Amino acid dipepetide frequency for Aspergillus parasiticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.976AlaAla: 7.976 ± 0.056	1.168AlaCys: 1.168 ± 0.016	3.968AlaAsp: 3.968 ± 0.024	4.753AlaGlu: 4.753 ± 0.037	3.207AlaPhe: 3.207 ± 0.023	5.536AlaGly: 5.536 ± 0.037	1.771AlaHis: 1.771 ± 0.016	4.422AlaIle: 4.422 ± 0.027	3.684AlaLys: 3.684 ± 0.028	7.803AlaLeu: 7.803 ± 0.041	1.956AlaMet: 1.956 ± 0.02	2.849AlaAsn: 2.849 ± 0.023	4.287AlaPro: 4.287 ± 0.034	3.206AlaGln: 3.206 ± 0.027	4.578AlaArg: 4.578 ± 0.03	6.813AlaSer: 6.813 ± 0.037	5.068AlaThr: 5.068 ± 0.031	5.362AlaVal: 5.362 ± 0.034	1.202AlaTrp: 1.202 ± 0.015	2.277AlaTyr: 2.277 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.033CysAla: 1.033 ± 0.013	0.284CysCys: 0.284 ± 0.007	0.731CysAsp: 0.731 ± 0.012	0.65CysGlu: 0.65 ± 0.012	0.607CysPhe: 0.607 ± 0.01	0.991CysGly: 0.991 ± 0.015	0.381CysHis: 0.381 ± 0.009	0.803CysIle: 0.803 ± 0.014	0.516CysLys: 0.516 ± 0.009	1.471CysLeu: 1.471 ± 0.018	0.31CysMet: 0.31 ± 0.007	0.479CysAsn: 0.479 ± 0.009	0.714CysPro: 0.714 ± 0.017	0.518CysGln: 0.518 ± 0.01	0.852CysArg: 0.852 ± 0.015	1.049CysSer: 1.049 ± 0.015	0.773CysThr: 0.773 ± 0.013	0.894CysVal: 0.894 ± 0.014	0.224CysTrp: 0.224 ± 0.006	0.416CysTyr: 0.416 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.37AspAla: 4.37 ± 0.026	0.663AspCys: 0.663 ± 0.011	3.725AspAsp: 3.725 ± 0.034	4.047AspGlu: 4.047 ± 0.033	2.136AspPhe: 2.136 ± 0.019	3.914AspGly: 3.914 ± 0.027	1.294AspHis: 1.294 ± 0.016	3.299AspIle: 3.299 ± 0.024	2.254AspLys: 2.254 ± 0.021	5.148AspLeu: 5.148 ± 0.033	1.269AspMet: 1.269 ± 0.016	1.944AspAsn: 1.944 ± 0.018	3.311AspPro: 3.311 ± 0.025	1.931AspGln: 1.931 ± 0.019	3.06AspArg: 3.06 ± 0.025	4.092AspSer: 4.092 ± 0.03	3.021AspThr: 3.021 ± 0.027	3.62AspVal: 3.62 ± 0.023	0.909AspTrp: 0.909 ± 0.012	1.693AspTyr: 1.693 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.036GluAla: 5.036 ± 0.04	0.69GluCys: 0.69 ± 0.011	3.909GluAsp: 3.909 ± 0.031	5.093GluGlu: 5.093 ± 0.051	1.967GluPhe: 1.967 ± 0.018	3.641GluGly: 3.641 ± 0.026	1.408GluHis: 1.408 ± 0.018	3.099GluIle: 3.099 ± 0.023	3.558GluLys: 3.558 ± 0.032	5.18GluLeu: 5.18 ± 0.032	1.395GluMet: 1.395 ± 0.015	2.355GluAsn: 2.355 ± 0.02	2.733GluPro: 2.733 ± 0.042	2.433GluGln: 2.433 ± 0.022	3.781GluArg: 3.781 ± 0.028	4.33GluSer: 4.33 ± 0.033	3.496GluThr: 3.496 ± 0.023	3.532GluVal: 3.532 ± 0.026	0.901GluTrp: 0.901 ± 0.013	1.779GluTyr: 1.779 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.043PheAla: 3.043 ± 0.027	0.623PheCys: 0.623 ± 0.01	2.262PheAsp: 2.262 ± 0.019	2.106PheGlu: 2.106 ± 0.019	1.777PhePhe: 1.777 ± 0.022	2.879PheGly: 2.879 ± 0.026	1.015PheHis: 1.015 ± 0.012	2.014PheIle: 2.014 ± 0.023	1.451PheLys: 1.451 ± 0.017	3.805PheLeu: 3.805 ± 0.026	0.82PheMet: 0.82 ± 0.013	1.492PheAsn: 1.492 ± 0.015	2.088PhePro: 2.088 ± 0.02	1.493PheGln: 1.493 ± 0.016	2.022PheArg: 2.022 ± 0.017	3.134PheSer: 3.134 ± 0.024	2.261PheThr: 2.261 ± 0.02	2.46PheVal: 2.46 ± 0.021	0.693PheTrp: 0.693 ± 0.011	1.241PheTyr: 1.241 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.089GlyAla: 5.089 ± 0.038	0.977GlyCys: 0.977 ± 0.015	3.592GlyAsp: 3.592 ± 0.026	3.531GlyGlu: 3.531 ± 0.025	2.915GlyPhe: 2.915 ± 0.026	5.287GlyGly: 5.287 ± 0.044	1.702GlyHis: 1.702 ± 0.019	3.785GlyIle: 3.785 ± 0.029	3.281GlyLys: 3.281 ± 0.027	6.36GlyLeu: 6.36 ± 0.036	1.552GlyMet: 1.552 ± 0.017	2.57GlyAsn: 2.57 ± 0.02	3.286GlyPro: 3.286 ± 0.024	2.576GlyGln: 2.576 ± 0.025	3.937GlyArg: 3.937 ± 0.027	5.624GlySer: 5.624 ± 0.036	3.987GlyThr: 3.987 ± 0.029	4.553GlyVal: 4.553 ± 0.032	1.231GlyTrp: 1.231 ± 0.017	2.296GlyTyr: 2.296 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.824HisAla: 1.824 ± 0.019	0.385HisCys: 0.385 ± 0.009	1.342HisAsp: 1.342 ± 0.015	1.335HisGlu: 1.335 ± 0.016	0.968HisPhe: 0.968 ± 0.011	1.766HisGly: 1.766 ± 0.019	0.85HisHis: 0.85 ± 0.015	1.352HisIle: 1.352 ± 0.014	0.882HisLys: 0.882 ± 0.012	2.352HisLeu: 2.352 ± 0.023	0.52HisMet: 0.52 ± 0.01	0.885HisAsn: 0.885 ± 0.012	1.705HisPro: 1.705 ± 0.018	0.965HisGln: 0.965 ± 0.013	1.581HisArg: 1.581 ± 0.016	1.959HisSer: 1.959 ± 0.021	1.333HisThr: 1.333 ± 0.016	1.466HisVal: 1.466 ± 0.015	0.393HisTrp: 0.393 ± 0.008	0.756HisTyr: 0.756 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.356IleAla: 4.356 ± 0.03	0.873IleCys: 0.873 ± 0.012	2.916IleAsp: 2.916 ± 0.022	2.919IleGlu: 2.919 ± 0.022	2.18IlePhe: 2.18 ± 0.022	3.454IleGly: 3.454 ± 0.026	1.332IleHis: 1.332 ± 0.017	2.759IleIle: 2.759 ± 0.023	2.073IleLys: 2.073 ± 0.018	5.013IleLeu: 5.013 ± 0.033	1.079IleMet: 1.079 ± 0.015	1.897IleAsn: 1.897 ± 0.017	3.268IlePro: 3.268 ± 0.024	2.045IleGln: 2.045 ± 0.018	2.905IleArg: 2.905 ± 0.021	4.143IleSer: 4.143 ± 0.026	2.984IleThr: 2.984 ± 0.023	3.434IleVal: 3.434 ± 0.025	0.776IleTrp: 0.776 ± 0.012	1.617IleTyr: 1.617 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.906LysAla: 3.906 ± 0.027	0.562LysCys: 0.562 ± 0.011	2.724LysAsp: 2.724 ± 0.021	3.229LysGlu: 3.229 ± 0.029	1.399LysPhe: 1.399 ± 0.015	2.897LysGly: 2.897 ± 0.023	1.087LysHis: 1.087 ± 0.013	2.17LysIle: 2.17 ± 0.02	2.823LysLys: 2.823 ± 0.035	3.953LysLeu: 3.953 ± 0.028	0.908LysMet: 0.908 ± 0.012	1.684LysAsn: 1.684 ± 0.016	2.55LysPro: 2.55 ± 0.024	1.789LysGln: 1.789 ± 0.017	3.111LysArg: 3.111 ± 0.027	3.301LysSer: 3.301 ± 0.027	2.613LysThr: 2.613 ± 0.024	2.785LysVal: 2.785 ± 0.024	0.675LysTrp: 0.675 ± 0.012	1.385LysTyr: 1.385 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.768LeuAla: 7.768 ± 0.038	1.38LeuCys: 1.38 ± 0.017	5.226LeuAsp: 5.226 ± 0.031	5.581LeuGlu: 5.581 ± 0.036	3.612LeuPhe: 3.612 ± 0.028	6.229LeuGly: 6.229 ± 0.035	2.393LeuHis: 2.393 ± 0.022	4.325LeuIle: 4.325 ± 0.031	4.026LeuLys: 4.026 ± 0.026	8.898LeuLeu: 8.898 ± 0.052	1.899LeuMet: 1.899 ± 0.019	3.348LeuAsn: 3.348 ± 0.025	5.54LeuPro: 5.54 ± 0.033	3.976LeuGln: 3.976 ± 0.03	5.795LeuArg: 5.795 ± 0.029	7.764LeuSer: 7.764 ± 0.042	5.01LeuThr: 5.01 ± 0.032	5.716LeuVal: 5.716 ± 0.035	1.307LeuTrp: 1.307 ± 0.018	2.659LeuTyr: 2.659 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.132MetAla: 2.132 ± 0.018	0.284MetCys: 0.284 ± 0.007	1.218MetAsp: 1.218 ± 0.014	1.287MetGlu: 1.287 ± 0.015	0.758MetPhe: 0.758 ± 0.011	1.492MetGly: 1.492 ± 0.017	0.492MetHis: 0.492 ± 0.009	1.078MetIle: 1.078 ± 0.014	1.014MetLys: 1.014 ± 0.012	1.898MetLeu: 1.898 ± 0.016	0.556MetMet: 0.556 ± 0.01	0.84MetAsn: 0.84 ± 0.012	1.183MetPro: 1.183 ± 0.013	0.859MetGln: 0.859 ± 0.014	1.231MetArg: 1.231 ± 0.013	1.871MetSer: 1.871 ± 0.018	1.325MetThr: 1.325 ± 0.015	1.417MetVal: 1.417 ± 0.016	0.278MetTrp: 0.278 ± 0.006	0.559MetTyr: 0.559 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.075AsnAla: 3.075 ± 0.023	0.501AsnCys: 0.501 ± 0.01	1.989AsnAsp: 1.989 ± 0.02	2.061AsnGlu: 2.061 ± 0.019	1.39AsnPhe: 1.39 ± 0.015	2.95AsnGly: 2.95 ± 0.026	0.906AsnHis: 0.906 ± 0.014	2.213AsnIle: 2.213 ± 0.02	1.499AsnLys: 1.499 ± 0.016	3.328AsnLeu: 3.328 ± 0.019	0.864AsnMet: 0.864 ± 0.012	1.519AsnAsn: 1.519 ± 0.015	2.483AsnPro: 2.483 ± 0.024	1.365AsnGln: 1.365 ± 0.016	1.963AsnArg: 1.963 ± 0.019	2.751AsnSer: 2.751 ± 0.025	2.255AsnThr: 2.255 ± 0.021	2.406AsnVal: 2.406 ± 0.02	0.59AsnTrp: 0.59 ± 0.009	1.132AsnTyr: 1.132 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.619ProAla: 4.619 ± 0.033	0.611ProCys: 0.611 ± 0.012	3.187ProAsp: 3.187 ± 0.023	3.862ProGlu: 3.862 ± 0.034	2.156ProPhe: 2.156 ± 0.021	3.832ProGly: 3.832 ± 0.03	1.323ProHis: 1.323 ± 0.017	2.608ProIle: 2.608 ± 0.021	2.489ProLys: 2.489 ± 0.021	4.769ProLeu: 4.769 ± 0.034	1.062ProMet: 1.062 ± 0.012	2.191ProAsn: 2.191 ± 0.018	4.35ProPro: 4.35 ± 0.052	2.359ProGln: 2.359 ± 0.023	3.294ProArg: 3.294 ± 0.029	5.833ProSer: 5.833 ± 0.044	3.844ProThr: 3.844 ± 0.03	3.611ProVal: 3.611 ± 0.025	0.806ProTrp: 0.806 ± 0.013	1.592ProTyr: 1.592 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.26GlnAla: 3.26 ± 0.026	0.508GlnCys: 0.508 ± 0.01	2.052GlnAsp: 2.052 ± 0.019	2.426GlnGlu: 2.426 ± 0.022	1.34GlnPhe: 1.34 ± 0.015	2.5GlnGly: 2.5 ± 0.022	1.035GlnHis: 1.035 ± 0.013	1.966GlnIle: 1.966 ± 0.017	1.969GlnLys: 1.969 ± 0.02	3.576GlnLeu: 3.576 ± 0.031	0.885GlnMet: 0.885 ± 0.011	1.577GlnAsn: 1.577 ± 0.017	2.432GlnPro: 2.432 ± 0.027	2.17GlnGln: 2.17 ± 0.039	2.58GlnArg: 2.58 ± 0.021	3.178GlnSer: 3.178 ± 0.029	2.35GlnThr: 2.35 ± 0.018	2.253GlnVal: 2.253 ± 0.02	0.624GlnTrp: 0.624 ± 0.01	1.24GlnTyr: 1.24 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.413ArgAla: 4.413 ± 0.025	0.773ArgCys: 0.773 ± 0.013	3.255ArgAsp: 3.255 ± 0.028	3.672ArgGlu: 3.672 ± 0.029	2.23ArgPhe: 2.23 ± 0.018	3.556ArgGly: 3.556 ± 0.033	1.565ArgHis: 1.565 ± 0.016	2.95ArgIle: 2.95 ± 0.022	3.235ArgLys: 3.235 ± 0.026	5.65ArgLeu: 5.65 ± 0.031	1.301ArgMet: 1.301 ± 0.015	2.219ArgAsn: 2.219 ± 0.019	3.312ArgPro: 3.312 ± 0.029	2.545ArgGln: 2.545 ± 0.02	4.791ArgArg: 4.791 ± 0.041	4.693ArgSer: 4.693 ± 0.035	3.212ArgThr: 3.212 ± 0.027	3.46ArgVal: 3.46 ± 0.026	0.997ArgTrp: 0.997 ± 0.012	1.791ArgTyr: 1.791 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.354SerAla: 6.354 ± 0.038	1.01SerCys: 1.01 ± 0.015	4.242SerAsp: 4.242 ± 0.03	4.249SerGlu: 4.249 ± 0.028	3.224SerPhe: 3.224 ± 0.026	5.517SerGly: 5.517 ± 0.037	2.035SerHis: 2.035 ± 0.018	4.234SerIle: 4.234 ± 0.027	3.546SerLys: 3.546 ± 0.027	7.624SerLeu: 7.624 ± 0.041	1.722SerMet: 1.722 ± 0.018	3.036SerAsn: 3.036 ± 0.021	5.204SerPro: 5.204 ± 0.041	3.336SerGln: 3.336 ± 0.029	4.917SerArg: 4.917 ± 0.043	8.42SerSer: 8.42 ± 0.057	5.452SerThr: 5.452 ± 0.032	4.763SerVal: 4.763 ± 0.03	1.237SerTrp: 1.237 ± 0.014	2.231SerTyr: 2.231 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.03ThrAla: 5.03 ± 0.026	0.81ThrCys: 0.81 ± 0.013	2.946ThrAsp: 2.946 ± 0.021	3.208ThrGlu: 3.208 ± 0.028	2.326ThrPhe: 2.326 ± 0.021	4.274ThrGly: 4.274 ± 0.036	1.341ThrHis: 1.341 ± 0.016	3.241ThrIle: 3.241 ± 0.025	2.504ThrLys: 2.504 ± 0.023	5.398ThrLeu: 5.398 ± 0.031	1.237ThrMet: 1.237 ± 0.013	2.117ThrAsn: 2.117 ± 0.019	4.053ThrPro: 4.053 ± 0.028	2.085ThrGln: 2.085 ± 0.018	3.015ThrArg: 3.015 ± 0.022	5.17ThrSer: 5.17 ± 0.037	4.12ThrThr: 4.12 ± 0.034	3.962ThrVal: 3.962 ± 0.025	0.932ThrTrp: 0.932 ± 0.012	1.742ThrTyr: 1.742 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.174ValAla: 5.174 ± 0.034	0.924ValCys: 0.924 ± 0.013	3.767ValAsp: 3.767 ± 0.028	3.792ValGlu: 3.792 ± 0.028	2.603ValPhe: 2.603 ± 0.025	4.165ValGly: 4.165 ± 0.031	1.48ValHis: 1.48 ± 0.015	3.231ValIle: 3.231 ± 0.022	2.769ValLys: 2.769 ± 0.023	5.849ValLeu: 5.849 ± 0.035	1.362ValMet: 1.362 ± 0.015	2.343ValAsn: 2.343 ± 0.021	3.615ValPro: 3.615 ± 0.028	2.464ValGln: 2.464 ± 0.022	3.464ValArg: 3.464 ± 0.025	4.909ValSer: 4.909 ± 0.027	3.661ValThr: 3.661 ± 0.02	4.384ValVal: 4.384 ± 0.031	0.921ValTrp: 0.921 ± 0.014	1.92ValTyr: 1.92 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.168TrpAla: 1.168 ± 0.014	0.218TrpCys: 0.218 ± 0.006	0.943TrpAsp: 0.943 ± 0.013	0.889TrpGlu: 0.889 ± 0.013	0.585TrpPhe: 0.585 ± 0.011	1.0TrpGly: 1.0 ± 0.015	0.383TrpHis: 0.383 ± 0.009	0.846TrpIle: 0.846 ± 0.013	0.854TrpLys: 0.854 ± 0.011	1.469TrpLeu: 1.469 ± 0.017	0.397TrpMet: 0.397 ± 0.008	0.684TrpAsn: 0.684 ± 0.01	0.644TrpPro: 0.644 ± 0.01	0.592TrpGln: 0.592 ± 0.01	0.99TrpArg: 0.99 ± 0.017	1.118TrpSer: 1.118 ± 0.014	0.976TrpThr: 0.976 ± 0.013	0.964TrpVal: 0.964 ± 0.014	0.297TrpTrp: 0.297 ± 0.008	0.477TrpTyr: 0.477 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.26TyrAla: 2.26 ± 0.019	0.453TyrCys: 0.453 ± 0.009	1.709TyrAsp: 1.709 ± 0.019	1.622TyrGlu: 1.622 ± 0.016	1.3TyrPhe: 1.3 ± 0.014	2.249TyrGly: 2.249 ± 0.024	0.825TyrHis: 0.825 ± 0.012	1.629TyrIle: 1.629 ± 0.018	1.126TyrLys: 1.126 ± 0.014	2.906TyrLeu: 2.906 ± 0.027	0.678TyrMet: 0.678 ± 0.01	1.212TyrAsn: 1.212 ± 0.013	1.638TyrPro: 1.638 ± 0.017	1.217TyrGln: 1.217 ± 0.013	1.751TyrArg: 1.751 ± 0.02	2.201TyrSer: 2.201 ± 0.022	1.771TyrThr: 1.771 ± 0.018	1.756TyrVal: 1.756 ± 0.017	0.499TyrTrp: 0.499 ± 0.009	1.035TyrTyr: 1.035 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 13752 proteins (6381041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---