Amino acid dipepetide frequency for Brachymonas denitrificans DSM 15123

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.311AlaAla: 16.311 ± 0.23	1.324AlaCys: 1.324 ± 0.046	6.098AlaAsp: 6.098 ± 0.106	6.773AlaGlu: 6.773 ± 0.12	3.757AlaPhe: 3.757 ± 0.075	10.186AlaGly: 10.186 ± 0.127	2.569AlaHis: 2.569 ± 0.063	5.263AlaIle: 5.263 ± 0.086	3.602AlaLys: 3.602 ± 0.092	14.03AlaLeu: 14.03 ± 0.196	3.755AlaMet: 3.755 ± 0.072	2.925AlaAsn: 2.925 ± 0.077	5.809AlaPro: 5.809 ± 0.117	5.728AlaGln: 5.728 ± 0.112	8.032AlaArg: 8.032 ± 0.114	6.883AlaSer: 6.883 ± 0.126	5.781AlaThr: 5.781 ± 0.086	8.374AlaVal: 8.374 ± 0.121	1.808AlaTrp: 1.808 ± 0.052	2.402AlaTyr: 2.402 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.06CysAla: 1.06 ± 0.041	0.129CysCys: 0.129 ± 0.014	0.584CysAsp: 0.584 ± 0.03	0.533CysGlu: 0.533 ± 0.026	0.283CysPhe: 0.283 ± 0.017	0.985CysGly: 0.985 ± 0.038	0.341CysHis: 0.341 ± 0.022	0.453CysIle: 0.453 ± 0.024	0.3CysLys: 0.3 ± 0.019	0.862CysLeu: 0.862 ± 0.032	0.242CysMet: 0.242 ± 0.016	0.266CysAsn: 0.266 ± 0.02	0.548CysPro: 0.548 ± 0.031	0.331CysGln: 0.331 ± 0.022	0.503CysArg: 0.503 ± 0.024	0.534CysSer: 0.534 ± 0.027	0.508CysThr: 0.508 ± 0.023	0.781CysVal: 0.781 ± 0.03	0.126CysTrp: 0.126 ± 0.013	0.224CysTyr: 0.224 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.902AspAla: 6.902 ± 0.106	0.522AspCys: 0.522 ± 0.028	2.596AspAsp: 2.596 ± 0.071	3.043AspGlu: 3.043 ± 0.066	2.028AspPhe: 2.028 ± 0.047	4.243AspGly: 4.243 ± 0.088	1.097AspHis: 1.097 ± 0.045	2.481AspIle: 2.481 ± 0.057	1.998AspLys: 1.998 ± 0.056	4.847AspLeu: 4.847 ± 0.082	1.502AspMet: 1.502 ± 0.041	1.375AspAsn: 1.375 ± 0.044	2.818AspPro: 2.818 ± 0.059	1.68AspGln: 1.68 ± 0.04	2.988AspArg: 2.988 ± 0.069	2.462AspSer: 2.462 ± 0.064	2.543AspThr: 2.543 ± 0.061	4.0AspVal: 4.0 ± 0.088	1.011AspTrp: 1.011 ± 0.034	1.452AspTyr: 1.452 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.856GluAla: 6.856 ± 0.109	0.438GluCys: 0.438 ± 0.025	2.509GluAsp: 2.509 ± 0.058	3.002GluGlu: 3.002 ± 0.086	1.715GluPhe: 1.715 ± 0.055	3.984GluGly: 3.984 ± 0.084	1.431GluHis: 1.431 ± 0.042	2.668GluIle: 2.668 ± 0.075	2.182GluLys: 2.182 ± 0.069	5.849GluLeu: 5.849 ± 0.104	1.434GluMet: 1.434 ± 0.042	1.434GluAsn: 1.434 ± 0.044	2.504GluPro: 2.504 ± 0.057	3.445GluGln: 3.445 ± 0.072	4.524GluArg: 4.524 ± 0.078	2.532GluSer: 2.532 ± 0.052	2.485GluThr: 2.485 ± 0.062	4.105GluVal: 4.105 ± 0.09	0.733GluTrp: 0.733 ± 0.029	1.095GluTyr: 1.095 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.952PheAla: 3.952 ± 0.08	0.383PheCys: 0.383 ± 0.023	2.245PheAsp: 2.245 ± 0.05	1.91PheGlu: 1.91 ± 0.052	1.33PhePhe: 1.33 ± 0.05	3.272PheGly: 3.272 ± 0.076	0.715PheHis: 0.715 ± 0.031	1.48PheIle: 1.48 ± 0.048	1.146PheLys: 1.146 ± 0.039	3.107PheLeu: 3.107 ± 0.072	0.837PheMet: 0.837 ± 0.036	1.155PheAsn: 1.155 ± 0.042	1.5PhePro: 1.5 ± 0.043	1.072PheGln: 1.072 ± 0.034	1.881PheArg: 1.881 ± 0.05	2.043PheSer: 2.043 ± 0.05	1.825PheThr: 1.825 ± 0.048	2.622PheVal: 2.622 ± 0.054	0.551PheTrp: 0.551 ± 0.031	0.867PheTyr: 0.867 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.246GlyAla: 8.246 ± 0.115	0.971GlyCys: 0.971 ± 0.037	3.932GlyAsp: 3.932 ± 0.074	4.456GlyGlu: 4.456 ± 0.075	3.097GlyPhe: 3.097 ± 0.07	6.459GlyGly: 6.459 ± 0.138	1.988GlyHis: 1.988 ± 0.051	4.027GlyIle: 4.027 ± 0.072	3.934GlyLys: 3.934 ± 0.087	8.64GlyLeu: 8.64 ± 0.116	2.705GlyMet: 2.705 ± 0.06	2.499GlyAsn: 2.499 ± 0.071	2.656GlyPro: 2.656 ± 0.066	3.541GlyGln: 3.541 ± 0.067	4.832GlyArg: 4.832 ± 0.075	4.8GlySer: 4.8 ± 0.106	4.413GlyThr: 4.413 ± 0.08	6.46GlyVal: 6.46 ± 0.096	1.499GlyTrp: 1.499 ± 0.045	2.276GlyTyr: 2.276 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	3.1HisAla: 3.1 ± 0.075	0.321HisCys: 0.321 ± 0.022	1.217HisAsp: 1.217 ± 0.041	1.149HisGlu: 1.149 ± 0.042	0.88HisPhe: 0.88 ± 0.033	2.29HisGly: 2.29 ± 0.053	0.628HisHis: 0.628 ± 0.031	1.058HisIle: 1.058 ± 0.035	0.696HisLys: 0.696 ± 0.031	2.209HisLeu: 2.209 ± 0.059	0.613HisMet: 0.613 ± 0.024	0.576HisAsn: 0.576 ± 0.024	1.605HisPro: 1.605 ± 0.042	0.854HisGln: 0.854 ± 0.031	1.418HisArg: 1.418 ± 0.046	1.115HisSer: 1.115 ± 0.041	1.218HisThr: 1.218 ± 0.034	1.693HisVal: 1.693 ± 0.049	0.504HisTrp: 0.504 ± 0.025	0.697HisTyr: 0.697 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.748IleAla: 5.748 ± 0.091	0.422IleCys: 0.422 ± 0.029	2.826IleAsp: 2.826 ± 0.066	2.899IleGlu: 2.899 ± 0.063	1.32IlePhe: 1.32 ± 0.045	4.251IleGly: 4.251 ± 0.081	0.921IleHis: 0.921 ± 0.037	1.792IleIle: 1.792 ± 0.055	1.579IleLys: 1.579 ± 0.046	3.631IleLeu: 3.631 ± 0.078	0.947IleMet: 0.947 ± 0.041	1.459IleAsn: 1.459 ± 0.044	2.286IlePro: 2.286 ± 0.055	1.484IleGln: 1.484 ± 0.037	2.751IleArg: 2.751 ± 0.063	2.401IleSer: 2.401 ± 0.054	2.614IleThr: 2.614 ± 0.056	3.429IleVal: 3.429 ± 0.065	0.544IleTrp: 0.544 ± 0.028	1.045IleTyr: 1.045 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.241LysAla: 4.241 ± 0.103	0.185LysCys: 0.185 ± 0.016	1.873LysAsp: 1.873 ± 0.054	1.762LysGlu: 1.762 ± 0.052	0.952LysPhe: 0.952 ± 0.037	2.731LysGly: 2.731 ± 0.079	0.685LysHis: 0.685 ± 0.031	1.482LysIle: 1.482 ± 0.054	1.465LysLys: 1.465 ± 0.054	3.681LysLeu: 3.681 ± 0.086	0.861LysMet: 0.861 ± 0.038	1.039LysAsn: 1.039 ± 0.035	2.289LysPro: 2.289 ± 0.064	1.592LysGln: 1.592 ± 0.042	2.328LysArg: 2.328 ± 0.061	1.685LysSer: 1.685 ± 0.049	1.944LysThr: 1.944 ± 0.063	2.765LysVal: 2.765 ± 0.067	0.389LysTrp: 0.389 ± 0.023	0.758LysTyr: 0.758 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	13.557LeuAla: 13.557 ± 0.183	1.05LeuCys: 1.05 ± 0.039	5.741LeuAsp: 5.741 ± 0.097	5.6LeuGlu: 5.6 ± 0.102	3.489LeuPhe: 3.489 ± 0.079	8.481LeuGly: 8.481 ± 0.126	2.681LeuHis: 2.681 ± 0.065	4.299LeuIle: 4.299 ± 0.082	3.45LeuLys: 3.45 ± 0.071	12.057LeuLeu: 12.057 ± 0.188	2.69LeuMet: 2.69 ± 0.055	2.745LeuAsn: 2.745 ± 0.054	6.554LeuPro: 6.554 ± 0.105	5.884LeuGln: 5.884 ± 0.104	7.367LeuArg: 7.367 ± 0.11	5.642LeuSer: 5.642 ± 0.085	5.118LeuThr: 5.118 ± 0.079	7.535LeuVal: 7.535 ± 0.098	1.517LeuTrp: 1.517 ± 0.05	2.104LeuTyr: 2.104 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.305MetAla: 3.305 ± 0.065	0.192MetCys: 0.192 ± 0.015	1.283MetAsp: 1.283 ± 0.042	1.385MetGlu: 1.385 ± 0.048	0.706MetPhe: 0.706 ± 0.028	2.103MetGly: 2.103 ± 0.057	0.649MetHis: 0.649 ± 0.028	1.025MetIle: 1.025 ± 0.037	1.031MetLys: 1.031 ± 0.034	3.131MetLeu: 3.131 ± 0.068	0.689MetMet: 0.689 ± 0.032	0.841MetAsn: 0.841 ± 0.032	1.685MetPro: 1.685 ± 0.05	1.616MetGln: 1.616 ± 0.048	1.772MetArg: 1.772 ± 0.045	1.659MetSer: 1.659 ± 0.049	1.621MetThr: 1.621 ± 0.048	2.002MetVal: 2.002 ± 0.054	0.215MetTrp: 0.215 ± 0.017	0.423MetTyr: 0.423 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.415AsnAla: 3.415 ± 0.071	0.27AsnCys: 0.27 ± 0.02	1.333AsnAsp: 1.333 ± 0.039	1.328AsnGlu: 1.328 ± 0.044	0.963AsnPhe: 0.963 ± 0.035	2.35AsnGly: 2.35 ± 0.064	0.548AsnHis: 0.548 ± 0.029	1.312AsnIle: 1.312 ± 0.041	0.995AsnLys: 0.995 ± 0.039	2.689AsnLeu: 2.689 ± 0.067	0.684AsnMet: 0.684 ± 0.03	0.835AsnAsn: 0.835 ± 0.041	1.913AsnPro: 1.913 ± 0.055	0.973AsnGln: 0.973 ± 0.036	1.684AsnArg: 1.684 ± 0.055	1.267AsnSer: 1.267 ± 0.055	1.482AsnThr: 1.482 ± 0.046	2.052AsnVal: 2.052 ± 0.05	0.521AsnTrp: 0.521 ± 0.026	0.752AsnTyr: 0.752 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	7.257ProAla: 7.257 ± 0.117	0.427ProCys: 0.427 ± 0.024	3.284ProAsp: 3.284 ± 0.064	3.895ProGlu: 3.895 ± 0.068	1.731ProPhe: 1.731 ± 0.046	4.274ProGly: 4.274 ± 0.075	1.251ProHis: 1.251 ± 0.046	1.848ProIle: 1.848 ± 0.046	1.513ProLys: 1.513 ± 0.049	5.354ProLeu: 5.354 ± 0.081	1.334ProMet: 1.334 ± 0.044	1.382ProAsn: 1.382 ± 0.044	2.447ProPro: 2.447 ± 0.072	2.397ProGln: 2.397 ± 0.06	2.851ProArg: 2.851 ± 0.057	2.653ProSer: 2.653 ± 0.053	2.35ProThr: 2.35 ± 0.063	4.616ProVal: 4.616 ± 0.079	0.809ProTrp: 0.809 ± 0.036	1.198ProTyr: 1.198 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	6.485GlnAla: 6.485 ± 0.113	0.364GlnCys: 0.364 ± 0.021	2.004GlnAsp: 2.004 ± 0.05	2.244GlnGlu: 2.244 ± 0.057	1.393GlnPhe: 1.393 ± 0.039	3.692GlnGly: 3.692 ± 0.073	1.353GlnHis: 1.353 ± 0.037	1.951GlnIle: 1.951 ± 0.051	1.432GlnLys: 1.432 ± 0.045	4.899GlnLeu: 4.899 ± 0.094	1.145GlnMet: 1.145 ± 0.039	0.967GlnAsn: 0.967 ± 0.037	2.889GlnPro: 2.889 ± 0.065	3.23GlnGln: 3.23 ± 0.097	3.713GlnArg: 3.713 ± 0.078	2.12GlnSer: 2.12 ± 0.059	2.14GlnThr: 2.14 ± 0.049	3.29GlnVal: 3.29 ± 0.071	0.83GlnTrp: 0.83 ± 0.036	0.926GlnTyr: 0.926 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.628ArgAla: 6.628 ± 0.109	0.529ArgCys: 0.529 ± 0.028	3.321ArgAsp: 3.321 ± 0.066	3.949ArgGlu: 3.949 ± 0.081	2.542ArgPhe: 2.542 ± 0.063	4.219ArgGly: 4.219 ± 0.08	1.858ArgHis: 1.858 ± 0.051	3.474ArgIle: 3.474 ± 0.065	2.551ArgLys: 2.551 ± 0.056	7.129ArgLeu: 7.129 ± 0.105	2.201ArgMet: 2.201 ± 0.044	2.014ArgAsn: 2.014 ± 0.047	2.932ArgPro: 2.932 ± 0.07	3.385ArgGln: 3.385 ± 0.076	4.272ArgArg: 4.272 ± 0.098	3.38ArgSer: 3.38 ± 0.061	3.15ArgThr: 3.15 ± 0.069	4.616ArgVal: 4.616 ± 0.093	1.159ArgTrp: 1.159 ± 0.039	1.822ArgTyr: 1.822 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.993SerAla: 5.993 ± 0.118	0.487SerCys: 0.487 ± 0.025	2.495SerAsp: 2.495 ± 0.056	2.574SerGlu: 2.574 ± 0.067	1.893SerPhe: 1.893 ± 0.05	5.172SerGly: 5.172 ± 0.081	1.286SerHis: 1.286 ± 0.045	2.457SerIle: 2.457 ± 0.059	1.733SerLys: 1.733 ± 0.049	5.453SerLeu: 5.453 ± 0.085	1.44SerMet: 1.44 ± 0.043	1.474SerAsn: 1.474 ± 0.048	2.824SerPro: 2.824 ± 0.059	2.071SerGln: 2.071 ± 0.049	3.338SerArg: 3.338 ± 0.077	3.166SerSer: 3.166 ± 0.064	2.901SerThr: 2.901 ± 0.057	3.83SerVal: 3.83 ± 0.073	0.801SerTrp: 0.801 ± 0.037	1.392SerTyr: 1.392 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.796ThrAla: 5.796 ± 0.09	0.428ThrCys: 0.428 ± 0.026	2.41ThrAsp: 2.41 ± 0.055	2.472ThrGlu: 2.472 ± 0.055	1.609ThrPhe: 1.609 ± 0.04	4.588ThrGly: 4.588 ± 0.078	1.213ThrHis: 1.213 ± 0.041	2.202ThrIle: 2.202 ± 0.057	1.274ThrLys: 1.274 ± 0.049	6.387ThrLeu: 6.387 ± 0.096	1.159ThrMet: 1.159 ± 0.037	1.199ThrAsn: 1.199 ± 0.046	3.635ThrPro: 3.635 ± 0.076	2.072ThrGln: 2.072 ± 0.052	3.221ThrArg: 3.221 ± 0.061	2.569ThrSer: 2.569 ± 0.055	2.724ThrThr: 2.724 ± 0.066	4.047ThrVal: 4.047 ± 0.067	0.623ThrTrp: 0.623 ± 0.028	1.01ThrTyr: 1.01 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.728ValAla: 8.728 ± 0.123	0.743ValCys: 0.743 ± 0.035	3.98ValAsp: 3.98 ± 0.083	4.126ValGlu: 4.126 ± 0.071	2.635ValPhe: 2.635 ± 0.063	5.137ValGly: 5.137 ± 0.082	1.693ValHis: 1.693 ± 0.048	3.477ValIle: 3.477 ± 0.069	2.521ValLys: 2.521 ± 0.065	8.782ValLeu: 8.782 ± 0.11	2.054ValMet: 2.054 ± 0.052	2.045ValAsn: 2.045 ± 0.063	4.099ValPro: 4.099 ± 0.074	3.668ValGln: 3.668 ± 0.076	4.766ValArg: 4.766 ± 0.085	3.954ValSer: 3.954 ± 0.073	3.898ValThr: 3.898 ± 0.065	6.083ValVal: 6.083 ± 0.102	1.095ValTrp: 1.095 ± 0.037	1.57ValTyr: 1.57 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.276TrpAla: 1.276 ± 0.042	0.159TrpCys: 0.159 ± 0.014	0.622TrpAsp: 0.622 ± 0.028	0.648TrpGlu: 0.648 ± 0.028	0.593TrpPhe: 0.593 ± 0.028	0.998TrpGly: 0.998 ± 0.036	0.435TrpHis: 0.435 ± 0.024	0.721TrpIle: 0.721 ± 0.035	0.553TrpLys: 0.553 ± 0.027	2.384TrpLeu: 2.384 ± 0.067	0.568TrpMet: 0.568 ± 0.03	0.471TrpAsn: 0.471 ± 0.025	0.717TrpPro: 0.717 ± 0.026	1.027TrpGln: 1.027 ± 0.036	1.17TrpArg: 1.17 ± 0.045	0.755TrpSer: 0.755 ± 0.03	0.634TrpThr: 0.634 ± 0.031	1.034TrpVal: 1.034 ± 0.038	0.333TrpTrp: 0.333 ± 0.022	0.365TrpTyr: 0.365 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.557TyrAla: 2.557 ± 0.061	0.251TyrCys: 0.251 ± 0.019	1.235TyrAsp: 1.235 ± 0.039	1.178TyrGlu: 1.178 ± 0.041	0.974TyrPhe: 0.974 ± 0.037	2.015TyrGly: 2.015 ± 0.049	0.502TyrHis: 0.502 ± 0.027	0.878TyrIle: 0.878 ± 0.034	0.752TyrLys: 0.752 ± 0.031	2.438TyrLeu: 2.438 ± 0.055	0.471TyrMet: 0.471 ± 0.027	0.665TyrAsn: 0.665 ± 0.027	1.163TyrPro: 1.163 ± 0.039	1.014TyrGln: 1.014 ± 0.041	1.721TyrArg: 1.721 ± 0.053	1.159TyrSer: 1.159 ± 0.044	1.288TyrThr: 1.288 ± 0.043	1.722TyrVal: 1.722 ± 0.046	0.394TyrTrp: 0.394 ± 0.026	0.619TyrTyr: 0.619 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2470 proteins (808793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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