Amino acid dipepetide frequency for Staphylococcus phage phi7247PVL

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.428AlaAla: 2.428 ± 0.526
0.09AlaCys: 0.09 ± 0.099
2.968AlaAsp: 2.968 ± 0.464
3.687AlaGlu: 3.687 ± 0.698
2.338AlaPhe: 2.338 ± 0.67
4.406AlaGly: 4.406 ± 0.962
0.719AlaHis: 0.719 ± 0.26
4.676AlaIle: 4.676 ± 0.715
4.586AlaLys: 4.586 ± 0.583
4.856AlaLeu: 4.856 ± 0.623
1.619AlaMet: 1.619 ± 0.355
4.137AlaAsn: 4.137 ± 0.685
1.709AlaPro: 1.709 ± 0.386
2.248AlaGln: 2.248 ± 0.463
2.428AlaArg: 2.428 ± 0.487
2.698AlaSer: 2.698 ± 0.579
3.147AlaThr: 3.147 ± 0.544
3.327AlaVal: 3.327 ± 0.597
0.27AlaTrp: 0.27 ± 0.157
2.968AlaTyr: 2.968 ± 0.6
0.0AlaXaa: 0.0 ± 0.0
Cys
0.27CysAla: 0.27 ± 0.139
0.0CysCys: 0.0 ± 0.0
0.09CysAsp: 0.09 ± 0.101
0.36CysGlu: 0.36 ± 0.202
0.09CysPhe: 0.09 ± 0.102
0.18CysGly: 0.18 ± 0.136
0.09CysHis: 0.09 ± 0.105
0.629CysIle: 0.629 ± 0.216
0.36CysLys: 0.36 ± 0.199
0.18CysLeu: 0.18 ± 0.12
0.0CysMet: 0.0 ± 0.0
0.27CysAsn: 0.27 ± 0.139
0.18CysPro: 0.18 ± 0.124
0.09CysGln: 0.09 ± 0.105
0.18CysArg: 0.18 ± 0.141
0.0CysSer: 0.0 ± 0.0
0.27CysThr: 0.27 ± 0.177
0.36CysVal: 0.36 ± 0.195
0.09CysTrp: 0.09 ± 0.085
0.27CysTyr: 0.27 ± 0.154
0.0CysXaa: 0.0 ± 0.0
Asp
3.058AspAla: 3.058 ± 0.387
0.45AspCys: 0.45 ± 0.211
3.867AspAsp: 3.867 ± 0.752
4.586AspGlu: 4.586 ± 0.795
3.777AspPhe: 3.777 ± 0.609
4.496AspGly: 4.496 ± 0.911
0.809AspHis: 0.809 ± 0.27
4.676AspIle: 4.676 ± 0.471
5.755AspLys: 5.755 ± 0.818
5.755AspLeu: 5.755 ± 0.702
1.799AspMet: 1.799 ± 0.356
3.597AspAsn: 3.597 ± 0.473
1.799AspPro: 1.799 ± 0.405
0.54AspGln: 0.54 ± 0.218
2.248AspArg: 2.248 ± 0.631
3.507AspSer: 3.507 ± 0.637
3.507AspThr: 3.507 ± 0.681
3.597AspVal: 3.597 ± 0.645
0.629AspTrp: 0.629 ± 0.175
2.698AspTyr: 2.698 ± 0.502
0.0AspXaa: 0.0 ± 0.0
Glu
3.597GluAla: 3.597 ± 0.623
0.54GluCys: 0.54 ± 0.214
3.597GluAsp: 3.597 ± 0.584
6.385GluGlu: 6.385 ± 1.142
2.878GluPhe: 2.878 ± 0.518
2.698GluGly: 2.698 ± 0.475
1.349GluHis: 1.349 ± 0.315
5.935GluIle: 5.935 ± 0.79
7.284GluLys: 7.284 ± 1.128
6.745GluLeu: 6.745 ± 0.873
2.338GluMet: 2.338 ± 0.515
4.676GluAsn: 4.676 ± 0.549
1.079GluPro: 1.079 ± 0.255
3.777GluGln: 3.777 ± 0.841
4.317GluArg: 4.317 ± 0.656
3.957GluSer: 3.957 ± 0.594
3.867GluThr: 3.867 ± 0.859
4.406GluVal: 4.406 ± 0.558
1.079GluTrp: 1.079 ± 0.314
4.496GluTyr: 4.496 ± 0.67
0.0GluXaa: 0.0 ± 0.0
Phe
2.338PheAla: 2.338 ± 0.579
0.09PheCys: 0.09 ± 0.091
2.068PheAsp: 2.068 ± 0.36
2.878PheGlu: 2.878 ± 0.578
1.259PhePhe: 1.259 ± 0.376
2.698PheGly: 2.698 ± 0.521
0.54PheHis: 0.54 ± 0.168
4.496PheIle: 4.496 ± 0.644
3.957PheLys: 3.957 ± 0.7
2.608PheLeu: 2.608 ± 0.422
1.349PheMet: 1.349 ± 0.375
4.047PheAsn: 4.047 ± 0.609
0.989PhePro: 0.989 ± 0.282
0.719PheGln: 0.719 ± 0.217
1.978PheArg: 1.978 ± 0.373
2.968PheSer: 2.968 ± 0.586
2.698PheThr: 2.698 ± 0.534
2.518PheVal: 2.518 ± 0.511
0.18PheTrp: 0.18 ± 0.132
1.259PheTyr: 1.259 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
2.878GlyAla: 2.878 ± 0.567
0.36GlyCys: 0.36 ± 0.153
3.417GlyAsp: 3.417 ± 0.502
3.957GlyGlu: 3.957 ± 0.719
2.788GlyPhe: 2.788 ± 0.439
5.216GlyGly: 5.216 ± 1.049
1.349GlyHis: 1.349 ± 0.392
3.597GlyIle: 3.597 ± 0.84
7.464GlyLys: 7.464 ± 0.991
5.126GlyLeu: 5.126 ± 0.918
1.169GlyMet: 1.169 ± 0.325
3.597GlyAsn: 3.597 ± 0.794
1.349GlyPro: 1.349 ± 0.323
2.338GlyGln: 2.338 ± 0.698
2.338GlyArg: 2.338 ± 0.452
3.687GlySer: 3.687 ± 0.582
2.878GlyThr: 2.878 ± 0.592
4.406GlyVal: 4.406 ± 0.758
0.899GlyTrp: 0.899 ± 0.297
3.147GlyTyr: 3.147 ± 0.596
0.0GlyXaa: 0.0 ± 0.0
His
1.439HisAla: 1.439 ± 0.363
0.0HisCys: 0.0 ± 0.0
1.169HisAsp: 1.169 ± 0.345
1.259HisGlu: 1.259 ± 0.387
0.989HisPhe: 0.989 ± 0.24
0.629HisGly: 0.629 ± 0.24
0.45HisHis: 0.45 ± 0.194
1.799HisIle: 1.799 ± 0.332
1.439HisLys: 1.439 ± 0.452
0.899HisLeu: 0.899 ± 0.221
0.0HisMet: 0.0 ± 0.0
1.259HisAsn: 1.259 ± 0.413
0.629HisPro: 0.629 ± 0.192
0.54HisGln: 0.54 ± 0.178
0.27HisArg: 0.27 ± 0.149
0.809HisSer: 0.809 ± 0.172
1.619HisThr: 1.619 ± 0.326
1.259HisVal: 1.259 ± 0.373
0.27HisTrp: 0.27 ± 0.158
0.899HisTyr: 0.899 ± 0.317
0.0HisXaa: 0.0 ± 0.0
Ile
5.755IleAla: 5.755 ± 0.665
0.27IleCys: 0.27 ± 0.16
4.496IleAsp: 4.496 ± 0.667
6.385IleGlu: 6.385 ± 0.655
3.777IlePhe: 3.777 ± 0.572
4.586IleGly: 4.586 ± 0.586
1.709IleHis: 1.709 ± 0.491
4.496IleIle: 4.496 ± 0.891
8.633IleLys: 8.633 ± 0.781
3.957IleLeu: 3.957 ± 0.552
1.079IleMet: 1.079 ± 0.296
5.935IleAsn: 5.935 ± 0.92
2.158IlePro: 2.158 ± 0.389
3.327IleGln: 3.327 ± 0.486
2.968IleArg: 2.968 ± 0.5
4.676IleSer: 4.676 ± 0.452
5.216IleThr: 5.216 ± 0.572
4.496IleVal: 4.496 ± 0.585
1.079IleTrp: 1.079 ± 0.478
2.518IleTyr: 2.518 ± 0.608
0.0IleXaa: 0.0 ± 0.0
Lys
6.655LysAla: 6.655 ± 0.912
0.36LysCys: 0.36 ± 0.196
6.924LysAsp: 6.924 ± 0.655
8.363LysGlu: 8.363 ± 0.942
3.058LysPhe: 3.058 ± 0.467
6.205LysGly: 6.205 ± 0.775
1.079LysHis: 1.079 ± 0.331
6.385LysIle: 6.385 ± 0.822
7.734LysLys: 7.734 ± 0.966
7.374LysLeu: 7.374 ± 0.735
2.608LysMet: 2.608 ± 0.615
6.205LysAsn: 6.205 ± 0.82
3.147LysPro: 3.147 ± 0.643
3.777LysGln: 3.777 ± 0.425
4.856LysArg: 4.856 ± 0.799
4.766LysSer: 4.766 ± 0.887
4.946LysThr: 4.946 ± 0.773
6.205LysVal: 6.205 ± 0.787
1.619LysTrp: 1.619 ± 0.401
4.496LysTyr: 4.496 ± 0.628
0.0LysXaa: 0.0 ± 0.0
Leu
3.507LeuAla: 3.507 ± 0.564
0.54LeuCys: 0.54 ± 0.256
5.036LeuAsp: 5.036 ± 0.66
6.205LeuGlu: 6.205 ± 0.91
3.058LeuPhe: 3.058 ± 0.489
3.777LeuGly: 3.777 ± 0.573
1.259LeuHis: 1.259 ± 0.26
5.486LeuIle: 5.486 ± 0.715
7.644LeuLys: 7.644 ± 0.773
5.126LeuLeu: 5.126 ± 0.728
1.529LeuMet: 1.529 ± 0.451
6.025LeuAsn: 6.025 ± 0.85
2.608LeuPro: 2.608 ± 0.612
2.788LeuGln: 2.788 ± 0.438
3.058LeuArg: 3.058 ± 0.731
5.306LeuSer: 5.306 ± 0.706
4.137LeuThr: 4.137 ± 0.797
3.777LeuVal: 3.777 ± 0.664
0.809LeuTrp: 0.809 ± 0.277
3.597LeuTyr: 3.597 ± 0.639
0.0LeuXaa: 0.0 ± 0.0
Met
1.079MetAla: 1.079 ± 0.38
0.09MetCys: 0.09 ± 0.074
1.529MetAsp: 1.529 ± 0.412
1.079MetGlu: 1.079 ± 0.349
0.809MetPhe: 0.809 ± 0.203
1.169MetGly: 1.169 ± 0.505
0.719MetHis: 0.719 ± 0.244
2.608MetIle: 2.608 ± 0.428
2.158MetLys: 2.158 ± 0.454
1.709MetLeu: 1.709 ± 0.292
0.54MetMet: 0.54 ± 0.231
2.248MetAsn: 2.248 ± 0.497
0.45MetPro: 0.45 ± 0.222
0.899MetGln: 0.899 ± 0.284
1.079MetArg: 1.079 ± 0.322
1.619MetSer: 1.619 ± 0.339
0.809MetThr: 0.809 ± 0.225
1.079MetVal: 1.079 ± 0.271
0.36MetTrp: 0.36 ± 0.151
0.54MetTyr: 0.54 ± 0.264
0.0MetXaa: 0.0 ± 0.0
Asn
3.687AsnAla: 3.687 ± 0.526
0.09AsnCys: 0.09 ± 0.101
3.777AsnAsp: 3.777 ± 0.56
5.665AsnGlu: 5.665 ± 1.101
2.338AsnPhe: 2.338 ± 0.636
5.665AsnGly: 5.665 ± 0.613
0.989AsnHis: 0.989 ± 0.315
5.576AsnIle: 5.576 ± 0.585
7.374AsnLys: 7.374 ± 0.804
4.496AsnLeu: 4.496 ± 0.871
1.799AsnMet: 1.799 ± 0.345
5.576AsnAsn: 5.576 ± 1.139
2.968AsnPro: 2.968 ± 0.359
3.327AsnGln: 3.327 ± 0.538
3.237AsnArg: 3.237 ± 0.542
3.597AsnSer: 3.597 ± 0.516
3.687AsnThr: 3.687 ± 0.44
4.406AsnVal: 4.406 ± 0.759
1.439AsnTrp: 1.439 ± 0.516
3.237AsnTyr: 3.237 ± 0.531
0.0AsnXaa: 0.0 ± 0.0
Pro
0.719ProAla: 0.719 ± 0.254
0.0ProCys: 0.0 ± 0.0
1.169ProAsp: 1.169 ± 0.305
2.428ProGlu: 2.428 ± 0.4
1.349ProPhe: 1.349 ± 0.441
0.989ProGly: 0.989 ± 0.263
0.45ProHis: 0.45 ± 0.209
2.338ProIle: 2.338 ± 0.458
2.878ProLys: 2.878 ± 0.601
2.608ProLeu: 2.608 ± 0.57
0.719ProMet: 0.719 ± 0.208
1.888ProAsn: 1.888 ± 0.344
1.079ProPro: 1.079 ± 0.279
0.809ProGln: 0.809 ± 0.232
1.259ProArg: 1.259 ± 0.322
1.888ProSer: 1.888 ± 0.429
1.709ProThr: 1.709 ± 0.433
1.439ProVal: 1.439 ± 0.343
0.27ProTrp: 0.27 ± 0.126
1.349ProTyr: 1.349 ± 0.372
0.0ProXaa: 0.0 ± 0.0
Gln
2.878GlnAla: 2.878 ± 0.507
0.18GlnCys: 0.18 ± 0.135
2.338GlnAsp: 2.338 ± 0.566
2.428GlnGlu: 2.428 ± 0.473
1.349GlnPhe: 1.349 ± 0.295
1.709GlnGly: 1.709 ± 0.469
0.989GlnHis: 0.989 ± 0.29
3.597GlnIle: 3.597 ± 0.626
2.968GlnLys: 2.968 ± 0.507
3.147GlnLeu: 3.147 ± 0.433
0.629GlnMet: 0.629 ± 0.209
3.237GlnAsn: 3.237 ± 0.598
1.079GlnPro: 1.079 ± 0.323
1.799GlnGln: 1.799 ± 0.515
2.338GlnArg: 2.338 ± 0.371
2.158GlnSer: 2.158 ± 0.49
1.799GlnThr: 1.799 ± 0.513
1.978GlnVal: 1.978 ± 0.362
0.36GlnTrp: 0.36 ± 0.179
1.259GlnTyr: 1.259 ± 0.383
0.0GlnXaa: 0.0 ± 0.0
Arg
2.068ArgAla: 2.068 ± 0.436
0.27ArgCys: 0.27 ± 0.161
2.788ArgAsp: 2.788 ± 0.425
3.867ArgGlu: 3.867 ± 0.631
1.709ArgPhe: 1.709 ± 0.337
2.068ArgGly: 2.068 ± 0.418
0.719ArgHis: 0.719 ± 0.25
3.867ArgIle: 3.867 ± 0.511
4.317ArgLys: 4.317 ± 0.637
3.417ArgLeu: 3.417 ± 0.487
0.809ArgMet: 0.809 ± 0.252
3.058ArgAsn: 3.058 ± 0.547
0.629ArgPro: 0.629 ± 0.22
1.619ArgGln: 1.619 ± 0.506
2.068ArgArg: 2.068 ± 0.443
1.619ArgSer: 1.619 ± 0.307
2.698ArgThr: 2.698 ± 0.685
2.428ArgVal: 2.428 ± 0.414
0.629ArgTrp: 0.629 ± 0.191
2.788ArgTyr: 2.788 ± 0.714
0.0ArgXaa: 0.0 ± 0.0
Ser
3.417SerAla: 3.417 ± 0.742
0.18SerCys: 0.18 ± 0.12
4.317SerAsp: 4.317 ± 0.577
4.676SerGlu: 4.676 ± 0.655
3.058SerPhe: 3.058 ± 0.636
4.137SerGly: 4.137 ± 0.693
0.989SerHis: 0.989 ± 0.201
4.676SerIle: 4.676 ± 0.625
4.676SerLys: 4.676 ± 0.703
3.327SerLeu: 3.327 ± 0.521
1.169SerMet: 1.169 ± 0.288
4.766SerAsn: 4.766 ± 0.504
0.54SerPro: 0.54 ± 0.245
2.968SerGln: 2.968 ± 0.483
1.799SerArg: 1.799 ± 0.328
3.687SerSer: 3.687 ± 0.656
2.698SerThr: 2.698 ± 0.408
2.608SerVal: 2.608 ± 0.488
0.629SerTrp: 0.629 ± 0.283
2.608SerTyr: 2.608 ± 0.54
0.0SerXaa: 0.0 ± 0.0
Thr
3.597ThrAla: 3.597 ± 0.621
0.18ThrCys: 0.18 ± 0.137
3.417ThrAsp: 3.417 ± 0.898
3.147ThrGlu: 3.147 ± 0.506
2.068ThrPhe: 2.068 ± 0.366
4.047ThrGly: 4.047 ± 0.958
1.619ThrHis: 1.619 ± 0.363
3.327ThrIle: 3.327 ± 0.588
4.766ThrLys: 4.766 ± 0.712
4.856ThrLeu: 4.856 ± 0.539
0.629ThrMet: 0.629 ± 0.204
3.147ThrAsn: 3.147 ± 0.639
2.878ThrPro: 2.878 ± 0.375
1.439ThrGln: 1.439 ± 0.437
2.158ThrArg: 2.158 ± 0.381
3.597ThrSer: 3.597 ± 0.774
3.507ThrThr: 3.507 ± 0.768
4.317ThrVal: 4.317 ± 0.59
0.719ThrTrp: 0.719 ± 0.221
2.518ThrTyr: 2.518 ± 0.457
0.0ThrXaa: 0.0 ± 0.0
Val
3.507ValAla: 3.507 ± 0.764
0.09ValCys: 0.09 ± 0.095
4.406ValAsp: 4.406 ± 0.662
3.687ValGlu: 3.687 ± 0.63
2.068ValPhe: 2.068 ± 0.507
3.237ValGly: 3.237 ± 0.571
1.079ValHis: 1.079 ± 0.329
4.586ValIle: 4.586 ± 0.728
6.745ValLys: 6.745 ± 0.705
4.317ValLeu: 4.317 ± 0.471
1.349ValMet: 1.349 ± 0.339
4.406ValAsn: 4.406 ± 0.544
1.259ValPro: 1.259 ± 0.32
2.518ValGln: 2.518 ± 0.507
2.428ValArg: 2.428 ± 0.518
3.417ValSer: 3.417 ± 0.612
3.867ValThr: 3.867 ± 0.689
3.867ValVal: 3.867 ± 0.71
0.719ValTrp: 0.719 ± 0.247
2.068ValTyr: 2.068 ± 0.387
0.0ValXaa: 0.0 ± 0.0
Trp
0.45TrpAla: 0.45 ± 0.193
0.0TrpCys: 0.0 ± 0.0
0.809TrpAsp: 0.809 ± 0.23
0.629TrpGlu: 0.629 ± 0.239
0.989TrpPhe: 0.989 ± 0.231
0.899TrpGly: 0.899 ± 0.266
0.0TrpHis: 0.0 ± 0.0
1.349TrpIle: 1.349 ± 0.333
1.169TrpLys: 1.169 ± 0.285
1.349TrpLeu: 1.349 ± 0.286
0.54TrpMet: 0.54 ± 0.206
1.169TrpAsn: 1.169 ± 0.336
0.18TrpPro: 0.18 ± 0.093
0.629TrpGln: 0.629 ± 0.167
0.45TrpArg: 0.45 ± 0.183
0.27TrpSer: 0.27 ± 0.144
0.36TrpThr: 0.36 ± 0.155
0.899TrpVal: 0.899 ± 0.274
0.09TrpTrp: 0.09 ± 0.081
0.54TrpTyr: 0.54 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.978TyrAla: 1.978 ± 0.363
0.18TyrCys: 0.18 ± 0.118
2.968TyrAsp: 2.968 ± 0.664
3.327TyrGlu: 3.327 ± 0.589
1.888TyrPhe: 1.888 ± 0.442
3.147TyrGly: 3.147 ± 0.555
0.719TyrHis: 0.719 ± 0.317
3.417TyrIle: 3.417 ± 0.649
4.856TyrLys: 4.856 ± 0.621
3.507TyrLeu: 3.507 ± 0.689
0.809TyrMet: 0.809 ± 0.248
3.687TyrAsn: 3.687 ± 0.52
0.629TyrPro: 0.629 ± 0.213
2.068TyrGln: 2.068 ± 0.442
1.978TyrArg: 1.978 ± 0.364
2.698TyrSer: 2.698 ± 0.391
2.518TyrThr: 2.518 ± 0.416
2.248TyrVal: 2.248 ± 0.435
0.629TyrTrp: 0.629 ± 0.215
0.809TyrTyr: 0.809 ± 0.211
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (11121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski