Amino acid dipepetide frequency for Alligator mississippiensis (American alligator)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.411AlaAla: 6.411 ± 0.033	1.448AlaCys: 1.448 ± 0.012	2.992AlaAsp: 2.992 ± 0.015	4.9AlaGlu: 4.9 ± 0.024	2.439AlaPhe: 2.439 ± 0.013	4.555AlaGly: 4.555 ± 0.028	1.437AlaHis: 1.437 ± 0.01	2.883AlaIle: 2.883 ± 0.017	3.646AlaLys: 3.646 ± 0.018	6.823AlaLeu: 6.823 ± 0.029	1.575AlaMet: 1.575 ± 0.012	2.134AlaAsn: 2.134 ± 0.011	3.609AlaPro: 3.609 ± 0.026	3.084AlaGln: 3.084 ± 0.018	3.403AlaArg: 3.403 ± 0.018	5.501AlaSer: 5.501 ± 0.022	3.578AlaThr: 3.578 ± 0.019	4.84AlaVal: 4.84 ± 0.022	0.824AlaTrp: 0.824 ± 0.009	1.556AlaTyr: 1.556 ± 0.011	0.003AlaXaa: 0.003 ± 0.0
Cys	1.25CysAla: 1.25 ± 0.011	0.662CysCys: 0.662 ± 0.009	1.043CysAsp: 1.043 ± 0.013	1.338CysGlu: 1.338 ± 0.015	0.871CysPhe: 0.871 ± 0.009	1.597CysGly: 1.597 ± 0.018	0.687CysHis: 0.687 ± 0.008	1.105CysIle: 1.105 ± 0.011	1.282CysLys: 1.282 ± 0.011	2.235CysLeu: 2.235 ± 0.014	0.479CysMet: 0.479 ± 0.005	0.891CysAsn: 0.891 ± 0.009	1.505CysPro: 1.505 ± 0.038	1.164CysGln: 1.164 ± 0.012	1.273CysArg: 1.273 ± 0.01	2.1CysSer: 2.1 ± 0.016	1.265CysThr: 1.265 ± 0.012	1.257CysVal: 1.257 ± 0.011	0.319CysTrp: 0.319 ± 0.005	0.632CysTyr: 0.632 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	2.973AspAla: 2.973 ± 0.015	1.152AspCys: 1.152 ± 0.013	2.7AspAsp: 2.7 ± 0.021	3.564AspGlu: 3.564 ± 0.021	2.103AspPhe: 2.103 ± 0.012	3.317AspGly: 3.317 ± 0.023	1.147AspHis: 1.147 ± 0.009	2.752AspIle: 2.752 ± 0.017	2.692AspLys: 2.692 ± 0.017	5.028AspLeu: 5.028 ± 0.02	1.185AspMet: 1.185 ± 0.009	1.816AspAsn: 1.816 ± 0.014	2.801AspPro: 2.801 ± 0.015	1.91AspGln: 1.91 ± 0.014	2.365AspArg: 2.365 ± 0.015	4.175AspSer: 4.175 ± 0.021	2.563AspThr: 2.563 ± 0.015	3.042AspVal: 3.042 ± 0.016	0.664AspTrp: 0.664 ± 0.007	1.555AspTyr: 1.555 ± 0.011	0.001AspXaa: 0.001 ± 0.0
Glu	5.08GluAla: 5.08 ± 0.024	1.368GluCys: 1.368 ± 0.017	4.513GluAsp: 4.513 ± 0.023	8.075GluGlu: 8.075 ± 0.055	2.011GluPhe: 2.011 ± 0.013	4.093GluGly: 4.093 ± 0.022	1.581GluHis: 1.581 ± 0.012	3.411GluIle: 3.411 ± 0.02	5.641GluLys: 5.641 ± 0.035	6.561GluLeu: 6.561 ± 0.036	1.878GluMet: 1.878 ± 0.011	3.281GluAsn: 3.281 ± 0.019	3.091GluPro: 3.091 ± 0.025	3.427GluGln: 3.427 ± 0.024	4.069GluArg: 4.069 ± 0.024	4.559GluSer: 4.559 ± 0.023	3.683GluThr: 3.683 ± 0.017	4.245GluVal: 4.245 ± 0.024	0.744GluTrp: 0.744 ± 0.007	1.676GluTyr: 1.676 ± 0.012	0.001GluXaa: 0.001 ± 0.0
Phe	1.956PheAla: 1.956 ± 0.011	0.938PheCys: 0.938 ± 0.012	1.654PheAsp: 1.654 ± 0.013	1.982PheGlu: 1.982 ± 0.014	1.494PhePhe: 1.494 ± 0.012	2.106PheGly: 2.106 ± 0.013	1.024PheHis: 1.024 ± 0.008	1.859PheIle: 1.859 ± 0.013	1.823PheLys: 1.823 ± 0.014	3.835PheLeu: 3.835 ± 0.021	0.797PheMet: 0.797 ± 0.007	1.361PheAsn: 1.361 ± 0.011	1.94PhePro: 1.94 ± 0.013	1.802PheGln: 1.802 ± 0.011	1.808PheArg: 1.808 ± 0.012	3.221PheSer: 3.221 ± 0.015	2.124PheThr: 2.124 ± 0.013	2.052PheVal: 2.052 ± 0.015	0.487PheTrp: 0.487 ± 0.006	1.185PheTyr: 1.185 ± 0.01	0.001PheXaa: 0.001 ± 0.0
Gly	4.11GlyAla: 4.11 ± 0.028	1.282GlyCys: 1.282 ± 0.013	3.073GlyAsp: 3.073 ± 0.022	4.064GlyGlu: 4.064 ± 0.026	2.356GlyPhe: 2.356 ± 0.016	4.178GlyGly: 4.178 ± 0.026	1.608GlyHis: 1.608 ± 0.013	2.927GlyIle: 2.927 ± 0.017	4.008GlyLys: 4.008 ± 0.023	5.551GlyLeu: 5.551 ± 0.028	1.374GlyMet: 1.374 ± 0.012	2.5GlyAsn: 2.5 ± 0.015	3.405GlyPro: 3.405 ± 0.042	2.77GlyGln: 2.77 ± 0.016	3.434GlyArg: 3.434 ± 0.018	5.534GlySer: 5.534 ± 0.028	3.648GlyThr: 3.648 ± 0.022	3.38GlyVal: 3.38 ± 0.019	0.809GlyTrp: 0.809 ± 0.008	1.828GlyTyr: 1.828 ± 0.016	0.003GlyXaa: 0.003 ± 0.0
His	1.381HisAla: 1.381 ± 0.01	0.756HisCys: 0.756 ± 0.008	0.945HisAsp: 0.945 ± 0.008	1.381HisGlu: 1.381 ± 0.011	1.055HisPhe: 1.055 ± 0.008	1.521HisGly: 1.521 ± 0.011	0.856HisHis: 0.856 ± 0.009	1.294HisIle: 1.294 ± 0.01	1.328HisLys: 1.328 ± 0.009	2.892HisLeu: 2.892 ± 0.014	0.601HisMet: 0.601 ± 0.007	0.918HisAsn: 0.918 ± 0.008	1.548HisPro: 1.548 ± 0.012	1.39HisGln: 1.39 ± 0.016	1.528HisArg: 1.528 ± 0.011	2.173HisSer: 2.173 ± 0.015	1.402HisThr: 1.402 ± 0.013	1.499HisVal: 1.499 ± 0.01	0.377HisTrp: 0.377 ± 0.005	0.856HisTyr: 0.856 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.792IleAla: 2.792 ± 0.016	1.165IleCys: 1.165 ± 0.01	2.134IleAsp: 2.134 ± 0.015	2.771IleGlu: 2.771 ± 0.017	1.888IlePhe: 1.888 ± 0.014	2.332IleGly: 2.332 ± 0.015	1.37IleHis: 1.37 ± 0.011	2.551IleIle: 2.551 ± 0.015	2.814IleLys: 2.814 ± 0.017	4.693IleLeu: 4.693 ± 0.021	1.065IleMet: 1.065 ± 0.009	1.982IleAsn: 1.982 ± 0.014	2.711IlePro: 2.711 ± 0.015	2.493IleGln: 2.493 ± 0.014	2.405IleArg: 2.405 ± 0.013	3.984IleSer: 3.984 ± 0.02	2.792IleThr: 2.792 ± 0.019	2.626IleVal: 2.626 ± 0.016	0.561IleTrp: 0.561 ± 0.006	1.426IleTyr: 1.426 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.995LysAla: 3.995 ± 0.02	1.195LysCys: 1.195 ± 0.01	3.341LysAsp: 3.341 ± 0.018	5.52LysGlu: 5.52 ± 0.034	1.697LysPhe: 1.697 ± 0.012	3.501LysGly: 3.501 ± 0.027	1.501LysHis: 1.501 ± 0.011	2.923LysIle: 2.923 ± 0.019	4.996LysLys: 4.996 ± 0.038	5.461LysLeu: 5.461 ± 0.025	1.584LysMet: 1.584 ± 0.011	2.517LysAsn: 2.517 ± 0.015	3.205LysPro: 3.205 ± 0.022	2.955LysGln: 2.955 ± 0.02	3.435LysArg: 3.435 ± 0.019	4.185LysSer: 4.185 ± 0.022	3.292LysThr: 3.292 ± 0.017	3.57LysVal: 3.57 ± 0.026	0.675LysTrp: 0.675 ± 0.007	1.654LysTyr: 1.654 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	6.604LeuAla: 6.604 ± 0.031	2.202LeuCys: 2.202 ± 0.015	4.811LeuAsp: 4.811 ± 0.021	7.306LeuGlu: 7.306 ± 0.035	3.198LeuPhe: 3.198 ± 0.018	5.451LeuGly: 5.451 ± 0.025	2.801LeuHis: 2.801 ± 0.017	3.94LeuIle: 3.94 ± 0.019	6.104LeuLys: 6.104 ± 0.029	10.232LeuLeu: 10.232 ± 0.046	2.074LeuMet: 2.074 ± 0.013	3.649LeuAsn: 3.649 ± 0.019	5.672LeuPro: 5.672 ± 0.026	5.968LeuGln: 5.968 ± 0.029	5.507LeuArg: 5.507 ± 0.024	7.733LeuSer: 7.733 ± 0.029	4.911LeuThr: 4.911 ± 0.021	5.336LeuVal: 5.336 ± 0.025	1.119LeuTrp: 1.119 ± 0.01	2.554LeuTyr: 2.554 ± 0.014	0.002LeuXaa: 0.002 ± 0.0
Met	1.854MetAla: 1.854 ± 0.012	0.443MetCys: 0.443 ± 0.005	1.333MetAsp: 1.333 ± 0.011	2.056MetGlu: 2.056 ± 0.013	0.754MetPhe: 0.754 ± 0.009	1.339MetGly: 1.339 ± 0.012	0.531MetHis: 0.531 ± 0.006	0.917MetIle: 0.917 ± 0.008	1.593MetLys: 1.593 ± 0.011	2.07MetLeu: 2.07 ± 0.011	0.615MetMet: 0.615 ± 0.006	0.931MetAsn: 0.931 ± 0.009	1.178MetPro: 1.178 ± 0.011	1.11MetGln: 1.11 ± 0.009	1.099MetArg: 1.099 ± 0.009	1.622MetSer: 1.622 ± 0.01	1.175MetThr: 1.175 ± 0.009	1.41MetVal: 1.41 ± 0.009	0.261MetTrp: 0.261 ± 0.005	0.606MetTyr: 0.606 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.194AsnAla: 2.194 ± 0.013	0.934AsnCys: 0.934 ± 0.01	1.605AsnAsp: 1.605 ± 0.013	2.435AsnGlu: 2.435 ± 0.013	1.457AsnPhe: 1.457 ± 0.011	2.659AsnGly: 2.659 ± 0.019	0.958AsnHis: 0.958 ± 0.008	2.299AsnIle: 2.299 ± 0.014	2.368AsnLys: 2.368 ± 0.016	3.808AsnLeu: 3.808 ± 0.018	1.003AsnMet: 1.003 ± 0.009	1.675AsnAsn: 1.675 ± 0.012	2.167AsnPro: 2.167 ± 0.014	1.751AsnGln: 1.751 ± 0.012	1.917AsnArg: 1.917 ± 0.014	3.207AsnSer: 3.207 ± 0.018	2.108AsnThr: 2.108 ± 0.014	2.259AsnVal: 2.259 ± 0.015	0.474AsnTrp: 0.474 ± 0.006	1.157AsnTyr: 1.157 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.528ProAla: 4.528 ± 0.029	1.216ProCys: 1.216 ± 0.021	2.786ProAsp: 2.786 ± 0.016	4.218ProGlu: 4.218 ± 0.031	1.829ProPhe: 1.829 ± 0.013	4.684ProGly: 4.684 ± 0.062	1.368ProHis: 1.368 ± 0.011	1.959ProIle: 1.959 ± 0.014	2.802ProLys: 2.802 ± 0.023	4.782ProLeu: 4.782 ± 0.024	1.054ProMet: 1.054 ± 0.01	1.849ProAsn: 1.849 ± 0.014	4.955ProPro: 4.955 ± 0.049	2.575ProGln: 2.575 ± 0.017	2.867ProArg: 2.867 ± 0.019	5.15ProSer: 5.15 ± 0.026	2.864ProThr: 2.864 ± 0.017	3.804ProVal: 3.804 ± 0.024	0.65ProTrp: 0.65 ± 0.007	1.425ProTyr: 1.425 ± 0.014	0.003ProXaa: 0.003 ± 0.0
Gln	3.463GlnAla: 3.463 ± 0.022	1.095GlnCys: 1.095 ± 0.015	2.448GlnAsp: 2.448 ± 0.013	4.027GlnGlu: 4.027 ± 0.028	1.392GlnPhe: 1.392 ± 0.011	2.799GlnGly: 2.799 ± 0.019	1.417GlnHis: 1.417 ± 0.011	2.155GlnIle: 2.155 ± 0.015	3.165GlnLys: 3.165 ± 0.02	4.908GlnLeu: 4.908 ± 0.023	1.173GlnMet: 1.173 ± 0.01	1.979GlnAsn: 1.979 ± 0.013	2.653GlnPro: 2.653 ± 0.02	3.265GlnGln: 3.265 ± 0.033	2.932GlnArg: 2.932 ± 0.019	3.293GlnSer: 3.293 ± 0.018	2.444GlnThr: 2.444 ± 0.015	2.828GlnVal: 2.828 ± 0.015	0.579GlnTrp: 0.579 ± 0.006	1.243GlnTyr: 1.243 ± 0.011	0.001GlnXaa: 0.001 ± 0.0
Arg	3.484ArgAla: 3.484 ± 0.021	1.24ArgCys: 1.24 ± 0.012	2.678ArgAsp: 2.678 ± 0.015	3.848ArgGlu: 3.848 ± 0.021	1.795ArgPhe: 1.795 ± 0.012	3.282ArgGly: 3.282 ± 0.023	1.491ArgHis: 1.491 ± 0.011	2.527ArgIle: 2.527 ± 0.015	3.735ArgLys: 3.735 ± 0.019	5.053ArgLeu: 5.053 ± 0.025	1.222ArgMet: 1.222 ± 0.008	2.123ArgAsn: 2.123 ± 0.012	2.743ArgPro: 2.743 ± 0.018	2.627ArgGln: 2.627 ± 0.015	3.991ArgArg: 3.991 ± 0.028	4.117ArgSer: 4.117 ± 0.02	2.796ArgThr: 2.796 ± 0.013	3.018ArgVal: 3.018 ± 0.018	0.697ArgTrp: 0.697 ± 0.006	1.48ArgTyr: 1.48 ± 0.011	0.003ArgXaa: 0.003 ± 0.0
Ser	5.247SerAla: 5.247 ± 0.025	1.931SerCys: 1.931 ± 0.014	3.936SerAsp: 3.936 ± 0.018	5.154SerGlu: 5.154 ± 0.026	3.081SerPhe: 3.081 ± 0.015	5.187SerGly: 5.187 ± 0.024	2.048SerHis: 2.048 ± 0.013	3.46SerIle: 3.46 ± 0.015	4.289SerLys: 4.289 ± 0.02	7.99SerLeu: 7.99 ± 0.027	1.695SerMet: 1.695 ± 0.011	2.882SerAsn: 2.882 ± 0.015	5.509SerPro: 5.509 ± 0.032	3.888SerGln: 3.888 ± 0.02	4.25SerArg: 4.25 ± 0.022	9.219SerSer: 9.219 ± 0.056	4.671SerThr: 4.671 ± 0.024	4.812SerVal: 4.812 ± 0.02	1.091SerTrp: 1.091 ± 0.009	2.09SerTyr: 2.09 ± 0.013	0.003SerXaa: 0.003 ± 0.0
Thr	3.939ThrAla: 3.939 ± 0.019	1.432ThrCys: 1.432 ± 0.017	2.665ThrAsp: 2.665 ± 0.015	3.832ThrGlu: 3.832 ± 0.02	2.059ThrPhe: 2.059 ± 0.013	3.669ThrGly: 3.669 ± 0.022	1.242ThrHis: 1.242 ± 0.011	2.521ThrIle: 2.521 ± 0.018	2.835ThrLys: 2.835 ± 0.016	5.208ThrLeu: 5.208 ± 0.024	1.176ThrMet: 1.176 ± 0.009	1.872ThrAsn: 1.872 ± 0.013	3.331ThrPro: 3.331 ± 0.02	2.302ThrGln: 2.302 ± 0.016	2.463ThrArg: 2.463 ± 0.013	4.722ThrSer: 4.722 ± 0.027	3.111ThrThr: 3.111 ± 0.022	3.924ThrVal: 3.924 ± 0.023	0.743ThrTrp: 0.743 ± 0.008	1.484ThrTyr: 1.484 ± 0.012	0.002ThrXaa: 0.002 ± 0.0
Val	4.139ValAla: 4.139 ± 0.021	1.455ValCys: 1.455 ± 0.013	2.834ValAsp: 2.834 ± 0.018	3.956ValGlu: 3.956 ± 0.025	2.314ValPhe: 2.314 ± 0.013	3.224ValGly: 3.224 ± 0.019	1.55ValHis: 1.55 ± 0.01	2.961ValIle: 2.961 ± 0.017	3.624ValLys: 3.624 ± 0.019	6.149ValLeu: 6.149 ± 0.026	1.365ValMet: 1.365 ± 0.01	2.329ValAsn: 2.329 ± 0.015	3.582ValPro: 3.582 ± 0.035	2.891ValGln: 2.891 ± 0.015	2.837ValArg: 2.837 ± 0.016	4.768ValSer: 4.768 ± 0.02	3.812ValThr: 3.812 ± 0.025	3.889ValVal: 3.889 ± 0.022	0.711ValTrp: 0.711 ± 0.008	1.644ValTyr: 1.644 ± 0.011	0.001ValXaa: 0.001 ± 0.0
Trp	0.772TrpAla: 0.772 ± 0.008	0.271TrpCys: 0.271 ± 0.005	0.692TrpAsp: 0.692 ± 0.007	0.847TrpGlu: 0.847 ± 0.007	0.437TrpPhe: 0.437 ± 0.006	0.681TrpGly: 0.681 ± 0.008	0.327TrpHis: 0.327 ± 0.005	0.625TrpIle: 0.625 ± 0.008	0.882TrpLys: 0.882 ± 0.008	1.258TrpLeu: 1.258 ± 0.011	0.339TrpMet: 0.339 ± 0.005	0.56TrpAsn: 0.56 ± 0.007	0.487TrpPro: 0.487 ± 0.006	0.593TrpGln: 0.593 ± 0.006	0.738TrpArg: 0.738 ± 0.007	0.926TrpSer: 0.926 ± 0.009	0.703TrpThr: 0.703 ± 0.008	0.692TrpVal: 0.692 ± 0.007	0.188TrpTrp: 0.188 ± 0.004	0.358TrpTyr: 0.358 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.466TyrAla: 1.466 ± 0.01	0.769TyrCys: 0.769 ± 0.017	1.321TyrAsp: 1.321 ± 0.01	1.715TyrGlu: 1.715 ± 0.012	1.218TyrPhe: 1.218 ± 0.011	1.664TyrGly: 1.664 ± 0.012	0.757TyrHis: 0.757 ± 0.007	1.484TyrIle: 1.484 ± 0.011	1.575TyrLys: 1.575 ± 0.016	2.635TyrLeu: 2.635 ± 0.013	0.643TyrMet: 0.643 ± 0.007	1.184TyrAsn: 1.184 ± 0.011	1.274TyrPro: 1.274 ± 0.012	1.296TyrGln: 1.296 ± 0.011	1.627TyrArg: 1.627 ± 0.013	2.241TyrSer: 2.241 ± 0.013	1.588TyrThr: 1.588 ± 0.014	1.55TyrVal: 1.55 ± 0.012	0.403TyrTrp: 0.403 ± 0.007	1.015TyrTyr: 1.015 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.254XaaXaa: 0.254 ± 0.021

Statistics based on 31974 proteins (16476323 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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