Amino acid dipepetide frequency for Hydrogenovibrio sp. SC-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.727AlaAla: 6.727 ± 0.138
0.789AlaCys: 0.789 ± 0.032
4.722AlaAsp: 4.722 ± 0.09
5.849AlaGlu: 5.849 ± 0.106
3.49AlaPhe: 3.49 ± 0.077
5.411AlaGly: 5.411 ± 0.104
1.715AlaHis: 1.715 ± 0.052
5.98AlaIle: 5.98 ± 0.1
5.016AlaLys: 5.016 ± 0.086
9.944AlaLeu: 9.944 ± 0.136
2.568AlaMet: 2.568 ± 0.062
3.354AlaAsn: 3.354 ± 0.067
2.714AlaPro: 2.714 ± 0.07
4.47AlaGln: 4.47 ± 0.079
3.22AlaArg: 3.22 ± 0.063
5.098AlaSer: 5.098 ± 0.091
4.283AlaThr: 4.283 ± 0.084
5.553AlaVal: 5.553 ± 0.09
1.147AlaTrp: 1.147 ± 0.043
2.436AlaTyr: 2.436 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.595CysAla: 0.595 ± 0.031
0.098CysCys: 0.098 ± 0.013
0.526CysAsp: 0.526 ± 0.028
0.542CysGlu: 0.542 ± 0.03
0.346CysPhe: 0.346 ± 0.025
0.706CysGly: 0.706 ± 0.037
0.328CysHis: 0.328 ± 0.021
0.462CysIle: 0.462 ± 0.025
0.342CysLys: 0.342 ± 0.021
0.865CysLeu: 0.865 ± 0.039
0.164CysMet: 0.164 ± 0.017
0.245CysAsn: 0.245 ± 0.018
0.431CysPro: 0.431 ± 0.029
0.55CysGln: 0.55 ± 0.028
0.395CysArg: 0.395 ± 0.026
0.53CysSer: 0.53 ± 0.029
0.34CysThr: 0.34 ± 0.019
0.447CysVal: 0.447 ± 0.027
0.098CysTrp: 0.098 ± 0.014
0.263CysTyr: 0.263 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.729AspAla: 4.729 ± 0.095
0.489AspCys: 0.489 ± 0.028
2.806AspAsp: 2.806 ± 0.076
3.69AspGlu: 3.69 ± 0.075
2.759AspPhe: 2.759 ± 0.06
3.368AspGly: 3.368 ± 0.08
1.197AspHis: 1.197 ± 0.044
3.826AspIle: 3.826 ± 0.068
2.782AspLys: 2.782 ± 0.062
5.813AspLeu: 5.813 ± 0.09
1.373AspMet: 1.373 ± 0.042
1.982AspAsn: 1.982 ± 0.056
2.207AspPro: 2.207 ± 0.059
2.937AspGln: 2.937 ± 0.067
2.417AspArg: 2.417 ± 0.059
3.187AspSer: 3.187 ± 0.057
2.637AspThr: 2.637 ± 0.058
3.666AspVal: 3.666 ± 0.077
1.013AspTrp: 1.013 ± 0.045
2.232AspTyr: 2.232 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.015GluAla: 6.015 ± 0.11
0.371GluCys: 0.371 ± 0.025
2.987GluAsp: 2.987 ± 0.074
3.488GluGlu: 3.488 ± 0.081
2.157GluPhe: 2.157 ± 0.054
3.621GluGly: 3.621 ± 0.087
1.312GluHis: 1.312 ± 0.042
4.174GluIle: 4.174 ± 0.074
4.188GluLys: 4.188 ± 0.069
6.18GluLeu: 6.18 ± 0.095
2.017GluMet: 2.017 ± 0.053
2.713GluAsn: 2.713 ± 0.064
2.143GluPro: 2.143 ± 0.052
3.605GluGln: 3.605 ± 0.07
2.859GluArg: 2.859 ± 0.071
3.941GluSer: 3.941 ± 0.079
3.994GluThr: 3.994 ± 0.077
4.695GluVal: 4.695 ± 0.088
0.729GluTrp: 0.729 ± 0.031
1.493GluTyr: 1.493 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.145PheAla: 3.145 ± 0.073
0.408PheCys: 0.408 ± 0.023
2.758PheAsp: 2.758 ± 0.058
2.947PheGlu: 2.947 ± 0.063
1.898PhePhe: 1.898 ± 0.058
2.983PheGly: 2.983 ± 0.073
0.914PheHis: 0.914 ± 0.035
2.717PheIle: 2.717 ± 0.066
2.356PheLys: 2.356 ± 0.058
3.694PheLeu: 3.694 ± 0.08
1.07PheMet: 1.07 ± 0.044
1.924PheAsn: 1.924 ± 0.045
1.382PhePro: 1.382 ± 0.044
1.844PheGln: 1.844 ± 0.047
1.48PheArg: 1.48 ± 0.046
3.155PheSer: 3.155 ± 0.072
1.916PheThr: 1.916 ± 0.06
2.614PheVal: 2.614 ± 0.068
0.632PheTrp: 0.632 ± 0.032
1.46PheTyr: 1.46 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.741GlyAla: 4.741 ± 0.101
0.771GlyCys: 0.771 ± 0.037
3.548GlyAsp: 3.548 ± 0.075
3.891GlyGlu: 3.891 ± 0.084
3.231GlyPhe: 3.231 ± 0.07
4.347GlyGly: 4.347 ± 0.105
1.718GlyHis: 1.718 ± 0.052
4.394GlyIle: 4.394 ± 0.093
3.625GlyLys: 3.625 ± 0.083
7.175GlyLeu: 7.175 ± 0.119
1.971GlyMet: 1.971 ± 0.057
2.264GlyAsn: 2.264 ± 0.063
1.516GlyPro: 1.516 ± 0.049
3.332GlyGln: 3.332 ± 0.079
2.951GlyArg: 2.951 ± 0.071
3.616GlySer: 3.616 ± 0.07
3.178GlyThr: 3.178 ± 0.072
4.957GlyVal: 4.957 ± 0.093
0.903GlyTrp: 0.903 ± 0.038
2.398GlyTyr: 2.398 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.744HisAla: 1.744 ± 0.047
0.27HisCys: 0.27 ± 0.022
1.07HisAsp: 1.07 ± 0.041
1.106HisGlu: 1.106 ± 0.04
1.22HisPhe: 1.22 ± 0.039
1.403HisGly: 1.403 ± 0.046
0.809HisHis: 0.809 ± 0.04
1.372HisIle: 1.372 ± 0.05
1.006HisLys: 1.006 ± 0.039
2.706HisLeu: 2.706 ± 0.074
0.489HisMet: 0.489 ± 0.027
0.854HisAsn: 0.854 ± 0.041
1.376HisPro: 1.376 ± 0.042
1.76HisGln: 1.76 ± 0.049
1.114HisArg: 1.114 ± 0.04
1.43HisSer: 1.43 ± 0.045
1.11HisThr: 1.11 ± 0.038
1.033HisVal: 1.033 ± 0.04
0.377HisTrp: 0.377 ± 0.026
1.011HisTyr: 1.011 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.837IleAla: 5.837 ± 0.095
0.616IleCys: 0.616 ± 0.026
4.513IleAsp: 4.513 ± 0.082
5.384IleGlu: 5.384 ± 0.088
2.272IlePhe: 2.272 ± 0.055
4.534IleGly: 4.534 ± 0.084
1.541IleHis: 1.541 ± 0.046
3.537IleIle: 3.537 ± 0.083
3.435IleLys: 3.435 ± 0.075
5.902IleLeu: 5.902 ± 0.1
1.369IleMet: 1.369 ± 0.049
2.764IleAsn: 2.764 ± 0.068
2.572IlePro: 2.572 ± 0.065
3.373IleGln: 3.373 ± 0.079
2.88IleArg: 2.88 ± 0.055
4.279IleSer: 4.279 ± 0.096
3.384IleThr: 3.384 ± 0.073
3.86IleVal: 3.86 ± 0.07
0.724IleTrp: 0.724 ± 0.034
1.596IleTyr: 1.596 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
5.016LysAla: 5.016 ± 0.081
0.298LysCys: 0.298 ± 0.022
2.64LysAsp: 2.64 ± 0.067
3.038LysGlu: 3.038 ± 0.075
1.497LysPhe: 1.497 ± 0.048
3.426LysGly: 3.426 ± 0.081
1.268LysHis: 1.268 ± 0.046
3.435LysIle: 3.435 ± 0.062
3.2LysLys: 3.2 ± 0.087
5.415LysLeu: 5.415 ± 0.098
1.688LysMet: 1.688 ± 0.048
2.482LysAsn: 2.482 ± 0.076
2.42LysPro: 2.42 ± 0.06
3.435LysGln: 3.435 ± 0.063
2.882LysArg: 2.882 ± 0.076
3.522LysSer: 3.522 ± 0.076
3.566LysThr: 3.566 ± 0.073
3.922LysVal: 3.922 ± 0.081
0.59LysTrp: 0.59 ± 0.029
1.243LysTyr: 1.243 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
9.587LeuAla: 9.587 ± 0.128
0.751LeuCys: 0.751 ± 0.031
5.865LeuAsp: 5.865 ± 0.091
6.371LeuGlu: 6.371 ± 0.107
4.347LeuPhe: 4.347 ± 0.09
6.654LeuGly: 6.654 ± 0.13
1.993LeuHis: 1.993 ± 0.057
6.776LeuIle: 6.776 ± 0.123
6.806LeuLys: 6.806 ± 0.112
10.496LeuLeu: 10.496 ± 0.164
2.918LeuMet: 2.918 ± 0.065
5.029LeuAsn: 5.029 ± 0.089
4.869LeuPro: 4.869 ± 0.086
4.713LeuGln: 4.713 ± 0.091
4.12LeuArg: 4.12 ± 0.078
8.003LeuSer: 8.003 ± 0.118
6.395LeuThr: 6.395 ± 0.1
6.843LeuVal: 6.843 ± 0.11
1.067LeuTrp: 1.067 ± 0.045
2.688LeuTyr: 2.688 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.745MetAla: 2.745 ± 0.062
0.129MetCys: 0.129 ± 0.015
1.482MetAsp: 1.482 ± 0.046
1.403MetGlu: 1.403 ± 0.043
0.697MetPhe: 0.697 ± 0.032
1.912MetGly: 1.912 ± 0.052
0.538MetHis: 0.538 ± 0.029
1.723MetIle: 1.723 ± 0.049
1.56MetLys: 1.56 ± 0.048
2.337MetLeu: 2.337 ± 0.06
0.902MetMet: 0.902 ± 0.04
1.196MetAsn: 1.196 ± 0.037
1.316MetPro: 1.316 ± 0.046
1.405MetGln: 1.405 ± 0.044
1.22MetArg: 1.22 ± 0.044
1.902MetSer: 1.902 ± 0.054
1.822MetThr: 1.822 ± 0.05
1.91MetVal: 1.91 ± 0.052
0.157MetTrp: 0.157 ± 0.015
0.451MetTyr: 0.451 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.544AsnAla: 3.544 ± 0.067
0.344AsnCys: 0.344 ± 0.022
2.287AsnAsp: 2.287 ± 0.063
2.499AsnGlu: 2.499 ± 0.067
1.418AsnPhe: 1.418 ± 0.051
2.718AsnGly: 2.718 ± 0.058
1.143AsnHis: 1.143 ± 0.04
2.606AsnIle: 2.606 ± 0.058
1.914AsnLys: 1.914 ± 0.062
4.257AsnLeu: 4.257 ± 0.086
0.982AsnMet: 0.982 ± 0.034
1.723AsnAsn: 1.723 ± 0.061
2.268AsnPro: 2.268 ± 0.054
2.8AsnGln: 2.8 ± 0.07
2.233AsnArg: 2.233 ± 0.058
2.377AsnSer: 2.377 ± 0.063
2.115AsnThr: 2.115 ± 0.058
2.211AsnVal: 2.211 ± 0.062
0.63AsnTrp: 0.63 ± 0.031
1.18AsnTyr: 1.18 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
2.866ProAla: 2.866 ± 0.069
0.306ProCys: 0.306 ± 0.024
2.466ProAsp: 2.466 ± 0.057
3.221ProGlu: 3.221 ± 0.071
1.84ProPhe: 1.84 ± 0.05
2.543ProGly: 2.543 ± 0.054
0.835ProHis: 0.835 ± 0.038
2.885ProIle: 2.885 ± 0.073
2.448ProLys: 2.448 ± 0.059
4.04ProLeu: 4.04 ± 0.075
1.161ProMet: 1.161 ± 0.044
1.982ProAsn: 1.982 ± 0.055
1.377ProPro: 1.377 ± 0.051
1.83ProGln: 1.83 ± 0.049
1.231ProArg: 1.231 ± 0.043
2.526ProSer: 2.526 ± 0.066
2.096ProThr: 2.096 ± 0.057
3.08ProVal: 3.08 ± 0.073
0.458ProTrp: 0.458 ± 0.026
1.335ProTyr: 1.335 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
5.744GlnAla: 5.744 ± 0.111
0.338GlnCys: 0.338 ± 0.021
2.297GlnAsp: 2.297 ± 0.05
2.301GlnGlu: 2.301 ± 0.053
2.275GlnPhe: 2.275 ± 0.049
3.124GlnGly: 3.124 ± 0.056
1.285GlnHis: 1.285 ± 0.047
3.148GlnIle: 3.148 ± 0.071
3.198GlnLys: 3.198 ± 0.071
6.51GlnLeu: 6.51 ± 0.124
1.295GlnMet: 1.295 ± 0.041
2.232GlnAsn: 2.232 ± 0.06
2.415GlnPro: 2.415 ± 0.066
4.364GlnGln: 4.364 ± 0.117
2.355GlnArg: 2.355 ± 0.056
3.568GlnSer: 3.568 ± 0.085
3.379GlnThr: 3.379 ± 0.079
3.704GlnVal: 3.704 ± 0.065
0.708GlnTrp: 0.708 ± 0.031
1.52GlnTyr: 1.52 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.017ArgAla: 3.017 ± 0.069
0.331ArgCys: 0.331 ± 0.023
2.112ArgAsp: 2.112 ± 0.049
2.37ArgGlu: 2.37 ± 0.061
2.229ArgPhe: 2.229 ± 0.056
2.253ArgGly: 2.253 ± 0.061
1.186ArgHis: 1.186 ± 0.042
2.938ArgIle: 2.938 ± 0.065
2.28ArgLys: 2.28 ± 0.065
5.207ArgLeu: 5.207 ± 0.093
1.222ArgMet: 1.222 ± 0.041
1.783ArgAsn: 1.783 ± 0.054
1.744ArgPro: 1.744 ± 0.052
2.565ArgGln: 2.565 ± 0.072
2.092ArgArg: 2.092 ± 0.072
2.5ArgSer: 2.5 ± 0.052
1.861ArgThr: 1.861 ± 0.049
3.046ArgVal: 3.046 ± 0.063
0.609ArgTrp: 0.609 ± 0.03
1.769ArgTyr: 1.769 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.241SerAla: 5.241 ± 0.073
0.538SerCys: 0.538 ± 0.028
3.67SerAsp: 3.67 ± 0.069
4.398SerGlu: 4.398 ± 0.079
2.706SerPhe: 2.706 ± 0.064
4.755SerGly: 4.755 ± 0.089
1.628SerHis: 1.628 ± 0.045
4.128SerIle: 4.128 ± 0.088
3.033SerLys: 3.033 ± 0.079
7.087SerLeu: 7.087 ± 0.129
1.628SerMet: 1.628 ± 0.052
2.572SerAsn: 2.572 ± 0.061
2.52SerPro: 2.52 ± 0.067
3.501SerGln: 3.501 ± 0.077
2.694SerArg: 2.694 ± 0.06
4.051SerSer: 4.051 ± 0.091
3.109SerThr: 3.109 ± 0.083
4.321SerVal: 4.321 ± 0.071
0.709SerTrp: 0.709 ± 0.034
1.829SerTyr: 1.829 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.466ThrAla: 4.466 ± 0.085
0.386ThrCys: 0.386 ± 0.023
3.106ThrAsp: 3.106 ± 0.068
3.417ThrGlu: 3.417 ± 0.064
2.039ThrPhe: 2.039 ± 0.058
3.873ThrGly: 3.873 ± 0.075
1.382ThrHis: 1.382 ± 0.046
3.137ThrIle: 3.137 ± 0.065
2.275ThrLys: 2.275 ± 0.057
6.75ThrLeu: 6.75 ± 0.107
1.076ThrMet: 1.076 ± 0.041
1.878ThrAsn: 1.878 ± 0.056
2.981ThrPro: 2.981 ± 0.075
3.011ThrGln: 3.011 ± 0.066
2.016ThrArg: 2.016 ± 0.062
3.137ThrSer: 3.137 ± 0.072
2.912ThrThr: 2.912 ± 0.092
3.652ThrVal: 3.652 ± 0.076
0.571ThrTrp: 0.571 ± 0.031
1.513ThrTyr: 1.513 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.743ValAla: 5.743 ± 0.096
0.563ValCys: 0.563 ± 0.026
3.892ValAsp: 3.892 ± 0.078
4.435ValGlu: 4.435 ± 0.087
2.846ValPhe: 2.846 ± 0.073
4.296ValGly: 4.296 ± 0.093
1.269ValHis: 1.269 ± 0.043
4.747ValIle: 4.747 ± 0.086
3.753ValLys: 3.753 ± 0.078
6.833ValLeu: 6.833 ± 0.102
1.978ValMet: 1.978 ± 0.054
2.916ValAsn: 2.916 ± 0.074
2.48ValPro: 2.48 ± 0.062
2.625ValGln: 2.625 ± 0.066
2.728ValArg: 2.728 ± 0.063
4.856ValSer: 4.856 ± 0.091
3.723ValThr: 3.723 ± 0.077
5.298ValVal: 5.298 ± 0.108
0.778ValTrp: 0.778 ± 0.032
1.783ValTyr: 1.783 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.713TrpAla: 0.713 ± 0.03
0.127TrpCys: 0.127 ± 0.013
0.546TrpAsp: 0.546 ± 0.029
0.506TrpGlu: 0.506 ± 0.024
0.599TrpPhe: 0.599 ± 0.03
0.668TrpGly: 0.668 ± 0.03
0.39TrpHis: 0.39 ± 0.024
0.763TrpIle: 0.763 ± 0.035
0.521TrpLys: 0.521 ± 0.027
1.815TrpLeu: 1.815 ± 0.061
0.382TrpMet: 0.382 ± 0.021
0.374TrpAsn: 0.374 ± 0.023
0.491TrpPro: 0.491 ± 0.026
1.22TrpGln: 1.22 ± 0.043
0.603TrpArg: 0.603 ± 0.03
0.671TrpSer: 0.671 ± 0.03
0.479TrpThr: 0.479 ± 0.027
1.135TrpVal: 1.135 ± 0.042
0.164TrpTrp: 0.164 ± 0.015
0.321TrpTyr: 0.321 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.271TyrAla: 2.271 ± 0.062
0.35TyrCys: 0.35 ± 0.023
1.818TyrAsp: 1.818 ± 0.049
1.829TyrGlu: 1.829 ± 0.056
1.432TyrPhe: 1.432 ± 0.052
1.932TyrGly: 1.932 ± 0.048
0.809TyrHis: 0.809 ± 0.032
1.621TyrIle: 1.621 ± 0.053
1.245TyrLys: 1.245 ± 0.049
3.261TyrLeu: 3.261 ± 0.072
0.555TyrMet: 0.555 ± 0.032
0.983TyrAsn: 0.983 ± 0.036
1.307TyrPro: 1.307 ± 0.045
2.419TyrGln: 2.419 ± 0.06
1.623TyrArg: 1.623 ± 0.05
1.768TyrSer: 1.768 ± 0.051
1.281TyrThr: 1.281 ± 0.048
1.593TyrVal: 1.593 ± 0.054
0.427TyrTrp: 0.427 ± 0.022
1.002TyrTyr: 1.002 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2220 proteins (737596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski