Amino acid dipepetide frequency for Idiomarina aquatica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.229AlaAla: 9.229 ± 0.145
0.876AlaCys: 0.876 ± 0.033
5.836AlaAsp: 5.836 ± 0.088
6.765AlaGlu: 6.765 ± 0.113
3.401AlaPhe: 3.401 ± 0.061
6.488AlaGly: 6.488 ± 0.113
1.661AlaHis: 1.661 ± 0.041
5.917AlaIle: 5.917 ± 0.099
4.405AlaLys: 4.405 ± 0.083
10.378AlaLeu: 10.378 ± 0.122
2.717AlaMet: 2.717 ± 0.054
3.452AlaAsn: 3.452 ± 0.064
3.103AlaPro: 3.103 ± 0.057
4.529AlaGln: 4.529 ± 0.075
4.635AlaArg: 4.635 ± 0.072
5.254AlaSer: 5.254 ± 0.078
4.734AlaThr: 4.734 ± 0.077
6.674AlaVal: 6.674 ± 0.094
1.079AlaTrp: 1.079 ± 0.038
2.375AlaTyr: 2.375 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.745CysAla: 0.745 ± 0.032
0.138CysCys: 0.138 ± 0.012
0.529CysAsp: 0.529 ± 0.021
0.51CysGlu: 0.51 ± 0.022
0.346CysPhe: 0.346 ± 0.018
0.769CysGly: 0.769 ± 0.033
0.307CysHis: 0.307 ± 0.019
0.462CysIle: 0.462 ± 0.023
0.325CysLys: 0.325 ± 0.02
0.785CysLeu: 0.785 ± 0.029
0.178CysMet: 0.178 ± 0.013
0.301CysAsn: 0.301 ± 0.019
0.435CysPro: 0.435 ± 0.025
0.415CysGln: 0.415 ± 0.021
0.483CysArg: 0.483 ± 0.024
0.589CysSer: 0.589 ± 0.025
0.352CysThr: 0.352 ± 0.02
0.587CysVal: 0.587 ± 0.027
0.147CysTrp: 0.147 ± 0.013
0.298CysTyr: 0.298 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.396AspAla: 5.396 ± 0.088
0.513AspCys: 0.513 ± 0.027
4.016AspAsp: 4.016 ± 0.087
4.379AspGlu: 4.379 ± 0.08
2.63AspPhe: 2.63 ± 0.06
4.263AspGly: 4.263 ± 0.075
1.136AspHis: 1.136 ± 0.033
3.86AspIle: 3.86 ± 0.064
2.979AspLys: 2.979 ± 0.066
4.96AspLeu: 4.96 ± 0.078
1.485AspMet: 1.485 ± 0.042
2.649AspAsn: 2.649 ± 0.057
2.129AspPro: 2.129 ± 0.053
2.166AspGln: 2.166 ± 0.05
2.574AspArg: 2.574 ± 0.05
3.301AspSer: 3.301 ± 0.065
2.927AspThr: 2.927 ± 0.062
4.261AspVal: 4.261 ± 0.07
1.069AspTrp: 1.069 ± 0.035
2.368AspTyr: 2.368 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.49GluAla: 5.49 ± 0.1
0.418GluCys: 0.418 ± 0.022
2.902GluAsp: 2.902 ± 0.072
3.536GluGlu: 3.536 ± 0.088
2.488GluPhe: 2.488 ± 0.057
3.538GluGly: 3.538 ± 0.078
1.777GluHis: 1.777 ± 0.056
3.293GluIle: 3.293 ± 0.069
3.117GluLys: 3.117 ± 0.072
7.447GluLeu: 7.447 ± 0.081
1.448GluMet: 1.448 ± 0.041
2.426GluAsn: 2.426 ± 0.053
2.464GluPro: 2.464 ± 0.068
5.514GluGln: 5.514 ± 0.09
4.379GluArg: 4.379 ± 0.082
3.477GluSer: 3.477 ± 0.075
2.945GluThr: 2.945 ± 0.062
4.24GluVal: 4.24 ± 0.076
0.751GluTrp: 0.751 ± 0.028
1.697GluTyr: 1.697 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.683PheAla: 3.683 ± 0.073
0.417PheCys: 0.417 ± 0.024
2.705PheAsp: 2.705 ± 0.059
2.486PheGlu: 2.486 ± 0.058
1.612PhePhe: 1.612 ± 0.051
3.057PheGly: 3.057 ± 0.063
0.728PheHis: 0.728 ± 0.028
2.544PheIle: 2.544 ± 0.056
1.789PheLys: 1.789 ± 0.049
3.096PheLeu: 3.096 ± 0.068
0.902PheMet: 0.902 ± 0.029
1.845PheAsn: 1.845 ± 0.042
1.305PhePro: 1.305 ± 0.043
1.14PheGln: 1.14 ± 0.035
1.743PheArg: 1.743 ± 0.047
3.008PheSer: 3.008 ± 0.056
2.11PheThr: 2.11 ± 0.051
2.701PheVal: 2.701 ± 0.055
0.586PheTrp: 0.586 ± 0.027
1.382PheTyr: 1.382 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
5.547GlyAla: 5.547 ± 0.11
0.765GlyCys: 0.765 ± 0.032
3.994GlyAsp: 3.994 ± 0.069
4.504GlyGlu: 4.504 ± 0.07
3.105GlyPhe: 3.105 ± 0.06
4.922GlyGly: 4.922 ± 0.104
1.593GlyHis: 1.593 ± 0.046
4.367GlyIle: 4.367 ± 0.074
3.46GlyLys: 3.46 ± 0.069
6.912GlyLeu: 6.912 ± 0.111
1.948GlyMet: 1.948 ± 0.057
2.563GlyAsn: 2.563 ± 0.07
1.863GlyPro: 1.863 ± 0.042
3.023GlyGln: 3.023 ± 0.055
3.491GlyArg: 3.491 ± 0.067
4.246GlySer: 4.246 ± 0.084
3.308GlyThr: 3.308 ± 0.074
5.128GlyVal: 5.128 ± 0.083
1.042GlyTrp: 1.042 ± 0.037
2.586GlyTyr: 2.586 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.742HisAla: 1.742 ± 0.04
0.336HisCys: 0.336 ± 0.02
1.258HisAsp: 1.258 ± 0.036
1.266HisGlu: 1.266 ± 0.041
1.005HisPhe: 1.005 ± 0.032
1.672HisGly: 1.672 ± 0.043
0.656HisHis: 0.656 ± 0.031
1.291HisIle: 1.291 ± 0.041
0.905HisLys: 0.905 ± 0.031
2.026HisLeu: 2.026 ± 0.054
0.479HisMet: 0.479 ± 0.026
0.84HisAsn: 0.84 ± 0.03
1.212HisPro: 1.212 ± 0.036
1.274HisGln: 1.274 ± 0.039
1.261HisArg: 1.261 ± 0.038
1.302HisSer: 1.302 ± 0.034
0.975HisThr: 0.975 ± 0.035
1.294HisVal: 1.294 ± 0.04
0.429HisTrp: 0.429 ± 0.023
0.92HisTyr: 0.92 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.276IleAla: 6.276 ± 0.091
0.517IleCys: 0.517 ± 0.025
4.191IleAsp: 4.191 ± 0.066
4.243IleGlu: 4.243 ± 0.077
1.877IlePhe: 1.877 ± 0.044
4.199IleGly: 4.199 ± 0.079
1.055IleHis: 1.055 ± 0.037
3.231IleIle: 3.231 ± 0.069
2.775IleLys: 2.775 ± 0.06
4.411IleLeu: 4.411 ± 0.08
1.108IleMet: 1.108 ± 0.032
2.83IleAsn: 2.83 ± 0.059
2.41IlePro: 2.41 ± 0.057
1.998IleGln: 1.998 ± 0.038
2.821IleArg: 2.821 ± 0.057
3.79IleSer: 3.79 ± 0.071
3.278IleThr: 3.278 ± 0.064
3.801IleVal: 3.801 ± 0.073
0.583IleTrp: 0.583 ± 0.03
1.502IleTyr: 1.502 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.396LysAla: 4.396 ± 0.081
0.221LysCys: 0.221 ± 0.021
2.371LysAsp: 2.371 ± 0.053
2.684LysGlu: 2.684 ± 0.063
1.343LysPhe: 1.343 ± 0.04
2.719LysGly: 2.719 ± 0.062
1.132LysHis: 1.132 ± 0.036
2.132LysIle: 2.132 ± 0.055
2.372LysLys: 2.372 ± 0.057
4.801LysLeu: 4.801 ± 0.063
1.033LysMet: 1.033 ± 0.039
1.738LysAsn: 1.738 ± 0.048
2.324LysPro: 2.324 ± 0.056
3.07LysGln: 3.07 ± 0.064
3.064LysArg: 3.064 ± 0.065
2.683LysSer: 2.683 ± 0.057
2.62LysThr: 2.62 ± 0.059
3.233LysVal: 3.233 ± 0.066
0.444LysTrp: 0.444 ± 0.022
1.033LysTyr: 1.033 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.67LeuAla: 10.67 ± 0.127
0.878LeuCys: 0.878 ± 0.03
5.755LeuAsp: 5.755 ± 0.08
5.92LeuGlu: 5.92 ± 0.096
3.8LeuPhe: 3.8 ± 0.079
6.734LeuGly: 6.734 ± 0.092
2.1LeuHis: 2.1 ± 0.051
5.675LeuIle: 5.675 ± 0.09
5.085LeuLys: 5.085 ± 0.089
11.158LeuLeu: 11.158 ± 0.162
2.597LeuMet: 2.597 ± 0.063
4.263LeuAsn: 4.263 ± 0.068
4.944LeuPro: 4.944 ± 0.078
5.259LeuGln: 5.259 ± 0.097
5.293LeuArg: 5.293 ± 0.092
7.22LeuSer: 7.22 ± 0.107
6.351LeuThr: 6.351 ± 0.08
6.851LeuVal: 6.851 ± 0.094
1.234LeuTrp: 1.234 ± 0.04
2.529LeuTyr: 2.529 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.629MetAla: 2.629 ± 0.059
0.148MetCys: 0.148 ± 0.013
1.18MetAsp: 1.18 ± 0.034
1.146MetGlu: 1.146 ± 0.036
0.754MetPhe: 0.754 ± 0.029
1.641MetGly: 1.641 ± 0.043
0.465MetHis: 0.465 ± 0.024
1.224MetIle: 1.224 ± 0.041
1.224MetLys: 1.224 ± 0.041
2.614MetLeu: 2.614 ± 0.062
0.684MetMet: 0.684 ± 0.028
0.949MetAsn: 0.949 ± 0.033
1.237MetPro: 1.237 ± 0.031
1.349MetGln: 1.349 ± 0.041
1.326MetArg: 1.326 ± 0.038
1.837MetSer: 1.837 ± 0.049
1.607MetThr: 1.607 ± 0.048
1.667MetVal: 1.667 ± 0.046
0.189MetTrp: 0.189 ± 0.013
0.457MetTyr: 0.457 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.637AsnAla: 3.637 ± 0.079
0.357AsnCys: 0.357 ± 0.021
2.596AsnAsp: 2.596 ± 0.053
2.52AsnGlu: 2.52 ± 0.056
1.465AsnPhe: 1.465 ± 0.045
2.925AsnGly: 2.925 ± 0.067
0.812AsnHis: 0.812 ± 0.03
2.181AsnIle: 2.181 ± 0.049
1.688AsnLys: 1.688 ± 0.035
3.517AsnLeu: 3.517 ± 0.061
0.808AsnMet: 0.808 ± 0.033
1.717AsnAsn: 1.717 ± 0.052
1.998AsnPro: 1.998 ± 0.046
2.014AsnGln: 2.014 ± 0.043
2.083AsnArg: 2.083 ± 0.044
2.347AsnSer: 2.347 ± 0.055
2.051AsnThr: 2.051 ± 0.053
2.552AsnVal: 2.552 ± 0.057
0.652AsnTrp: 0.652 ± 0.027
1.316AsnTyr: 1.316 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
3.635ProAla: 3.635 ± 0.074
0.291ProCys: 0.291 ± 0.02
2.724ProAsp: 2.724 ± 0.064
3.251ProGlu: 3.251 ± 0.071
1.585ProPhe: 1.585 ± 0.04
2.782ProGly: 2.782 ± 0.063
0.887ProHis: 0.887 ± 0.033
2.199ProIle: 2.199 ± 0.053
1.784ProLys: 1.784 ± 0.047
4.388ProLeu: 4.388 ± 0.07
1.025ProMet: 1.025 ± 0.038
1.568ProAsn: 1.568 ± 0.045
1.332ProPro: 1.332 ± 0.04
2.073ProGln: 2.073 ± 0.05
1.676ProArg: 1.676 ± 0.046
2.275ProSer: 2.275 ± 0.051
2.126ProThr: 2.126 ± 0.05
3.216ProVal: 3.216 ± 0.065
0.561ProTrp: 0.561 ± 0.025
1.227ProTyr: 1.227 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.956GlnAla: 4.956 ± 0.088
0.385GlnCys: 0.385 ± 0.02
2.045GlnAsp: 2.045 ± 0.049
2.324GlnGlu: 2.324 ± 0.053
1.852GlnPhe: 1.852 ± 0.044
3.137GlnGly: 3.137 ± 0.063
1.588GlnHis: 1.588 ± 0.046
2.4GlnIle: 2.4 ± 0.051
2.072GlnLys: 2.072 ± 0.05
6.998GlnLeu: 6.998 ± 0.127
1.095GlnMet: 1.095 ± 0.033
1.573GlnAsn: 1.573 ± 0.039
2.402GlnPro: 2.402 ± 0.058
5.923GlnGln: 5.923 ± 0.182
3.725GlnArg: 3.725 ± 0.076
3.013GlnSer: 3.013 ± 0.065
2.562GlnThr: 2.562 ± 0.065
3.567GlnVal: 3.567 ± 0.067
1.005GlnTrp: 1.005 ± 0.036
1.397GlnTyr: 1.397 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
4.345ArgAla: 4.345 ± 0.07
0.446ArgCys: 0.446 ± 0.027
3.096ArgAsp: 3.096 ± 0.061
3.608ArgGlu: 3.608 ± 0.071
2.543ArgPhe: 2.543 ± 0.057
3.125ArgGly: 3.125 ± 0.057
1.36ArgHis: 1.36 ± 0.042
3.135ArgIle: 3.135 ± 0.064
2.377ArgLys: 2.377 ± 0.061
6.072ArgLeu: 6.072 ± 0.088
1.342ArgMet: 1.342 ± 0.04
1.958ArgAsn: 1.958 ± 0.04
1.923ArgPro: 1.923 ± 0.047
3.184ArgGln: 3.184 ± 0.06
3.22ArgArg: 3.22 ± 0.069
2.958ArgSer: 2.958 ± 0.059
2.287ArgThr: 2.287 ± 0.051
3.804ArgVal: 3.804 ± 0.074
0.968ArgTrp: 0.968 ± 0.033
2.159ArgTyr: 2.159 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.802SerAla: 5.802 ± 0.079
0.543SerCys: 0.543 ± 0.023
3.81SerAsp: 3.81 ± 0.066
3.917SerGlu: 3.917 ± 0.073
2.498SerPhe: 2.498 ± 0.061
4.948SerGly: 4.948 ± 0.102
1.313SerHis: 1.313 ± 0.04
3.319SerIle: 3.319 ± 0.054
2.405SerLys: 2.405 ± 0.053
6.628SerLeu: 6.628 ± 0.092
1.575SerMet: 1.575 ± 0.038
2.3SerAsn: 2.3 ± 0.055
2.365SerPro: 2.365 ± 0.047
2.972SerGln: 2.972 ± 0.06
3.167SerArg: 3.167 ± 0.07
3.899SerSer: 3.899 ± 0.077
2.904SerThr: 2.904 ± 0.054
4.64SerVal: 4.64 ± 0.077
0.83SerTrp: 0.83 ± 0.029
1.763SerTyr: 1.763 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.045ThrAla: 5.045 ± 0.082
0.384ThrCys: 0.384 ± 0.022
3.261ThrAsp: 3.261 ± 0.057
3.422ThrGlu: 3.422 ± 0.064
1.93ThrPhe: 1.93 ± 0.044
3.946ThrGly: 3.946 ± 0.07
1.135ThrHis: 1.135 ± 0.035
3.038ThrIle: 3.038 ± 0.054
1.789ThrLys: 1.789 ± 0.047
6.154ThrLeu: 6.154 ± 0.083
1.034ThrMet: 1.034 ± 0.034
1.737ThrAsn: 1.737 ± 0.055
2.528ThrPro: 2.528 ± 0.059
2.452ThrGln: 2.452 ± 0.049
2.612ThrArg: 2.612 ± 0.056
2.927ThrSer: 2.927 ± 0.072
2.744ThrThr: 2.744 ± 0.058
4.024ThrVal: 4.024 ± 0.074
0.54ThrTrp: 0.54 ± 0.026
1.363ThrTyr: 1.363 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
7.017ValAla: 7.017 ± 0.091
0.614ValCys: 0.614 ± 0.025
4.367ValAsp: 4.367 ± 0.076
4.646ValGlu: 4.646 ± 0.083
2.642ValPhe: 2.642 ± 0.059
4.66ValGly: 4.66 ± 0.092
1.275ValHis: 1.275 ± 0.036
4.592ValIle: 4.592 ± 0.074
3.336ValLys: 3.336 ± 0.072
6.738ValLeu: 6.738 ± 0.095
1.915ValMet: 1.915 ± 0.044
3.014ValAsn: 3.014 ± 0.056
2.743ValPro: 2.743 ± 0.053
2.378ValGln: 2.378 ± 0.059
3.441ValArg: 3.441 ± 0.074
4.847ValSer: 4.847 ± 0.068
4.215ValThr: 4.215 ± 0.078
5.359ValVal: 5.359 ± 0.09
0.787ValTrp: 0.787 ± 0.031
1.826ValTyr: 1.826 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.869TrpAla: 0.869 ± 0.031
0.143TrpCys: 0.143 ± 0.012
0.584TrpAsp: 0.584 ± 0.024
0.502TrpGlu: 0.502 ± 0.026
0.656TrpPhe: 0.656 ± 0.027
0.795TrpGly: 0.795 ± 0.031
0.401TrpHis: 0.401 ± 0.02
0.652TrpIle: 0.652 ± 0.026
0.412TrpLys: 0.412 ± 0.02
2.102TrpLeu: 2.102 ± 0.054
0.369TrpMet: 0.369 ± 0.019
0.437TrpAsn: 0.437 ± 0.02
0.54TrpPro: 0.54 ± 0.025
1.297TrpGln: 1.297 ± 0.051
0.933TrpArg: 0.933 ± 0.039
0.765TrpSer: 0.765 ± 0.033
0.532TrpThr: 0.532 ± 0.024
0.963TrpVal: 0.963 ± 0.04
0.245TrpTrp: 0.245 ± 0.019
0.415TrpTyr: 0.415 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.398TyrAla: 2.398 ± 0.047
0.311TyrCys: 0.311 ± 0.021
1.842TyrAsp: 1.842 ± 0.044
1.716TyrGlu: 1.716 ± 0.046
1.306TyrPhe: 1.306 ± 0.038
2.049TyrGly: 2.049 ± 0.049
0.761TyrHis: 0.761 ± 0.028
1.383TyrIle: 1.383 ± 0.044
1.113TyrLys: 1.113 ± 0.037
3.135TyrLeu: 3.135 ± 0.058
0.584TyrMet: 0.584 ± 0.024
1.075TyrAsn: 1.075 ± 0.036
1.348TyrPro: 1.348 ± 0.045
1.986TyrGln: 1.986 ± 0.051
1.984TyrArg: 1.984 ± 0.048
1.863TyrSer: 1.863 ± 0.051
1.437TyrThr: 1.437 ± 0.046
1.851TyrVal: 1.851 ± 0.047
0.473TyrTrp: 0.473 ± 0.026
1.01TyrTyr: 1.01 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2765 proteins (909821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski