Amino acid dipepetide frequency for Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.588AlaAla: 3.588 ± 0.108
0.583AlaCys: 0.583 ± 0.029
2.772AlaAsp: 2.772 ± 0.068
3.621AlaGlu: 3.621 ± 0.087
2.526AlaPhe: 2.526 ± 0.066
3.713AlaGly: 3.713 ± 0.083
0.935AlaHis: 0.935 ± 0.044
5.174AlaIle: 5.174 ± 0.089
5.2AlaLys: 5.2 ± 0.095
5.601AlaLeu: 5.601 ± 0.105
1.18AlaMet: 1.18 ± 0.047
2.467AlaAsn: 2.467 ± 0.056
1.349AlaPro: 1.349 ± 0.048
1.114AlaGln: 1.114 ± 0.043
1.657AlaArg: 1.657 ± 0.051
2.669AlaSer: 2.669 ± 0.071
2.56AlaThr: 2.56 ± 0.068
3.736AlaVal: 3.736 ± 0.085
0.241AlaTrp: 0.241 ± 0.018
2.113AlaTyr: 2.113 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.517CysAla: 0.517 ± 0.027
0.121CysCys: 0.121 ± 0.014
0.59CysAsp: 0.59 ± 0.028
0.688CysGlu: 0.688 ± 0.033
0.461CysPhe: 0.461 ± 0.025
0.883CysGly: 0.883 ± 0.041
0.415CysHis: 0.415 ± 0.059
0.697CysIle: 0.697 ± 0.031
0.854CysLys: 0.854 ± 0.033
0.685CysLeu: 0.685 ± 0.03
0.219CysMet: 0.219 ± 0.017
0.579CysAsn: 0.579 ± 0.032
0.462CysPro: 0.462 ± 0.031
0.186CysGln: 0.186 ± 0.018
0.305CysArg: 0.305 ± 0.02
0.639CysSer: 0.639 ± 0.032
0.414CysThr: 0.414 ± 0.025
0.552CysVal: 0.552 ± 0.028
0.068CysTrp: 0.068 ± 0.01
0.405CysTyr: 0.405 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.781AspAla: 2.781 ± 0.072
0.567AspCys: 0.567 ± 0.029
3.287AspAsp: 3.287 ± 0.08
4.84AspGlu: 4.84 ± 0.086
3.624AspPhe: 3.624 ± 0.075
3.109AspGly: 3.109 ± 0.08
0.637AspHis: 0.637 ± 0.032
6.606AspIle: 6.606 ± 0.098
6.082AspLys: 6.082 ± 0.097
5.385AspLeu: 5.385 ± 0.09
1.182AspMet: 1.182 ± 0.034
3.556AspAsn: 3.556 ± 0.085
1.639AspPro: 1.639 ± 0.049
0.719AspGln: 0.719 ± 0.035
1.795AspArg: 1.795 ± 0.051
2.836AspSer: 2.836 ± 0.062
2.394AspThr: 2.394 ± 0.064
3.888AspVal: 3.888 ± 0.082
0.375AspTrp: 0.375 ± 0.024
3.004AspTyr: 3.004 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
3.54GluAla: 3.54 ± 0.08
0.546GluCys: 0.546 ± 0.028
3.765GluAsp: 3.765 ± 0.081
5.484GluGlu: 5.484 ± 0.122
3.233GluPhe: 3.233 ± 0.066
3.291GluGly: 3.291 ± 0.071
1.08GluHis: 1.08 ± 0.033
7.719GluIle: 7.719 ± 0.109
8.456GluLys: 8.456 ± 0.135
6.967GluLeu: 6.967 ± 0.099
1.606GluMet: 1.606 ± 0.047
5.031GluAsn: 5.031 ± 0.104
1.505GluPro: 1.505 ± 0.047
1.826GluGln: 1.826 ± 0.053
2.542GluArg: 2.542 ± 0.064
3.317GluSer: 3.317 ± 0.064
2.852GluThr: 2.852 ± 0.073
4.461GluVal: 4.461 ± 0.089
0.362GluTrp: 0.362 ± 0.02
3.034GluTyr: 3.034 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
2.813PheAla: 2.813 ± 0.077
0.531PheCys: 0.531 ± 0.025
3.583PheAsp: 3.583 ± 0.08
3.722PheGlu: 3.722 ± 0.078
2.974PhePhe: 2.974 ± 0.078
3.219PheGly: 3.219 ± 0.062
0.764PheHis: 0.764 ± 0.037
5.45PheIle: 5.45 ± 0.118
4.545PheLys: 4.545 ± 0.09
5.672PheLeu: 5.672 ± 0.108
1.078PheMet: 1.078 ± 0.04
3.174PheAsn: 3.174 ± 0.073
1.399PhePro: 1.399 ± 0.045
1.131PheGln: 1.131 ± 0.04
1.63PheArg: 1.63 ± 0.048
3.4PheSer: 3.4 ± 0.084
2.62PheThr: 2.62 ± 0.069
3.587PheVal: 3.587 ± 0.071
0.325PheTrp: 0.325 ± 0.022
2.722PheTyr: 2.722 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
3.45GlyAla: 3.45 ± 0.092
0.8GlyCys: 0.8 ± 0.035
3.113GlyAsp: 3.113 ± 0.074
3.718GlyGlu: 3.718 ± 0.082
3.545GlyPhe: 3.545 ± 0.078
3.87GlyGly: 3.87 ± 0.101
0.984GlyHis: 0.984 ± 0.042
5.499GlyIle: 5.499 ± 0.099
5.4GlyLys: 5.4 ± 0.096
5.535GlyLeu: 5.535 ± 0.11
1.399GlyMet: 1.399 ± 0.05
2.629GlyAsn: 2.629 ± 0.063
1.148GlyPro: 1.148 ± 0.046
1.053GlyGln: 1.053 ± 0.04
2.079GlyArg: 2.079 ± 0.055
3.067GlySer: 3.067 ± 0.063
2.768GlyThr: 2.768 ± 0.069
4.533GlyVal: 4.533 ± 0.081
0.557GlyTrp: 0.557 ± 0.039
2.973GlyTyr: 2.973 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
0.704HisAla: 0.704 ± 0.032
0.172HisCys: 0.172 ± 0.015
0.742HisAsp: 0.742 ± 0.032
0.861HisGlu: 0.861 ± 0.039
0.863HisPhe: 0.863 ± 0.037
0.95HisGly: 0.95 ± 0.037
0.31HisHis: 0.31 ± 0.024
1.538HisIle: 1.538 ± 0.046
1.275HisLys: 1.275 ± 0.041
1.513HisLeu: 1.513 ± 0.046
0.244HisMet: 0.244 ± 0.015
0.856HisAsn: 0.856 ± 0.039
0.789HisPro: 0.789 ± 0.031
0.339HisGln: 0.339 ± 0.022
0.541HisArg: 0.541 ± 0.028
0.814HisSer: 0.814 ± 0.037
0.755HisThr: 0.755 ± 0.032
0.827HisVal: 0.827 ± 0.035
0.097HisTrp: 0.097 ± 0.012
0.663HisTyr: 0.663 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.468IleAla: 5.468 ± 0.096
0.899IleCys: 0.899 ± 0.04
6.615IleAsp: 6.615 ± 0.105
6.98IleGlu: 6.98 ± 0.109
5.311IlePhe: 5.311 ± 0.108
5.138IleGly: 5.138 ± 0.093
1.243IleHis: 1.243 ± 0.042
8.986IleIle: 8.986 ± 0.137
9.753IleLys: 9.753 ± 0.125
9.456IleLeu: 9.456 ± 0.142
1.739IleMet: 1.739 ± 0.056
6.558IleAsn: 6.558 ± 0.099
3.422IlePro: 3.422 ± 0.071
1.944IleGln: 1.944 ± 0.061
2.891IleArg: 2.891 ± 0.077
6.148IleSer: 6.148 ± 0.103
4.847IleThr: 4.847 ± 0.073
6.027IleVal: 6.027 ± 0.095
0.436IleTrp: 0.436 ± 0.023
4.064IleTyr: 4.064 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
4.342LysAla: 4.342 ± 0.082
0.759LysCys: 0.759 ± 0.037
5.99LysAsp: 5.99 ± 0.1
8.028LysGlu: 8.028 ± 0.133
4.209LysPhe: 4.209 ± 0.075
5.246LysGly: 5.246 ± 0.088
1.416LysHis: 1.416 ± 0.043
10.188LysIle: 10.188 ± 0.121
10.256LysLys: 10.256 ± 0.147
9.111LysLeu: 9.111 ± 0.119
2.193LysMet: 2.193 ± 0.054
7.394LysAsn: 7.394 ± 0.144
2.612LysPro: 2.612 ± 0.06
2.27LysGln: 2.27 ± 0.061
3.684LysArg: 3.684 ± 0.076
5.542LysSer: 5.542 ± 0.1
4.407LysThr: 4.407 ± 0.076
6.194LysVal: 6.194 ± 0.111
0.599LysTrp: 0.599 ± 0.032
5.103LysTyr: 5.103 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
5.361LeuAla: 5.361 ± 0.095
0.825LeuCys: 0.825 ± 0.039
5.345LeuAsp: 5.345 ± 0.086
6.486LeuGlu: 6.486 ± 0.107
5.175LeuPhe: 5.175 ± 0.118
5.474LeuGly: 5.474 ± 0.098
1.403LeuHis: 1.403 ± 0.041
9.331LeuIle: 9.331 ± 0.129
10.857LeuLys: 10.857 ± 0.12
9.481LeuLeu: 9.481 ± 0.161
2.01LeuMet: 2.01 ± 0.057
6.481LeuAsn: 6.481 ± 0.117
3.264LeuPro: 3.264 ± 0.073
2.367LeuGln: 2.367 ± 0.062
3.207LeuArg: 3.207 ± 0.069
6.59LeuSer: 6.59 ± 0.107
4.57LeuThr: 4.57 ± 0.08
5.373LeuVal: 5.373 ± 0.099
0.531LeuTrp: 0.531 ± 0.031
3.812LeuTyr: 3.812 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.254MetAla: 1.254 ± 0.041
0.194MetCys: 0.194 ± 0.015
1.174MetAsp: 1.174 ± 0.039
1.221MetGlu: 1.221 ± 0.031
1.026MetPhe: 1.026 ± 0.038
1.351MetGly: 1.351 ± 0.046
0.301MetHis: 0.301 ± 0.022
1.905MetIle: 1.905 ± 0.059
2.158MetLys: 2.158 ± 0.053
1.972MetLeu: 1.972 ± 0.053
0.516MetMet: 0.516 ± 0.028
1.229MetAsn: 1.229 ± 0.042
0.732MetPro: 0.732 ± 0.033
0.525MetGln: 0.525 ± 0.022
0.798MetArg: 0.798 ± 0.034
1.232MetSer: 1.232 ± 0.039
0.907MetThr: 0.907 ± 0.04
1.308MetVal: 1.308 ± 0.041
0.13MetTrp: 0.13 ± 0.014
0.697MetTyr: 0.697 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.508AsnAla: 2.508 ± 0.068
0.649AsnCys: 0.649 ± 0.032
3.161AsnAsp: 3.161 ± 0.066
4.068AsnGlu: 4.068 ± 0.075
3.562AsnPhe: 3.562 ± 0.079
3.198AsnGly: 3.198 ± 0.074
0.81AsnHis: 0.81 ± 0.03
6.944AsnIle: 6.944 ± 0.116
6.338AsnLys: 6.338 ± 0.123
6.268AsnLeu: 6.268 ± 0.105
1.216AsnMet: 1.216 ± 0.041
4.469AsnAsn: 4.469 ± 0.112
2.204AsnPro: 2.204 ± 0.054
1.404AsnGln: 1.404 ± 0.05
2.065AsnArg: 2.065 ± 0.051
3.439AsnSer: 3.439 ± 0.079
2.696AsnThr: 2.696 ± 0.073
3.526AsnVal: 3.526 ± 0.076
0.372AsnTrp: 0.372 ± 0.02
3.077AsnTyr: 3.077 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
1.573ProAla: 1.573 ± 0.052
0.252ProCys: 0.252 ± 0.019
2.066ProAsp: 2.066 ± 0.045
2.643ProGlu: 2.643 ± 0.06
1.863ProPhe: 1.863 ± 0.051
1.837ProGly: 1.837 ± 0.06
0.554ProHis: 0.554 ± 0.027
2.646ProIle: 2.646 ± 0.057
2.37ProLys: 2.37 ± 0.058
2.707ProLeu: 2.707 ± 0.065
0.536ProMet: 0.536 ± 0.028
1.442ProAsn: 1.442 ± 0.046
0.904ProPro: 0.904 ± 0.038
0.71ProGln: 0.71 ± 0.035
0.74ProArg: 0.74 ± 0.032
1.492ProSer: 1.492 ± 0.05
1.509ProThr: 1.509 ± 0.049
2.513ProVal: 2.513 ± 0.057
0.233ProTrp: 0.233 ± 0.017
1.432ProTyr: 1.432 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.165GlnAla: 1.165 ± 0.043
0.193GlnCys: 0.193 ± 0.018
1.039GlnAsp: 1.039 ± 0.042
1.427GlnGlu: 1.427 ± 0.042
1.158GlnPhe: 1.158 ± 0.039
1.063GlnGly: 1.063 ± 0.039
0.314GlnHis: 0.314 ± 0.02
2.352GlnIle: 2.352 ± 0.068
2.274GlnLys: 2.274 ± 0.059
2.16GlnLeu: 2.16 ± 0.05
0.59GlnMet: 0.59 ± 0.03
1.48GlnAsn: 1.48 ± 0.055
0.621GlnPro: 0.621 ± 0.033
0.666GlnGln: 0.666 ± 0.04
0.752GlnArg: 0.752 ± 0.033
1.121GlnSer: 1.121 ± 0.044
0.987GlnThr: 0.987 ± 0.035
1.29GlnVal: 1.29 ± 0.039
0.134GlnTrp: 0.134 ± 0.013
0.964GlnTyr: 0.964 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
1.638ArgAla: 1.638 ± 0.042
0.358ArgCys: 0.358 ± 0.022
1.791ArgAsp: 1.791 ± 0.053
2.502ArgGlu: 2.502 ± 0.057
1.914ArgPhe: 1.914 ± 0.051
1.949ArgGly: 1.949 ± 0.048
0.445ArgHis: 0.445 ± 0.026
2.916ArgIle: 2.916 ± 0.072
3.144ArgLys: 3.144 ± 0.072
3.362ArgLeu: 3.362 ± 0.07
0.764ArgMet: 0.764 ± 0.033
1.854ArgAsn: 1.854 ± 0.059
0.897ArgPro: 0.897 ± 0.04
0.814ArgGln: 0.814 ± 0.035
1.326ArgArg: 1.326 ± 0.048
1.435ArgSer: 1.435 ± 0.042
1.232ArgThr: 1.232 ± 0.042
2.352ArgVal: 2.352 ± 0.064
0.287ArgTrp: 0.287 ± 0.021
1.6ArgTyr: 1.6 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
2.857SerAla: 2.857 ± 0.069
0.631SerCys: 0.631 ± 0.037
3.36SerAsp: 3.36 ± 0.071
3.557SerGlu: 3.557 ± 0.071
3.539SerPhe: 3.539 ± 0.077
3.689SerGly: 3.689 ± 0.085
0.795SerHis: 0.795 ± 0.037
5.377SerIle: 5.377 ± 0.094
5.538SerLys: 5.538 ± 0.092
5.78SerLeu: 5.78 ± 0.089
1.106SerMet: 1.106 ± 0.036
3.324SerAsn: 3.324 ± 0.081
1.583SerPro: 1.583 ± 0.048
1.26SerGln: 1.26 ± 0.045
1.631SerArg: 1.631 ± 0.05
3.41SerSer: 3.41 ± 0.082
2.58SerThr: 2.58 ± 0.064
3.615SerVal: 3.615 ± 0.065
0.364SerTrp: 0.364 ± 0.026
2.561SerTyr: 2.561 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
2.703ThrAla: 2.703 ± 0.067
0.457ThrCys: 0.457 ± 0.026
2.636ThrAsp: 2.636 ± 0.06
2.692ThrGlu: 2.692 ± 0.059
2.658ThrPhe: 2.658 ± 0.063
3.427ThrGly: 3.427 ± 0.078
0.8ThrHis: 0.8 ± 0.033
4.217ThrIle: 4.217 ± 0.078
3.887ThrLys: 3.887 ± 0.073
4.443ThrLeu: 4.443 ± 0.071
0.778ThrMet: 0.778 ± 0.037
2.618ThrAsn: 2.618 ± 0.077
1.846ThrPro: 1.846 ± 0.047
0.977ThrGln: 0.977 ± 0.038
1.149ThrArg: 1.149 ± 0.039
2.46ThrSer: 2.46 ± 0.074
2.555ThrThr: 2.555 ± 0.07
3.406ThrVal: 3.406 ± 0.077
0.237ThrTrp: 0.237 ± 0.018
1.902ThrTyr: 1.902 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.057ValAla: 4.057 ± 0.091
0.694ValCys: 0.694 ± 0.033
4.13ValAsp: 4.13 ± 0.077
4.701ValGlu: 4.701 ± 0.09
3.392ValPhe: 3.392 ± 0.072
3.849ValGly: 3.849 ± 0.081
0.795ValHis: 0.795 ± 0.034
5.99ValIle: 5.99 ± 0.109
6.334ValLys: 6.334 ± 0.101
6.207ValLeu: 6.207 ± 0.087
1.322ValMet: 1.322 ± 0.045
3.557ValAsn: 3.557 ± 0.061
1.891ValPro: 1.891 ± 0.06
1.114ValGln: 1.114 ± 0.044
2.122ValArg: 2.122 ± 0.057
3.921ValSer: 3.921 ± 0.064
2.986ValThr: 2.986 ± 0.073
4.917ValVal: 4.917 ± 0.111
0.337ValTrp: 0.337 ± 0.024
2.673ValTyr: 2.673 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.348TrpAla: 0.348 ± 0.021
0.059TrpCys: 0.059 ± 0.011
0.4TrpAsp: 0.4 ± 0.03
0.4TrpGlu: 0.4 ± 0.022
0.364TrpPhe: 0.364 ± 0.025
0.41TrpGly: 0.41 ± 0.021
0.147TrpHis: 0.147 ± 0.015
0.521TrpIle: 0.521 ± 0.03
0.487TrpLys: 0.487 ± 0.026
0.607TrpLeu: 0.607 ± 0.028
0.168TrpMet: 0.168 ± 0.018
0.299TrpAsn: 0.299 ± 0.02
0.186TrpPro: 0.186 ± 0.015
0.182TrpGln: 0.182 ± 0.017
0.195TrpArg: 0.195 ± 0.015
0.293TrpSer: 0.293 ± 0.018
0.259TrpThr: 0.259 ± 0.031
0.377TrpVal: 0.377 ± 0.024
0.071TrpTrp: 0.071 ± 0.009
0.275TrpTyr: 0.275 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.133TyrAla: 2.133 ± 0.05
0.452TyrCys: 0.452 ± 0.023
2.746TyrAsp: 2.746 ± 0.068
2.979TyrGlu: 2.979 ± 0.069
2.94TyrPhe: 2.94 ± 0.069
2.455TyrGly: 2.455 ± 0.065
0.7TyrHis: 0.7 ± 0.028
3.873TyrIle: 3.873 ± 0.08
4.335TyrLys: 4.335 ± 0.088
5.033TyrLeu: 5.033 ± 0.092
0.782TyrMet: 0.782 ± 0.031
2.975TyrAsn: 2.975 ± 0.075
1.57TyrPro: 1.57 ± 0.05
1.146TyrGln: 1.146 ± 0.04
1.469TyrArg: 1.469 ± 0.041
2.732TyrSer: 2.732 ± 0.066
1.953TyrThr: 1.953 ± 0.048
2.508TyrVal: 2.508 ± 0.06
0.295TyrTrp: 0.295 ± 0.018
2.339TyrTyr: 2.339 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2338 proteins (763288 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski