Amino acid dipepetide frequency for Altererythrobacter sp. FM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.056AlaAla: 17.056 ± 0.177	1.08AlaCys: 1.08 ± 0.035	7.634AlaAsp: 7.634 ± 0.088	7.837AlaGlu: 7.837 ± 0.108	4.154AlaPhe: 4.154 ± 0.059	10.843AlaGly: 10.843 ± 0.116	2.337AlaHis: 2.337 ± 0.045	6.901AlaIle: 6.901 ± 0.097	4.348AlaLys: 4.348 ± 0.088	13.325AlaLeu: 13.325 ± 0.152	3.848AlaMet: 3.848 ± 0.067	3.441AlaAsn: 3.441 ± 0.067	5.815AlaPro: 5.815 ± 0.09	4.616AlaGln: 4.616 ± 0.074	8.94AlaArg: 8.94 ± 0.13	6.826AlaSer: 6.826 ± 0.098	6.316AlaThr: 6.316 ± 0.094	8.369AlaVal: 8.369 ± 0.109	1.552AlaTrp: 1.552 ± 0.04	2.533AlaTyr: 2.533 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.048CysAla: 1.048 ± 0.036	0.087CysCys: 0.087 ± 0.009	0.615CysAsp: 0.615 ± 0.028	0.481CysGlu: 0.481 ± 0.025	0.282CysPhe: 0.282 ± 0.019	0.886CysGly: 0.886 ± 0.032	0.22CysHis: 0.22 ± 0.015	0.36CysIle: 0.36 ± 0.019	0.207CysLys: 0.207 ± 0.013	0.668CysLeu: 0.668 ± 0.024	0.148CysMet: 0.148 ± 0.012	0.223CysAsn: 0.223 ± 0.017	0.45CysPro: 0.45 ± 0.023	0.213CysGln: 0.213 ± 0.015	0.566CysArg: 0.566 ± 0.026	0.5CysSer: 0.5 ± 0.023	0.401CysThr: 0.401 ± 0.021	0.58CysVal: 0.58 ± 0.025	0.107CysTrp: 0.107 ± 0.009	0.175CysTyr: 0.175 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.686AspAla: 7.686 ± 0.095	0.537AspCys: 0.537 ± 0.029	3.63AspAsp: 3.63 ± 0.075	3.595AspGlu: 3.595 ± 0.066	2.202AspPhe: 2.202 ± 0.049	5.96AspGly: 5.96 ± 0.093	1.299AspHis: 1.299 ± 0.039	3.075AspIle: 3.075 ± 0.063	1.948AspLys: 1.948 ± 0.051	5.884AspLeu: 5.884 ± 0.084	1.422AspMet: 1.422 ± 0.041	1.668AspAsn: 1.668 ± 0.047	3.828AspPro: 3.828 ± 0.052	1.739AspGln: 1.739 ± 0.05	4.763AspArg: 4.763 ± 0.082	2.985AspSer: 2.985 ± 0.071	3.022AspThr: 3.022 ± 0.078	4.01AspVal: 4.01 ± 0.079	1.147AspTrp: 1.147 ± 0.036	1.683AspTyr: 1.683 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.34GluAla: 7.34 ± 0.099	0.406GluCys: 0.406 ± 0.02	3.034GluAsp: 3.034 ± 0.055	3.313GluGlu: 3.313 ± 0.076	1.823GluPhe: 1.823 ± 0.044	4.548GluGly: 4.548 ± 0.07	1.166GluHis: 1.166 ± 0.037	3.082GluIle: 3.082 ± 0.052	2.214GluLys: 2.214 ± 0.059	5.309GluLeu: 5.309 ± 0.091	1.593GluMet: 1.593 ± 0.04	1.613GluAsn: 1.613 ± 0.04	2.624GluPro: 2.624 ± 0.058	2.302GluGln: 2.302 ± 0.052	4.972GluArg: 4.972 ± 0.069	2.669GluSer: 2.669 ± 0.052	3.209GluThr: 3.209 ± 0.067	3.75GluVal: 3.75 ± 0.064	0.928GluTrp: 0.928 ± 0.031	1.235GluTyr: 1.235 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.828PheAla: 4.828 ± 0.074	0.349PheCys: 0.349 ± 0.02	2.75PheAsp: 2.75 ± 0.063	2.038PheGlu: 2.038 ± 0.054	1.268PhePhe: 1.268 ± 0.048	3.582PheGly: 3.582 ± 0.066	0.687PheHis: 0.687 ± 0.027	1.49PheIle: 1.49 ± 0.039	0.889PheLys: 0.889 ± 0.036	2.954PheLeu: 2.954 ± 0.07	0.781PheMet: 0.781 ± 0.027	1.031PheAsn: 1.031 ± 0.038	1.5PhePro: 1.5 ± 0.036	0.874PheGln: 0.874 ± 0.032	2.131PheArg: 2.131 ± 0.047	2.1PheSer: 2.1 ± 0.052	2.054PheThr: 2.054 ± 0.052	2.569PheVal: 2.569 ± 0.052	0.496PheTrp: 0.496 ± 0.025	0.907PheTyr: 0.907 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	9.602GlyAla: 9.602 ± 0.12	0.86GlyCys: 0.86 ± 0.035	5.194GlyAsp: 5.194 ± 0.084	5.169GlyGlu: 5.169 ± 0.078	3.502GlyPhe: 3.502 ± 0.065	7.891GlyGly: 7.891 ± 0.13	1.796GlyHis: 1.796 ± 0.045	4.642GlyIle: 4.642 ± 0.074	3.703GlyLys: 3.703 ± 0.071	8.219GlyLeu: 8.219 ± 0.097	2.358GlyMet: 2.358 ± 0.054	2.551GlyAsn: 2.551 ± 0.067	3.472GlyPro: 3.472 ± 0.068	3.123GlyGln: 3.123 ± 0.052	5.774GlyArg: 5.774 ± 0.073	5.077GlySer: 5.077 ± 0.104	4.848GlyThr: 4.848 ± 0.106	5.908GlyVal: 5.908 ± 0.087	1.599GlyTrp: 1.599 ± 0.04	2.373GlyTyr: 2.373 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.251HisAla: 2.251 ± 0.048	0.225HisCys: 0.225 ± 0.016	1.21HisAsp: 1.21 ± 0.037	1.013HisGlu: 1.013 ± 0.033	0.818HisPhe: 0.818 ± 0.031	1.883HisGly: 1.883 ± 0.045	0.529HisHis: 0.529 ± 0.027	0.963HisIle: 0.963 ± 0.034	0.487HisLys: 0.487 ± 0.024	1.903HisLeu: 1.903 ± 0.039	0.441HisMet: 0.441 ± 0.02	0.532HisAsn: 0.532 ± 0.023	1.31HisPro: 1.31 ± 0.041	0.517HisGln: 0.517 ± 0.022	1.488HisArg: 1.488 ± 0.042	1.065HisSer: 1.065 ± 0.037	0.85HisThr: 0.85 ± 0.034	1.312HisVal: 1.312 ± 0.041	0.371HisTrp: 0.371 ± 0.019	0.584HisTyr: 0.584 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.151IleAla: 8.151 ± 0.101	0.446IleCys: 0.446 ± 0.024	4.161IleAsp: 4.161 ± 0.079	3.624IleGlu: 3.624 ± 0.068	1.459IlePhe: 1.459 ± 0.04	5.053IleGly: 5.053 ± 0.066	0.897IleHis: 0.897 ± 0.032	1.947IleIle: 1.947 ± 0.049	1.261IleLys: 1.261 ± 0.039	3.735IleLeu: 3.735 ± 0.064	0.95IleMet: 0.95 ± 0.037	1.339IleAsn: 1.339 ± 0.041	2.421IlePro: 2.421 ± 0.056	1.119IleGln: 1.119 ± 0.035	3.114IleArg: 3.114 ± 0.057	2.838IleSer: 2.838 ± 0.05	2.556IleThr: 2.556 ± 0.059	4.233IleVal: 4.233 ± 0.074	0.583IleTrp: 0.583 ± 0.022	1.085IleTyr: 1.085 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.151LysAla: 4.151 ± 0.072	0.164LysCys: 0.164 ± 0.012	1.666LysAsp: 1.666 ± 0.043	1.533LysGlu: 1.533 ± 0.046	0.874LysPhe: 0.874 ± 0.031	2.724LysGly: 2.724 ± 0.058	0.595LysHis: 0.595 ± 0.027	1.563LysIle: 1.563 ± 0.039	1.235LysLys: 1.235 ± 0.046	3.297LysLeu: 3.297 ± 0.061	0.815LysMet: 0.815 ± 0.03	0.818LysAsn: 0.818 ± 0.034	1.987LysPro: 1.987 ± 0.06	1.032LysGln: 1.032 ± 0.036	2.411LysArg: 2.411 ± 0.055	1.791LysSer: 1.791 ± 0.053	1.806LysThr: 1.806 ± 0.038	2.402LysVal: 2.402 ± 0.065	0.457LysTrp: 0.457 ± 0.02	0.708LysTyr: 0.708 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.9LeuAla: 13.9 ± 0.154	0.773LeuCys: 0.773 ± 0.032	6.061LeuAsp: 6.061 ± 0.079	4.925LeuGlu: 4.925 ± 0.078	3.376LeuPhe: 3.376 ± 0.068	7.915LeuGly: 7.915 ± 0.095	1.811LeuHis: 1.811 ± 0.046	4.686LeuIle: 4.686 ± 0.076	2.94LeuLys: 2.94 ± 0.058	8.835LeuLeu: 8.835 ± 0.124	2.223LeuMet: 2.223 ± 0.049	2.438LeuAsn: 2.438 ± 0.051	5.29LeuPro: 5.29 ± 0.07	2.637LeuGln: 2.637 ± 0.061	6.538LeuArg: 6.538 ± 0.09	6.352LeuSer: 6.352 ± 0.088	5.59LeuThr: 5.59 ± 0.093	6.927LeuVal: 6.927 ± 0.09	1.159LeuTrp: 1.159 ± 0.037	1.947LeuTyr: 1.947 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.303MetAla: 3.303 ± 0.062	0.158MetCys: 0.158 ± 0.013	1.132MetAsp: 1.132 ± 0.039	1.22MetGlu: 1.22 ± 0.041	0.705MetPhe: 0.705 ± 0.027	1.969MetGly: 1.969 ± 0.047	0.478MetHis: 0.478 ± 0.023	1.374MetIle: 1.374 ± 0.036	0.986MetLys: 0.986 ± 0.034	2.548MetLeu: 2.548 ± 0.06	0.669MetMet: 0.669 ± 0.027	0.73MetAsn: 0.73 ± 0.029	1.424MetPro: 1.424 ± 0.044	0.826MetGln: 0.826 ± 0.029	1.81MetArg: 1.81 ± 0.048	1.425MetSer: 1.425 ± 0.036	1.665MetThr: 1.665 ± 0.043	1.663MetVal: 1.663 ± 0.043	0.248MetTrp: 0.248 ± 0.016	0.312MetTyr: 0.312 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.41AsnAla: 3.41 ± 0.063	0.269AsnCys: 0.269 ± 0.02	1.598AsnAsp: 1.598 ± 0.055	1.326AsnGlu: 1.326 ± 0.035	0.982AsnPhe: 0.982 ± 0.039	2.735AsnGly: 2.735 ± 0.068	0.488AsnHis: 0.488 ± 0.023	1.332AsnIle: 1.332 ± 0.037	0.725AsnLys: 0.725 ± 0.027	2.683AsnLeu: 2.683 ± 0.057	0.568AsnMet: 0.568 ± 0.026	0.724AsnAsn: 0.724 ± 0.031	1.942AsnPro: 1.942 ± 0.052	0.784AsnGln: 0.784 ± 0.03	2.026AsnArg: 2.026 ± 0.048	1.37AsnSer: 1.37 ± 0.037	1.273AsnThr: 1.273 ± 0.045	1.902AsnVal: 1.902 ± 0.046	0.476AsnTrp: 0.476 ± 0.025	0.744AsnTyr: 0.744 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.417ProAla: 6.417 ± 0.095	0.33ProCys: 0.33 ± 0.019	4.015ProAsp: 4.015 ± 0.067	3.561ProGlu: 3.561 ± 0.069	1.844ProPhe: 1.844 ± 0.041	4.479ProGly: 4.479 ± 0.074	1.034ProHis: 1.034 ± 0.032	2.398ProIle: 2.398 ± 0.048	1.576ProLys: 1.576 ± 0.043	4.787ProLeu: 4.787 ± 0.087	1.135ProMet: 1.135 ± 0.033	1.281ProAsn: 1.281 ± 0.037	2.655ProPro: 2.655 ± 0.076	1.88ProGln: 1.88 ± 0.044	2.862ProArg: 2.862 ± 0.067	2.711ProSer: 2.711 ± 0.057	2.635ProThr: 2.635 ± 0.053	4.266ProVal: 4.266 ± 0.076	0.67ProTrp: 0.67 ± 0.03	1.114ProTyr: 1.114 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.121GlnAla: 4.121 ± 0.071	0.258GlnCys: 0.258 ± 0.015	1.473GlnAsp: 1.473 ± 0.042	1.432GlnGlu: 1.432 ± 0.037	1.202GlnPhe: 1.202 ± 0.034	2.461GlnGly: 2.461 ± 0.048	0.642GlnHis: 0.642 ± 0.026	1.9GlnIle: 1.9 ± 0.045	0.943GlnLys: 0.943 ± 0.029	3.218GlnLeu: 3.218 ± 0.058	0.881GlnMet: 0.881 ± 0.03	0.823GlnAsn: 0.823 ± 0.03	1.866GlnPro: 1.866 ± 0.044	1.301GlnGln: 1.301 ± 0.047	2.491GlnArg: 2.491 ± 0.059	1.882GlnSer: 1.882 ± 0.046	1.742GlnThr: 1.742 ± 0.046	2.427GlnVal: 2.427 ± 0.056	0.539GlnTrp: 0.539 ± 0.025	0.734GlnTyr: 0.734 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.179ArgAla: 8.179 ± 0.123	0.487ArgCys: 0.487 ± 0.024	4.353ArgAsp: 4.353 ± 0.072	4.158ArgGlu: 4.158 ± 0.068	3.033ArgPhe: 3.033 ± 0.054	4.78ArgGly: 4.78 ± 0.081	1.578ArgHis: 1.578 ± 0.038	4.06ArgIle: 4.06 ± 0.063	2.466ArgLys: 2.466 ± 0.05	7.396ArgLeu: 7.396 ± 0.107	1.905ArgMet: 1.905 ± 0.049	1.993ArgAsn: 1.993 ± 0.049	3.278ArgPro: 3.278 ± 0.061	2.575ArgGln: 2.575 ± 0.052	5.11ArgArg: 5.11 ± 0.103	3.536ArgSer: 3.536 ± 0.06	3.472ArgThr: 3.472 ± 0.059	4.511ArgVal: 4.511 ± 0.074	1.16ArgTrp: 1.16 ± 0.042	1.881ArgTyr: 1.881 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.768SerAla: 6.768 ± 0.098	0.44SerCys: 0.44 ± 0.023	3.668SerAsp: 3.668 ± 0.072	3.136SerGlu: 3.136 ± 0.06	2.041SerPhe: 2.041 ± 0.05	5.952SerGly: 5.952 ± 0.106	1.065SerHis: 1.065 ± 0.029	2.652SerIle: 2.652 ± 0.065	1.601SerLys: 1.601 ± 0.047	5.279SerLeu: 5.279 ± 0.088	1.258SerMet: 1.258 ± 0.035	1.597SerAsn: 1.597 ± 0.047	2.853SerPro: 2.853 ± 0.055	1.787SerGln: 1.787 ± 0.042	3.536SerArg: 3.536 ± 0.072	3.274SerSer: 3.274 ± 0.136	2.752SerThr: 2.752 ± 0.067	3.92SerVal: 3.92 ± 0.077	0.756SerTrp: 0.756 ± 0.024	1.375SerTyr: 1.375 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.326ThrAla: 6.326 ± 0.102	0.387ThrCys: 0.387 ± 0.021	3.193ThrAsp: 3.193 ± 0.065	2.541ThrGlu: 2.541 ± 0.06	1.85ThrPhe: 1.85 ± 0.043	5.32ThrGly: 5.32 ± 0.101	1.002ThrHis: 1.002 ± 0.03	3.081ThrIle: 3.081 ± 0.074	1.296ThrLys: 1.296 ± 0.038	5.633ThrLeu: 5.633 ± 0.084	1.267ThrMet: 1.267 ± 0.035	1.443ThrAsn: 1.443 ± 0.048	3.324ThrPro: 3.324 ± 0.06	1.555ThrGln: 1.555 ± 0.038	3.317ThrArg: 3.317 ± 0.06	2.749ThrSer: 2.749 ± 0.063	2.736ThrThr: 2.736 ± 0.068	4.391ThrVal: 4.391 ± 0.108	0.597ThrTrp: 0.597 ± 0.025	1.248ThrTyr: 1.248 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	9.125ValAla: 9.125 ± 0.109	0.601ValCys: 0.601 ± 0.026	4.3ValAsp: 4.3 ± 0.078	4.374ValGlu: 4.374 ± 0.067	2.37ValPhe: 2.37 ± 0.058	5.542ValGly: 5.542 ± 0.085	1.283ValHis: 1.283 ± 0.038	3.814ValIle: 3.814 ± 0.07	2.125ValLys: 2.125 ± 0.058	6.693ValLeu: 6.693 ± 0.096	1.625ValMet: 1.625 ± 0.043	1.962ValAsn: 1.962 ± 0.056	3.83ValPro: 3.83 ± 0.071	2.028ValGln: 2.028 ± 0.05	4.847ValArg: 4.847 ± 0.081	4.362ValSer: 4.362 ± 0.082	4.404ValThr: 4.404 ± 0.106	5.161ValVal: 5.161 ± 0.088	0.878ValTrp: 0.878 ± 0.03	1.342ValTyr: 1.342 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.409TrpAla: 1.409 ± 0.04	0.131TrpCys: 0.131 ± 0.012	0.74TrpAsp: 0.74 ± 0.03	0.619TrpGlu: 0.619 ± 0.025	0.602TrpPhe: 0.602 ± 0.028	0.982TrpGly: 0.982 ± 0.037	0.346TrpHis: 0.346 ± 0.02	0.726TrpIle: 0.726 ± 0.031	0.479TrpLys: 0.479 ± 0.024	1.772TrpLeu: 1.772 ± 0.046	0.349TrpMet: 0.349 ± 0.021	0.495TrpAsn: 0.495 ± 0.022	0.685TrpPro: 0.685 ± 0.026	0.702TrpGln: 0.702 ± 0.029	1.239TrpArg: 1.239 ± 0.038	0.879TrpSer: 0.879 ± 0.031	0.774TrpThr: 0.774 ± 0.033	0.859TrpVal: 0.859 ± 0.029	0.262TrpTrp: 0.262 ± 0.018	0.283TrpTyr: 0.283 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.697TyrAla: 2.697 ± 0.058	0.228TyrCys: 0.228 ± 0.016	1.657TyrAsp: 1.657 ± 0.045	1.237TyrGlu: 1.237 ± 0.036	0.889TyrPhe: 0.889 ± 0.035	2.158TyrGly: 2.158 ± 0.056	0.499TyrHis: 0.499 ± 0.021	0.927TyrIle: 0.927 ± 0.028	0.599TyrLys: 0.599 ± 0.026	2.185TyrLeu: 2.185 ± 0.045	0.41TyrMet: 0.41 ± 0.017	0.657TyrAsn: 0.657 ± 0.034	1.096TyrPro: 1.096 ± 0.034	0.723TyrGln: 0.723 ± 0.034	1.975TyrArg: 1.975 ± 0.046	1.32TyrSer: 1.32 ± 0.043	1.15TyrThr: 1.15 ± 0.05	1.507TyrVal: 1.507 ± 0.045	0.349TyrTrp: 0.349 ± 0.02	0.661TyrTyr: 0.661 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3033 proteins (983523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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