Amino acid dipepetide frequency for Flagellimonas maritima

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.099AlaAla: 4.099 ± 0.091	0.535AlaCys: 0.535 ± 0.026	3.247AlaAsp: 3.247 ± 0.069	3.881AlaGlu: 3.881 ± 0.072	3.216AlaPhe: 3.216 ± 0.057	4.022AlaGly: 4.022 ± 0.081	1.12AlaHis: 1.12 ± 0.032	5.251AlaIle: 5.251 ± 0.079	4.475AlaLys: 4.475 ± 0.074	5.977AlaLeu: 5.977 ± 0.096	1.574AlaMet: 1.574 ± 0.039	3.253AlaAsn: 3.253 ± 0.055	1.963AlaPro: 1.963 ± 0.054	2.282AlaGln: 2.282 ± 0.043	2.06AlaArg: 2.06 ± 0.047	4.153AlaSer: 4.153 ± 0.071	3.445AlaThr: 3.445 ± 0.078	3.963AlaVal: 3.963 ± 0.075	0.61AlaTrp: 0.61 ± 0.023	2.372AlaTyr: 2.372 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.444CysAla: 0.444 ± 0.026	0.097CysCys: 0.097 ± 0.009	0.414CysAsp: 0.414 ± 0.026	0.451CysGlu: 0.451 ± 0.02	0.41CysPhe: 0.41 ± 0.019	0.608CysGly: 0.608 ± 0.029	0.156CysHis: 0.156 ± 0.014	0.595CysIle: 0.595 ± 0.024	0.462CysLys: 0.462 ± 0.021	0.639CysLeu: 0.639 ± 0.024	0.142CysMet: 0.142 ± 0.012	0.415CysAsn: 0.415 ± 0.025	0.33CysPro: 0.33 ± 0.021	0.209CysGln: 0.209 ± 0.014	0.196CysArg: 0.196 ± 0.013	0.58CysSer: 0.58 ± 0.03	0.443CysThr: 0.443 ± 0.027	0.382CysVal: 0.382 ± 0.018	0.068CysTrp: 0.068 ± 0.008	0.292CysTyr: 0.292 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.645AspAla: 3.645 ± 0.062	0.447AspCys: 0.447 ± 0.033	3.388AspAsp: 3.388 ± 0.118	3.946AspGlu: 3.946 ± 0.067	3.928AspPhe: 3.928 ± 0.065	4.481AspGly: 4.481 ± 0.13	0.862AspHis: 0.862 ± 0.025	4.687AspIle: 4.687 ± 0.068	3.843AspLys: 3.843 ± 0.065	5.185AspLeu: 5.185 ± 0.068	1.225AspMet: 1.225 ± 0.036	3.071AspAsn: 3.071 ± 0.065	1.855AspPro: 1.855 ± 0.061	1.419AspGln: 1.419 ± 0.042	2.025AspArg: 2.025 ± 0.041	3.702AspSer: 3.702 ± 0.074	2.985AspThr: 2.985 ± 0.067	3.589AspVal: 3.589 ± 0.07	0.811AspTrp: 0.811 ± 0.027	2.84AspTyr: 2.84 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.075GluAla: 4.075 ± 0.067	0.309GluCys: 0.309 ± 0.018	3.816GluAsp: 3.816 ± 0.07	5.064GluGlu: 5.064 ± 0.093	2.933GluPhe: 2.933 ± 0.051	3.952GluGly: 3.952 ± 0.07	1.228GluHis: 1.228 ± 0.032	5.478GluIle: 5.478 ± 0.07	6.0GluLys: 6.0 ± 0.101	6.357GluLeu: 6.357 ± 0.079	1.546GluMet: 1.546 ± 0.044	4.932GluAsn: 4.932 ± 0.08	1.749GluPro: 1.749 ± 0.043	2.339GluGln: 2.339 ± 0.052	2.831GluArg: 2.831 ± 0.056	3.607GluSer: 3.607 ± 0.062	3.601GluThr: 3.601 ± 0.061	4.258GluVal: 4.258 ± 0.064	0.67GluTrp: 0.67 ± 0.026	2.384GluTyr: 2.384 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.908PheAla: 2.908 ± 0.053	0.449PheCys: 0.449 ± 0.02	3.482PheAsp: 3.482 ± 0.062	3.58PheGlu: 3.58 ± 0.055	2.984PhePhe: 2.984 ± 0.063	3.921PheGly: 3.921 ± 0.069	0.793PheHis: 0.793 ± 0.028	3.706PheIle: 3.706 ± 0.07	3.691PheLys: 3.691 ± 0.07	5.211PheLeu: 5.211 ± 0.088	1.209PheMet: 1.209 ± 0.031	3.143PheAsn: 3.143 ± 0.061	1.81PhePro: 1.81 ± 0.041	1.639PheGln: 1.639 ± 0.036	1.793PheArg: 1.793 ± 0.04	4.084PheSer: 4.084 ± 0.078	3.111PheThr: 3.111 ± 0.057	3.071PheVal: 3.071 ± 0.063	0.618PheTrp: 0.618 ± 0.025	2.19PheTyr: 2.19 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.212GlyAla: 4.212 ± 0.072	0.641GlyCys: 0.641 ± 0.031	3.694GlyAsp: 3.694 ± 0.074	3.971GlyGlu: 3.971 ± 0.065	3.937GlyPhe: 3.937 ± 0.075	4.728GlyGly: 4.728 ± 0.104	1.252GlyHis: 1.252 ± 0.035	5.716GlyIle: 5.716 ± 0.08	5.025GlyLys: 5.025 ± 0.073	6.189GlyLeu: 6.189 ± 0.088	1.632GlyMet: 1.632 ± 0.042	4.03GlyAsn: 4.03 ± 0.093	1.546GlyPro: 1.546 ± 0.042	2.033GlyGln: 2.033 ± 0.045	2.342GlyArg: 2.342 ± 0.046	4.306GlySer: 4.306 ± 0.078	4.17GlyThr: 4.17 ± 0.092	4.14GlyVal: 4.14 ± 0.077	0.819GlyTrp: 0.819 ± 0.038	2.907GlyTyr: 2.907 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.865HisAla: 0.865 ± 0.028	0.187HisCys: 0.187 ± 0.013	0.841HisAsp: 0.841 ± 0.024	1.003HisGlu: 1.003 ± 0.026	1.104HisPhe: 1.104 ± 0.035	1.074HisGly: 1.074 ± 0.033	0.475HisHis: 0.475 ± 0.022	1.398HisIle: 1.398 ± 0.034	1.212HisLys: 1.212 ± 0.036	1.797HisLeu: 1.797 ± 0.047	0.359HisMet: 0.359 ± 0.018	0.855HisAsn: 0.855 ± 0.028	0.888HisPro: 0.888 ± 0.031	0.701HisGln: 0.701 ± 0.025	0.729HisArg: 0.729 ± 0.028	1.043HisSer: 1.043 ± 0.034	0.963HisThr: 0.963 ± 0.029	0.995HisVal: 0.995 ± 0.03	0.231HisTrp: 0.231 ± 0.014	0.793HisTyr: 0.793 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.49IleAla: 5.49 ± 0.077	0.587IleCys: 0.587 ± 0.026	4.796IleAsp: 4.796 ± 0.065	5.073IleGlu: 5.073 ± 0.076	3.899IlePhe: 3.899 ± 0.066	5.188IleGly: 5.188 ± 0.076	1.323IleHis: 1.323 ± 0.04	5.635IleIle: 5.635 ± 0.088	5.499IleLys: 5.499 ± 0.08	7.402IleLeu: 7.402 ± 0.096	1.428IleMet: 1.428 ± 0.032	4.438IleAsn: 4.438 ± 0.077	3.277IlePro: 3.277 ± 0.057	2.449IleGln: 2.449 ± 0.052	2.741IleArg: 2.741 ± 0.057	5.737IleSer: 5.737 ± 0.068	4.64IleThr: 4.64 ± 0.094	4.709IleVal: 4.709 ± 0.077	0.766IleTrp: 0.766 ± 0.032	2.786IleTyr: 2.786 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.504LysAla: 4.504 ± 0.083	0.322LysCys: 0.322 ± 0.016	4.226LysAsp: 4.226 ± 0.067	6.114LysGlu: 6.114 ± 0.096	2.797LysPhe: 2.797 ± 0.057	4.492LysGly: 4.492 ± 0.071	1.303LysHis: 1.303 ± 0.037	6.1LysIle: 6.1 ± 0.093	7.062LysLys: 7.062 ± 0.115	6.446LysLeu: 6.446 ± 0.099	1.888LysMet: 1.888 ± 0.042	5.115LysAsn: 5.115 ± 0.09	2.335LysPro: 2.335 ± 0.042	2.443LysGln: 2.443 ± 0.055	3.133LysArg: 3.133 ± 0.059	4.665LysSer: 4.665 ± 0.079	4.209LysThr: 4.209 ± 0.06	4.565LysVal: 4.565 ± 0.077	0.842LysTrp: 0.842 ± 0.027	2.754LysTyr: 2.754 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	5.826LeuAla: 5.826 ± 0.08	0.714LeuCys: 0.714 ± 0.029	5.414LeuAsp: 5.414 ± 0.079	6.628LeuGlu: 6.628 ± 0.1	5.094LeuPhe: 5.094 ± 0.095	6.464LeuGly: 6.464 ± 0.086	1.533LeuHis: 1.533 ± 0.04	6.552LeuIle: 6.552 ± 0.096	7.75LeuLys: 7.75 ± 0.113	9.035LeuLeu: 9.035 ± 0.144	2.151LeuMet: 2.151 ± 0.047	5.595LeuAsn: 5.595 ± 0.081	3.543LeuPro: 3.543 ± 0.061	3.253LeuGln: 3.253 ± 0.054	3.551LeuArg: 3.551 ± 0.066	6.689LeuSer: 6.689 ± 0.079	4.878LeuThr: 4.878 ± 0.071	5.632LeuVal: 5.632 ± 0.083	0.884LeuTrp: 0.884 ± 0.037	3.169LeuTyr: 3.169 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.645MetAla: 1.645 ± 0.037	0.139MetCys: 0.139 ± 0.012	1.455MetAsp: 1.455 ± 0.036	1.667MetGlu: 1.667 ± 0.039	0.864MetPhe: 0.864 ± 0.03	1.595MetGly: 1.595 ± 0.034	0.416MetHis: 0.416 ± 0.018	1.412MetIle: 1.412 ± 0.034	2.002MetLys: 2.002 ± 0.04	1.987MetLeu: 1.987 ± 0.043	0.533MetMet: 0.533 ± 0.023	1.23MetAsn: 1.23 ± 0.032	0.85MetPro: 0.85 ± 0.029	0.773MetGln: 0.773 ± 0.03	0.925MetArg: 0.925 ± 0.03	1.228MetSer: 1.228 ± 0.033	1.107MetThr: 1.107 ± 0.028	1.52MetVal: 1.52 ± 0.042	0.153MetTrp: 0.153 ± 0.012	0.684MetTyr: 0.684 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.594AsnAla: 3.594 ± 0.056	0.441AsnCys: 0.441 ± 0.024	3.278AsnAsp: 3.278 ± 0.068	3.598AsnGlu: 3.598 ± 0.065	3.214AsnPhe: 3.214 ± 0.066	4.352AsnGly: 4.352 ± 0.087	1.075AsnHis: 1.075 ± 0.032	4.774AsnIle: 4.774 ± 0.074	3.723AsnLys: 3.723 ± 0.081	5.492AsnLeu: 5.492 ± 0.092	1.241AsnMet: 1.241 ± 0.031	3.47AsnAsn: 3.47 ± 0.072	2.896AsnPro: 2.896 ± 0.062	2.097AsnGln: 2.097 ± 0.044	2.372AsnArg: 2.372 ± 0.049	3.801AsnSer: 3.801 ± 0.073	3.545AsnThr: 3.545 ± 0.062	3.592AsnVal: 3.592 ± 0.073	0.755AsnTrp: 0.755 ± 0.027	2.606AsnTyr: 2.606 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.753ProAla: 1.753 ± 0.048	0.201ProCys: 0.201 ± 0.015	2.294ProAsp: 2.294 ± 0.067	2.815ProGlu: 2.815 ± 0.054	2.023ProPhe: 2.023 ± 0.043	1.993ProGly: 1.993 ± 0.058	0.594ProHis: 0.594 ± 0.022	2.851ProIle: 2.851 ± 0.053	2.784ProLys: 2.784 ± 0.056	3.15ProLeu: 3.15 ± 0.059	0.753ProMet: 0.753 ± 0.024	2.429ProAsn: 2.429 ± 0.049	0.999ProPro: 0.999 ± 0.047	1.093ProGln: 1.093 ± 0.032	1.058ProArg: 1.058 ± 0.034	2.309ProSer: 2.309 ± 0.044	2.022ProThr: 2.022 ± 0.066	2.188ProVal: 2.188 ± 0.044	0.365ProTrp: 0.365 ± 0.019	1.418ProTyr: 1.418 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.827GlnAla: 1.827 ± 0.047	0.16GlnCys: 0.16 ± 0.011	1.711GlnAsp: 1.711 ± 0.039	2.289GlnGlu: 2.289 ± 0.045	1.699GlnPhe: 1.699 ± 0.043	1.915GlnGly: 1.915 ± 0.053	0.586GlnHis: 0.586 ± 0.023	2.562GlnIle: 2.562 ± 0.049	2.721GlnLys: 2.721 ± 0.065	3.434GlnLeu: 3.434 ± 0.054	0.783GlnMet: 0.783 ± 0.024	2.224GlnAsn: 2.224 ± 0.047	1.007GlnPro: 1.007 ± 0.037	1.312GlnGln: 1.312 ± 0.038	1.344GlnArg: 1.344 ± 0.039	1.827GlnSer: 1.827 ± 0.042	1.688GlnThr: 1.688 ± 0.042	1.941GlnVal: 1.941 ± 0.044	0.402GlnTrp: 0.402 ± 0.02	1.248GlnTyr: 1.248 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.182ArgAla: 2.182 ± 0.047	0.218ArgCys: 0.218 ± 0.013	1.957ArgAsp: 1.957 ± 0.042	2.412ArgGlu: 2.412 ± 0.051	2.12ArgPhe: 2.12 ± 0.049	2.125ArgGly: 2.125 ± 0.046	0.64ArgHis: 0.64 ± 0.025	3.14ArgIle: 3.14 ± 0.059	3.005ArgLys: 3.005 ± 0.055	3.623ArgLeu: 3.623 ± 0.055	0.948ArgMet: 0.948 ± 0.026	2.334ArgAsn: 2.334 ± 0.049	1.245ArgPro: 1.245 ± 0.039	1.164ArgGln: 1.164 ± 0.034	1.499ArgArg: 1.499 ± 0.043	2.136ArgSer: 2.136 ± 0.061	2.049ArgThr: 2.049 ± 0.048	2.145ArgVal: 2.145 ± 0.049	0.444ArgTrp: 0.444 ± 0.02	1.708ArgTyr: 1.708 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.787SerAla: 3.787 ± 0.076	0.618SerCys: 0.618 ± 0.022	3.693SerAsp: 3.693 ± 0.079	4.173SerGlu: 4.173 ± 0.069	3.814SerPhe: 3.814 ± 0.066	4.796SerGly: 4.796 ± 0.079	1.069SerHis: 1.069 ± 0.032	5.414SerIle: 5.414 ± 0.08	4.95SerLys: 4.95 ± 0.079	6.281SerLeu: 6.281 ± 0.142	1.354SerMet: 1.354 ± 0.029	3.904SerAsn: 3.904 ± 0.063	2.246SerPro: 2.246 ± 0.047	2.034SerGln: 2.034 ± 0.043	2.307SerArg: 2.307 ± 0.046	4.309SerSer: 4.309 ± 0.077	3.481SerThr: 3.481 ± 0.072	3.846SerVal: 3.846 ± 0.065	0.67SerTrp: 0.67 ± 0.025	2.748SerTyr: 2.748 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.602ThrAla: 3.602 ± 0.079	0.344ThrCys: 0.344 ± 0.029	3.397ThrAsp: 3.397 ± 0.097	3.398ThrGlu: 3.398 ± 0.063	3.052ThrPhe: 3.052 ± 0.051	3.968ThrGly: 3.968 ± 0.079	0.92ThrHis: 0.92 ± 0.027	4.746ThrIle: 4.746 ± 0.072	3.607ThrLys: 3.607 ± 0.073	5.325ThrLeu: 5.325 ± 0.071	1.034ThrMet: 1.034 ± 0.032	3.137ThrAsn: 3.137 ± 0.068	2.314ThrPro: 2.314 ± 0.059	1.662ThrGln: 1.662 ± 0.045	1.704ThrArg: 1.704 ± 0.039	3.706ThrSer: 3.706 ± 0.057	3.308ThrThr: 3.308 ± 0.09	3.909ThrVal: 3.909 ± 0.089	0.579ThrTrp: 0.579 ± 0.031	2.252ThrTyr: 2.252 ± 0.072	0.0ThrXaa: 0.0 ± 0.0
Val	4.002ValAla: 4.002 ± 0.076	0.495ValCys: 0.495 ± 0.019	3.857ValAsp: 3.857 ± 0.068	3.935ValGlu: 3.935 ± 0.065	3.412ValPhe: 3.412 ± 0.063	4.027ValGly: 4.027 ± 0.071	1.116ValHis: 1.116 ± 0.03	4.432ValIle: 4.432 ± 0.073	3.979ValLys: 3.979 ± 0.068	6.112ValLeu: 6.112 ± 0.084	1.311ValMet: 1.311 ± 0.032	3.268ValAsn: 3.268 ± 0.056	2.485ValPro: 2.485 ± 0.056	1.925ValGln: 1.925 ± 0.048	2.177ValArg: 2.177 ± 0.045	4.418ValSer: 4.418 ± 0.063	3.487ValThr: 3.487 ± 0.096	4.141ValVal: 4.141 ± 0.072	0.623ValTrp: 0.623 ± 0.024	2.258ValTyr: 2.258 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.61TrpAla: 0.61 ± 0.024	0.103TrpCys: 0.103 ± 0.009	0.671TrpAsp: 0.671 ± 0.025	0.778TrpGlu: 0.778 ± 0.025	0.541TrpPhe: 0.541 ± 0.023	0.74TrpGly: 0.74 ± 0.03	0.23TrpHis: 0.23 ± 0.014	0.757TrpIle: 0.757 ± 0.028	0.849TrpLys: 0.849 ± 0.03	0.971TrpLeu: 0.971 ± 0.036	0.325TrpMet: 0.325 ± 0.018	0.69TrpAsn: 0.69 ± 0.027	0.312TrpPro: 0.312 ± 0.02	0.423TrpGln: 0.423 ± 0.02	0.458TrpArg: 0.458 ± 0.023	0.665TrpSer: 0.665 ± 0.034	0.569TrpThr: 0.569 ± 0.023	0.654TrpVal: 0.654 ± 0.025	0.167TrpTrp: 0.167 ± 0.012	0.445TrpTyr: 0.445 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.045	0.329TyrCys: 0.329 ± 0.018	2.303TyrAsp: 2.303 ± 0.055	2.352TyrGlu: 2.352 ± 0.051	2.352TyrPhe: 2.352 ± 0.058	2.848TyrGly: 2.848 ± 0.054	0.824TyrHis: 0.824 ± 0.031	2.657TyrIle: 2.657 ± 0.054	2.672TyrLys: 2.672 ± 0.051	3.742TyrLeu: 3.742 ± 0.065	0.753TyrMet: 0.753 ± 0.025	2.384TyrAsn: 2.384 ± 0.055	1.443TyrPro: 1.443 ± 0.035	1.428TyrGln: 1.428 ± 0.032	1.849TyrArg: 1.849 ± 0.044	2.528TyrSer: 2.528 ± 0.055	2.263TyrThr: 2.263 ± 0.049	2.221TyrVal: 2.221 ± 0.044	0.48TyrTrp: 0.48 ± 0.025	1.674TyrTyr: 1.674 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3376 proteins (1140652 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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