.721PheGly: 2.721 ± 0.44
0.698PheHis: 0.698 ± 0.201
3.07PheIle: 3.07 ± 0.516
3.698PheLys: 3.698 ± 0.589
3.489PheLeu: 3.489 ± 0.485
0.907PheMet: 0.907 ± 0.255
2.582PheAsn: 2.582 ± 0.484
1.675PhePro: 1.675 ± 0.433
1.116PheGln: 1.116 ± 0.258
2.582PheArg: 2.582 ± 0.381
2.931PheSer: 2.931 ± 0.452
2.442PheThr: 2.442 ± 0.44
2.303PheVal: 2.303 ± 0.493
0.419PheTrp: 0.419 ± 0.166
2.442PheTyr: 2.442 ± 0.398
0.0PheXaa: 0.0 ± 0.0
Gly
4.466GlyAla: 4.466 ± 0.521
0.349GlyCys: 0.349 ± 0.158
3.768GlyAsp: 3.768 ± 0.534
6.28GlyGlu: 6.28 ± 0.772
3.279GlyPhe: 3.279 ± 0.499
7.466GlyGly: 7.466 ± 1.173
1.675GlyHis: 1.675 ± 0.387
3.628GlyIle: 3.628 ± 0.43
5.652GlyLys: 5.652 ± 0.614
5.233GlyLeu: 5.233 ± 0.686
2.023GlyMet: 2.023 ± 0.262
3.21GlyAsn: 3.21 ± 0.533
1.395GlyPro: 1.395 ± 0.359
1.605GlyGln: 1.605 ± 0.284
3.279GlyArg: 3.279 ± 0.429
3.977GlySer: 3.977 ± 0.697
4.535GlyThr: 4.535 ± 0.576
3.349GlyVal: 3.349 ± 0.546
0.837GlyTrp: 0.837 ± 0.296
3.07GlyTyr: 3.07 ± 0.43
0.0GlyXaa: 0.0 ± 0.0
His
0.768HisAla: 0.768 ± 0.204
0.209HisCys: 0.209 ± 0.126
0.837HisAsp: 0.837 ± 0.216
1.465HisGlu: 1.465 ± 0.299
1.047HisPhe: 1.047 ± 0.322
1.116HisGly: 1.116 ± 0.31
0.628HisHis: 0.628 ± 0.218
0.837HisIle: 0.837 ± 0.212
1.744HisLys: 1.744 ± 0.364
1.954HisLeu: 1.954 ± 0.372
0.209HisMet: 0.209 ± 0.112
0.907HisAsn: 0.907 ± 0.27
1.047HisPro: 1.047 ± 0.319
1.047HisGln: 1.047 ± 0.381
0.837HisArg: 0.837 ± 0.246
1.395HisSer: 1.395 ± 0.529
1.395HisThr: 1.395 ± 0.834
0.907HisVal: 0.907 ± 0.268
0.279HisTrp: 0.279 ± 0.145
0.907HisTyr: 0.907 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
3.489IleAla: 3.489 ± 0.532
0.698IleCys: 0.698 ± 0.221
4.326IleAsp: 4.326 ± 0.561
4.535IleGlu: 4.535 ± 0.498
2.303IlePhe: 2.303 ± 0.485
4.186IleGly: 4.186 ± 0.532
1.047IleHis: 1.047 ± 0.332
3.838IleIle: 3.838 ± 0.416
5.024IleLys: 5.024 ± 0.581
4.047IleLeu: 4.047 ± 0.512
1.675IleMet: 1.675 ± 0.336
3.279IleAsn: 3.279 ± 0.422
2.582IlePro: 2.582 ± 0.354
1.884IleGln: 1.884 ± 0.41
2.512IleArg: 2.512 ± 0.389
3.07IleSer: 3.07 ± 0.636
2.791IleThr: 2.791 ± 0.535
3.907IleVal: 3.907 ± 0.492
0.698IleTrp: 0.698 ± 0.211
2.442IleTyr: 2.442 ± 0.351
0.0IleXaa: 0.0 ± 0.0
Lys
5.582LysAla: 5.582 ± 0.748
1.116LysCys: 1.116 ± 0.367
5.652LysAsp: 5.652 ± 0.731
6.838LysGlu: 6.838 ± 0.923
3.21LysPhe: 3.21 ± 0.453
5.093LysGly: 5.093 ± 0.65
1.814LysHis: 1.814 ± 0.429
4.884LysIle: 4.884 ± 0.585
7.396LysLys: 7.396 ± 1.158
5.931LysLeu: 5.931 ± 0.975
1.884LysMet: 1.884 ± 0.369
3.628LysAsn: 3.628 ± 0.631
3.838LysPro: 3.838 ± 0.582
2.303LysGln: 2.303 ± 0.324
4.326LysArg: 4.326 ± 0.586
3.768LysSer: 3.768 ± 0.603
4.117LysThr: 4.117 ± 0.611
3.21LysVal: 3.21 ± 0.472
1.326LysTrp: 1.326 ± 0.343
4.117LysTyr: 4.117 ± 0.479
0.0LysXaa: 0.0 ± 0.0
Leu
5.442LeuAla: 5.442 ± 0.676
0.698LeuCys: 0.698 ± 0.226
4.535LeuAsp: 4.535 ± 0.426
5.303LeuGlu: 5.303 ± 0.627
2.651LeuPhe: 2.651 ± 0.484
4.117LeuGly: 4.117 ± 0.545
1.395LeuHis: 1.395 ± 0.331
4.814LeuIle: 4.814 ± 0.584
7.815LeuLys: 7.815 ± 0.675
5.442LeuLeu: 5.442 ± 0.584
2.023LeuMet: 2.023 ± 0.425
3.558LeuAsn: 3.558 ± 0.482
3.907LeuPro: 3.907 ± 0.745
3.349LeuGln: 3.349 ± 0.613
4.117LeuArg: 4.117 ± 0.529
3.977LeuSer: 3.977 ± 0.658
4.047LeuThr: 4.047 ± 0.522
5.093LeuVal: 5.093 ± 0.75
1.326LeuTrp: 1.326 ± 0.299
2.023LeuTyr: 2.023 ± 0.371
0.0LeuXaa: 0.0 ± 0.0
Met
2.233MetAla: 2.233 ± 0.331
0.14MetCys: 0.14 ± 0.099
1.675MetAsp: 1.675 ± 0.271
1.744MetGlu: 1.744 ± 0.306
0.698MetPhe: 0.698 ± 0.215
1.535MetGly: 1.535 ± 0.312
0.209MetHis: 0.209 ± 0.114
1.395MetIle: 1.395 ± 0.302
2.372MetLys: 2.372 ± 0.398
1.535MetLeu: 1.535 ± 0.339
0.419MetMet: 0.419 ± 0.172
1.744MetAsn: 1.744 ± 0.28
0.698MetPro: 0.698 ± 0.233
0.698MetGln: 0.698 ± 0.204
1.326MetArg: 1.326 ± 0.373
1.744MetSer: 1.744 ± 0.344
1.326MetThr: 1.326 ± 0.284
1.047MetVal: 1.047 ± 0.252
0.209MetTrp: 0.209 ± 0.133
0.837MetTyr: 0.837 ± 0.272
0.0MetXaa: 0.0 ± 0.0
Asn
2.582AsnAla: 2.582 ± 0.402
0.558AsnCys: 0.558 ± 0.221
3.558AsnAsp: 3.558 ± 0.529
2.582AsnGlu: 2.582 ± 0.511
2.233AsnPhe: 2.233 ± 0.389
3.0AsnGly: 3.0 ± 0.482
1.047AsnHis: 1.047 ± 0.355
3.21AsnIle: 3.21 ± 0.485
3.349AsnLys: 3.349 ± 0.477
3.558AsnLeu: 3.558 ± 0.523
1.256AsnMet: 1.256 ± 0.229
1.884AsnAsn: 1.884 ± 0.353
2.582AsnPro: 2.582 ± 0.445
1.675AsnGln: 1.675 ± 0.388
2.372AsnArg: 2.372 ± 0.497
3.0AsnSer: 3.0 ± 0.513
2.931AsnThr: 2.931 ± 0.725
2.651AsnVal: 2.651 ± 0.419
1.186AsnTrp: 1.186 ± 0.326
1.744AsnTyr: 1.744 ± 0.315
0.0AsnXaa: 0.0 ± 0.0
Pro
2.791ProAla: 2.791 ± 0.585
0.14ProCys: 0.14 ± 0.088
2.372ProAsp: 2.372 ± 0.397
4.256ProGlu: 4.256 ± 0.704
2.093ProPhe: 2.093 ± 0.346
2.651ProGly: 2.651 ± 0.417
0.628ProHis: 0.628 ± 0.199
1.884ProIle: 1.884 ± 0.36
3.907ProLys: 3.907 ± 0.605
3.0ProLeu: 3.0 ± 0.43
1.047ProMet: 1.047 ± 0.296
1.605ProAsn: 1.605 ± 0.364
1.535ProPro: 1.535 ± 0.351
1.465ProGln: 1.465 ± 0.431
2.303ProArg: 2.303 ± 0.412
2.861ProSer: 2.861 ± 0.478
2.163ProThr: 2.163 ± 0.383
3.0ProVal: 3.0 ± 0.487
0.837ProTrp: 0.837 ± 0.315
1.395ProTyr: 1.395 ± 0.361
0.0ProXaa: 0.0 ± 0.0
Gln
3.279GlnAla: 3.279 ± 0.719
0.07GlnCys: 0.07 ± 0.069
1.395GlnAsp: 1.395 ± 0.275
2.721GlnGlu: 2.721 ± 0.533
1.326GlnPhe: 1.326 ± 0.289
2.163GlnGly: 2.163 ± 0.331
0.837GlnHis: 0.837 ± 0.302
1.465GlnIle: 1.465 ± 0.37
2.721GlnLys: 2.721 ± 0.525
3.419GlnLeu: 3.419 ± 0.601
0.837GlnMet: 0.837 ± 0.225
1.884GlnAsn: 1.884 ± 0.439
2.023GlnPro: 2.023 ± 0.657
1.675GlnGln: 1.675 ± 0.584
2.303GlnArg: 2.303 ± 0.429
1.744GlnSer: 1.744 ± 0.356
1.814GlnThr: 1.814 ± 0.398
2.512GlnVal: 2.512 ± 0.65
0.279GlnTrp: 0.279 ± 0.114
1.675GlnTyr: 1.675 ± 0.406
0.0GlnXaa: 0.0 ± 0.0
Arg
3.14ArgAla: 3.14 ± 0.469
0.14ArgCys: 0.14 ± 0.088
2.791ArgAsp: 2.791 ± 0.522
4.117ArgGlu: 4.117 ± 0.718
2.582ArgPhe: 2.582 ± 0.399
4.117ArgGly: 4.117 ± 0.634
1.047ArgHis: 1.047 ± 0.287
2.582ArgIle: 2.582 ± 0.448
3.419ArgLys: 3.419 ± 0.677
4.675ArgLeu: 4.675 ± 0.534
1.605ArgMet: 1.605 ± 0.309
1.675ArgAsn: 1.675 ± 0.373
2.093ArgPro: 2.093 ± 0.49
2.442ArgGln: 2.442 ± 0.664
2.512ArgArg: 2.512 ± 0.492
2.931ArgSer: 2.931 ± 0.508
2.233ArgThr: 2.233 ± 0.391
4.326ArgVal: 4.326 ± 0.609
1.186ArgTrp: 1.186 ± 0.287
1.814ArgTyr: 1.814 ± 0.382
0.0ArgXaa: 0.0 ± 0.0
Ser
3.977SerAla: 3.977 ± 0.588
0.349SerCys: 0.349 ± 0.159
4.047SerAsp: 4.047 ± 0.52
3.698SerGlu: 3.698 ± 0.544
2.163SerPhe: 2.163 ± 0.402
5.093SerGly: 5.093 ± 0.907
1.186SerHis: 1.186 ± 0.52
2.791SerIle: 2.791 ± 0.48
4.326SerLys: 4.326 ± 0.493
4.396SerLeu: 4.396 ± 0.489
1.326SerMet: 1.326 ± 0.251
3.07SerAsn: 3.07 ± 0.478
1.675SerPro: 1.675 ± 0.322
1.535SerGln: 1.535 ± 0.293
3.07SerArg: 3.07 ± 0.41
11.094SerSer: 11.094 ± 4.645
8.722SerThr: 8.722 ± 4.011
3.349SerVal: 3.349 ± 0.546
0.907SerTrp: 0.907 ± 0.219
2.512SerTyr: 2.512 ± 0.388
0.0SerXaa: 0.0 ± 0.0
Thr
3.768ThrAla: 3.768 ± 0.673
0.279ThrCys: 0.279 ± 0.122
2.931ThrAsp: 2.931 ± 0.47
2.651ThrGlu: 2.651 ± 0.377
2.093ThrPhe: 2.093 ± 0.304
4.256ThrGly: 4.256 ± 0.688
1.535ThrHis: 1.535 ± 0.573
3.0ThrIle: 3.0 ± 0.422
3.907ThrLys: 3.907 ± 0.476
3.279ThrLeu: 3.279 ± 0.431
1.395ThrMet: 1.395 ± 0.287
1.954ThrAsn: 1.954 ± 0.36
3.489ThrPro: 3.489 ± 0.396
1.744ThrGln: 1.744 ± 0.35
2.163ThrArg: 2.163 ± 0.298
8.652ThrSer: 8.652 ± 4.014
8.233ThrThr: 8.233 ± 3.484
2.931ThrVal: 2.931 ± 0.454
1.326ThrTrp: 1.326 ± 0.297
2.023ThrTyr: 2.023 ± 0.329
0.0ThrXaa: 0.0 ± 0.0
Val
4.535ValAla: 4.535 ± 0.704
0.698ValCys: 0.698 ± 0.248
3.489ValAsp: 3.489 ± 0.532
4.256ValGlu: 4.256 ± 0.53
2.582ValPhe: 2.582 ± 0.519
3.977ValGly: 3.977 ± 0.65
0.837ValHis: 0.837 ± 0.28
3.279ValIle: 3.279 ± 0.499
4.256ValLys: 4.256 ± 0.461
4.396ValLeu: 4.396 ± 0.758
1.465ValMet: 1.465 ± 0.312
2.721ValAsn: 2.721 ± 0.459
2.582ValPro: 2.582 ± 0.408
2.093ValGln: 2.093 ± 0.694
3.419ValArg: 3.419 ± 0.576
3.838ValSer: 3.838 ± 0.582
2.582ValThr: 2.582 ± 0.453
4.256ValVal: 4.256 ± 0.638
0.628ValTrp: 0.628 ± 0.205
2.931ValTyr: 2.931 ± 0.441
0.0ValXaa: 0.0 ± 0.0
Trp
0.977TrpAla: 0.977 ± 0.251
0.209TrpCys: 0.209 ± 0.105
1.814TrpAsp: 1.814 ± 0.375
0.977TrpGlu: 0.977 ± 0.24
0.698TrpPhe: 0.698 ± 0.224
1.465TrpGly: 1.465 ± 0.32
0.419TrpHis: 0.419 ± 0.164
0.628TrpIle: 0.628 ± 0.206
1.256TrpLys: 1.256 ± 0.321
1.186TrpLeu: 1.186 ± 0.321
0.14TrpMet: 0.14 ± 0.107
1.116TrpAsn: 1.116 ± 0.32
0.768TrpPro: 0.768 ± 0.217
0.977TrpGln: 0.977 ± 0.286
0.628TrpArg: 0.628 ± 0.19
0.768TrpSer: 0.768 ± 0.163
0.768TrpThr: 0.768 ± 0.254
0.768TrpVal: 0.768 ± 0.208
0.419TrpTrp: 0.419 ± 0.162
0.558TrpTyr: 0.558 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.303TyrAla: 2.303 ± 0.416
0.279TyrCys: 0.279 ± 0.167
2.442TyrAsp: 2.442 ± 0.388
2.233TyrGlu: 2.233 ± 0.425
2.861TyrPhe: 2.861 ± 0.459
3.419TyrGly: 3.419 ± 0.592
0.977TyrHis: 0.977 ± 0.27
2.582TyrIle: 2.582 ± 0.388
3.21TyrLys: 3.21 ± 0.434
2.791TyrLeu: 2.791 ± 0.404
0.837TyrMet: 0.837 ± 0.24
2.651TyrAsn: 2.651 ± 0.371
1.814TyrPro: 1.814 ± 0.308
1.535TyrGln: 1.535 ± 0.298
2.023TyrArg: 2.023 ± 0.36
2.721TyrSer: 2.721 ± 0.564
2.233TyrThr: 2.233 ± 0.314
1.814TyrVal: 1.814 ± 0.382
0.628TyrTrp: 0.628 ± 0.173
1.186TyrTyr: 1.186 ± 0.289
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (14333 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski