Amino acid dipepetide frequency for Escherichia phage K1F (Bacteriophage K1F)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.668AlaAla: 9.668 ± 1.031
0.95AlaCys: 0.95 ± 0.298
5.265AlaAsp: 5.265 ± 0.778
5.697AlaGlu: 5.697 ± 0.706
3.021AlaPhe: 3.021 ± 0.461
7.423AlaGly: 7.423 ± 1.085
0.777AlaHis: 0.777 ± 0.217
5.524AlaIle: 5.524 ± 0.77
6.129AlaLys: 6.129 ± 0.633
7.51AlaLeu: 7.51 ± 1.012
2.59AlaMet: 2.59 ± 0.369
3.107AlaAsn: 3.107 ± 0.438
3.021AlaPro: 3.021 ± 0.649
3.021AlaGln: 3.021 ± 0.47
4.143AlaArg: 4.143 ± 0.508
5.093AlaSer: 5.093 ± 0.571
3.625AlaThr: 3.625 ± 0.625
5.956AlaVal: 5.956 ± 0.967
1.64AlaTrp: 1.64 ± 0.46
2.762AlaTyr: 2.762 ± 0.484
0.0AlaXaa: 0.0 ± 0.0
Cys
0.777CysAla: 0.777 ± 0.233
0.086CysCys: 0.086 ± 0.098
0.604CysAsp: 0.604 ± 0.338
0.777CysGlu: 0.777 ± 0.238
0.604CysPhe: 0.604 ± 0.236
0.691CysGly: 0.691 ± 0.288
0.173CysHis: 0.173 ± 0.111
0.259CysIle: 0.259 ± 0.159
0.345CysLys: 0.345 ± 0.177
0.863CysLeu: 0.863 ± 0.398
0.259CysMet: 0.259 ± 0.195
0.345CysAsn: 0.345 ± 0.167
0.432CysPro: 0.432 ± 0.224
0.345CysGln: 0.345 ± 0.204
0.95CysArg: 0.95 ± 0.315
0.432CysSer: 0.432 ± 0.224
0.259CysThr: 0.259 ± 0.161
0.432CysVal: 0.432 ± 0.208
0.086CysTrp: 0.086 ± 0.082
0.259CysTyr: 0.259 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
6.388AspAla: 6.388 ± 0.695
0.518AspCys: 0.518 ± 0.283
5.006AspAsp: 5.006 ± 0.872
4.23AspGlu: 4.23 ± 0.486
1.813AspPhe: 1.813 ± 0.399
6.301AspGly: 6.301 ± 0.539
1.381AspHis: 1.381 ± 0.334
3.539AspIle: 3.539 ± 0.446
3.625AspLys: 3.625 ± 0.587
5.179AspLeu: 5.179 ± 0.639
2.244AspMet: 2.244 ± 0.409
2.849AspAsn: 2.849 ± 0.568
2.849AspPro: 2.849 ± 0.554
1.813AspGln: 1.813 ± 0.392
2.331AspArg: 2.331 ± 0.44
3.107AspSer: 3.107 ± 0.439
4.489AspThr: 4.489 ± 0.572
4.402AspVal: 4.402 ± 0.603
0.691AspTrp: 0.691 ± 0.273
2.417AspTyr: 2.417 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
7.078GluAla: 7.078 ± 0.985
0.518GluCys: 0.518 ± 0.26
4.661GluAsp: 4.661 ± 0.726
5.352GluGlu: 5.352 ± 0.767
2.503GluPhe: 2.503 ± 0.442
5.006GluGly: 5.006 ± 0.721
1.036GluHis: 1.036 ± 0.255
2.762GluIle: 2.762 ± 0.496
3.107GluLys: 3.107 ± 0.467
5.524GluLeu: 5.524 ± 0.793
2.158GluMet: 2.158 ± 0.413
2.762GluAsn: 2.762 ± 0.566
2.244GluPro: 2.244 ± 0.389
2.849GluGln: 2.849 ± 0.489
4.575GluArg: 4.575 ± 0.54
4.057GluSer: 4.057 ± 0.627
3.971GluThr: 3.971 ± 0.491
4.402GluVal: 4.402 ± 0.703
1.726GluTrp: 1.726 ± 0.362
3.107GluTyr: 3.107 ± 0.6
0.0GluXaa: 0.0 ± 0.0
Phe
3.194PheAla: 3.194 ± 0.412
0.345PheCys: 0.345 ± 0.177
2.762PheAsp: 2.762 ± 0.429
1.726PheGlu: 1.726 ± 0.291
1.295PhePhe: 1.295 ± 0.327
2.503PheGly: 2.503 ± 0.573
0.863PheHis: 0.863 ± 0.23
1.899PheIle: 1.899 ± 0.485
3.021PheLys: 3.021 ± 0.468
2.935PheLeu: 2.935 ± 0.389
0.518PheMet: 0.518 ± 0.24
2.503PheAsn: 2.503 ± 0.462
1.467PhePro: 1.467 ± 0.323
0.863PheGln: 0.863 ± 0.314
1.295PheArg: 1.295 ± 0.278
2.676PheSer: 2.676 ± 0.335
1.985PheThr: 1.985 ± 0.303
2.762PheVal: 2.762 ± 0.513
0.432PheTrp: 0.432 ± 0.17
1.295PheTyr: 1.295 ± 0.276
0.0PheXaa: 0.0 ± 0.0
Gly
6.215GlyAla: 6.215 ± 0.96
0.432GlyCys: 0.432 ± 0.239
5.524GlyAsp: 5.524 ± 1.044
5.438GlyGlu: 5.438 ± 0.505
2.158GlyPhe: 2.158 ± 0.333
5.352GlyGly: 5.352 ± 0.639
1.208GlyHis: 1.208 ± 0.329
4.057GlyIle: 4.057 ± 0.62
5.611GlyLys: 5.611 ± 0.775
5.956GlyLeu: 5.956 ± 0.637
2.676GlyMet: 2.676 ± 0.518
2.849GlyAsn: 2.849 ± 0.488
1.295GlyPro: 1.295 ± 0.339
3.021GlyGln: 3.021 ± 0.428
5.093GlyArg: 5.093 ± 0.717
6.042GlySer: 6.042 ± 0.634
4.661GlyThr: 4.661 ± 0.491
6.301GlyVal: 6.301 ± 0.846
1.122GlyTrp: 1.122 ± 0.255
3.453GlyTyr: 3.453 ± 0.433
0.0GlyXaa: 0.0 ± 0.0
His
0.604HisAla: 0.604 ± 0.239
0.259HisCys: 0.259 ± 0.138
1.295HisAsp: 1.295 ± 0.502
1.208HisGlu: 1.208 ± 0.385
0.518HisPhe: 0.518 ± 0.223
1.036HisGly: 1.036 ± 0.337
0.432HisHis: 0.432 ± 0.185
0.777HisIle: 0.777 ± 0.181
1.122HisLys: 1.122 ± 0.303
1.899HisLeu: 1.899 ± 0.394
0.518HisMet: 0.518 ± 0.185
0.604HisAsn: 0.604 ± 0.236
0.691HisPro: 0.691 ± 0.242
0.691HisGln: 0.691 ± 0.225
1.036HisArg: 1.036 ± 0.272
0.863HisSer: 0.863 ± 0.225
1.295HisThr: 1.295 ± 0.29
1.381HisVal: 1.381 ± 0.295
0.345HisTrp: 0.345 ± 0.178
0.691HisTyr: 0.691 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
3.798IleAla: 3.798 ± 0.608
0.691IleCys: 0.691 ± 0.261
3.107IleAsp: 3.107 ± 0.327
3.366IleGlu: 3.366 ± 0.479
1.381IlePhe: 1.381 ± 0.305
4.489IleGly: 4.489 ± 0.628
1.208IleHis: 1.208 ± 0.393
1.985IleIle: 1.985 ± 0.358
3.539IleLys: 3.539 ± 0.544
3.194IleLeu: 3.194 ± 0.493
0.95IleMet: 0.95 ± 0.216
2.417IleAsn: 2.417 ± 0.467
2.244IlePro: 2.244 ± 0.575
1.467IleGln: 1.467 ± 0.543
3.194IleArg: 3.194 ± 0.52
2.762IleSer: 2.762 ± 0.464
3.366IleThr: 3.366 ± 0.492
4.661IleVal: 4.661 ± 0.456
0.518IleTrp: 0.518 ± 0.216
1.554IleTyr: 1.554 ± 0.263
0.0IleXaa: 0.0 ± 0.0
Lys
6.819LysAla: 6.819 ± 0.808
0.432LysCys: 0.432 ± 0.192
4.057LysAsp: 4.057 ± 0.459
3.539LysGlu: 3.539 ± 0.574
2.244LysPhe: 2.244 ± 0.421
3.971LysGly: 3.971 ± 0.547
1.295LysHis: 1.295 ± 0.376
2.244LysIle: 2.244 ± 0.337
3.971LysLys: 3.971 ± 0.927
5.265LysLeu: 5.265 ± 0.733
1.726LysMet: 1.726 ± 0.33
1.985LysAsn: 1.985 ± 0.462
2.676LysPro: 2.676 ± 0.629
1.726LysGln: 1.726 ± 0.421
4.402LysArg: 4.402 ± 0.831
4.143LysSer: 4.143 ± 0.514
3.884LysThr: 3.884 ± 0.505
5.179LysVal: 5.179 ± 0.664
1.036LysTrp: 1.036 ± 0.347
2.244LysTyr: 2.244 ± 0.359
0.0LysXaa: 0.0 ± 0.0
Leu
5.956LeuAla: 5.956 ± 0.749
0.345LeuCys: 0.345 ± 0.167
4.23LeuAsp: 4.23 ± 0.428
6.56LeuGlu: 6.56 ± 0.836
2.503LeuPhe: 2.503 ± 0.427
5.352LeuGly: 5.352 ± 0.748
1.208LeuHis: 1.208 ± 0.416
3.798LeuIle: 3.798 ± 0.599
6.042LeuLys: 6.042 ± 0.928
5.006LeuLeu: 5.006 ± 0.704
3.021LeuMet: 3.021 ± 0.473
3.884LeuAsn: 3.884 ± 0.533
3.28LeuPro: 3.28 ± 0.393
3.625LeuGln: 3.625 ± 0.682
4.661LeuArg: 4.661 ± 0.448
4.92LeuSer: 4.92 ± 0.811
4.834LeuThr: 4.834 ± 0.633
4.23LeuVal: 4.23 ± 0.502
1.036LeuTrp: 1.036 ± 0.282
2.762LeuTyr: 2.762 ± 0.533
0.0LeuXaa: 0.0 ± 0.0
Met
2.935MetAla: 2.935 ± 0.591
0.432MetCys: 0.432 ± 0.207
1.381MetAsp: 1.381 ± 0.309
2.072MetGlu: 2.072 ± 0.367
1.381MetPhe: 1.381 ± 0.326
2.331MetGly: 2.331 ± 0.428
0.259MetHis: 0.259 ± 0.145
1.381MetIle: 1.381 ± 0.229
1.208MetLys: 1.208 ± 0.219
2.417MetLeu: 2.417 ± 0.431
0.518MetMet: 0.518 ± 0.196
1.122MetAsn: 1.122 ± 0.29
0.95MetPro: 0.95 ± 0.302
0.777MetGln: 0.777 ± 0.297
1.208MetArg: 1.208 ± 0.294
2.072MetSer: 2.072 ± 0.336
2.331MetThr: 2.331 ± 0.446
2.417MetVal: 2.417 ± 0.481
0.345MetTrp: 0.345 ± 0.193
0.95MetTyr: 0.95 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
4.661AsnAla: 4.661 ± 0.735
0.777AsnCys: 0.777 ± 0.321
2.158AsnAsp: 2.158 ± 0.464
2.503AsnGlu: 2.503 ± 0.516
1.467AsnPhe: 1.467 ± 0.241
4.661AsnGly: 4.661 ± 0.731
0.432AsnHis: 0.432 ± 0.15
2.503AsnIle: 2.503 ± 0.383
2.158AsnLys: 2.158 ± 0.556
2.935AsnLeu: 2.935 ± 0.676
0.95AsnMet: 0.95 ± 0.308
2.072AsnAsn: 2.072 ± 0.428
3.28AsnPro: 3.28 ± 0.563
1.554AsnGln: 1.554 ± 0.355
2.417AsnArg: 2.417 ± 0.579
2.417AsnSer: 2.417 ± 0.505
1.726AsnThr: 1.726 ± 0.357
3.194AsnVal: 3.194 ± 0.6
0.259AsnTrp: 0.259 ± 0.175
1.726AsnTyr: 1.726 ± 0.423
0.0AsnXaa: 0.0 ± 0.0
Pro
3.107ProAla: 3.107 ± 0.613
0.604ProCys: 0.604 ± 0.26
3.021ProAsp: 3.021 ± 0.491
3.28ProGlu: 3.28 ± 0.481
1.467ProPhe: 1.467 ± 0.275
1.64ProGly: 1.64 ± 0.309
0.691ProHis: 0.691 ± 0.198
2.072ProIle: 2.072 ± 0.376
3.107ProLys: 3.107 ± 0.628
1.985ProLeu: 1.985 ± 0.445
0.95ProMet: 0.95 ± 0.294
2.244ProAsn: 2.244 ± 0.429
0.777ProPro: 0.777 ± 0.232
1.64ProGln: 1.64 ± 0.428
1.726ProArg: 1.726 ± 0.392
3.107ProSer: 3.107 ± 0.515
3.194ProThr: 3.194 ± 0.379
3.107ProVal: 3.107 ± 0.347
0.95ProTrp: 0.95 ± 0.254
0.95ProTyr: 0.95 ± 0.243
0.0ProXaa: 0.0 ± 0.0
Gln
3.971GlnAla: 3.971 ± 0.568
0.173GlnCys: 0.173 ± 0.134
2.935GlnAsp: 2.935 ± 0.787
1.813GlnGlu: 1.813 ± 0.344
1.985GlnPhe: 1.985 ± 0.358
2.762GlnGly: 2.762 ± 0.521
0.432GlnHis: 0.432 ± 0.19
1.554GlnIle: 1.554 ± 0.364
1.813GlnLys: 1.813 ± 0.34
3.625GlnLeu: 3.625 ± 0.733
1.208GlnMet: 1.208 ± 0.44
1.208GlnAsn: 1.208 ± 0.434
1.295GlnPro: 1.295 ± 0.373
1.813GlnGln: 1.813 ± 0.606
2.158GlnArg: 2.158 ± 0.611
2.935GlnSer: 2.935 ± 0.431
2.158GlnThr: 2.158 ± 0.536
2.072GlnVal: 2.072 ± 0.401
0.863GlnTrp: 0.863 ± 0.272
1.036GlnTyr: 1.036 ± 0.365
0.0GlnXaa: 0.0 ± 0.0
Arg
4.834ArgAla: 4.834 ± 0.709
0.345ArgCys: 0.345 ± 0.161
4.575ArgAsp: 4.575 ± 0.444
4.23ArgGlu: 4.23 ± 0.622
2.676ArgPhe: 2.676 ± 0.369
3.971ArgGly: 3.971 ± 0.494
0.604ArgHis: 0.604 ± 0.226
3.625ArgIle: 3.625 ± 0.647
3.366ArgLys: 3.366 ± 0.581
5.438ArgLeu: 5.438 ± 0.654
1.208ArgMet: 1.208 ± 0.302
2.417ArgAsn: 2.417 ± 0.399
1.813ArgPro: 1.813 ± 0.308
2.59ArgGln: 2.59 ± 0.418
2.762ArgArg: 2.762 ± 0.457
3.366ArgSer: 3.366 ± 0.547
2.503ArgThr: 2.503 ± 0.418
2.331ArgVal: 2.331 ± 0.566
0.95ArgTrp: 0.95 ± 0.25
1.813ArgTyr: 1.813 ± 0.351
0.0ArgXaa: 0.0 ± 0.0
Ser
4.748SerAla: 4.748 ± 0.577
0.691SerCys: 0.691 ± 0.346
5.179SerAsp: 5.179 ± 0.538
3.798SerGlu: 3.798 ± 0.69
2.849SerPhe: 2.849 ± 0.338
5.438SerGly: 5.438 ± 0.74
2.158SerHis: 2.158 ± 0.435
2.849SerIle: 2.849 ± 0.531
3.194SerLys: 3.194 ± 0.525
3.539SerLeu: 3.539 ± 0.43
1.467SerMet: 1.467 ± 0.309
3.366SerAsn: 3.366 ± 0.669
2.762SerPro: 2.762 ± 0.467
2.244SerGln: 2.244 ± 0.488
3.366SerArg: 3.366 ± 0.496
3.971SerSer: 3.971 ± 0.576
2.935SerThr: 2.935 ± 0.41
4.23SerVal: 4.23 ± 0.63
0.863SerTrp: 0.863 ± 0.204
2.59SerTyr: 2.59 ± 0.531
0.0SerXaa: 0.0 ± 0.0
Thr
3.625ThrAla: 3.625 ± 0.815
0.345ThrCys: 0.345 ± 0.2
3.28ThrAsp: 3.28 ± 0.665
5.352ThrGlu: 5.352 ± 0.596
2.331ThrPhe: 2.331 ± 0.384
5.697ThrGly: 5.697 ± 0.608
0.604ThrHis: 0.604 ± 0.236
3.712ThrIle: 3.712 ± 0.652
2.676ThrLys: 2.676 ± 0.39
4.575ThrLeu: 4.575 ± 0.521
1.813ThrMet: 1.813 ± 0.384
1.813ThrAsn: 1.813 ± 0.449
3.28ThrPro: 3.28 ± 0.381
2.59ThrGln: 2.59 ± 0.516
2.849ThrArg: 2.849 ± 0.416
3.021ThrSer: 3.021 ± 0.654
3.798ThrThr: 3.798 ± 0.591
4.748ThrVal: 4.748 ± 0.59
0.604ThrTrp: 0.604 ± 0.245
1.64ThrTyr: 1.64 ± 0.287
0.0ThrXaa: 0.0 ± 0.0
Val
4.402ValAla: 4.402 ± 0.619
0.432ValCys: 0.432 ± 0.188
3.539ValAsp: 3.539 ± 0.652
5.179ValGlu: 5.179 ± 0.748
2.503ValPhe: 2.503 ± 0.568
5.87ValGly: 5.87 ± 0.651
1.208ValHis: 1.208 ± 0.498
3.021ValIle: 3.021 ± 0.405
5.093ValLys: 5.093 ± 0.591
4.834ValLeu: 4.834 ± 0.573
2.158ValMet: 2.158 ± 0.488
3.366ValAsn: 3.366 ± 0.502
3.28ValPro: 3.28 ± 0.509
3.194ValGln: 3.194 ± 0.52
4.316ValArg: 4.316 ± 0.537
4.575ValSer: 4.575 ± 0.517
4.92ValThr: 4.92 ± 0.649
5.783ValVal: 5.783 ± 0.904
0.777ValTrp: 0.777 ± 0.311
2.503ValTyr: 2.503 ± 0.454
0.0ValXaa: 0.0 ± 0.0
Trp
0.432TrpAla: 0.432 ± 0.14
0.173TrpCys: 0.173 ± 0.152
0.604TrpAsp: 0.604 ± 0.208
1.122TrpGlu: 1.122 ± 0.267
0.518TrpPhe: 0.518 ± 0.191
1.208TrpGly: 1.208 ± 0.339
0.518TrpHis: 0.518 ± 0.203
0.691TrpIle: 0.691 ± 0.251
1.381TrpLys: 1.381 ± 0.366
2.158TrpLeu: 2.158 ± 0.456
0.259TrpMet: 0.259 ± 0.151
0.863TrpAsn: 0.863 ± 0.235
0.345TrpPro: 0.345 ± 0.169
0.518TrpGln: 0.518 ± 0.281
0.691TrpArg: 0.691 ± 0.23
0.95TrpSer: 0.95 ± 0.392
0.604TrpThr: 0.604 ± 0.203
1.467TrpVal: 1.467 ± 0.392
0.086TrpTrp: 0.086 ± 0.075
0.345TrpTyr: 0.345 ± 0.148
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.712TyrAla: 3.712 ± 0.582
0.432TyrCys: 0.432 ± 0.197
1.985TyrAsp: 1.985 ± 0.373
2.158TyrGlu: 2.158 ± 0.573
1.122TyrPhe: 1.122 ± 0.247
2.762TyrGly: 2.762 ± 0.49
0.777TyrHis: 0.777 ± 0.262
1.64TyrIle: 1.64 ± 0.483
2.331TyrLys: 2.331 ± 0.434
2.417TyrLeu: 2.417 ± 0.371
1.208TyrMet: 1.208 ± 0.315
2.072TyrAsn: 2.072 ± 0.45
1.64TyrPro: 1.64 ± 0.416
1.554TyrGln: 1.554 ± 0.488
2.244TyrArg: 2.244 ± 0.443
1.726TyrSer: 1.726 ± 0.41
1.813TyrThr: 1.813 ± 0.318
1.899TyrVal: 1.899 ± 0.388
0.604TyrTrp: 0.604 ± 0.225
1.726TyrTyr: 1.726 ± 0.441
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (11586 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski