Amino acid dipepetide frequency for Prochlorococcus marinus (strain NATL2A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.356AlaAla: 5.356 ± 0.258	0.893AlaCys: 0.893 ± 0.046	3.069AlaAsp: 3.069 ± 0.103	4.018AlaGlu: 4.018 ± 0.096	2.839AlaPhe: 2.839 ± 0.114	4.688AlaGly: 4.688 ± 0.182	1.024AlaHis: 1.024 ± 0.056	5.474AlaIle: 5.474 ± 0.122	4.256AlaLys: 4.256 ± 0.097	7.314AlaLeu: 7.314 ± 0.131	1.789AlaMet: 1.789 ± 0.104	2.772AlaAsn: 2.772 ± 0.074	2.075AlaPro: 2.075 ± 0.076	2.077AlaGln: 2.077 ± 0.068	2.89AlaArg: 2.89 ± 0.085	4.924AlaSer: 4.924 ± 0.1	2.867AlaThr: 2.867 ± 0.078	3.838AlaVal: 3.838 ± 0.106	0.842AlaTrp: 0.842 ± 0.036	1.654AlaTyr: 1.654 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.576CysAla: 0.576 ± 0.035	0.197CysCys: 0.197 ± 0.02	0.681CysAsp: 0.681 ± 0.034	0.691CysGlu: 0.691 ± 0.041	0.571CysPhe: 0.571 ± 0.033	0.917CysGly: 0.917 ± 0.046	0.268CysHis: 0.268 ± 0.024	0.814CysIle: 0.814 ± 0.039	0.677CysLys: 0.677 ± 0.036	1.235CysLeu: 1.235 ± 0.054	0.163CysMet: 0.163 ± 0.017	0.526CysAsn: 0.526 ± 0.035	0.55CysPro: 0.55 ± 0.03	0.35CysGln: 0.35 ± 0.025	0.545CysArg: 0.545 ± 0.033	0.971CysSer: 0.971 ± 0.048	0.492CysThr: 0.492 ± 0.03	0.584CysVal: 0.584 ± 0.039	0.243CysTrp: 0.243 ± 0.021	0.296CysTyr: 0.296 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.906AspAla: 2.906 ± 0.087	0.588AspCys: 0.588 ± 0.04	2.425AspAsp: 2.425 ± 0.079	3.374AspGlu: 3.374 ± 0.084	2.48AspPhe: 2.48 ± 0.067	3.385AspGly: 3.385 ± 0.087	1.05AspHis: 1.05 ± 0.08	3.73AspIle: 3.73 ± 0.088	3.354AspLys: 3.354 ± 0.099	7.147AspLeu: 7.147 ± 0.121	0.958AspMet: 0.958 ± 0.042	2.409AspAsn: 2.409 ± 0.071	2.781AspPro: 2.781 ± 0.129	2.369AspGln: 2.369 ± 0.086	2.319AspArg: 2.319 ± 0.063	3.891AspSer: 3.891 ± 0.094	1.941AspThr: 1.941 ± 0.07	2.792AspVal: 2.792 ± 0.077	0.951AspTrp: 0.951 ± 0.043	1.598AspTyr: 1.598 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.68GluAla: 4.68 ± 0.101	0.571GluCys: 0.571 ± 0.029	3.241GluAsp: 3.241 ± 0.083	4.815GluGlu: 4.815 ± 0.12	2.289GluPhe: 2.289 ± 0.066	3.932GluGly: 3.932 ± 0.082	0.895GluHis: 0.895 ± 0.04	5.938GluIle: 5.938 ± 0.128	5.581GluLys: 5.581 ± 0.108	7.684GluLeu: 7.684 ± 0.139	1.51GluMet: 1.51 ± 0.06	3.507GluAsn: 3.507 ± 0.087	2.025GluPro: 2.025 ± 0.069	2.049GluGln: 2.049 ± 0.066	3.211GluArg: 3.211 ± 0.087	4.276GluSer: 4.276 ± 0.093	2.976GluThr: 2.976 ± 0.079	3.908GluVal: 3.908 ± 0.095	0.898GluTrp: 0.898 ± 0.04	1.449GluTyr: 1.449 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.802PheAla: 2.802 ± 0.087	0.608PheCys: 0.608 ± 0.036	2.906PheAsp: 2.906 ± 0.174	2.555PheGlu: 2.555 ± 0.068	1.974PhePhe: 1.974 ± 0.078	3.103PheGly: 3.103 ± 0.099	0.777PheHis: 0.777 ± 0.039	3.221PheIle: 3.221 ± 0.094	2.599PheLys: 2.599 ± 0.077	4.941PheLeu: 4.941 ± 0.11	0.773PheMet: 0.773 ± 0.041	2.362PheAsn: 2.362 ± 0.067	1.641PhePro: 1.641 ± 0.057	1.419PheGln: 1.419 ± 0.06	1.74PheArg: 1.74 ± 0.058	3.75PheSer: 3.75 ± 0.091	1.967PheThr: 1.967 ± 0.067	2.156PheVal: 2.156 ± 0.07	0.655PheTrp: 0.655 ± 0.039	1.22PheTyr: 1.22 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.505GlyAla: 4.505 ± 0.119	0.928GlyCys: 0.928 ± 0.04	3.232GlyAsp: 3.232 ± 0.095	3.887GlyGlu: 3.887 ± 0.083	3.58GlyPhe: 3.58 ± 0.134	5.311GlyGly: 5.311 ± 0.231	1.243GlyHis: 1.243 ± 0.057	5.852GlyIle: 5.852 ± 0.116	4.473GlyLys: 4.473 ± 0.121	7.624GlyLeu: 7.624 ± 0.133	1.596GlyMet: 1.596 ± 0.056	2.82GlyAsn: 2.82 ± 0.088	2.216GlyPro: 2.216 ± 0.063	2.199GlyGln: 2.199 ± 0.075	3.11GlyArg: 3.11 ± 0.085	4.89GlySer: 4.89 ± 0.124	3.103GlyThr: 3.103 ± 0.08	4.375GlyVal: 4.375 ± 0.102	1.151GlyTrp: 1.151 ± 0.05	2.001GlyTyr: 2.001 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	0.971HisAla: 0.971 ± 0.055	0.221HisCys: 0.221 ± 0.022	0.704HisAsp: 0.704 ± 0.045	0.831HisGlu: 0.831 ± 0.042	0.775HisPhe: 0.775 ± 0.052	1.177HisGly: 1.177 ± 0.053	0.513HisHis: 0.513 ± 0.042	1.112HisIle: 1.112 ± 0.044	0.999HisLys: 0.999 ± 0.046	2.16HisLeu: 2.16 ± 0.081	0.313HisMet: 0.313 ± 0.027	0.741HisAsn: 0.741 ± 0.04	1.044HisPro: 1.044 ± 0.041	0.715HisGln: 0.715 ± 0.032	0.887HisArg: 0.887 ± 0.041	1.299HisSer: 1.299 ± 0.054	0.767HisThr: 0.767 ± 0.039	0.775HisVal: 0.775 ± 0.049	0.303HisTrp: 0.303 ± 0.027	0.492HisTyr: 0.492 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.556IleAla: 5.556 ± 0.111	1.055IleCys: 1.055 ± 0.046	5.203IleAsp: 5.203 ± 0.109	5.59IleGlu: 5.59 ± 0.114	3.329IlePhe: 3.329 ± 0.085	5.7IleGly: 5.7 ± 0.129	1.394IleHis: 1.394 ± 0.056	5.425IleIle: 5.425 ± 0.134	5.908IleLys: 5.908 ± 0.123	7.226IleLeu: 7.226 ± 0.142	1.016IleMet: 1.016 ± 0.045	5.345IleAsn: 5.345 ± 0.13	3.606IlePro: 3.606 ± 0.084	2.558IleGln: 2.558 ± 0.075	3.228IleArg: 3.228 ± 0.098	6.999IleSer: 6.999 ± 0.135	3.956IleThr: 3.956 ± 0.092	3.915IleVal: 3.915 ± 0.107	1.031IleTrp: 1.031 ± 0.048	1.935IleTyr: 1.935 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.591LysAla: 4.591 ± 0.12	0.591LysCys: 0.591 ± 0.038	4.194LysAsp: 4.194 ± 0.138	5.845LysGlu: 5.845 ± 0.12	2.319LysPhe: 2.319 ± 0.077	4.186LysGly: 4.186 ± 0.094	0.93LysHis: 0.93 ± 0.041	5.598LysIle: 5.598 ± 0.118	6.34LysLys: 6.34 ± 0.141	7.093LysLeu: 7.093 ± 0.131	1.349LysMet: 1.349 ± 0.051	4.645LysAsn: 4.645 ± 0.106	2.637LysPro: 2.637 ± 0.081	2.231LysGln: 2.231 ± 0.069	3.427LysArg: 3.427 ± 0.082	5.354LysSer: 5.354 ± 0.099	3.803LysThr: 3.803 ± 0.08	3.823LysVal: 3.823 ± 0.076	0.962LysTrp: 0.962 ± 0.045	1.965LysTyr: 1.965 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	7.433LeuAla: 7.433 ± 0.143	1.089LeuCys: 1.089 ± 0.053	5.747LeuAsp: 5.747 ± 0.101	7.478LeuGlu: 7.478 ± 0.133	4.703LeuPhe: 4.703 ± 0.112	7.602LeuGly: 7.602 ± 0.144	1.651LeuHis: 1.651 ± 0.059	9.793LeuIle: 9.793 ± 0.166	8.174LeuLys: 8.174 ± 0.137	12.151LeuLeu: 12.151 ± 0.206	2.221LeuMet: 2.221 ± 0.072	5.931LeuAsn: 5.931 ± 0.133	4.836LeuPro: 4.836 ± 0.11	3.603LeuGln: 3.603 ± 0.095	4.868LeuArg: 4.868 ± 0.095	8.964LeuSer: 8.964 ± 0.144	5.33LeuThr: 5.33 ± 0.115	6.284LeuVal: 6.284 ± 0.116	1.241LeuTrp: 1.241 ± 0.065	2.21LeuTyr: 2.21 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.862MetAla: 1.862 ± 0.127	0.146MetCys: 0.146 ± 0.016	0.979MetAsp: 0.979 ± 0.042	1.145MetGlu: 1.145 ± 0.05	0.661MetPhe: 0.661 ± 0.043	1.593MetGly: 1.593 ± 0.07	0.314MetHis: 0.314 ± 0.024	1.4MetIle: 1.4 ± 0.06	1.527MetLys: 1.527 ± 0.06	1.694MetLeu: 1.694 ± 0.058	0.309MetMet: 0.309 ± 0.028	1.235MetAsn: 1.235 ± 0.049	1.037MetPro: 1.037 ± 0.036	0.681MetGln: 0.681 ± 0.04	0.943MetArg: 0.943 ± 0.044	1.666MetSer: 1.666 ± 0.057	1.282MetThr: 1.282 ± 0.05	1.128MetVal: 1.128 ± 0.045	0.122MetTrp: 0.122 ± 0.015	0.314MetTyr: 0.314 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.759AsnAla: 2.759 ± 0.078	0.657AsnCys: 0.657 ± 0.038	2.723AsnAsp: 2.723 ± 0.077	3.316AsnGlu: 3.316 ± 0.078	2.293AsnPhe: 2.293 ± 0.076	2.961AsnGly: 2.961 ± 0.086	0.984AsnHis: 0.984 ± 0.042	4.188AsnIle: 4.188 ± 0.111	4.158AsnLys: 4.158 ± 0.104	6.097AsnLeu: 6.097 ± 0.142	0.997AsnMet: 0.997 ± 0.042	3.253AsnAsn: 3.253 ± 0.096	2.626AsnPro: 2.626 ± 0.082	2.474AsnGln: 2.474 ± 0.072	2.268AsnArg: 2.268 ± 0.063	4.334AsnSer: 4.334 ± 0.093	2.242AsnThr: 2.242 ± 0.077	2.412AsnVal: 2.412 ± 0.073	0.876AsnTrp: 0.876 ± 0.045	1.638AsnTyr: 1.638 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.094ProAla: 2.094 ± 0.073	0.417ProCys: 0.417 ± 0.03	2.188ProAsp: 2.188 ± 0.059	3.002ProGlu: 3.002 ± 0.089	1.888ProPhe: 1.888 ± 0.065	2.656ProGly: 2.656 ± 0.083	0.721ProHis: 0.721 ± 0.039	3.374ProIle: 3.374 ± 0.072	2.659ProLys: 2.659 ± 0.069	4.512ProLeu: 4.512 ± 0.089	0.788ProMet: 0.788 ± 0.067	2.165ProAsn: 2.165 ± 0.067	1.538ProPro: 1.538 ± 0.076	1.271ProGln: 1.271 ± 0.048	1.563ProArg: 1.563 ± 0.047	3.442ProSer: 3.442 ± 0.09	2.251ProThr: 2.251 ± 0.079	2.495ProVal: 2.495 ± 0.075	0.648ProTrp: 0.648 ± 0.038	1.149ProTyr: 1.149 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.319GlnAla: 2.319 ± 0.075	0.286GlnCys: 0.286 ± 0.022	1.54GlnAsp: 1.54 ± 0.054	2.373GlnGlu: 2.373 ± 0.073	1.269GlnPhe: 1.269 ± 0.045	2.072GlnGly: 2.072 ± 0.066	0.46GlnHis: 0.46 ± 0.033	3.067GlnIle: 3.067 ± 0.075	2.813GlnLys: 2.813 ± 0.071	4.136GlnLeu: 4.136 ± 0.088	0.743GlnMet: 0.743 ± 0.037	1.767GlnAsn: 1.767 ± 0.066	1.235GlnPro: 1.235 ± 0.05	1.258GlnGln: 1.258 ± 0.053	1.767GlnArg: 1.767 ± 0.06	2.513GlnSer: 2.513 ± 0.071	1.54GlnThr: 1.54 ± 0.054	2.152GlnVal: 2.152 ± 0.082	0.479GlnTrp: 0.479 ± 0.036	0.724GlnTyr: 0.724 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.579ArgAla: 2.579 ± 0.07	0.498ArgCys: 0.498 ± 0.029	2.272ArgAsp: 2.272 ± 0.066	2.91ArgGlu: 2.91 ± 0.089	2.019ArgPhe: 2.019 ± 0.063	2.734ArgGly: 2.734 ± 0.081	0.784ArgHis: 0.784 ± 0.043	3.528ArgIle: 3.528 ± 0.084	3.277ArgLys: 3.277 ± 0.096	5.334ArgLeu: 5.334 ± 0.13	0.956ArgMet: 0.956 ± 0.045	2.231ArgAsn: 2.231 ± 0.068	1.776ArgPro: 1.776 ± 0.068	1.765ArgGln: 1.765 ± 0.055	2.695ArgArg: 2.695 ± 0.081	3.245ArgSer: 3.245 ± 0.077	1.842ArgThr: 1.842 ± 0.062	2.641ArgVal: 2.641 ± 0.076	0.771ArgTrp: 0.771 ± 0.044	1.379ArgTyr: 1.379 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.248SerAla: 4.248 ± 0.095	0.876SerCys: 0.876 ± 0.041	3.949SerAsp: 3.949 ± 0.096	4.804SerGlu: 4.804 ± 0.095	3.762SerPhe: 3.762 ± 0.089	5.403SerGly: 5.403 ± 0.135	1.312SerHis: 1.312 ± 0.046	6.492SerIle: 6.492 ± 0.112	5.777SerLys: 5.777 ± 0.103	8.979SerLeu: 8.979 ± 0.155	1.688SerMet: 1.688 ± 0.056	4.594SerAsn: 4.594 ± 0.12	2.818SerPro: 2.818 ± 0.07	2.693SerGln: 2.693 ± 0.073	3.419SerArg: 3.419 ± 0.089	6.632SerSer: 6.632 ± 0.157	3.885SerThr: 3.885 ± 0.08	3.831SerVal: 3.831 ± 0.094	1.125SerTrp: 1.125 ± 0.047	2.051SerTyr: 2.051 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	3.047ThrAla: 3.047 ± 0.104	0.591ThrCys: 0.591 ± 0.031	2.375ThrAsp: 2.375 ± 0.068	2.614ThrGlu: 2.614 ± 0.069	2.081ThrPhe: 2.081 ± 0.068	3.685ThrGly: 3.685 ± 0.114	0.889ThrHis: 0.889 ± 0.039	3.597ThrIle: 3.597 ± 0.08	3.174ThrLys: 3.174 ± 0.083	4.961ThrLeu: 4.961 ± 0.097	0.786ThrMet: 0.786 ± 0.04	2.588ThrAsn: 2.588 ± 0.082	2.322ThrPro: 2.322 ± 0.076	1.492ThrGln: 1.492 ± 0.052	1.943ThrArg: 1.943 ± 0.065	3.915ThrSer: 3.915 ± 0.107	2.629ThrThr: 2.629 ± 0.077	2.551ThrVal: 2.551 ± 0.075	0.586ThrTrp: 0.586 ± 0.044	1.344ThrTyr: 1.344 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.115ValAla: 4.115 ± 0.149	0.601ValCys: 0.601 ± 0.035	3.18ValAsp: 3.18 ± 0.081	3.661ValGlu: 3.661 ± 0.088	2.538ValPhe: 2.538 ± 0.083	3.934ValGly: 3.934 ± 0.11	0.932ValHis: 0.932 ± 0.045	4.499ValIle: 4.499 ± 0.092	3.322ValLys: 3.322 ± 0.082	6.193ValLeu: 6.193 ± 0.112	1.198ValMet: 1.198 ± 0.051	2.626ValAsn: 2.626 ± 0.074	2.296ValPro: 2.296 ± 0.064	1.658ValGln: 1.658 ± 0.054	2.407ValArg: 2.407 ± 0.073	4.158ValSer: 4.158 ± 0.084	2.702ValThr: 2.702 ± 0.088	3.878ValVal: 3.878 ± 0.109	0.633ValTrp: 0.633 ± 0.039	1.196ValTyr: 1.196 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.835TrpAla: 0.835 ± 0.046	0.182TrpCys: 0.182 ± 0.021	0.745TrpAsp: 0.745 ± 0.041	0.853TrpGlu: 0.853 ± 0.041	0.633TrpPhe: 0.633 ± 0.037	0.921TrpGly: 0.921 ± 0.042	0.284TrpHis: 0.284 ± 0.025	1.205TrpIle: 1.205 ± 0.055	0.928TrpLys: 0.928 ± 0.038	1.727TrpLeu: 1.727 ± 0.058	0.387TrpMet: 0.387 ± 0.029	0.687TrpAsn: 0.687 ± 0.041	0.586TrpPro: 0.586 ± 0.037	0.545TrpGln: 0.545 ± 0.032	0.692TrpArg: 0.692 ± 0.039	1.082TrpSer: 1.082 ± 0.05	0.588TrpThr: 0.588 ± 0.033	0.866TrpVal: 0.866 ± 0.05	0.241TrpTrp: 0.241 ± 0.022	0.298TrpTyr: 0.298 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.424TyrAla: 1.424 ± 0.058	0.352TyrCys: 0.352 ± 0.025	1.095TyrAsp: 1.095 ± 0.047	1.673TyrGlu: 1.673 ± 0.055	1.168TyrPhe: 1.168 ± 0.047	2.137TyrGly: 2.137 ± 0.077	0.374TyrHis: 0.374 ± 0.028	1.673TyrIle: 1.673 ± 0.054	1.885TyrLys: 1.885 ± 0.06	3.103TyrLeu: 3.103 ± 0.092	0.494TyrMet: 0.494 ± 0.029	1.054TyrAsn: 1.054 ± 0.048	1.173TyrPro: 1.173 ± 0.045	1.108TyrGln: 1.108 ± 0.048	1.314TyrArg: 1.314 ± 0.059	2.032TyrSer: 2.032 ± 0.063	1.007TyrThr: 1.007 ± 0.051	1.319TyrVal: 1.319 ± 0.057	0.528TyrTrp: 0.528 ± 0.033	0.586TyrTyr: 0.586 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2142 proteins (534346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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