Amino acid dipepetide frequency for Yado-nushi virus 1-A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.808AlaAla: 1.808 ± 1.048
0.362AlaCys: 0.362 ± 0.21
2.893AlaAsp: 2.893 ± 1.155
2.17AlaGlu: 2.17 ± 0.307
3.978AlaPhe: 3.978 ± 0.301
1.085AlaGly: 1.085 ± 0.107
3.255AlaHis: 3.255 ± 0.322
5.787AlaIle: 5.787 ± 1.267
2.893AlaLys: 2.893 ± 0.634
5.063AlaLeu: 5.063 ± 2.279
1.808AlaMet: 1.808 ± 0.526
4.702AlaAsn: 4.702 ± 2.203
2.893AlaPro: 2.893 ± 0.113
1.447AlaGln: 1.447 ± 0.726
1.447AlaArg: 1.447 ± 0.838
4.702AlaSer: 4.702 ± 2.203
6.872AlaThr: 6.872 ± 0.332
2.17AlaVal: 2.17 ± 0.307
0.362AlaTrp: 0.362 ± 0.21
1.808AlaTyr: 1.808 ± 0.516
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.362CysGlu: 0.362 ± 0.312
0.0CysPhe: 0.0 ± 0.0
0.362CysGly: 0.362 ± 0.21
0.723CysHis: 0.723 ± 0.623
0.362CysIle: 0.362 ± 0.21
0.362CysLys: 0.362 ± 0.312
0.362CysLeu: 0.362 ± 0.21
0.362CysMet: 0.362 ± 0.21
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.362CysGln: 0.362 ± 0.312
1.808CysArg: 1.808 ± 0.526
0.723CysSer: 0.723 ± 0.419
0.0CysThr: 0.0 ± 0.0
0.362CysVal: 0.362 ± 0.21
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.808AspAla: 1.808 ± 0.005
0.0AspCys: 0.0 ± 0.0
3.255AspAsp: 3.255 ± 0.72
2.17AspGlu: 2.17 ± 0.736
4.702AspPhe: 4.702 ± 0.403
1.447AspGly: 1.447 ± 0.838
1.085AspHis: 1.085 ± 0.107
7.595AspIle: 7.595 ± 0.23
2.532AspLys: 2.532 ± 0.097
5.063AspLeu: 5.063 ± 0.848
1.808AspMet: 1.808 ± 0.005
3.617AspAsn: 3.617 ± 0.532
1.447AspPro: 1.447 ± 0.204
2.893AspGln: 2.893 ± 0.113
1.085AspArg: 1.085 ± 0.107
2.532AspSer: 2.532 ± 0.097
4.34AspThr: 4.34 ± 1.472
3.617AspVal: 3.617 ± 0.01
1.085AspTrp: 1.085 ± 0.414
2.893AspTyr: 2.893 ± 0.93
0.0AspXaa: 0.0 ± 0.0
Glu
1.447GluAla: 1.447 ± 0.204
0.0GluCys: 0.0 ± 0.0
2.893GluAsp: 2.893 ± 0.634
2.17GluGlu: 2.17 ± 0.215
1.808GluPhe: 1.808 ± 1.037
2.532GluGly: 2.532 ± 0.424
2.17GluHis: 2.17 ± 0.215
4.34GluIle: 4.34 ± 0.429
1.808GluLys: 1.808 ± 0.005
2.532GluLeu: 2.532 ± 0.097
0.362GluMet: 0.362 ± 0.312
4.702GluAsn: 4.702 ± 0.639
2.17GluPro: 2.17 ± 0.736
2.532GluGln: 2.532 ± 0.097
1.447GluArg: 1.447 ± 0.204
1.085GluSer: 1.085 ± 0.414
0.723GluThr: 0.723 ± 0.102
2.893GluVal: 2.893 ± 0.634
1.085GluTrp: 1.085 ± 0.629
2.893GluTyr: 2.893 ± 0.113
0.0GluXaa: 0.0 ± 0.0
Phe
2.17PheAla: 2.17 ± 0.215
0.362PheCys: 0.362 ± 0.312
4.702PheAsp: 4.702 ± 0.118
2.893PheGlu: 2.893 ± 0.409
4.34PhePhe: 4.34 ± 1.134
1.808PheGly: 1.808 ± 0.516
0.723PheHis: 0.723 ± 0.102
5.787PheIle: 5.787 ± 1.339
3.617PheLys: 3.617 ± 1.553
4.702PheLeu: 4.702 ± 1.967
1.808PheMet: 1.808 ± 0.694
3.978PheAsn: 3.978 ± 0.301
3.255PhePro: 3.255 ± 0.72
2.17PheGln: 2.17 ± 0.307
3.255PheArg: 3.255 ± 0.199
5.063PheSer: 5.063 ± 0.194
3.255PheThr: 3.255 ± 0.72
1.447PheVal: 1.447 ± 0.317
0.362PheTrp: 0.362 ± 0.21
2.532PheTyr: 2.532 ± 1.139
0.0PheXaa: 0.0 ± 0.0
Gly
2.17GlyAla: 2.17 ± 0.215
0.0GlyCys: 0.0 ± 0.0
0.362GlyAsp: 0.362 ± 0.312
2.17GlyGlu: 2.17 ± 0.736
1.808GlyPhe: 1.808 ± 0.516
1.447GlyGly: 1.447 ± 0.317
0.723GlyHis: 0.723 ± 0.102
2.17GlyIle: 2.17 ± 0.828
3.255GlyLys: 3.255 ± 0.322
3.255GlyLeu: 3.255 ± 1.364
0.362GlyMet: 0.362 ± 0.312
3.617GlyAsn: 3.617 ± 0.532
1.085GlyPro: 1.085 ± 0.414
0.723GlyGln: 0.723 ± 0.102
0.723GlyArg: 0.723 ± 0.102
2.532GlySer: 2.532 ± 0.097
2.532GlyThr: 2.532 ± 0.424
1.447GlyVal: 1.447 ± 0.838
0.0GlyTrp: 0.0 ± 0.0
2.17GlyTyr: 2.17 ± 0.307
0.0GlyXaa: 0.0 ± 0.0
His
2.17HisAla: 2.17 ± 0.828
0.362HisCys: 0.362 ± 0.312
2.17HisAsp: 2.17 ± 1.257
0.362HisGlu: 0.362 ± 0.21
2.17HisPhe: 2.17 ± 1.349
1.447HisGly: 1.447 ± 0.726
1.447HisHis: 1.447 ± 0.726
0.0HisIle: 0.0 ± 0.0
1.447HisLys: 1.447 ± 0.204
4.34HisLeu: 4.34 ± 1.134
0.362HisMet: 0.362 ± 0.21
1.808HisAsn: 1.808 ± 0.005
2.532HisPro: 2.532 ± 0.097
0.723HisGln: 0.723 ± 0.102
0.362HisArg: 0.362 ± 0.312
1.808HisSer: 1.808 ± 1.037
1.085HisThr: 1.085 ± 0.107
1.447HisVal: 1.447 ± 0.838
0.723HisTrp: 0.723 ± 0.102
0.362HisTyr: 0.362 ± 0.21
0.362HisXaa: 0.362 ± 0.21
Ile
6.148IleAla: 6.148 ± 0.087
0.0IleCys: 0.0 ± 0.0
3.978IleAsp: 3.978 ± 0.301
3.978IleGlu: 3.978 ± 1.344
3.617IlePhe: 3.617 ± 0.511
1.808IleGly: 1.808 ± 0.526
1.085IleHis: 1.085 ± 0.414
3.978IleIle: 3.978 ± 0.741
4.702IleLys: 4.702 ± 0.639
3.978IleLeu: 3.978 ± 0.823
1.447IleMet: 1.447 ± 1.247
5.787IleAsn: 5.787 ± 1.267
5.425IlePro: 5.425 ± 1.058
2.17IleGln: 2.17 ± 0.828
5.425IleArg: 5.425 ± 0.016
7.957IleSer: 7.957 ± 0.961
6.148IleThr: 6.148 ± 0.956
4.702IleVal: 4.702 ± 0.403
0.362IleTrp: 0.362 ± 0.312
0.723IleTyr: 0.723 ± 0.623
0.0IleXaa: 0.0 ± 0.0
Lys
4.702LysAla: 4.702 ± 1.16
0.0LysCys: 0.0 ± 0.0
4.34LysAsp: 4.34 ± 0.092
3.978LysGlu: 3.978 ± 0.741
1.447LysPhe: 1.447 ± 0.204
2.17LysGly: 2.17 ± 0.307
2.17LysHis: 2.17 ± 0.215
7.595LysIle: 7.595 ± 2.376
6.148LysLys: 6.148 ± 0.956
5.425LysLeu: 5.425 ± 0.016
2.532LysMet: 2.532 ± 0.097
4.34LysAsn: 4.34 ± 1.134
1.808LysPro: 1.808 ± 0.005
0.723LysGln: 0.723 ± 0.102
2.17LysArg: 2.17 ± 0.828
2.17LysSer: 2.17 ± 0.828
4.702LysThr: 4.702 ± 0.403
2.532LysVal: 2.532 ± 0.097
0.362LysTrp: 0.362 ± 0.312
3.617LysTyr: 3.617 ± 1.553
0.0LysXaa: 0.0 ± 0.0
Leu
6.872LeuAla: 6.872 ± 1.375
1.085LeuCys: 1.085 ± 0.107
3.978LeuAsp: 3.978 ± 0.741
3.617LeuGlu: 3.617 ± 0.01
4.702LeuPhe: 4.702 ± 1.446
4.34LeuGly: 4.34 ± 0.092
2.17LeuHis: 2.17 ± 1.349
3.978LeuIle: 3.978 ± 1.344
6.872LeuLys: 6.872 ± 1.231
8.318LeuLeu: 8.318 ± 1.436
1.085LeuMet: 1.085 ± 0.107
6.148LeuAsn: 6.148 ± 0.956
8.318LeuPro: 8.318 ± 0.914
2.893LeuGln: 2.893 ± 0.93
3.255LeuArg: 3.255 ± 0.199
7.595LeuSer: 7.595 ± 0.23
7.233LeuThr: 7.233 ± 1.584
3.255LeuVal: 3.255 ± 0.843
0.723LeuTrp: 0.723 ± 0.623
2.893LeuTyr: 2.893 ± 0.409
0.0LeuXaa: 0.0 ± 0.0
Met
1.808MetAla: 1.808 ± 0.516
0.0MetCys: 0.0 ± 0.0
1.808MetAsp: 1.808 ± 0.516
0.0MetGlu: 0.0 ± 0.0
1.808MetPhe: 1.808 ± 0.516
0.723MetGly: 0.723 ± 0.102
0.723MetHis: 0.723 ± 0.102
1.447MetIle: 1.447 ± 0.317
0.362MetLys: 0.362 ± 0.312
2.17MetLeu: 2.17 ± 1.257
0.723MetMet: 0.723 ± 0.419
2.17MetAsn: 2.17 ± 0.307
1.085MetPro: 1.085 ± 0.414
1.085MetGln: 1.085 ± 0.107
1.808MetArg: 1.808 ± 0.005
2.17MetSer: 2.17 ± 0.307
2.532MetThr: 2.532 ± 1.467
1.447MetVal: 1.447 ± 0.317
0.362MetTrp: 0.362 ± 0.21
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.617AsnAla: 3.617 ± 1.574
0.362AsnCys: 0.362 ± 0.21
3.978AsnAsp: 3.978 ± 0.22
2.17AsnGlu: 2.17 ± 0.215
4.702AsnPhe: 4.702 ± 0.118
2.532AsnGly: 2.532 ± 0.424
2.17AsnHis: 2.17 ± 0.828
5.063AsnIle: 5.063 ± 0.327
4.34AsnLys: 4.34 ± 0.613
6.51AsnLeu: 6.51 ± 1.687
1.085AsnMet: 1.085 ± 0.251
4.34AsnAsn: 4.34 ± 1.472
3.255AsnPro: 3.255 ± 0.72
3.255AsnGln: 3.255 ± 1.364
5.787AsnArg: 5.787 ± 0.296
3.978AsnSer: 3.978 ± 1.262
7.595AsnThr: 7.595 ± 0.812
3.255AsnVal: 3.255 ± 1.364
0.723AsnTrp: 0.723 ± 0.102
2.532AsnTyr: 2.532 ± 1.661
0.0AsnXaa: 0.0 ± 0.0
Pro
2.532ProAla: 2.532 ± 0.097
0.362ProCys: 0.362 ± 0.312
3.255ProAsp: 3.255 ± 0.843
2.532ProGlu: 2.532 ± 0.097
3.617ProPhe: 3.617 ± 1.553
1.085ProGly: 1.085 ± 0.107
1.447ProHis: 1.447 ± 0.204
5.425ProIle: 5.425 ± 0.016
3.255ProLys: 3.255 ± 1.763
9.765ProLeu: 9.765 ± 0.597
1.808ProMet: 1.808 ± 0.005
2.17ProAsn: 2.17 ± 0.828
4.702ProPro: 4.702 ± 0.118
3.617ProGln: 3.617 ± 0.01
2.532ProArg: 2.532 ± 0.424
3.255ProSer: 3.255 ± 0.199
5.787ProThr: 5.787 ± 1.789
5.063ProVal: 5.063 ± 1.37
0.0ProTrp: 0.0 ± 0.0
2.532ProTyr: 2.532 ± 0.424
0.0ProXaa: 0.0 ± 0.0
Gln
1.085GlnAla: 1.085 ± 0.629
0.723GlnCys: 0.723 ± 0.102
1.808GlnAsp: 1.808 ± 0.516
1.447GlnGlu: 1.447 ± 0.317
2.17GlnPhe: 2.17 ± 0.828
1.808GlnGly: 1.808 ± 0.526
0.723GlnHis: 0.723 ± 0.419
3.255GlnIle: 3.255 ± 0.322
3.255GlnLys: 3.255 ± 0.72
4.34GlnLeu: 4.34 ± 1.134
1.808GlnMet: 1.808 ± 0.516
1.447GlnAsn: 1.447 ± 0.204
2.17GlnPro: 2.17 ± 0.828
1.447GlnGln: 1.447 ± 0.726
1.808GlnArg: 1.808 ± 0.005
2.17GlnSer: 2.17 ± 0.307
3.617GlnThr: 3.617 ± 0.532
1.085GlnVal: 1.085 ± 0.107
1.085GlnTrp: 1.085 ± 0.414
1.447GlnTyr: 1.447 ± 0.204
0.0GlnXaa: 0.0 ± 0.0
Arg
4.34ArgAla: 4.34 ± 0.951
0.362ArgCys: 0.362 ± 0.21
2.893ArgAsp: 2.893 ± 0.113
1.447ArgGlu: 1.447 ± 0.204
3.617ArgPhe: 3.617 ± 0.01
2.17ArgGly: 2.17 ± 0.215
0.723ArgHis: 0.723 ± 0.102
3.255ArgIle: 3.255 ± 0.322
2.893ArgLys: 2.893 ± 0.113
4.34ArgLeu: 4.34 ± 0.092
1.085ArgMet: 1.085 ± 0.414
3.255ArgAsn: 3.255 ± 0.322
3.978ArgPro: 3.978 ± 0.301
1.085ArgGln: 1.085 ± 0.935
2.532ArgArg: 2.532 ± 0.424
3.255ArgSer: 3.255 ± 0.322
3.255ArgThr: 3.255 ± 0.72
3.255ArgVal: 3.255 ± 0.322
0.0ArgTrp: 0.0 ± 0.0
2.17ArgTyr: 2.17 ± 0.307
0.0ArgXaa: 0.0 ± 0.0
Ser
2.17SerAla: 2.17 ± 0.215
1.447SerCys: 1.447 ± 0.317
3.617SerAsp: 3.617 ± 0.511
2.893SerGlu: 2.893 ± 0.634
3.617SerPhe: 3.617 ± 0.01
2.532SerGly: 2.532 ± 0.618
1.447SerHis: 1.447 ± 0.838
4.702SerIle: 4.702 ± 0.639
3.617SerLys: 3.617 ± 1.032
7.595SerLeu: 7.595 ± 0.291
2.17SerMet: 2.17 ± 0.736
4.702SerAsn: 4.702 ± 0.403
4.34SerPro: 4.34 ± 0.613
3.255SerGln: 3.255 ± 0.199
3.978SerArg: 3.978 ± 0.301
6.148SerSer: 6.148 ± 0.435
6.148SerThr: 6.148 ± 1.477
3.255SerVal: 3.255 ± 0.322
0.362SerTrp: 0.362 ± 0.21
2.17SerTyr: 2.17 ± 0.307
0.0SerXaa: 0.0 ± 0.0
Thr
3.978ThrAla: 3.978 ± 0.301
0.362ThrCys: 0.362 ± 0.21
3.978ThrAsp: 3.978 ± 0.22
4.34ThrGlu: 4.34 ± 0.429
3.255ThrPhe: 3.255 ± 0.322
2.893ThrGly: 2.893 ± 0.113
2.17ThrHis: 2.17 ± 0.828
2.893ThrIle: 2.893 ± 0.113
4.702ThrLys: 4.702 ± 0.118
6.148ThrLeu: 6.148 ± 1.477
1.808ThrMet: 1.808 ± 0.526
5.425ThrAsn: 5.425 ± 1.058
8.318ThrPro: 8.318 ± 2.213
5.063ThrGln: 5.063 ± 0.194
4.34ThrArg: 4.34 ± 0.092
5.063ThrSer: 5.063 ± 0.848
6.872ThrThr: 6.872 ± 0.189
4.34ThrVal: 4.34 ± 1.472
0.723ThrTrp: 0.723 ± 0.623
3.617ThrTyr: 3.617 ± 0.511
0.0ThrXaa: 0.0 ± 0.0
Val
5.787ValAla: 5.787 ± 1.267
0.0ValCys: 0.0 ± 0.0
2.532ValAsp: 2.532 ± 0.097
1.808ValGlu: 1.808 ± 1.048
2.532ValPhe: 2.532 ± 0.945
0.362ValGly: 0.362 ± 0.21
1.447ValHis: 1.447 ± 0.204
2.893ValIle: 2.893 ± 0.634
2.17ValLys: 2.17 ± 1.257
2.893ValLeu: 2.893 ± 0.634
0.362ValMet: 0.362 ± 0.21
5.425ValAsn: 5.425 ± 0.537
4.702ValPro: 4.702 ± 0.639
2.17ValGln: 2.17 ± 0.215
2.532ValArg: 2.532 ± 1.467
5.063ValSer: 5.063 ± 1.236
3.617ValThr: 3.617 ± 0.532
1.447ValVal: 1.447 ± 0.838
0.0ValTrp: 0.0 ± 0.0
2.17ValTyr: 2.17 ± 0.215
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.362TrpCys: 0.362 ± 0.21
0.723TrpAsp: 0.723 ± 0.102
0.0TrpGlu: 0.0 ± 0.0
1.085TrpPhe: 1.085 ± 0.414
0.0TrpGly: 0.0 ± 0.0
0.362TrpHis: 0.362 ± 0.312
0.723TrpIle: 0.723 ± 0.102
0.362TrpLys: 0.362 ± 0.21
0.0TrpLeu: 0.0 ± 0.0
0.362TrpMet: 0.362 ± 0.21
0.723TrpAsn: 0.723 ± 0.102
0.362TrpPro: 0.362 ± 0.21
0.362TrpGln: 0.362 ± 0.312
0.362TrpArg: 0.362 ± 0.312
1.085TrpSer: 1.085 ± 0.107
0.0TrpThr: 0.0 ± 0.0
1.085TrpVal: 1.085 ± 0.107
0.0TrpTrp: 0.0 ± 0.0
0.723TrpTyr: 0.723 ± 0.623
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.893TyrAla: 2.893 ± 0.113
0.0TyrCys: 0.0 ± 0.0
1.808TyrAsp: 1.808 ± 0.005
1.085TyrGlu: 1.085 ± 0.414
3.255TyrPhe: 3.255 ± 0.72
0.0TyrGly: 0.0 ± 0.0
0.723TyrHis: 0.723 ± 0.102
2.17TyrIle: 2.17 ± 0.307
3.978TyrLys: 3.978 ± 1.865
2.532TyrLeu: 2.532 ± 1.661
0.723TyrMet: 0.723 ± 0.102
3.255TyrAsn: 3.255 ± 0.72
2.893TyrPro: 2.893 ± 0.409
0.723TyrGln: 0.723 ± 0.419
3.255TyrArg: 3.255 ± 0.72
1.808TyrSer: 1.808 ± 0.516
3.978TyrThr: 3.978 ± 1.344
1.808TyrVal: 1.808 ± 0.005
0.362TyrTrp: 0.362 ± 0.21
0.362TyrTyr: 0.362 ± 0.312
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.362XaaLys: 0.362 ± 0.21
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2766 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski