Amino acid dipepetide frequency for Lentinula edodes (Shiitake mushroom) (Lentinus edodes)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.214AlaAla: 7.214 ± 0.051	0.917AlaCys: 0.917 ± 0.014	3.667AlaAsp: 3.667 ± 0.027	4.523AlaGlu: 4.523 ± 0.04	3.14AlaPhe: 3.14 ± 0.026	4.931AlaGly: 4.931 ± 0.038	1.786AlaHis: 1.786 ± 0.017	4.12AlaIle: 4.12 ± 0.029	3.688AlaLys: 3.688 ± 0.033	7.712AlaLeu: 7.712 ± 0.048	1.722AlaMet: 1.722 ± 0.017	2.841AlaAsn: 2.841 ± 0.024	4.275AlaPro: 4.275 ± 0.037	3.139AlaGln: 3.139 ± 0.025	4.352AlaArg: 4.352 ± 0.033	7.359AlaSer: 7.359 ± 0.047	4.814AlaThr: 4.814 ± 0.032	4.862AlaVal: 4.862 ± 0.033	1.004AlaTrp: 1.004 ± 0.014	2.096AlaTyr: 2.096 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.837CysAla: 0.837 ± 0.013	0.222CysCys: 0.222 ± 0.006	0.598CysAsp: 0.598 ± 0.012	0.546CysGlu: 0.546 ± 0.01	0.533CysPhe: 0.533 ± 0.01	0.787CysGly: 0.787 ± 0.013	0.304CysHis: 0.304 ± 0.008	0.727CysIle: 0.727 ± 0.013	0.492CysLys: 0.492 ± 0.009	1.156CysLeu: 1.156 ± 0.015	0.232CysMet: 0.232 ± 0.007	0.421CysAsn: 0.421 ± 0.009	0.587CysPro: 0.587 ± 0.011	0.401CysGln: 0.401 ± 0.009	0.645CysArg: 0.645 ± 0.012	0.957CysSer: 0.957 ± 0.013	0.713CysThr: 0.713 ± 0.013	0.759CysVal: 0.759 ± 0.013	0.2CysTrp: 0.2 ± 0.007	0.335CysTyr: 0.335 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.239AspAla: 4.239 ± 0.031	0.567AspCys: 0.567 ± 0.011	4.144AspAsp: 4.144 ± 0.04	4.406AspGlu: 4.406 ± 0.036	2.203AspPhe: 2.203 ± 0.021	3.636AspGly: 3.636 ± 0.028	1.187AspHis: 1.187 ± 0.016	3.273AspIle: 3.273 ± 0.025	2.197AspLys: 2.197 ± 0.025	5.015AspLeu: 5.015 ± 0.034	1.204AspMet: 1.204 ± 0.017	2.018AspAsn: 2.018 ± 0.021	3.358AspPro: 3.358 ± 0.025	1.65AspGln: 1.65 ± 0.017	2.651AspArg: 2.651 ± 0.025	4.542AspSer: 4.542 ± 0.038	3.011AspThr: 3.011 ± 0.025	3.837AspVal: 3.837 ± 0.025	0.864AspTrp: 0.864 ± 0.013	1.552AspTyr: 1.552 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	4.657GluAla: 4.657 ± 0.033	0.612GluCys: 0.612 ± 0.011	4.287GluAsp: 4.287 ± 0.037	5.663GluGlu: 5.663 ± 0.06	2.061GluPhe: 2.061 ± 0.021	3.663GluGly: 3.663 ± 0.026	1.412GluHis: 1.412 ± 0.018	3.265GluIle: 3.265 ± 0.03	3.499GluLys: 3.499 ± 0.031	5.371GluLeu: 5.371 ± 0.038	1.386GluMet: 1.386 ± 0.018	2.368GluAsn: 2.368 ± 0.023	2.468GluPro: 2.468 ± 0.025	2.282GluGln: 2.282 ± 0.027	3.683GluArg: 3.683 ± 0.033	4.316GluSer: 4.316 ± 0.026	3.193GluThr: 3.193 ± 0.027	3.696GluVal: 3.696 ± 0.03	0.863GluTrp: 0.863 ± 0.013	1.693GluTyr: 1.693 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.094PheAla: 3.094 ± 0.027	0.562PheCys: 0.562 ± 0.011	2.407PheAsp: 2.407 ± 0.024	2.192PheGlu: 2.192 ± 0.02	1.749PhePhe: 1.749 ± 0.023	2.806PheGly: 2.806 ± 0.029	0.971PheHis: 0.971 ± 0.014	2.088PheIle: 2.088 ± 0.02	1.62PheLys: 1.62 ± 0.016	3.679PheLeu: 3.679 ± 0.029	0.779PheMet: 0.779 ± 0.012	1.614PheAsn: 1.614 ± 0.02	2.126PhePro: 2.126 ± 0.021	1.353PheGln: 1.353 ± 0.017	1.947PheArg: 1.947 ± 0.02	3.502PheSer: 3.502 ± 0.03	2.408PheThr: 2.408 ± 0.024	2.607PheVal: 2.607 ± 0.021	0.619PheTrp: 0.619 ± 0.011	1.142PheTyr: 1.142 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.492GlyAla: 4.492 ± 0.034	0.747GlyCys: 0.747 ± 0.013	3.275GlyAsp: 3.275 ± 0.025	3.325GlyGlu: 3.325 ± 0.029	2.685GlyPhe: 2.685 ± 0.024	5.246GlyGly: 5.246 ± 0.05	1.498GlyHis: 1.498 ± 0.021	3.483GlyIle: 3.483 ± 0.028	3.431GlyLys: 3.431 ± 0.029	5.568GlyLeu: 5.568 ± 0.035	1.474GlyMet: 1.474 ± 0.018	2.569GlyAsn: 2.569 ± 0.025	3.1GlyPro: 3.1 ± 0.028	2.115GlyGln: 2.115 ± 0.02	3.538GlyArg: 3.538 ± 0.026	5.839GlySer: 5.839 ± 0.038	3.943GlyThr: 3.943 ± 0.031	4.196GlyVal: 4.196 ± 0.033	1.025GlyTrp: 1.025 ± 0.015	1.982GlyTyr: 1.982 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.744HisAla: 1.744 ± 0.017	0.324HisCys: 0.324 ± 0.007	1.282HisAsp: 1.282 ± 0.016	1.273HisGlu: 1.273 ± 0.016	1.015HisPhe: 1.015 ± 0.015	1.482HisGly: 1.482 ± 0.017	0.843HisHis: 0.843 ± 0.023	1.408HisIle: 1.408 ± 0.017	0.955HisLys: 0.955 ± 0.014	2.386HisLeu: 2.386 ± 0.021	0.456HisMet: 0.456 ± 0.008	0.965HisAsn: 0.965 ± 0.015	1.809HisPro: 1.809 ± 0.02	0.877HisGln: 0.877 ± 0.012	1.514HisArg: 1.514 ± 0.017	2.211HisSer: 2.211 ± 0.024	1.403HisThr: 1.403 ± 0.016	1.424HisVal: 1.424 ± 0.015	0.345HisTrp: 0.345 ± 0.008	0.703HisTyr: 0.703 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.192IleAla: 4.192 ± 0.033	0.734IleCys: 0.734 ± 0.012	3.001IleAsp: 3.001 ± 0.025	2.986IleGlu: 2.986 ± 0.025	2.176IlePhe: 2.176 ± 0.022	3.204IleGly: 3.204 ± 0.028	1.396IleHis: 1.396 ± 0.017	2.966IleIle: 2.966 ± 0.025	2.206IleLys: 2.206 ± 0.02	5.119IleLeu: 5.119 ± 0.037	1.086IleMet: 1.086 ± 0.013	1.946IleAsn: 1.946 ± 0.021	3.641IlePro: 3.641 ± 0.032	2.09IleGln: 2.09 ± 0.023	2.987IleArg: 2.987 ± 0.025	4.667IleSer: 4.667 ± 0.032	3.162IleThr: 3.162 ± 0.026	3.511IleVal: 3.511 ± 0.029	0.732IleTrp: 0.732 ± 0.013	1.52IleTyr: 1.52 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.962LysAla: 3.962 ± 0.039	0.482LysCys: 0.482 ± 0.01	2.704LysAsp: 2.704 ± 0.024	3.478LysGlu: 3.478 ± 0.032	1.606LysPhe: 1.606 ± 0.015	2.85LysGly: 2.85 ± 0.026	1.1LysHis: 1.1 ± 0.016	2.461LysIle: 2.461 ± 0.026	3.303LysLys: 3.303 ± 0.041	4.205LysLeu: 4.205 ± 0.033	1.005LysMet: 1.005 ± 0.015	1.822LysAsn: 1.822 ± 0.021	2.545LysPro: 2.545 ± 0.022	1.714LysGln: 1.714 ± 0.019	3.353LysArg: 3.353 ± 0.033	3.676LysSer: 3.676 ± 0.032	2.716LysThr: 2.716 ± 0.023	2.836LysVal: 2.836 ± 0.028	0.676LysTrp: 0.676 ± 0.012	1.378LysTyr: 1.378 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.348LeuAla: 7.348 ± 0.04	1.182LeuCys: 1.182 ± 0.015	5.179LeuAsp: 5.179 ± 0.034	5.539LeuGlu: 5.539 ± 0.037	3.557LeuPhe: 3.557 ± 0.028	5.589LeuGly: 5.589 ± 0.036	2.374LeuHis: 2.374 ± 0.022	4.393LeuIle: 4.393 ± 0.031	4.481LeuLys: 4.481 ± 0.035	8.737LeuLeu: 8.737 ± 0.055	1.773LeuMet: 1.773 ± 0.018	3.745LeuAsn: 3.745 ± 0.027	5.954LeuPro: 5.954 ± 0.039	3.77LeuGln: 3.77 ± 0.032	5.528LeuArg: 5.528 ± 0.036	8.377LeuSer: 8.377 ± 0.046	5.236LeuThr: 5.236 ± 0.032	5.545LeuVal: 5.545 ± 0.035	1.167LeuTrp: 1.167 ± 0.015	2.511LeuTyr: 2.511 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.64MetAla: 1.64 ± 0.018	0.222MetCys: 0.222 ± 0.007	1.199MetAsp: 1.199 ± 0.014	1.256MetGlu: 1.256 ± 0.018	0.808MetPhe: 0.808 ± 0.013	1.293MetGly: 1.293 ± 0.02	0.51MetHis: 0.51 ± 0.011	1.066MetIle: 1.066 ± 0.015	1.095MetLys: 1.095 ± 0.015	1.885MetLeu: 1.885 ± 0.02	0.56MetMet: 0.56 ± 0.01	0.931MetAsn: 0.931 ± 0.014	1.14MetPro: 1.14 ± 0.016	0.839MetGln: 0.839 ± 0.014	1.215MetArg: 1.215 ± 0.016	2.003MetSer: 2.003 ± 0.018	1.213MetThr: 1.213 ± 0.016	1.19MetVal: 1.19 ± 0.016	0.237MetTrp: 0.237 ± 0.007	0.573MetTyr: 0.573 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.392AsnAla: 3.392 ± 0.03	0.419AsnCys: 0.419 ± 0.009	2.139AsnAsp: 2.139 ± 0.02	2.206AsnGlu: 2.206 ± 0.022	1.561AsnPhe: 1.561 ± 0.018	2.916AsnGly: 2.916 ± 0.025	0.955AsnHis: 0.955 ± 0.013	2.31AsnIle: 2.31 ± 0.024	1.573AsnLys: 1.573 ± 0.017	3.619AsnLeu: 3.619 ± 0.027	0.82AsnMet: 0.82 ± 0.015	1.681AsnAsn: 1.681 ± 0.025	2.609AsnPro: 2.609 ± 0.025	1.326AsnGln: 1.326 ± 0.015	1.885AsnArg: 1.885 ± 0.021	3.45AsnSer: 3.45 ± 0.029	2.48AsnThr: 2.48 ± 0.022	2.63AsnVal: 2.63 ± 0.024	0.524AsnTrp: 0.524 ± 0.01	1.078AsnTyr: 1.078 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.502ProAla: 4.502 ± 0.04	0.495ProCys: 0.495 ± 0.011	3.005ProAsp: 3.005 ± 0.024	3.479ProGlu: 3.479 ± 0.027	2.266ProPhe: 2.266 ± 0.026	3.51ProGly: 3.51 ± 0.031	1.457ProHis: 1.457 ± 0.019	2.894ProIle: 2.894 ± 0.024	2.507ProLys: 2.507 ± 0.025	5.189ProLeu: 5.189 ± 0.035	1.033ProMet: 1.033 ± 0.015	2.414ProAsn: 2.414 ± 0.023	5.699ProPro: 5.699 ± 0.074	2.188ProGln: 2.188 ± 0.027	3.097ProArg: 3.097 ± 0.031	7.226ProSer: 7.226 ± 0.056	4.252ProThr: 4.252 ± 0.031	3.633ProVal: 3.633 ± 0.031	0.638ProTrp: 0.638 ± 0.012	1.568ProTyr: 1.568 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.997GlnAla: 2.997 ± 0.025	0.429GlnCys: 0.429 ± 0.011	1.919GlnAsp: 1.919 ± 0.02	2.238GlnGlu: 2.238 ± 0.024	1.299GlnPhe: 1.299 ± 0.017	2.083GlnGly: 2.083 ± 0.022	0.963GlnHis: 0.963 ± 0.014	2.008GlnIle: 2.008 ± 0.021	1.826GlnLys: 1.826 ± 0.021	3.373GlnLeu: 3.373 ± 0.03	0.841GlnMet: 0.841 ± 0.015	1.603GlnAsn: 1.603 ± 0.021	2.087GlnPro: 2.087 ± 0.023	1.894GlnGln: 1.894 ± 0.034	2.357GlnArg: 2.357 ± 0.022	3.157GlnSer: 3.157 ± 0.027	2.287GlnThr: 2.287 ± 0.023	2.145GlnVal: 2.145 ± 0.022	0.535GlnTrp: 0.535 ± 0.01	1.154GlnTyr: 1.154 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.192ArgAla: 4.192 ± 0.029	0.656ArgCys: 0.656 ± 0.011	2.962ArgAsp: 2.962 ± 0.023	3.538ArgGlu: 3.538 ± 0.031	2.094ArgPhe: 2.094 ± 0.022	3.181ArgGly: 3.181 ± 0.031	1.377ArgHis: 1.377 ± 0.016	3.136ArgIle: 3.136 ± 0.028	3.456ArgLys: 3.456 ± 0.03	5.133ArgLeu: 5.133 ± 0.037	1.253ArgMet: 1.253 ± 0.015	2.281ArgAsn: 2.281 ± 0.022	3.112ArgPro: 3.112 ± 0.03	2.154ArgGln: 2.154 ± 0.021	4.52ArgArg: 4.52 ± 0.042	4.863ArgSer: 4.863 ± 0.039	3.31ArgThr: 3.31 ± 0.026	3.308ArgVal: 3.308 ± 0.023	0.856ArgTrp: 0.856 ± 0.014	1.597ArgTyr: 1.597 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.929SerAla: 6.929 ± 0.04	0.903SerCys: 0.903 ± 0.015	4.639SerAsp: 4.639 ± 0.033	4.504SerGlu: 4.504 ± 0.03	3.588SerPhe: 3.588 ± 0.027	5.79SerGly: 5.79 ± 0.039	2.178SerHis: 2.178 ± 0.021	4.726SerIle: 4.726 ± 0.036	3.976SerLys: 3.976 ± 0.033	8.198SerLeu: 8.198 ± 0.045	1.782SerMet: 1.782 ± 0.02	3.734SerAsn: 3.734 ± 0.03	6.195SerPro: 6.195 ± 0.063	3.353SerGln: 3.353 ± 0.026	5.074SerArg: 5.074 ± 0.044	12.034SerSer: 12.034 ± 0.107	6.846SerThr: 6.846 ± 0.047	5.214SerVal: 5.214 ± 0.035	1.053SerTrp: 1.053 ± 0.015	2.217SerTyr: 2.217 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.78ThrAla: 4.78 ± 0.035	0.671ThrCys: 0.671 ± 0.013	2.796ThrAsp: 2.796 ± 0.024	3.029ThrGlu: 3.029 ± 0.025	2.558ThrPhe: 2.558 ± 0.02	3.981ThrGly: 3.981 ± 0.033	1.436ThrHis: 1.436 ± 0.016	3.392ThrIle: 3.392 ± 0.028	2.609ThrLys: 2.609 ± 0.026	5.819ThrLeu: 5.819 ± 0.032	1.26ThrMet: 1.26 ± 0.015	2.342ThrAsn: 2.342 ± 0.024	4.442ThrPro: 4.442 ± 0.037	2.108ThrGln: 2.108 ± 0.022	3.148ThrArg: 3.148 ± 0.024	6.456ThrSer: 6.456 ± 0.045	4.479ThrThr: 4.479 ± 0.04	3.955ThrVal: 3.955 ± 0.036	0.758ThrTrp: 0.758 ± 0.013	1.654ThrTyr: 1.654 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.882ValAla: 4.882 ± 0.037	0.726ValCys: 0.726 ± 0.013	3.865ValAsp: 3.865 ± 0.031	3.948ValGlu: 3.948 ± 0.032	2.61ValPhe: 2.61 ± 0.025	3.8ValGly: 3.8 ± 0.031	1.546ValHis: 1.546 ± 0.017	3.23ValIle: 3.23 ± 0.029	3.03ValLys: 3.03 ± 0.027	5.935ValLeu: 5.935 ± 0.043	1.273ValMet: 1.273 ± 0.016	2.476ValAsn: 2.476 ± 0.026	3.752ValPro: 3.752 ± 0.027	2.439ValGln: 2.439 ± 0.02	3.109ValArg: 3.109 ± 0.028	4.971ValSer: 4.971 ± 0.034	3.55ValThr: 3.55 ± 0.028	4.473ValVal: 4.473 ± 0.037	0.859ValTrp: 0.859 ± 0.014	1.792ValTyr: 1.792 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.986TrpAla: 0.986 ± 0.013	0.19TrpCys: 0.19 ± 0.006	0.835TrpAsp: 0.835 ± 0.014	0.821TrpGlu: 0.821 ± 0.013	0.551TrpPhe: 0.551 ± 0.011	0.877TrpGly: 0.877 ± 0.015	0.317TrpHis: 0.317 ± 0.008	0.812TrpIle: 0.812 ± 0.012	0.816TrpLys: 0.816 ± 0.014	1.182TrpLeu: 1.182 ± 0.016	0.332TrpMet: 0.332 ± 0.008	0.65TrpAsn: 0.65 ± 0.01	0.551TrpPro: 0.551 ± 0.011	0.47TrpGln: 0.47 ± 0.009	0.837TrpArg: 0.837 ± 0.014	1.061TrpSer: 1.061 ± 0.014	0.888TrpThr: 0.888 ± 0.015	0.789TrpVal: 0.789 ± 0.012	0.244TrpTrp: 0.244 ± 0.007	0.392TrpTyr: 0.392 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.082TyrAla: 2.082 ± 0.022	0.39TyrCys: 0.39 ± 0.009	1.649TyrAsp: 1.649 ± 0.022	1.49TyrGlu: 1.49 ± 0.019	1.205TyrPhe: 1.205 ± 0.016	1.902TyrGly: 1.902 ± 0.025	0.807TyrHis: 0.807 ± 0.012	1.565TyrIle: 1.565 ± 0.016	1.112TyrLys: 1.112 ± 0.016	2.708TyrLeu: 2.708 ± 0.023	0.606TyrMet: 0.606 ± 0.012	1.148TyrAsn: 1.148 ± 0.017	1.602TyrPro: 1.602 ± 0.022	1.032TyrGln: 1.032 ± 0.015	1.539TyrArg: 1.539 ± 0.017	2.267TyrSer: 2.267 ± 0.023	1.77TyrThr: 1.77 ± 0.02	1.657TyrVal: 1.657 ± 0.015	0.404TyrTrp: 0.404 ± 0.009	0.914TyrTyr: 0.914 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12046 proteins (5294775 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---