Amino acid dipepetide frequency for Acinetobacter populi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.536AlaAla: 7.536 ± 0.118
0.894AlaCys: 0.894 ± 0.029
4.467AlaAsp: 4.467 ± 0.07
5.168AlaGlu: 5.168 ± 0.088
3.36AlaPhe: 3.36 ± 0.062
5.967AlaGly: 5.967 ± 0.095
1.795AlaHis: 1.795 ± 0.044
6.313AlaIle: 6.313 ± 0.084
5.016AlaLys: 5.016 ± 0.097
9.732AlaLeu: 9.732 ± 0.108
2.276AlaMet: 2.276 ± 0.048
3.534AlaAsn: 3.534 ± 0.06
2.902AlaPro: 2.902 ± 0.054
5.0AlaGln: 5.0 ± 0.079
3.454AlaArg: 3.454 ± 0.062
4.998AlaSer: 4.998 ± 0.079
4.745AlaThr: 4.745 ± 0.084
5.673AlaVal: 5.673 ± 0.085
1.114AlaTrp: 1.114 ± 0.034
2.732AlaTyr: 2.732 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.738CysAla: 0.738 ± 0.025
0.148CysCys: 0.148 ± 0.012
0.479CysAsp: 0.479 ± 0.021
0.482CysGlu: 0.482 ± 0.019
0.423CysPhe: 0.423 ± 0.021
0.717CysGly: 0.717 ± 0.027
0.295CysHis: 0.295 ± 0.016
0.674CysIle: 0.674 ± 0.023
0.37CysLys: 0.37 ± 0.02
1.021CysLeu: 1.021 ± 0.035
0.229CysMet: 0.229 ± 0.014
0.323CysAsn: 0.323 ± 0.019
0.405CysPro: 0.405 ± 0.02
0.461CysGln: 0.461 ± 0.021
0.394CysArg: 0.394 ± 0.019
0.612CysSer: 0.612 ± 0.026
0.42CysThr: 0.42 ± 0.02
0.61CysVal: 0.61 ± 0.022
0.121CysTrp: 0.121 ± 0.012
0.316CysTyr: 0.316 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.627AspAla: 4.627 ± 0.084
0.426AspCys: 0.426 ± 0.019
2.744AspAsp: 2.744 ± 0.075
3.168AspGlu: 3.168 ± 0.065
2.54AspPhe: 2.54 ± 0.054
3.351AspGly: 3.351 ± 0.08
1.426AspHis: 1.426 ± 0.036
4.063AspIle: 4.063 ± 0.07
2.56AspLys: 2.56 ± 0.053
5.741AspLeu: 5.741 ± 0.073
1.183AspMet: 1.183 ± 0.034
2.042AspAsn: 2.042 ± 0.052
2.1AspPro: 2.1 ± 0.045
3.304AspGln: 3.304 ± 0.067
2.426AspArg: 2.426 ± 0.05
2.719AspSer: 2.719 ± 0.054
2.524AspThr: 2.524 ± 0.063
3.648AspVal: 3.648 ± 0.06
0.878AspTrp: 0.878 ± 0.028
2.215AspTyr: 2.215 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.453GluAla: 4.453 ± 0.077
0.375GluCys: 0.375 ± 0.02
2.727GluAsp: 2.727 ± 0.061
2.85GluGlu: 2.85 ± 0.057
2.089GluPhe: 2.089 ± 0.045
2.971GluGly: 2.971 ± 0.057
1.528GluHis: 1.528 ± 0.039
4.291GluIle: 4.291 ± 0.068
3.648GluLys: 3.648 ± 0.061
5.573GluLeu: 5.573 ± 0.089
1.322GluMet: 1.322 ± 0.033
2.913GluAsn: 2.913 ± 0.048
1.624GluPro: 1.624 ± 0.045
4.547GluGln: 4.547 ± 0.076
2.767GluArg: 2.767 ± 0.057
2.742GluSer: 2.742 ± 0.058
2.836GluThr: 2.836 ± 0.051
3.434GluVal: 3.434 ± 0.058
0.696GluTrp: 0.696 ± 0.025
1.75GluTyr: 1.75 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.983PheAla: 3.983 ± 0.06
0.469PheCys: 0.469 ± 0.021
2.76PheAsp: 2.76 ± 0.06
2.333PheGlu: 2.333 ± 0.049
1.892PhePhe: 1.892 ± 0.056
3.073PheGly: 3.073 ± 0.066
0.818PheHis: 0.818 ± 0.028
3.099PheIle: 3.099 ± 0.065
2.301PheLys: 2.301 ± 0.055
3.8PheLeu: 3.8 ± 0.067
1.035PheMet: 1.035 ± 0.033
2.216PheAsn: 2.216 ± 0.043
1.507PhePro: 1.507 ± 0.041
1.567PheGln: 1.567 ± 0.038
1.417PheArg: 1.417 ± 0.04
3.087PheSer: 3.087 ± 0.063
2.067PheThr: 2.067 ± 0.049
2.491PheVal: 2.491 ± 0.048
0.628PheTrp: 0.628 ± 0.025
1.569PheTyr: 1.569 ± 0.041
0.001PheXaa: 0.001 ± 0.001
Gly
5.148GlyAla: 5.148 ± 0.106
0.785GlyCys: 0.785 ± 0.029
3.083GlyAsp: 3.083 ± 0.075
3.754GlyGlu: 3.754 ± 0.075
3.234GlyPhe: 3.234 ± 0.066
4.696GlyGly: 4.696 ± 0.083
1.526GlyHis: 1.526 ± 0.043
5.02GlyIle: 5.02 ± 0.079
3.704GlyLys: 3.704 ± 0.071
7.109GlyLeu: 7.109 ± 0.097
1.723GlyMet: 1.723 ± 0.05
2.674GlyAsn: 2.674 ± 0.068
1.387GlyPro: 1.387 ± 0.042
3.43GlyGln: 3.43 ± 0.066
2.852GlyArg: 2.852 ± 0.059
3.85GlySer: 3.85 ± 0.085
3.691GlyThr: 3.691 ± 0.085
4.571GlyVal: 4.571 ± 0.07
0.943GlyTrp: 0.943 ± 0.029
2.561GlyTyr: 2.561 ± 0.055
0.001GlyXaa: 0.001 ± 0.001
His
2.103HisAla: 2.103 ± 0.047
0.316HisCys: 0.316 ± 0.019
1.327HisAsp: 1.327 ± 0.039
1.1HisGlu: 1.1 ± 0.031
1.156HisPhe: 1.156 ± 0.032
1.577HisGly: 1.577 ± 0.046
0.835HisHis: 0.835 ± 0.027
1.745HisIle: 1.745 ± 0.043
0.895HisLys: 0.895 ± 0.033
2.645HisLeu: 2.645 ± 0.053
0.498HisMet: 0.498 ± 0.02
0.848HisAsn: 0.848 ± 0.028
1.277HisPro: 1.277 ± 0.032
1.548HisGln: 1.548 ± 0.048
1.049HisArg: 1.049 ± 0.036
1.281HisSer: 1.281 ± 0.037
1.156HisThr: 1.156 ± 0.036
1.415HisVal: 1.415 ± 0.039
0.386HisTrp: 0.386 ± 0.021
1.019HisTyr: 1.019 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.108IleAla: 7.108 ± 0.079
0.734IleCys: 0.734 ± 0.025
4.456IleAsp: 4.456 ± 0.07
4.684IleGlu: 4.684 ± 0.075
2.951IlePhe: 2.951 ± 0.066
5.081IleGly: 5.081 ± 0.093
1.642IleHis: 1.642 ± 0.046
4.427IleIle: 4.427 ± 0.077
3.571IleLys: 3.571 ± 0.064
6.932IleLeu: 6.932 ± 0.099
1.367IleMet: 1.367 ± 0.044
3.208IleAsn: 3.208 ± 0.063
2.936IlePro: 2.936 ± 0.054
3.59IleGln: 3.59 ± 0.061
3.05IleArg: 3.05 ± 0.055
4.638IleSer: 4.638 ± 0.062
3.677IleThr: 3.677 ± 0.076
4.385IleVal: 4.385 ± 0.076
0.78IleTrp: 0.78 ± 0.033
2.236IleTyr: 2.236 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.516LysAla: 4.516 ± 0.107
0.293LysCys: 0.293 ± 0.017
2.917LysAsp: 2.917 ± 0.056
2.672LysGlu: 2.672 ± 0.059
1.934LysPhe: 1.934 ± 0.043
2.944LysGly: 2.944 ± 0.063
1.242LysHis: 1.242 ± 0.037
4.025LysIle: 4.025 ± 0.066
3.212LysLys: 3.212 ± 0.059
5.15LysLeu: 5.15 ± 0.08
1.254LysMet: 1.254 ± 0.041
2.927LysAsn: 2.927 ± 0.052
2.141LysPro: 2.141 ± 0.049
3.427LysGln: 3.427 ± 0.061
2.333LysArg: 2.333 ± 0.046
2.988LysSer: 2.988 ± 0.059
3.224LysThr: 3.224 ± 0.057
3.421LysVal: 3.421 ± 0.062
0.556LysTrp: 0.556 ± 0.025
1.748LysTyr: 1.748 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
9.41LeuAla: 9.41 ± 0.119
1.099LeuCys: 1.099 ± 0.038
5.91LeuAsp: 5.91 ± 0.092
5.541LeuGlu: 5.541 ± 0.089
4.182LeuPhe: 4.182 ± 0.085
7.144LeuGly: 7.144 ± 0.1
2.205LeuHis: 2.205 ± 0.049
7.082LeuIle: 7.082 ± 0.096
6.331LeuLys: 6.331 ± 0.097
10.101LeuLeu: 10.101 ± 0.152
2.422LeuMet: 2.422 ± 0.054
5.252LeuAsn: 5.252 ± 0.077
4.73LeuPro: 4.73 ± 0.079
5.443LeuGln: 5.443 ± 0.101
4.223LeuArg: 4.223 ± 0.068
7.51LeuSer: 7.51 ± 0.089
5.745LeuThr: 5.745 ± 0.075
5.965LeuVal: 5.965 ± 0.083
1.18LeuTrp: 1.18 ± 0.038
2.949LeuTyr: 2.949 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.056MetAla: 2.056 ± 0.045
0.206MetCys: 0.206 ± 0.013
1.058MetAsp: 1.058 ± 0.031
0.907MetGlu: 0.907 ± 0.027
0.785MetPhe: 0.785 ± 0.028
1.58MetGly: 1.58 ± 0.046
0.474MetHis: 0.474 ± 0.023
1.499MetIle: 1.499 ± 0.036
1.161MetLys: 1.161 ± 0.035
2.393MetLeu: 2.393 ± 0.063
0.646MetMet: 0.646 ± 0.026
1.221MetAsn: 1.221 ± 0.039
1.048MetPro: 1.048 ± 0.034
1.532MetGln: 1.532 ± 0.04
1.019MetArg: 1.019 ± 0.033
1.753MetSer: 1.753 ± 0.04
1.401MetThr: 1.401 ± 0.038
1.47MetVal: 1.47 ± 0.042
0.189MetTrp: 0.189 ± 0.014
0.567MetTyr: 0.567 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.764AsnAla: 3.764 ± 0.067
0.329AsnCys: 0.329 ± 0.019
2.351AsnAsp: 2.351 ± 0.049
2.154AsnGlu: 2.154 ± 0.049
1.918AsnPhe: 1.918 ± 0.045
2.902AsnGly: 2.902 ± 0.066
1.093AsnHis: 1.093 ± 0.03
3.708AsnIle: 3.708 ± 0.068
2.233AsnLys: 2.233 ± 0.046
4.475AsnLeu: 4.475 ± 0.072
0.909AsnMet: 0.909 ± 0.024
2.163AsnAsn: 2.163 ± 0.061
2.267AsnPro: 2.267 ± 0.049
2.645AsnGln: 2.645 ± 0.064
1.867AsnArg: 1.867 ± 0.042
2.609AsnSer: 2.609 ± 0.06
2.651AsnThr: 2.651 ± 0.063
2.711AsnVal: 2.711 ± 0.052
0.609AsnTrp: 0.609 ± 0.026
1.691AsnTyr: 1.691 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.11ProAla: 3.11 ± 0.059
0.243ProCys: 0.243 ± 0.018
2.317ProAsp: 2.317 ± 0.048
3.164ProGlu: 3.164 ± 0.059
1.717ProPhe: 1.717 ± 0.043
1.652ProGly: 1.652 ± 0.039
0.944ProHis: 0.944 ± 0.031
2.647ProIle: 2.647 ± 0.055
2.169ProLys: 2.169 ± 0.05
3.985ProLeu: 3.985 ± 0.071
0.897ProMet: 0.897 ± 0.03
1.842ProAsn: 1.842 ± 0.049
1.154ProPro: 1.154 ± 0.035
2.233ProGln: 2.233 ± 0.044
1.398ProArg: 1.398 ± 0.041
2.339ProSer: 2.339 ± 0.048
2.227ProThr: 2.227 ± 0.049
3.011ProVal: 3.011 ± 0.055
0.449ProTrp: 0.449 ± 0.022
1.386ProTyr: 1.386 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
5.316GlnAla: 5.316 ± 0.088
0.46GlnCys: 0.46 ± 0.023
2.943GlnAsp: 2.943 ± 0.054
2.623GlnGlu: 2.623 ± 0.061
2.295GlnPhe: 2.295 ± 0.046
3.488GlnGly: 3.488 ± 0.071
2.09GlnHis: 2.09 ± 0.052
3.874GlnIle: 3.874 ± 0.069
2.977GlnLys: 2.977 ± 0.063
6.403GlnLeu: 6.403 ± 0.114
1.161GlnMet: 1.161 ± 0.037
2.589GlnAsn: 2.589 ± 0.054
2.374GlnPro: 2.374 ± 0.056
5.506GlnGln: 5.506 ± 0.153
2.667GlnArg: 2.667 ± 0.06
3.445GlnSer: 3.445 ± 0.07
2.921GlnThr: 2.921 ± 0.056
3.546GlnVal: 3.546 ± 0.065
0.783GlnTrp: 0.783 ± 0.028
2.058GlnTyr: 2.058 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.131ArgAla: 3.131 ± 0.053
0.35ArgCys: 0.35 ± 0.017
2.136ArgAsp: 2.136 ± 0.052
2.514ArgGlu: 2.514 ± 0.054
2.011ArgPhe: 2.011 ± 0.045
2.456ArgGly: 2.456 ± 0.056
1.194ArgHis: 1.194 ± 0.036
3.286ArgIle: 3.286 ± 0.057
2.12ArgLys: 2.12 ± 0.041
4.846ArgLeu: 4.846 ± 0.079
1.051ArgMet: 1.051 ± 0.03
1.784ArgAsn: 1.784 ± 0.039
1.654ArgPro: 1.654 ± 0.044
2.669ArgGln: 2.669 ± 0.055
1.923ArgArg: 1.923 ± 0.048
2.282ArgSer: 2.282 ± 0.05
1.98ArgThr: 1.98 ± 0.044
2.7ArgVal: 2.7 ± 0.056
0.571ArgTrp: 0.571 ± 0.023
1.87ArgTyr: 1.87 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.922SerAla: 4.922 ± 0.077
0.523SerCys: 0.523 ± 0.021
3.129SerAsp: 3.129 ± 0.062
3.232SerGlu: 3.232 ± 0.062
2.701SerPhe: 2.701 ± 0.054
4.547SerGly: 4.547 ± 0.078
1.428SerHis: 1.428 ± 0.043
4.48SerIle: 4.48 ± 0.075
3.02SerLys: 3.02 ± 0.061
6.272SerLeu: 6.272 ± 0.08
1.391SerMet: 1.391 ± 0.037
2.89SerAsn: 2.89 ± 0.067
2.342SerPro: 2.342 ± 0.053
3.039SerGln: 3.039 ± 0.057
2.629SerArg: 2.629 ± 0.051
4.23SerSer: 4.23 ± 0.082
3.53SerThr: 3.53 ± 0.072
3.732SerVal: 3.732 ± 0.063
0.77SerTrp: 0.77 ± 0.027
2.153SerTyr: 2.153 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.177ThrAla: 5.177 ± 0.096
0.428ThrCys: 0.428 ± 0.018
2.793ThrAsp: 2.793 ± 0.068
2.861ThrGlu: 2.861 ± 0.054
2.115ThrPhe: 2.115 ± 0.044
4.342ThrGly: 4.342 ± 0.114
1.214ThrHis: 1.214 ± 0.035
3.588ThrIle: 3.588 ± 0.068
2.181ThrLys: 2.181 ± 0.048
6.127ThrLeu: 6.127 ± 0.077
0.997ThrMet: 0.997 ± 0.033
1.893ThrAsn: 1.893 ± 0.052
2.667ThrPro: 2.667 ± 0.053
2.986ThrGln: 2.986 ± 0.058
2.121ThrArg: 2.121 ± 0.044
3.101ThrSer: 3.101 ± 0.074
3.422ThrThr: 3.422 ± 0.076
3.852ThrVal: 3.852 ± 0.068
0.655ThrTrp: 0.655 ± 0.025
1.648ThrTyr: 1.648 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.812ValAla: 5.812 ± 0.087
0.654ValCys: 0.654 ± 0.022
3.625ValAsp: 3.625 ± 0.063
3.952ValGlu: 3.952 ± 0.063
2.596ValPhe: 2.596 ± 0.052
4.268ValGly: 4.268 ± 0.075
1.158ValHis: 1.158 ± 0.034
4.688ValIle: 4.688 ± 0.075
3.352ValLys: 3.352 ± 0.063
6.571ValLeu: 6.571 ± 0.097
1.66ValMet: 1.66 ± 0.043
2.887ValAsn: 2.887 ± 0.055
2.531ValPro: 2.531 ± 0.052
2.96ValGln: 2.96 ± 0.063
2.531ValArg: 2.531 ± 0.047
3.925ValSer: 3.925 ± 0.064
3.624ValThr: 3.624 ± 0.07
4.423ValVal: 4.423 ± 0.071
0.762ValTrp: 0.762 ± 0.028
1.807ValTyr: 1.807 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.868TrpAla: 0.868 ± 0.027
0.144TrpCys: 0.144 ± 0.014
0.551TrpAsp: 0.551 ± 0.024
0.494TrpGlu: 0.494 ± 0.024
0.614TrpPhe: 0.614 ± 0.025
0.716TrpGly: 0.716 ± 0.027
0.385TrpHis: 0.385 ± 0.019
0.962TrpIle: 0.962 ± 0.033
0.576TrpLys: 0.576 ± 0.021
1.711TrpLeu: 1.711 ± 0.045
0.344TrpMet: 0.344 ± 0.019
0.573TrpAsn: 0.573 ± 0.024
0.316TrpPro: 0.316 ± 0.019
1.091TrpGln: 1.091 ± 0.036
0.611TrpArg: 0.611 ± 0.024
0.766TrpSer: 0.766 ± 0.029
0.635TrpThr: 0.635 ± 0.025
0.792TrpVal: 0.792 ± 0.029
0.157TrpTrp: 0.157 ± 0.013
0.395TrpTyr: 0.395 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.898TyrAla: 2.898 ± 0.06
0.362TyrCys: 0.362 ± 0.019
1.913TyrAsp: 1.913 ± 0.054
1.484TyrGlu: 1.484 ± 0.038
1.602TyrPhe: 1.602 ± 0.041
2.272TyrGly: 2.272 ± 0.052
0.882TyrHis: 0.882 ± 0.029
1.982TyrIle: 1.982 ± 0.044
1.525TyrLys: 1.525 ± 0.04
3.838TyrLeu: 3.838 ± 0.064
0.598TyrMet: 0.598 ± 0.024
1.268TyrAsn: 1.268 ± 0.036
1.525TyrPro: 1.525 ± 0.041
2.538TyrGln: 2.538 ± 0.053
1.795TyrArg: 1.795 ± 0.043
2.086TyrSer: 2.086 ± 0.054
1.693TyrThr: 1.693 ± 0.047
1.938TyrVal: 1.938 ± 0.041
0.473TyrTrp: 0.473 ± 0.021
1.198TyrTyr: 1.198 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3291 proteins (1064362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski