Amino acid dipepetide frequency for Avian orthoreovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.685AlaAla: 8.685 ± 1.366
1.579AlaCys: 1.579 ± 0.425
5.527AlaAsp: 5.527 ± 0.798
1.974AlaGlu: 1.974 ± 0.533
2.106AlaPhe: 2.106 ± 0.526
3.816AlaGly: 3.816 ± 0.498
1.316AlaHis: 1.316 ± 0.558
3.816AlaIle: 3.816 ± 0.778
2.632AlaLys: 2.632 ± 0.698
8.817AlaLeu: 8.817 ± 0.692
1.974AlaMet: 1.974 ± 0.676
4.474AlaAsn: 4.474 ± 0.82
4.737AlaPro: 4.737 ± 0.846
3.948AlaGln: 3.948 ± 0.867
6.448AlaArg: 6.448 ± 0.74
7.238AlaSer: 7.238 ± 0.653
6.843AlaThr: 6.843 ± 0.837
4.737AlaVal: 4.737 ± 0.678
1.184AlaTrp: 1.184 ± 0.358
1.974AlaTyr: 1.974 ± 0.336
0.0AlaXaa: 0.0 ± 0.0
Cys
1.448CysAla: 1.448 ± 0.368
0.395CysCys: 0.395 ± 0.307
1.579CysAsp: 1.579 ± 0.403
0.395CysGlu: 0.395 ± 0.265
0.658CysPhe: 0.658 ± 0.265
0.79CysGly: 0.79 ± 0.404
0.263CysHis: 0.263 ± 0.199
0.395CysIle: 0.395 ± 0.167
0.263CysLys: 0.263 ± 0.169
1.448CysLeu: 1.448 ± 0.429
0.263CysMet: 0.263 ± 0.148
0.79CysAsn: 0.79 ± 0.218
1.448CysPro: 1.448 ± 0.318
0.658CysGln: 0.658 ± 0.27
0.79CysArg: 0.79 ± 0.244
1.448CysSer: 1.448 ± 0.274
0.921CysThr: 0.921 ± 0.316
1.316CysVal: 1.316 ± 0.503
0.79CysTrp: 0.79 ± 0.37
0.263CysTyr: 0.263 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
6.843AspAla: 6.843 ± 0.525
0.526AspCys: 0.526 ± 0.298
3.816AspAsp: 3.816 ± 0.844
2.5AspGlu: 2.5 ± 0.923
1.974AspPhe: 1.974 ± 0.403
4.474AspGly: 4.474 ± 0.636
1.974AspHis: 1.974 ± 0.549
2.764AspIle: 2.764 ± 0.427
1.711AspLys: 1.711 ± 0.382
5.79AspLeu: 5.79 ± 0.777
1.711AspMet: 1.711 ± 0.532
1.974AspAsn: 1.974 ± 0.377
3.948AspPro: 3.948 ± 0.482
1.579AspGln: 1.579 ± 0.608
3.553AspArg: 3.553 ± 0.633
4.869AspSer: 4.869 ± 0.72
2.764AspThr: 2.764 ± 0.5
6.185AspVal: 6.185 ± 0.893
1.184AspTrp: 1.184 ± 0.504
1.316AspTyr: 1.316 ± 0.334
0.0AspXaa: 0.0 ± 0.0
Glu
3.027GluAla: 3.027 ± 0.599
0.79GluCys: 0.79 ± 0.379
1.316GluAsp: 1.316 ± 0.508
1.316GluGlu: 1.316 ± 0.598
0.921GluPhe: 0.921 ± 0.385
1.448GluGly: 1.448 ± 0.503
1.053GluHis: 1.053 ± 0.436
1.974GluIle: 1.974 ± 0.465
0.79GluLys: 0.79 ± 0.303
5.659GluLeu: 5.659 ± 1.084
0.79GluMet: 0.79 ± 0.338
0.395GluAsn: 0.395 ± 0.184
1.316GluPro: 1.316 ± 0.424
1.448GluGln: 1.448 ± 0.481
2.5GluArg: 2.5 ± 0.38
3.685GluSer: 3.685 ± 0.759
1.842GluThr: 1.842 ± 0.591
1.974GluVal: 1.974 ± 0.51
0.263GluTrp: 0.263 ± 0.159
1.579GluTyr: 1.579 ± 0.403
0.0GluXaa: 0.0 ± 0.0
Phe
2.632PheAla: 2.632 ± 0.679
0.658PheCys: 0.658 ± 0.282
3.158PheAsp: 3.158 ± 0.484
1.842PheGlu: 1.842 ± 0.432
1.316PhePhe: 1.316 ± 0.623
2.237PheGly: 2.237 ± 0.635
0.79PheHis: 0.79 ± 0.372
1.448PheIle: 1.448 ± 0.424
0.526PheLys: 0.526 ± 0.173
4.079PheLeu: 4.079 ± 0.617
1.448PheMet: 1.448 ± 0.304
1.842PheAsn: 1.842 ± 0.703
2.369PhePro: 2.369 ± 0.678
1.053PheGln: 1.053 ± 0.452
1.842PheArg: 1.842 ± 0.351
4.606PheSer: 4.606 ± 1.061
2.764PheThr: 2.764 ± 0.582
3.553PheVal: 3.553 ± 0.445
0.658PheTrp: 0.658 ± 0.398
1.184PheTyr: 1.184 ± 0.462
0.0PheXaa: 0.0 ± 0.0
Gly
4.343GlyAla: 4.343 ± 0.515
0.658GlyCys: 0.658 ± 0.208
3.158GlyAsp: 3.158 ± 0.665
1.053GlyGlu: 1.053 ± 0.216
2.764GlyPhe: 2.764 ± 0.751
2.369GlyGly: 2.369 ± 0.46
0.79GlyHis: 0.79 ± 0.287
3.29GlyIle: 3.29 ± 0.602
1.711GlyLys: 1.711 ± 0.501
4.869GlyLeu: 4.869 ± 1.044
1.184GlyMet: 1.184 ± 0.315
2.369GlyAsn: 2.369 ± 0.604
1.974GlyPro: 1.974 ± 0.306
1.842GlyGln: 1.842 ± 0.578
3.816GlyArg: 3.816 ± 0.583
4.606GlySer: 4.606 ± 0.498
2.5GlyThr: 2.5 ± 0.61
4.869GlyVal: 4.869 ± 0.72
0.921GlyTrp: 0.921 ± 0.366
0.921GlyTyr: 0.921 ± 0.33
0.0GlyXaa: 0.0 ± 0.0
His
1.974HisAla: 1.974 ± 0.358
0.658HisCys: 0.658 ± 0.279
0.921HisAsp: 0.921 ± 0.312
1.053HisGlu: 1.053 ± 0.358
1.053HisPhe: 1.053 ± 0.43
0.79HisGly: 0.79 ± 0.424
0.79HisHis: 0.79 ± 0.355
0.526HisIle: 0.526 ± 0.332
0.395HisLys: 0.395 ± 0.195
1.316HisLeu: 1.316 ± 0.468
0.79HisMet: 0.79 ± 0.268
0.79HisAsn: 0.79 ± 0.241
1.448HisPro: 1.448 ± 0.321
0.526HisGln: 0.526 ± 0.219
1.316HisArg: 1.316 ± 0.28
1.842HisSer: 1.842 ± 0.37
1.316HisThr: 1.316 ± 0.43
1.448HisVal: 1.448 ± 0.46
0.395HisTrp: 0.395 ± 0.23
1.053HisTyr: 1.053 ± 0.34
0.0HisXaa: 0.0 ± 0.0
Ile
3.422IleAla: 3.422 ± 0.714
0.79IleCys: 0.79 ± 0.356
3.816IleAsp: 3.816 ± 0.553
1.711IleGlu: 1.711 ± 0.535
2.106IlePhe: 2.106 ± 0.682
2.369IleGly: 2.369 ± 0.574
1.184IleHis: 1.184 ± 0.354
1.711IleIle: 1.711 ± 0.431
1.448IleLys: 1.448 ± 0.312
4.079IleLeu: 4.079 ± 0.674
0.658IleMet: 0.658 ± 0.296
1.974IleAsn: 1.974 ± 0.302
2.895IlePro: 2.895 ± 0.608
1.974IleGln: 1.974 ± 0.541
3.553IleArg: 3.553 ± 0.671
4.869IleSer: 4.869 ± 0.822
4.869IleThr: 4.869 ± 0.61
3.158IleVal: 3.158 ± 0.571
0.132IleTrp: 0.132 ± 0.111
1.316IleTyr: 1.316 ± 0.35
0.0IleXaa: 0.0 ± 0.0
Lys
2.237LysAla: 2.237 ± 0.489
0.395LysCys: 0.395 ± 0.222
1.711LysAsp: 1.711 ± 0.57
1.316LysGlu: 1.316 ± 0.421
1.053LysPhe: 1.053 ± 0.386
1.448LysGly: 1.448 ± 0.512
0.395LysHis: 0.395 ± 0.205
1.448LysIle: 1.448 ± 0.486
0.79LysLys: 0.79 ± 0.283
3.685LysLeu: 3.685 ± 0.751
0.395LysMet: 0.395 ± 0.175
0.395LysAsn: 0.395 ± 0.181
1.579LysPro: 1.579 ± 0.372
1.842LysGln: 1.842 ± 0.364
0.526LysArg: 0.526 ± 0.251
3.027LysSer: 3.027 ± 0.411
1.842LysThr: 1.842 ± 0.439
1.842LysVal: 1.842 ± 0.529
0.526LysTrp: 0.526 ± 0.212
0.658LysTyr: 0.658 ± 0.259
0.0LysXaa: 0.0 ± 0.0
Leu
8.817LeuAla: 8.817 ± 0.95
1.316LeuCys: 1.316 ± 0.337
5.132LeuAsp: 5.132 ± 0.904
3.422LeuGlu: 3.422 ± 0.49
4.474LeuPhe: 4.474 ± 0.827
2.895LeuGly: 2.895 ± 0.465
1.711LeuHis: 1.711 ± 0.25
4.211LeuIle: 4.211 ± 0.726
3.816LeuLys: 3.816 ± 0.891
11.186LeuLeu: 11.186 ± 1.116
3.027LeuMet: 3.027 ± 0.382
3.948LeuAsn: 3.948 ± 0.496
6.975LeuPro: 6.975 ± 0.829
4.343LeuGln: 4.343 ± 0.681
6.58LeuArg: 6.58 ± 0.644
13.423LeuSer: 13.423 ± 1.863
8.554LeuThr: 8.554 ± 1.355
5.79LeuVal: 5.79 ± 1.165
0.526LeuTrp: 0.526 ± 0.201
2.632LeuTyr: 2.632 ± 0.657
0.0LeuXaa: 0.0 ± 0.0
Met
2.5MetAla: 2.5 ± 0.646
0.526MetCys: 0.526 ± 0.258
2.106MetAsp: 2.106 ± 0.396
1.053MetGlu: 1.053 ± 0.497
0.79MetPhe: 0.79 ± 0.283
0.79MetGly: 0.79 ± 0.374
0.263MetHis: 0.263 ± 0.142
1.053MetIle: 1.053 ± 0.308
0.526MetLys: 0.526 ± 0.266
1.974MetLeu: 1.974 ± 0.423
1.053MetMet: 1.053 ± 0.322
1.053MetAsn: 1.053 ± 0.379
1.448MetPro: 1.448 ± 0.297
0.79MetGln: 0.79 ± 0.266
1.053MetArg: 1.053 ± 0.297
2.5MetSer: 2.5 ± 0.579
2.764MetThr: 2.764 ± 0.365
1.579MetVal: 1.579 ± 0.491
0.658MetTrp: 0.658 ± 0.282
1.316MetTyr: 1.316 ± 0.245
0.0MetXaa: 0.0 ± 0.0
Asn
4.474AsnAla: 4.474 ± 0.637
0.658AsnCys: 0.658 ± 0.27
1.974AsnAsp: 1.974 ± 0.545
0.921AsnGlu: 0.921 ± 0.397
2.106AsnPhe: 2.106 ± 0.503
2.764AsnGly: 2.764 ± 0.476
0.79AsnHis: 0.79 ± 0.254
2.632AsnIle: 2.632 ± 0.634
0.658AsnLys: 0.658 ± 0.325
3.553AsnLeu: 3.553 ± 0.894
0.921AsnMet: 0.921 ± 0.292
1.316AsnAsn: 1.316 ± 0.447
1.974AsnPro: 1.974 ± 0.578
1.974AsnGln: 1.974 ± 0.574
2.369AsnArg: 2.369 ± 0.795
1.711AsnSer: 1.711 ± 0.412
3.027AsnThr: 3.027 ± 0.886
3.816AsnVal: 3.816 ± 0.49
0.658AsnTrp: 0.658 ± 0.476
1.842AsnTyr: 1.842 ± 0.529
0.0AsnXaa: 0.0 ± 0.0
Pro
4.079ProAla: 4.079 ± 0.788
0.658ProCys: 0.658 ± 0.186
3.816ProAsp: 3.816 ± 0.623
1.842ProGlu: 1.842 ± 0.511
3.422ProPhe: 3.422 ± 0.548
3.158ProGly: 3.158 ± 0.945
0.658ProHis: 0.658 ± 0.393
2.895ProIle: 2.895 ± 0.61
0.921ProLys: 0.921 ± 0.468
7.896ProLeu: 7.896 ± 0.85
1.579ProMet: 1.579 ± 0.456
2.632ProAsn: 2.632 ± 0.664
4.343ProPro: 4.343 ± 0.724
1.448ProGln: 1.448 ± 0.396
2.632ProArg: 2.632 ± 0.457
7.896ProSer: 7.896 ± 0.664
4.606ProThr: 4.606 ± 0.963
3.948ProVal: 3.948 ± 0.652
1.316ProTrp: 1.316 ± 0.375
1.711ProTyr: 1.711 ± 0.528
0.0ProXaa: 0.0 ± 0.0
Gln
3.685GlnAla: 3.685 ± 1.05
1.184GlnCys: 1.184 ± 0.376
1.316GlnAsp: 1.316 ± 0.553
1.184GlnGlu: 1.184 ± 0.675
1.974GlnPhe: 1.974 ± 0.498
1.842GlnGly: 1.842 ± 0.665
0.921GlnHis: 0.921 ± 0.338
2.106GlnIle: 2.106 ± 0.487
1.184GlnLys: 1.184 ± 0.305
4.211GlnLeu: 4.211 ± 0.707
0.921GlnMet: 0.921 ± 0.355
1.184GlnAsn: 1.184 ± 0.282
2.5GlnPro: 2.5 ± 0.577
1.711GlnGln: 1.711 ± 0.49
2.764GlnArg: 2.764 ± 0.541
3.422GlnSer: 3.422 ± 0.375
2.5GlnThr: 2.5 ± 0.695
2.106GlnVal: 2.106 ± 0.551
0.658GlnTrp: 0.658 ± 0.35
2.237GlnTyr: 2.237 ± 0.561
0.0GlnXaa: 0.0 ± 0.0
Arg
4.343ArgAla: 4.343 ± 0.879
1.053ArgCys: 1.053 ± 0.421
3.422ArgAsp: 3.422 ± 0.608
3.29ArgGlu: 3.29 ± 0.859
1.579ArgPhe: 1.579 ± 0.604
2.764ArgGly: 2.764 ± 0.492
1.711ArgHis: 1.711 ± 0.509
2.764ArgIle: 2.764 ± 0.706
1.316ArgLys: 1.316 ± 0.398
5.922ArgLeu: 5.922 ± 0.82
1.842ArgMet: 1.842 ± 0.648
1.711ArgAsn: 1.711 ± 0.6
3.158ArgPro: 3.158 ± 0.796
2.369ArgGln: 2.369 ± 0.298
4.343ArgArg: 4.343 ± 1.059
6.317ArgSer: 6.317 ± 0.689
4.079ArgThr: 4.079 ± 0.71
4.869ArgVal: 4.869 ± 0.733
1.448ArgTrp: 1.448 ± 0.391
1.579ArgTyr: 1.579 ± 0.411
0.0ArgXaa: 0.0 ± 0.0
Ser
7.501SerAla: 7.501 ± 0.694
1.448SerCys: 1.448 ± 0.515
6.448SerAsp: 6.448 ± 0.571
2.237SerGlu: 2.237 ± 0.858
3.29SerPhe: 3.29 ± 0.535
6.448SerGly: 6.448 ± 1.036
2.237SerHis: 2.237 ± 0.58
5.264SerIle: 5.264 ± 0.58
2.632SerLys: 2.632 ± 0.603
9.607SerLeu: 9.607 ± 1.646
2.369SerMet: 2.369 ± 0.548
4.343SerAsn: 4.343 ± 1.023
6.053SerPro: 6.053 ± 0.65
3.816SerGln: 3.816 ± 0.676
6.317SerArg: 6.317 ± 0.677
9.475SerSer: 9.475 ± 0.791
7.764SerThr: 7.764 ± 0.965
6.58SerVal: 6.58 ± 1.071
1.842SerTrp: 1.842 ± 0.524
2.632SerTyr: 2.632 ± 0.448
0.0SerXaa: 0.0 ± 0.0
Thr
6.185ThrAla: 6.185 ± 0.981
0.79ThrCys: 0.79 ± 0.283
3.816ThrAsp: 3.816 ± 0.606
2.106ThrGlu: 2.106 ± 0.507
3.158ThrPhe: 3.158 ± 0.464
3.685ThrGly: 3.685 ± 0.659
1.579ThrHis: 1.579 ± 0.454
4.079ThrIle: 4.079 ± 0.477
1.842ThrLys: 1.842 ± 0.406
7.633ThrLeu: 7.633 ± 0.712
1.448ThrMet: 1.448 ± 0.274
3.685ThrAsn: 3.685 ± 0.925
5.264ThrPro: 5.264 ± 0.885
1.842ThrGln: 1.842 ± 0.58
2.5ThrArg: 2.5 ± 0.823
7.633ThrSer: 7.633 ± 1.011
4.606ThrThr: 4.606 ± 0.765
6.58ThrVal: 6.58 ± 1.064
1.053ThrTrp: 1.053 ± 0.379
2.5ThrTyr: 2.5 ± 0.535
0.0ThrXaa: 0.0 ± 0.0
Val
4.737ValAla: 4.737 ± 0.799
1.184ValCys: 1.184 ± 0.313
5.264ValAsp: 5.264 ± 0.321
3.422ValGlu: 3.422 ± 0.567
2.764ValPhe: 2.764 ± 0.689
4.079ValGly: 4.079 ± 0.66
1.316ValHis: 1.316 ± 0.447
3.29ValIle: 3.29 ± 0.741
2.764ValLys: 2.764 ± 0.437
6.053ValLeu: 6.053 ± 0.487
1.711ValMet: 1.711 ± 0.357
3.027ValAsn: 3.027 ± 0.522
5.132ValPro: 5.132 ± 0.301
4.211ValGln: 4.211 ± 0.551
3.685ValArg: 3.685 ± 0.473
5.922ValSer: 5.922 ± 0.913
5.922ValThr: 5.922 ± 0.832
5.395ValVal: 5.395 ± 0.896
0.79ValTrp: 0.79 ± 0.361
2.237ValTyr: 2.237 ± 0.36
0.0ValXaa: 0.0 ± 0.0
Trp
1.184TrpAla: 1.184 ± 0.372
0.263TrpCys: 0.263 ± 0.168
0.79TrpAsp: 0.79 ± 0.291
0.526TrpGlu: 0.526 ± 0.177
0.921TrpPhe: 0.921 ± 0.228
0.263TrpGly: 0.263 ± 0.155
0.0TrpHis: 0.0 ± 0.0
0.658TrpIle: 0.658 ± 0.25
0.395TrpLys: 0.395 ± 0.259
1.842TrpLeu: 1.842 ± 0.389
1.053TrpMet: 1.053 ± 0.268
0.658TrpAsn: 0.658 ± 0.198
0.921TrpPro: 0.921 ± 0.244
0.395TrpGln: 0.395 ± 0.204
1.711TrpArg: 1.711 ± 0.46
1.316TrpSer: 1.316 ± 0.238
1.448TrpThr: 1.448 ± 0.569
0.658TrpVal: 0.658 ± 0.187
0.132TrpTrp: 0.132 ± 0.111
0.526TrpTyr: 0.526 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.842TyrAla: 1.842 ± 0.326
0.79TyrCys: 0.79 ± 0.211
2.369TyrAsp: 2.369 ± 0.819
0.921TyrGlu: 0.921 ± 0.34
1.579TyrPhe: 1.579 ± 0.56
1.579TyrGly: 1.579 ± 0.255
0.658TyrHis: 0.658 ± 0.27
1.711TyrIle: 1.711 ± 0.312
0.79TyrLys: 0.79 ± 0.323
3.158TyrLeu: 3.158 ± 0.498
0.526TyrMet: 0.526 ± 0.288
1.579TyrAsn: 1.579 ± 0.435
1.974TyrPro: 1.974 ± 0.523
1.842TyrGln: 1.842 ± 0.768
1.579TyrArg: 1.579 ± 0.591
2.5TyrSer: 2.5 ± 0.627
1.053TyrThr: 1.053 ± 0.305
2.5TyrVal: 2.5 ± 0.442
0.526TyrTrp: 0.526 ± 0.204
0.79TyrTyr: 0.79 ± 0.199
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (7600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski