Amino acid dipepetide frequency for Roseicitreum antarcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.947AlaAla: 18.947 ± 0.192	1.165AlaCys: 1.165 ± 0.036	7.758AlaAsp: 7.758 ± 0.101	7.683AlaGlu: 7.683 ± 0.108	4.347AlaPhe: 4.347 ± 0.064	11.497AlaGly: 11.497 ± 0.117	2.747AlaHis: 2.747 ± 0.048	5.861AlaIle: 5.861 ± 0.072	3.154AlaLys: 3.154 ± 0.064	15.144AlaLeu: 15.144 ± 0.148	4.17AlaMet: 4.17 ± 0.062	2.618AlaAsn: 2.618 ± 0.051	6.773AlaPro: 6.773 ± 0.106	5.644AlaGln: 5.644 ± 0.084	10.215AlaArg: 10.215 ± 0.112	5.795AlaSer: 5.795 ± 0.072	6.766AlaThr: 6.766 ± 0.086	9.125AlaVal: 9.125 ± 0.104	1.485AlaTrp: 1.485 ± 0.04	2.439AlaTyr: 2.439 ± 0.05	0.001AlaXaa: 0.001 ± 0.001
Cys	1.156CysAla: 1.156 ± 0.037	0.102CysCys: 0.102 ± 0.009	0.627CysAsp: 0.627 ± 0.026	0.376CysGlu: 0.376 ± 0.017	0.318CysPhe: 0.318 ± 0.016	0.92CysGly: 0.92 ± 0.031	0.237CysHis: 0.237 ± 0.014	0.397CysIle: 0.397 ± 0.02	0.198CysLys: 0.198 ± 0.013	0.824CysLeu: 0.824 ± 0.028	0.19CysMet: 0.19 ± 0.012	0.212CysAsn: 0.212 ± 0.012	0.511CysPro: 0.511 ± 0.023	0.221CysGln: 0.221 ± 0.013	0.554CysArg: 0.554 ± 0.023	0.393CysSer: 0.393 ± 0.022	0.459CysThr: 0.459 ± 0.02	0.624CysVal: 0.624 ± 0.025	0.138CysTrp: 0.138 ± 0.01	0.184CysTyr: 0.184 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.598AspAla: 8.598 ± 0.106	0.531AspCys: 0.531 ± 0.022	3.374AspAsp: 3.374 ± 0.057	2.898AspGlu: 2.898 ± 0.057	2.114AspPhe: 2.114 ± 0.049	5.499AspGly: 5.499 ± 0.071	1.412AspHis: 1.412 ± 0.035	2.99AspIle: 2.99 ± 0.054	1.296AspLys: 1.296 ± 0.037	6.565AspLeu: 6.565 ± 0.068	1.733AspMet: 1.733 ± 0.04	1.253AspAsn: 1.253 ± 0.03	3.675AspPro: 3.675 ± 0.062	1.998AspGln: 1.998 ± 0.044	4.41AspArg: 4.41 ± 0.07	2.332AspSer: 2.332 ± 0.043	3.439AspThr: 3.439 ± 0.055	4.193AspVal: 4.193 ± 0.055	1.224AspTrp: 1.224 ± 0.029	1.387AspTyr: 1.387 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.017GluAla: 7.017 ± 0.103	0.335GluCys: 0.335 ± 0.016	2.798GluAsp: 2.798 ± 0.048	2.46GluGlu: 2.46 ± 0.05	1.647GluPhe: 1.647 ± 0.036	4.254GluGly: 4.254 ± 0.066	0.999GluHis: 0.999 ± 0.031	3.017GluIle: 3.017 ± 0.059	1.531GluLys: 1.531 ± 0.046	4.42GluLeu: 4.42 ± 0.061	1.623GluMet: 1.623 ± 0.04	1.445GluAsn: 1.445 ± 0.035	2.154GluPro: 2.154 ± 0.055	1.678GluGln: 1.678 ± 0.038	3.858GluArg: 3.858 ± 0.072	1.935GluSer: 1.935 ± 0.043	3.333GluThr: 3.333 ± 0.057	4.077GluVal: 4.077 ± 0.057	0.635GluTrp: 0.635 ± 0.025	0.981GluTyr: 0.981 ± 0.03	0.001GluXaa: 0.001 ± 0.001
Phe	4.493PheAla: 4.493 ± 0.069	0.389PheCys: 0.389 ± 0.017	2.853PheAsp: 2.853 ± 0.053	1.874PheGlu: 1.874 ± 0.043	1.35PhePhe: 1.35 ± 0.036	3.687PheGly: 3.687 ± 0.057	0.75PheHis: 0.75 ± 0.027	1.675PheIle: 1.675 ± 0.036	0.72PheLys: 0.72 ± 0.024	3.175PheLeu: 3.175 ± 0.059	0.861PheMet: 0.861 ± 0.031	1.006PheAsn: 1.006 ± 0.028	1.537PhePro: 1.537 ± 0.036	0.98PheGln: 0.98 ± 0.029	2.208PheArg: 2.208 ± 0.049	2.009PheSer: 2.009 ± 0.046	2.045PheThr: 2.045 ± 0.039	2.578PheVal: 2.578 ± 0.054	0.583PheTrp: 0.583 ± 0.025	0.868PheTyr: 0.868 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.194GlyAla: 11.194 ± 0.118	0.848GlyCys: 0.848 ± 0.027	4.657GlyAsp: 4.657 ± 0.072	3.714GlyGlu: 3.714 ± 0.056	3.64GlyPhe: 3.64 ± 0.06	7.569GlyGly: 7.569 ± 0.093	1.953GlyHis: 1.953 ± 0.041	4.47GlyIle: 4.47 ± 0.069	2.535GlyLys: 2.535 ± 0.058	9.394GlyLeu: 9.394 ± 0.085	2.791GlyMet: 2.791 ± 0.05	2.03GlyAsn: 2.03 ± 0.046	3.942GlyPro: 3.942 ± 0.067	3.465GlyGln: 3.465 ± 0.053	5.977GlyArg: 5.977 ± 0.074	4.098GlySer: 4.098 ± 0.057	4.972GlyThr: 4.972 ± 0.061	6.723GlyVal: 6.723 ± 0.08	1.558GlyTrp: 1.558 ± 0.038	2.211GlyTyr: 2.211 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.687HisAla: 2.687 ± 0.047	0.257HisCys: 0.257 ± 0.014	1.48HisAsp: 1.48 ± 0.036	0.972HisGlu: 0.972 ± 0.029	0.807HisPhe: 0.807 ± 0.03	1.925HisGly: 1.925 ± 0.047	0.575HisHis: 0.575 ± 0.026	1.038HisIle: 1.038 ± 0.026	0.47HisLys: 0.47 ± 0.023	2.279HisLeu: 2.279 ± 0.046	0.539HisMet: 0.539 ± 0.023	0.459HisAsn: 0.459 ± 0.017	1.458HisPro: 1.458 ± 0.036	0.639HisGln: 0.639 ± 0.023	1.424HisArg: 1.424 ± 0.034	0.976HisSer: 0.976 ± 0.029	0.912HisThr: 0.912 ± 0.03	1.488HisVal: 1.488 ± 0.036	0.347HisTrp: 0.347 ± 0.017	0.499HisTyr: 0.499 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.184IleAla: 7.184 ± 0.096	0.583IleCys: 0.583 ± 0.024	3.363IleAsp: 3.363 ± 0.05	2.919IleGlu: 2.919 ± 0.059	1.666IlePhe: 1.666 ± 0.038	4.715IleGly: 4.715 ± 0.064	0.963IleHis: 0.963 ± 0.029	2.315IleIle: 2.315 ± 0.06	1.176IleLys: 1.176 ± 0.037	4.461IleLeu: 4.461 ± 0.069	1.115IleMet: 1.115 ± 0.033	1.327IleAsn: 1.327 ± 0.04	2.408IlePro: 2.408 ± 0.047	1.095IleGln: 1.095 ± 0.035	3.205IleArg: 3.205 ± 0.046	2.86IleSer: 2.86 ± 0.052	2.964IleThr: 2.964 ± 0.045	3.781IleVal: 3.781 ± 0.067	0.745IleTrp: 0.745 ± 0.022	1.104IleTyr: 1.104 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.222LysAla: 3.222 ± 0.07	0.144LysCys: 0.144 ± 0.011	1.298LysAsp: 1.298 ± 0.036	1.053LysGlu: 1.053 ± 0.033	0.77LysPhe: 0.77 ± 0.025	2.124LysGly: 2.124 ± 0.043	0.548LysHis: 0.548 ± 0.023	1.328LysIle: 1.328 ± 0.033	0.87LysLys: 0.87 ± 0.03	2.513LysLeu: 2.513 ± 0.053	0.736LysMet: 0.736 ± 0.026	0.588LysAsn: 0.588 ± 0.026	1.514LysPro: 1.514 ± 0.043	0.723LysGln: 0.723 ± 0.025	1.882LysArg: 1.882 ± 0.043	1.507LysSer: 1.507 ± 0.038	1.676LysThr: 1.676 ± 0.041	1.821LysVal: 1.821 ± 0.05	0.286LysTrp: 0.286 ± 0.015	0.517LysTyr: 0.517 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.596LeuAla: 13.596 ± 0.123	0.929LeuCys: 0.929 ± 0.029	6.086LeuAsp: 6.086 ± 0.076	4.854LeuGlu: 4.854 ± 0.06	3.342LeuPhe: 3.342 ± 0.064	8.455LeuGly: 8.455 ± 0.102	2.167LeuHis: 2.167 ± 0.048	5.418LeuIle: 5.418 ± 0.078	2.486LeuLys: 2.486 ± 0.053	8.956LeuLeu: 8.956 ± 0.115	2.809LeuMet: 2.809 ± 0.052	2.635LeuAsn: 2.635 ± 0.046	5.892LeuPro: 5.892 ± 0.077	2.829LeuGln: 2.829 ± 0.052	7.967LeuArg: 7.967 ± 0.091	6.586LeuSer: 6.586 ± 0.081	6.447LeuThr: 6.447 ± 0.078	6.668LeuVal: 6.668 ± 0.074	1.354LeuTrp: 1.354 ± 0.034	1.826LeuTyr: 1.826 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.779MetAla: 3.779 ± 0.06	0.168MetCys: 0.168 ± 0.01	1.407MetAsp: 1.407 ± 0.036	1.231MetGlu: 1.231 ± 0.033	0.83MetPhe: 0.83 ± 0.033	2.444MetGly: 2.444 ± 0.049	0.506MetHis: 0.506 ± 0.02	1.537MetIle: 1.537 ± 0.04	0.859MetLys: 0.859 ± 0.026	2.812MetLeu: 2.812 ± 0.051	0.807MetMet: 0.807 ± 0.03	0.834MetAsn: 0.834 ± 0.026	1.668MetPro: 1.668 ± 0.038	1.116MetGln: 1.116 ± 0.034	2.078MetArg: 2.078 ± 0.034	1.706MetSer: 1.706 ± 0.035	2.185MetThr: 2.185 ± 0.041	2.022MetVal: 2.022 ± 0.048	0.233MetTrp: 0.233 ± 0.016	0.35MetTyr: 0.35 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.17AsnAla: 3.17 ± 0.054	0.207AsnCys: 0.207 ± 0.014	1.338AsnAsp: 1.338 ± 0.034	0.973AsnGlu: 0.973 ± 0.027	0.881AsnPhe: 0.881 ± 0.026	2.072AsnGly: 2.072 ± 0.042	0.489AsnHis: 0.489 ± 0.02	1.386AsnIle: 1.386 ± 0.036	0.566AsnLys: 0.566 ± 0.022	2.432AsnLeu: 2.432 ± 0.042	0.648AsnMet: 0.648 ± 0.024	0.643AsnAsn: 0.643 ± 0.027	1.818AsnPro: 1.818 ± 0.043	0.705AsnGln: 0.705 ± 0.024	1.693AsnArg: 1.693 ± 0.035	1.069AsnSer: 1.069 ± 0.031	1.344AsnThr: 1.344 ± 0.033	1.704AsnVal: 1.704 ± 0.04	0.418AsnTrp: 0.418 ± 0.023	0.582AsnTyr: 0.582 ± 0.025	0.001AsnXaa: 0.001 ± 0.001
Pro	6.827ProAla: 6.827 ± 0.106	0.387ProCys: 0.387 ± 0.018	4.368ProAsp: 4.368 ± 0.061	3.635ProGlu: 3.635 ± 0.057	1.924ProPhe: 1.924 ± 0.041	5.136ProGly: 5.136 ± 0.071	1.172ProHis: 1.172 ± 0.031	2.064ProIle: 2.064 ± 0.04	1.347ProLys: 1.347 ± 0.034	4.947ProLeu: 4.947 ± 0.075	1.431ProMet: 1.431 ± 0.035	1.189ProAsn: 1.189 ± 0.031	2.731ProPro: 2.731 ± 0.057	1.933ProGln: 1.933 ± 0.044	3.223ProArg: 3.223 ± 0.05	2.531ProSer: 2.531 ± 0.043	2.66ProThr: 2.66 ± 0.049	4.459ProVal: 4.459 ± 0.057	0.672ProTrp: 0.672 ± 0.024	1.07ProTyr: 1.07 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.563GlnAla: 4.563 ± 0.069	0.235GlnCys: 0.235 ± 0.017	1.787GlnAsp: 1.787 ± 0.038	1.443GlnGlu: 1.443 ± 0.04	1.151GlnPhe: 1.151 ± 0.034	2.854GlnGly: 2.854 ± 0.047	0.688GlnHis: 0.688 ± 0.025	2.22GlnIle: 2.22 ± 0.043	0.918GlnLys: 0.918 ± 0.03	2.82GlnLeu: 2.82 ± 0.049	1.17GlnMet: 1.17 ± 0.031	0.895GlnAsn: 0.895 ± 0.028	1.89GlnPro: 1.89 ± 0.046	1.147GlnGln: 1.147 ± 0.036	2.471GlnArg: 2.471 ± 0.049	1.888GlnSer: 1.888 ± 0.038	2.038GlnThr: 2.038 ± 0.04	2.608GlnVal: 2.608 ± 0.046	0.414GlnTrp: 0.414 ± 0.017	0.618GlnTyr: 0.618 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.742ArgAla: 9.742 ± 0.107	0.545ArgCys: 0.545 ± 0.024	4.746ArgAsp: 4.746 ± 0.069	3.359ArgGlu: 3.359 ± 0.055	2.65ArgPhe: 2.65 ± 0.045	5.121ArgGly: 5.121 ± 0.058	1.615ArgHis: 1.615 ± 0.04	3.801ArgIle: 3.801 ± 0.054	2.039ArgLys: 2.039 ± 0.04	7.698ArgLeu: 7.698 ± 0.102	2.191ArgMet: 2.191 ± 0.043	1.836ArgAsn: 1.836 ± 0.039	3.722ArgPro: 3.722 ± 0.055	2.482ArgGln: 2.482 ± 0.05	5.425ArgArg: 5.425 ± 0.078	3.201ArgSer: 3.201 ± 0.059	3.222ArgThr: 3.222 ± 0.047	5.076ArgVal: 5.076 ± 0.08	1.04ArgTrp: 1.04 ± 0.034	1.556ArgTyr: 1.556 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.176SerAla: 6.176 ± 0.077	0.395SerCys: 0.395 ± 0.021	3.369SerAsp: 3.369 ± 0.053	2.482SerGlu: 2.482 ± 0.048	2.012SerPhe: 2.012 ± 0.048	5.43SerGly: 5.43 ± 0.064	1.066SerHis: 1.066 ± 0.034	2.359SerIle: 2.359 ± 0.048	1.224SerLys: 1.224 ± 0.033	4.731SerLeu: 4.731 ± 0.07	1.376SerMet: 1.376 ± 0.03	1.194SerAsn: 1.194 ± 0.037	2.547SerPro: 2.547 ± 0.045	1.562SerGln: 1.562 ± 0.038	3.232SerArg: 3.232 ± 0.057	2.319SerSer: 2.319 ± 0.044	2.492SerThr: 2.492 ± 0.049	4.021SerVal: 4.021 ± 0.058	0.622SerTrp: 0.622 ± 0.025	1.169SerTyr: 1.169 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.058ThrAla: 7.058 ± 0.078	0.465ThrCys: 0.465 ± 0.021	3.408ThrAsp: 3.408 ± 0.057	2.774ThrGlu: 2.774 ± 0.051	1.947ThrPhe: 1.947 ± 0.041	5.736ThrGly: 5.736 ± 0.075	1.198ThrHis: 1.198 ± 0.03	2.546ThrIle: 2.546 ± 0.049	1.253ThrLys: 1.253 ± 0.035	6.421ThrLeu: 6.421 ± 0.074	1.318ThrMet: 1.318 ± 0.035	1.231ThrAsn: 1.231 ± 0.033	3.978ThrPro: 3.978 ± 0.058	1.811ThrGln: 1.811 ± 0.036	3.947ThrArg: 3.947 ± 0.055	2.616ThrSer: 2.616 ± 0.039	3.186ThrThr: 3.186 ± 0.055	4.162ThrVal: 4.162 ± 0.047	0.651ThrTrp: 0.651 ± 0.023	1.217ThrTyr: 1.217 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.779ValAla: 9.779 ± 0.109	0.601ValCys: 0.601 ± 0.021	3.977ValAsp: 3.977 ± 0.06	3.88ValGlu: 3.88 ± 0.059	2.89ValPhe: 2.89 ± 0.053	5.37ValGly: 5.37 ± 0.075	1.39ValHis: 1.39 ± 0.033	4.019ValIle: 4.019 ± 0.065	1.675ValLys: 1.675 ± 0.042	7.799ValLeu: 7.799 ± 0.085	2.196ValMet: 2.196 ± 0.044	1.792ValAsn: 1.792 ± 0.041	3.739ValPro: 3.739 ± 0.054	2.397ValGln: 2.397 ± 0.043	4.567ValArg: 4.567 ± 0.068	4.17ValSer: 4.17 ± 0.066	4.822ValThr: 4.822 ± 0.061	5.814ValVal: 5.814 ± 0.081	0.991ValTrp: 0.991 ± 0.031	1.391ValTyr: 1.391 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.561TrpAla: 1.561 ± 0.037	0.131TrpCys: 0.131 ± 0.01	0.783TrpAsp: 0.783 ± 0.026	0.599TrpGlu: 0.599 ± 0.022	0.545TrpPhe: 0.545 ± 0.021	0.986TrpGly: 0.986 ± 0.029	0.297TrpHis: 0.297 ± 0.016	0.637TrpIle: 0.637 ± 0.022	0.344TrpLys: 0.344 ± 0.017	1.697TrpLeu: 1.697 ± 0.041	0.399TrpMet: 0.399 ± 0.021	0.408TrpAsn: 0.408 ± 0.021	0.734TrpPro: 0.734 ± 0.026	0.688TrpGln: 0.688 ± 0.027	1.182TrpArg: 1.182 ± 0.032	0.737TrpSer: 0.737 ± 0.026	0.831TrpThr: 0.831 ± 0.029	0.935TrpVal: 0.935 ± 0.031	0.229TrpTrp: 0.229 ± 0.014	0.248TrpTyr: 0.248 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.044	0.224TyrCys: 0.224 ± 0.013	1.445TyrAsp: 1.445 ± 0.035	1.02TyrGlu: 1.02 ± 0.031	0.813TyrPhe: 0.813 ± 0.027	1.948TyrGly: 1.948 ± 0.044	0.46TyrHis: 0.46 ± 0.02	0.871TyrIle: 0.871 ± 0.029	0.459TyrLys: 0.459 ± 0.02	2.214TyrLeu: 2.214 ± 0.052	0.468TyrMet: 0.468 ± 0.02	0.544TyrAsn: 0.544 ± 0.02	1.014TyrPro: 1.014 ± 0.031	0.706TyrGln: 0.706 ± 0.027	1.544TyrArg: 1.544 ± 0.042	1.048TyrSer: 1.048 ± 0.03	1.131TyrThr: 1.131 ± 0.029	1.382TyrVal: 1.382 ± 0.037	0.344TyrTrp: 0.344 ± 0.016	0.468TyrTyr: 0.468 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 4002 proteins (1234146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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