Amino acid dipepetide frequency for Roseobacter cerasinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.877AlaAla: 15.877 ± 0.162	1.174AlaCys: 1.174 ± 0.034	7.077AlaAsp: 7.077 ± 0.087	8.18AlaGlu: 8.18 ± 0.084	4.444AlaPhe: 4.444 ± 0.062	9.912AlaGly: 9.912 ± 0.094	2.344AlaHis: 2.344 ± 0.044	5.639AlaIle: 5.639 ± 0.073	3.676AlaLys: 3.676 ± 0.069	13.75AlaLeu: 13.75 ± 0.137	3.694AlaMet: 3.694 ± 0.06	2.597AlaAsn: 2.597 ± 0.047	5.732AlaPro: 5.732 ± 0.079	5.037AlaGln: 5.037 ± 0.064	8.456AlaArg: 8.456 ± 0.089	5.688AlaSer: 5.688 ± 0.065	6.046AlaThr: 6.046 ± 0.072	8.408AlaVal: 8.408 ± 0.086	1.405AlaTrp: 1.405 ± 0.034	2.512AlaTyr: 2.512 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.174CysAla: 1.174 ± 0.032	0.118CysCys: 0.118 ± 0.009	0.638CysAsp: 0.638 ± 0.021	0.473CysGlu: 0.473 ± 0.02	0.359CysPhe: 0.359 ± 0.015	0.987CysGly: 0.987 ± 0.033	0.271CysHis: 0.271 ± 0.016	0.434CysIle: 0.434 ± 0.018	0.228CysLys: 0.228 ± 0.015	0.917CysLeu: 0.917 ± 0.027	0.187CysMet: 0.187 ± 0.011	0.225CysAsn: 0.225 ± 0.012	0.484CysPro: 0.484 ± 0.021	0.261CysGln: 0.261 ± 0.014	0.541CysArg: 0.541 ± 0.021	0.459CysSer: 0.459 ± 0.021	0.503CysThr: 0.503 ± 0.021	0.687CysVal: 0.687 ± 0.024	0.104CysTrp: 0.104 ± 0.008	0.216CysTyr: 0.216 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.583AspAla: 7.583 ± 0.087	0.494AspCys: 0.494 ± 0.021	3.538AspAsp: 3.538 ± 0.086	3.399AspGlu: 3.399 ± 0.067	2.342AspPhe: 2.342 ± 0.045	5.721AspGly: 5.721 ± 0.126	1.456AspHis: 1.456 ± 0.036	3.347AspIle: 3.347 ± 0.053	1.624AspLys: 1.624 ± 0.032	6.613AspLeu: 6.613 ± 0.087	1.691AspMet: 1.691 ± 0.038	1.339AspAsn: 1.339 ± 0.038	3.6AspPro: 3.6 ± 0.055	2.243AspGln: 2.243 ± 0.044	4.094AspArg: 4.094 ± 0.047	2.177AspSer: 2.177 ± 0.048	3.286AspThr: 3.286 ± 0.091	4.776AspVal: 4.776 ± 0.062	1.139AspTrp: 1.139 ± 0.029	1.548AspTyr: 1.548 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.94GluAla: 7.94 ± 0.087	0.337GluCys: 0.337 ± 0.014	3.535GluAsp: 3.535 ± 0.057	3.44GluGlu: 3.44 ± 0.06	1.849GluPhe: 1.849 ± 0.041	4.588GluGly: 4.588 ± 0.068	1.156GluHis: 1.156 ± 0.031	3.612GluIle: 3.612 ± 0.055	2.026GluLys: 2.026 ± 0.046	4.972GluLeu: 4.972 ± 0.073	1.828GluMet: 1.828 ± 0.036	1.741GluAsn: 1.741 ± 0.035	2.432GluPro: 2.432 ± 0.057	2.137GluGln: 2.137 ± 0.047	3.984GluArg: 3.984 ± 0.058	2.013GluSer: 2.013 ± 0.04	4.111GluThr: 4.111 ± 0.06	4.441GluVal: 4.441 ± 0.064	0.634GluTrp: 0.634 ± 0.024	1.002GluTyr: 1.002 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.605PheAla: 4.605 ± 0.054	0.452PheCys: 0.452 ± 0.016	3.071PheAsp: 3.071 ± 0.047	2.506PheGlu: 2.506 ± 0.044	1.546PhePhe: 1.546 ± 0.038	3.8PheGly: 3.8 ± 0.053	0.776PheHis: 0.776 ± 0.025	1.717PheIle: 1.717 ± 0.039	1.028PheLys: 1.028 ± 0.025	3.401PheLeu: 3.401 ± 0.059	0.869PheMet: 0.869 ± 0.028	1.077PheAsn: 1.077 ± 0.033	1.491PhePro: 1.491 ± 0.033	1.198PheGln: 1.198 ± 0.03	2.013PheArg: 2.013 ± 0.047	2.218PheSer: 2.218 ± 0.044	2.056PheThr: 2.056 ± 0.043	2.793PheVal: 2.793 ± 0.051	0.579PheTrp: 0.579 ± 0.026	0.931PheTyr: 0.931 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.707GlyAla: 9.707 ± 0.107	0.901GlyCys: 0.901 ± 0.029	4.769GlyAsp: 4.769 ± 0.099	4.385GlyGlu: 4.385 ± 0.067	3.769GlyPhe: 3.769 ± 0.058	7.282GlyGly: 7.282 ± 0.15	1.883GlyHis: 1.883 ± 0.044	4.241GlyIle: 4.241 ± 0.062	2.875GlyLys: 2.875 ± 0.045	9.148GlyLeu: 9.148 ± 0.091	2.411GlyMet: 2.411 ± 0.047	2.093GlyAsn: 2.093 ± 0.074	3.679GlyPro: 3.679 ± 0.052	3.359GlyGln: 3.359 ± 0.056	5.385GlyArg: 5.385 ± 0.065	4.291GlySer: 4.291 ± 0.084	4.835GlyThr: 4.835 ± 0.072	6.438GlyVal: 6.438 ± 0.078	1.412GlyTrp: 1.412 ± 0.04	2.323GlyTyr: 2.323 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.364HisAla: 2.364 ± 0.041	0.248HisCys: 0.248 ± 0.014	1.285HisAsp: 1.285 ± 0.03	1.062HisGlu: 1.062 ± 0.028	0.835HisPhe: 0.835 ± 0.025	1.863HisGly: 1.863 ± 0.04	0.548HisHis: 0.548 ± 0.021	1.035HisIle: 1.035 ± 0.028	0.555HisLys: 0.555 ± 0.022	2.261HisLeu: 2.261 ± 0.043	0.614HisMet: 0.614 ± 0.022	0.468HisAsn: 0.468 ± 0.018	1.335HisPro: 1.335 ± 0.037	0.638HisGln: 0.638 ± 0.024	1.345HisArg: 1.345 ± 0.036	0.984HisSer: 0.984 ± 0.026	0.926HisThr: 0.926 ± 0.027	1.533HisVal: 1.533 ± 0.034	0.356HisTrp: 0.356 ± 0.018	0.57HisTyr: 0.57 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.782IleAla: 6.782 ± 0.082	0.69IleCys: 0.69 ± 0.023	3.602IleAsp: 3.602 ± 0.061	3.431IleGlu: 3.431 ± 0.056	1.909IlePhe: 1.909 ± 0.043	4.781IleGly: 4.781 ± 0.066	0.923IleHis: 0.923 ± 0.027	2.28IleIle: 2.28 ± 0.048	1.527IleLys: 1.527 ± 0.034	4.626IleLeu: 4.626 ± 0.067	1.146IleMet: 1.146 ± 0.031	1.533IleAsn: 1.533 ± 0.036	2.31IlePro: 2.31 ± 0.042	1.262IleGln: 1.262 ± 0.034	3.035IleArg: 3.035 ± 0.05	3.156IleSer: 3.156 ± 0.053	3.141IleThr: 3.141 ± 0.057	3.76IleVal: 3.76 ± 0.061	0.777IleTrp: 0.777 ± 0.025	1.213IleTyr: 1.213 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.792LysAla: 3.792 ± 0.061	0.193LysCys: 0.193 ± 0.012	1.808LysAsp: 1.808 ± 0.041	1.536LysGlu: 1.536 ± 0.038	0.869LysPhe: 0.869 ± 0.023	2.544LysGly: 2.544 ± 0.049	0.626LysHis: 0.626 ± 0.024	1.67LysIle: 1.67 ± 0.037	1.109LysLys: 1.109 ± 0.039	2.872LysLeu: 2.872 ± 0.053	0.857LysMet: 0.857 ± 0.025	0.772LysAsn: 0.772 ± 0.024	1.749LysPro: 1.749 ± 0.042	0.956LysGln: 0.956 ± 0.026	2.171LysArg: 2.171 ± 0.043	1.811LysSer: 1.811 ± 0.039	2.021LysThr: 2.021 ± 0.046	2.191LysVal: 2.191 ± 0.048	0.388LysTrp: 0.388 ± 0.015	0.622LysTyr: 0.622 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.473LeuAla: 12.473 ± 0.107	1.025LeuCys: 1.025 ± 0.029	6.173LeuAsp: 6.173 ± 0.08	5.35LeuGlu: 5.35 ± 0.068	3.585LeuPhe: 3.585 ± 0.058	8.232LeuGly: 8.232 ± 0.09	1.934LeuHis: 1.934 ± 0.043	5.41LeuIle: 5.41 ± 0.076	3.135LeuLys: 3.135 ± 0.056	9.021LeuLeu: 9.021 ± 0.134	2.694LeuMet: 2.694 ± 0.048	2.74LeuAsn: 2.74 ± 0.047	5.531LeuPro: 5.531 ± 0.075	3.184LeuGln: 3.184 ± 0.049	7.048LeuArg: 7.048 ± 0.082	6.706LeuSer: 6.706 ± 0.08	6.127LeuThr: 6.127 ± 0.078	6.649LeuVal: 6.649 ± 0.07	1.306LeuTrp: 1.306 ± 0.033	1.994LeuTyr: 1.994 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.492MetAla: 3.492 ± 0.055	0.207MetCys: 0.207 ± 0.012	1.473MetAsp: 1.473 ± 0.034	1.306MetGlu: 1.306 ± 0.033	0.806MetPhe: 0.806 ± 0.027	2.273MetGly: 2.273 ± 0.049	0.502MetHis: 0.502 ± 0.019	1.642MetIle: 1.642 ± 0.031	1.002MetLys: 1.002 ± 0.028	2.666MetLeu: 2.666 ± 0.046	0.835MetMet: 0.835 ± 0.028	0.8MetAsn: 0.8 ± 0.023	1.465MetPro: 1.465 ± 0.034	1.141MetGln: 1.141 ± 0.027	1.863MetArg: 1.863 ± 0.041	1.867MetSer: 1.867 ± 0.036	2.076MetThr: 2.076 ± 0.042	1.853MetVal: 1.853 ± 0.04	0.27MetTrp: 0.27 ± 0.015	0.364MetTyr: 0.364 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.104AsnAla: 3.104 ± 0.054	0.264AsnCys: 0.264 ± 0.016	1.573AsnAsp: 1.573 ± 0.053	1.183AsnGlu: 1.183 ± 0.032	0.988AsnPhe: 0.988 ± 0.03	2.345AsnGly: 2.345 ± 0.059	0.507AsnHis: 0.507 ± 0.022	1.447AsnIle: 1.447 ± 0.039	0.648AsnLys: 0.648 ± 0.024	2.405AsnLeu: 2.405 ± 0.044	0.727AsnMet: 0.727 ± 0.022	0.709AsnAsn: 0.709 ± 0.032	1.766AsnPro: 1.766 ± 0.037	0.77AsnGln: 0.77 ± 0.024	1.726AsnArg: 1.726 ± 0.035	1.201AsnSer: 1.201 ± 0.03	1.485AsnThr: 1.485 ± 0.04	1.824AsnVal: 1.824 ± 0.042	0.455AsnTrp: 0.455 ± 0.021	0.663AsnTyr: 0.663 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.349ProAla: 5.349 ± 0.075	0.373ProCys: 0.373 ± 0.021	3.997ProAsp: 3.997 ± 0.056	4.045ProGlu: 4.045 ± 0.066	1.963ProPhe: 1.963 ± 0.045	4.313ProGly: 4.313 ± 0.065	1.081ProHis: 1.081 ± 0.03	2.3ProIle: 2.3 ± 0.046	1.694ProLys: 1.694 ± 0.045	4.607ProLeu: 4.607 ± 0.06	1.328ProMet: 1.328 ± 0.033	1.356ProAsn: 1.356 ± 0.033	2.277ProPro: 2.277 ± 0.049	1.838ProGln: 1.838 ± 0.037	2.703ProArg: 2.703 ± 0.052	2.519ProSer: 2.519 ± 0.049	2.555ProThr: 2.555 ± 0.045	4.06ProVal: 4.06 ± 0.059	0.7ProTrp: 0.7 ± 0.024	1.094ProTyr: 1.094 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.43GlnAla: 4.43 ± 0.069	0.216GlnCys: 0.216 ± 0.014	1.893GlnAsp: 1.893 ± 0.037	1.747GlnGlu: 1.747 ± 0.041	1.15GlnPhe: 1.15 ± 0.03	2.723GlnGly: 2.723 ± 0.05	0.683GlnHis: 0.683 ± 0.024	2.269GlnIle: 2.269 ± 0.041	1.056GlnLys: 1.056 ± 0.029	3.192GlnLeu: 3.192 ± 0.052	1.183GlnMet: 1.183 ± 0.028	0.998GlnAsn: 0.998 ± 0.024	1.785GlnPro: 1.785 ± 0.044	1.274GlnGln: 1.274 ± 0.035	2.445GlnArg: 2.445 ± 0.055	2.151GlnSer: 2.151 ± 0.042	2.25GlnThr: 2.25 ± 0.043	2.561GlnVal: 2.561 ± 0.04	0.376GlnTrp: 0.376 ± 0.018	0.612GlnTyr: 0.612 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.921ArgAla: 7.921 ± 0.083	0.5ArgCys: 0.5 ± 0.021	4.134ArgAsp: 4.134 ± 0.064	3.475ArgGlu: 3.475 ± 0.053	2.698ArgPhe: 2.698 ± 0.047	4.437ArgGly: 4.437 ± 0.07	1.538ArgHis: 1.538 ± 0.038	3.597ArgIle: 3.597 ± 0.063	2.217ArgLys: 2.217 ± 0.043	6.896ArgLeu: 6.896 ± 0.084	1.929ArgMet: 1.929 ± 0.046	1.644ArgAsn: 1.644 ± 0.035	3.119ArgPro: 3.119 ± 0.046	2.419ArgGln: 2.419 ± 0.052	4.695ArgArg: 4.695 ± 0.074	3.382ArgSer: 3.382 ± 0.057	3.053ArgThr: 3.053 ± 0.053	4.636ArgVal: 4.636 ± 0.061	0.914ArgTrp: 0.914 ± 0.028	1.576ArgTyr: 1.576 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.872SerAla: 5.872 ± 0.075	0.458SerCys: 0.458 ± 0.019	3.588SerAsp: 3.588 ± 0.062	2.887SerGlu: 2.887 ± 0.044	2.401SerPhe: 2.401 ± 0.042	5.425SerGly: 5.425 ± 0.087	1.119SerHis: 1.119 ± 0.026	2.582SerIle: 2.582 ± 0.05	1.631SerLys: 1.631 ± 0.038	5.137SerLeu: 5.137 ± 0.06	1.494SerMet: 1.494 ± 0.036	1.443SerAsn: 1.443 ± 0.042	2.49SerPro: 2.49 ± 0.04	1.675SerGln: 1.675 ± 0.039	3.093SerArg: 3.093 ± 0.05	2.673SerSer: 2.673 ± 0.059	2.742SerThr: 2.742 ± 0.053	3.864SerVal: 3.864 ± 0.061	0.709SerTrp: 0.709 ± 0.026	1.393SerTyr: 1.393 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.602ThrAla: 6.602 ± 0.074	0.519ThrCys: 0.519 ± 0.021	3.312ThrAsp: 3.312 ± 0.062	3.02ThrGlu: 3.02 ± 0.056	2.095ThrPhe: 2.095 ± 0.051	5.416ThrGly: 5.416 ± 0.084	1.232ThrHis: 1.232 ± 0.032	2.746ThrIle: 2.746 ± 0.062	1.47ThrLys: 1.47 ± 0.037	6.381ThrLeu: 6.381 ± 0.072	1.3ThrMet: 1.3 ± 0.032	1.373ThrAsn: 1.373 ± 0.037	3.465ThrPro: 3.465 ± 0.054	1.888ThrGln: 1.888 ± 0.038	3.556ThrArg: 3.556 ± 0.057	3.023ThrSer: 3.023 ± 0.053	2.996ThrThr: 2.996 ± 0.077	4.364ThrVal: 4.364 ± 0.071	0.733ThrTrp: 0.733 ± 0.024	1.333ThrTyr: 1.333 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.657ValAla: 8.657 ± 0.09	0.697ValCys: 0.697 ± 0.023	4.156ValAsp: 4.156 ± 0.059	4.431ValGlu: 4.431 ± 0.059	3.002ValPhe: 3.002 ± 0.047	5.533ValGly: 5.533 ± 0.066	1.346ValHis: 1.346 ± 0.031	4.262ValIle: 4.262 ± 0.065	2.091ValLys: 2.091 ± 0.044	7.611ValLeu: 7.611 ± 0.085	2.165ValMet: 2.165 ± 0.041	1.895ValAsn: 1.895 ± 0.045	3.657ValPro: 3.657 ± 0.057	2.35ValGln: 2.35 ± 0.039	4.041ValArg: 4.041 ± 0.057	4.404ValSer: 4.404 ± 0.061	4.709ValThr: 4.709 ± 0.07	5.791ValVal: 5.791 ± 0.08	0.956ValTrp: 0.956 ± 0.027	1.43ValTyr: 1.43 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.362TrpAla: 1.362 ± 0.035	0.144TrpCys: 0.144 ± 0.009	0.769TrpAsp: 0.769 ± 0.024	0.648TrpGlu: 0.648 ± 0.025	0.606TrpPhe: 0.606 ± 0.022	0.959TrpGly: 0.959 ± 0.034	0.34TrpHis: 0.34 ± 0.016	0.713TrpIle: 0.713 ± 0.024	0.399TrpLys: 0.399 ± 0.016	1.6TrpLeu: 1.6 ± 0.045	0.452TrpMet: 0.452 ± 0.02	0.414TrpAsn: 0.414 ± 0.017	0.71TrpPro: 0.71 ± 0.023	0.604TrpGln: 0.604 ± 0.021	1.039TrpArg: 1.039 ± 0.029	0.829TrpSer: 0.829 ± 0.026	0.748TrpThr: 0.748 ± 0.027	0.951TrpVal: 0.951 ± 0.028	0.214TrpTrp: 0.214 ± 0.013	0.301TrpTyr: 0.301 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.562TyrAla: 2.562 ± 0.048	0.255TyrCys: 0.255 ± 0.016	1.62TyrAsp: 1.62 ± 0.032	1.274TyrGlu: 1.274 ± 0.032	0.914TyrPhe: 0.914 ± 0.025	2.048TyrGly: 2.048 ± 0.037	0.559TyrHis: 0.559 ± 0.021	0.943TyrIle: 0.943 ± 0.025	0.564TyrLys: 0.564 ± 0.024	2.24TyrLeu: 2.24 ± 0.045	0.499TyrMet: 0.499 ± 0.019	0.574TyrAsn: 0.574 ± 0.019	1.074TyrPro: 1.074 ± 0.031	0.76TyrGln: 0.76 ± 0.024	1.548TyrArg: 1.548 ± 0.036	1.125TyrSer: 1.125 ± 0.032	1.157TyrThr: 1.157 ± 0.031	1.605TyrVal: 1.605 ± 0.037	0.375TyrTrp: 0.375 ± 0.017	0.593TyrTyr: 0.593 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4343 proteins (1330952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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