Amino acid dipepetide frequency for Leishmania major

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.056AlaAla: 21.056 ± 0.201	1.803AlaCys: 1.803 ± 0.024	5.466AlaAsp: 5.466 ± 0.053	7.466AlaGlu: 7.466 ± 0.09	2.995AlaPhe: 2.995 ± 0.039	7.083AlaGly: 7.083 ± 0.063	2.777AlaHis: 2.777 ± 0.032	2.918AlaIle: 2.918 ± 0.028	3.77AlaLys: 3.77 ± 0.052	10.282AlaLeu: 10.282 ± 0.073	2.566AlaMet: 2.566 ± 0.026	2.649AlaAsn: 2.649 ± 0.029	7.544AlaPro: 7.544 ± 0.385	4.451AlaGln: 4.451 ± 0.043	6.871AlaArg: 6.871 ± 0.066	11.199AlaSer: 11.199 ± 0.19	7.772AlaThr: 7.772 ± 0.065	8.73AlaVal: 8.73 ± 0.061	0.994AlaTrp: 0.994 ± 0.017	2.271AlaTyr: 2.271 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	2.13CysAla: 2.13 ± 0.024	0.547CysCys: 0.547 ± 0.01	0.938CysAsp: 0.938 ± 0.016	0.935CysGlu: 0.935 ± 0.015	0.692CysPhe: 0.692 ± 0.011	1.575CysGly: 1.575 ± 0.02	0.456CysHis: 0.456 ± 0.011	0.744CysIle: 0.744 ± 0.018	0.498CysLys: 0.498 ± 0.011	1.571CysLeu: 1.571 ± 0.02	0.417CysMet: 0.417 ± 0.01	0.492CysAsn: 0.492 ± 0.008	0.894CysPro: 0.894 ± 0.016	0.495CysGln: 0.495 ± 0.011	1.34CysArg: 1.34 ± 0.022	1.597CysSer: 1.597 ± 0.021	1.237CysThr: 1.237 ± 0.019	1.691CysVal: 1.691 ± 0.017	0.212CysTrp: 0.212 ± 0.007	0.459CysTyr: 0.459 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.662AspAla: 6.662 ± 0.054	0.771AspCys: 0.771 ± 0.012	3.494AspAsp: 3.494 ± 0.037	3.54AspGlu: 3.54 ± 0.041	1.422AspPhe: 1.422 ± 0.02	4.234AspGly: 4.234 ± 0.037	0.941AspHis: 0.941 ± 0.017	1.717AspIle: 1.717 ± 0.02	1.43AspLys: 1.43 ± 0.023	3.596AspLeu: 3.596 ± 0.044	1.16AspMet: 1.16 ± 0.018	1.272AspAsn: 1.272 ± 0.02	2.311AspPro: 2.311 ± 0.033	1.088AspGln: 1.088 ± 0.017	2.721AspArg: 2.721 ± 0.034	3.488AspSer: 3.488 ± 0.03	2.813AspThr: 2.813 ± 0.03	4.26AspVal: 4.26 ± 0.042	0.487AspTrp: 0.487 ± 0.011	1.17AspTyr: 1.17 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	7.618GluAla: 7.618 ± 0.096	0.918GluCys: 0.918 ± 0.017	3.492GluAsp: 3.492 ± 0.046	5.8GluGlu: 5.8 ± 0.08	1.283GluPhe: 1.283 ± 0.02	3.712GluGly: 3.712 ± 0.033	1.461GluHis: 1.461 ± 0.019	1.432GluIle: 1.432 ± 0.021	2.636GluLys: 2.636 ± 0.042	5.659GluLeu: 5.659 ± 0.054	1.517GluMet: 1.517 ± 0.021	1.532GluAsn: 1.532 ± 0.022	2.136GluPro: 2.136 ± 0.036	2.708GluGln: 2.708 ± 0.039	4.699GluArg: 4.699 ± 0.056	3.791GluSer: 3.791 ± 0.035	2.792GluThr: 2.792 ± 0.053	4.458GluVal: 4.458 ± 0.036	0.76GluTrp: 0.76 ± 0.014	1.339GluTyr: 1.339 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.852PheAla: 2.852 ± 0.029	0.65PheCys: 0.65 ± 0.012	1.551PheAsp: 1.551 ± 0.02	1.439PheGlu: 1.439 ± 0.019	1.433PhePhe: 1.433 ± 0.023	1.905PheGly: 1.905 ± 0.037	0.843PheHis: 0.843 ± 0.015	1.086PheIle: 1.086 ± 0.023	0.843PheLys: 0.843 ± 0.027	2.988PheLeu: 2.988 ± 0.03	0.686PheMet: 0.686 ± 0.013	0.86PheAsn: 0.86 ± 0.016	1.47PhePro: 1.47 ± 0.018	1.012PheGln: 1.012 ± 0.017	1.737PheArg: 1.737 ± 0.021	2.651PheSer: 2.651 ± 0.026	1.896PheThr: 1.896 ± 0.042	2.32PheVal: 2.32 ± 0.025	0.303PheTrp: 0.303 ± 0.008	0.933PheTyr: 0.933 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	7.89GlyAla: 7.89 ± 0.073	1.31GlyCys: 1.31 ± 0.016	3.802GlyAsp: 3.802 ± 0.038	3.661GlyGlu: 3.661 ± 0.034	1.854GlyPhe: 1.854 ± 0.029	6.906GlyGly: 6.906 ± 0.08	1.522GlyHis: 1.522 ± 0.023	2.064GlyIle: 2.064 ± 0.023	2.311GlyLys: 2.311 ± 0.029	4.422GlyLeu: 4.422 ± 0.034	1.372GlyMet: 1.372 ± 0.02	1.976GlyAsn: 1.976 ± 0.025	2.377GlyPro: 2.377 ± 0.026	1.838GlyGln: 1.838 ± 0.024	4.129GlyArg: 4.129 ± 0.042	6.062GlySer: 6.062 ± 0.054	4.044GlyThr: 4.044 ± 0.04	4.888GlyVal: 4.888 ± 0.036	0.65GlyTrp: 0.65 ± 0.014	1.492GlyTyr: 1.492 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.767HisAla: 2.767 ± 0.03	0.571HisCys: 0.571 ± 0.013	1.199HisAsp: 1.199 ± 0.017	1.353HisGlu: 1.353 ± 0.018	0.849HisPhe: 0.849 ± 0.015	1.823HisGly: 1.823 ± 0.024	1.107HisHis: 1.107 ± 0.02	0.931HisIle: 0.931 ± 0.015	0.752HisLys: 0.752 ± 0.013	2.486HisLeu: 2.486 ± 0.029	0.588HisMet: 0.588 ± 0.018	0.763HisAsn: 0.763 ± 0.014	1.648HisPro: 1.648 ± 0.02	1.142HisGln: 1.142 ± 0.016	2.313HisArg: 2.313 ± 0.026	2.134HisSer: 2.134 ± 0.023	1.682HisThr: 1.682 ± 0.037	1.973HisVal: 1.973 ± 0.03	0.3HisTrp: 0.3 ± 0.008	0.751HisTyr: 0.751 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.234IleAla: 3.234 ± 0.032	0.564IleCys: 0.564 ± 0.013	1.671IleAsp: 1.671 ± 0.022	1.772IleGlu: 1.772 ± 0.024	1.139IlePhe: 1.139 ± 0.032	1.899IleGly: 1.899 ± 0.025	0.784IleHis: 0.784 ± 0.011	1.179IleIle: 1.179 ± 0.019	0.99IleLys: 0.99 ± 0.017	2.548IleLeu: 2.548 ± 0.032	0.699IleMet: 0.699 ± 0.013	0.846IleAsn: 0.846 ± 0.015	1.778IlePro: 1.778 ± 0.023	1.041IleGln: 1.041 ± 0.017	1.927IleArg: 1.927 ± 0.021	2.348IleSer: 2.348 ± 0.025	1.902IleThr: 1.902 ± 0.021	2.289IleVal: 2.289 ± 0.028	0.237IleTrp: 0.237 ± 0.008	0.753IleTyr: 0.753 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.637LysAla: 3.637 ± 0.042	0.5LysCys: 0.5 ± 0.011	1.784LysAsp: 1.784 ± 0.03	2.52LysGlu: 2.52 ± 0.035	0.689LysPhe: 0.689 ± 0.015	2.082LysGly: 2.082 ± 0.028	0.845LysHis: 0.845 ± 0.015	0.926LysIle: 0.926 ± 0.017	1.899LysLys: 1.899 ± 0.033	2.838LysLeu: 2.838 ± 0.041	0.852LysMet: 0.852 ± 0.015	0.936LysAsn: 0.936 ± 0.016	1.659LysPro: 1.659 ± 0.029	1.456LysGln: 1.456 ± 0.023	2.721LysArg: 2.721 ± 0.033	2.296LysSer: 2.296 ± 0.038	1.838LysThr: 1.838 ± 0.028	2.188LysVal: 2.188 ± 0.029	0.36LysTrp: 0.36 ± 0.01	0.849LysTyr: 0.849 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.497LeuAla: 8.497 ± 0.064	2.128LeuCys: 2.128 ± 0.022	4.056LeuAsp: 4.056 ± 0.037	5.26LeuGlu: 5.26 ± 0.059	3.152LeuPhe: 3.152 ± 0.033	4.458LeuGly: 4.458 ± 0.033	3.04LeuHis: 3.04 ± 0.031	2.553LeuIle: 2.553 ± 0.027	2.976LeuLys: 2.976 ± 0.035	10.359LeuLeu: 10.359 ± 0.075	2.01LeuMet: 2.01 ± 0.023	2.34LeuAsn: 2.34 ± 0.025	5.953LeuPro: 5.953 ± 0.049	5.015LeuGln: 5.015 ± 0.052	7.961LeuArg: 7.961 ± 0.06	7.916LeuSer: 7.916 ± 0.055	4.979LeuThr: 4.979 ± 0.04	5.766LeuVal: 5.766 ± 0.047	1.129LeuTrp: 1.129 ± 0.019	2.404LeuTyr: 2.404 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.222MetAla: 2.222 ± 0.025	0.425MetCys: 0.425 ± 0.008	1.105MetAsp: 1.105 ± 0.019	1.543MetGlu: 1.543 ± 0.022	0.581MetPhe: 0.581 ± 0.011	1.189MetGly: 1.189 ± 0.018	0.647MetHis: 0.647 ± 0.014	0.644MetIle: 0.644 ± 0.013	0.888MetLys: 0.888 ± 0.017	2.114MetLeu: 2.114 ± 0.026	0.682MetMet: 0.682 ± 0.015	0.716MetAsn: 0.716 ± 0.016	1.374MetPro: 1.374 ± 0.019	1.138MetGln: 1.138 ± 0.017	1.787MetArg: 1.787 ± 0.018	1.89MetSer: 1.89 ± 0.023	1.285MetThr: 1.285 ± 0.017	1.314MetVal: 1.314 ± 0.018	0.287MetTrp: 0.287 ± 0.007	0.581MetTyr: 0.581 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.194AsnAla: 3.194 ± 0.03	0.475AsnCys: 0.475 ± 0.012	1.371AsnAsp: 1.371 ± 0.019	1.497AsnGlu: 1.497 ± 0.024	0.819AsnPhe: 0.819 ± 0.016	2.211AsnGly: 2.211 ± 0.025	0.588AsnHis: 0.588 ± 0.012	1.013AsnIle: 1.013 ± 0.017	0.857AsnLys: 0.857 ± 0.015	1.933AsnLeu: 1.933 ± 0.022	0.621AsnMet: 0.621 ± 0.011	0.862AsnAsn: 0.862 ± 0.016	1.458AsnPro: 1.458 ± 0.022	0.698AsnGln: 0.698 ± 0.014	1.61AsnArg: 1.61 ± 0.023	2.146AsnSer: 2.146 ± 0.024	1.747AsnThr: 1.747 ± 0.023	1.996AsnVal: 1.996 ± 0.025	0.255AsnTrp: 0.255 ± 0.007	0.725AsnTyr: 0.725 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.616ProAla: 6.616 ± 0.066	0.924ProCys: 0.924 ± 0.016	2.025ProAsp: 2.025 ± 0.03	2.57ProGlu: 2.57 ± 0.028	1.817ProPhe: 1.817 ± 0.03	2.764ProGly: 2.764 ± 0.033	1.699ProHis: 1.699 ± 0.022	1.514ProIle: 1.514 ± 0.019	1.522ProLys: 1.522 ± 0.022	5.939ProLeu: 5.939 ± 0.052	1.102ProMet: 1.102 ± 0.016	1.329ProAsn: 1.329 ± 0.018	5.787ProPro: 5.787 ± 0.077	2.468ProGln: 2.468 ± 0.037	3.65ProArg: 3.65 ± 0.037	7.072ProSer: 7.072 ± 0.385	3.744ProThr: 3.744 ± 0.038	3.761ProVal: 3.761 ± 0.039	0.553ProTrp: 0.553 ± 0.011	1.312ProTyr: 1.312 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.69GlnAla: 3.69 ± 0.037	0.756GlnCys: 0.756 ± 0.014	1.422GlnAsp: 1.422 ± 0.022	2.547GlnGlu: 2.547 ± 0.051	0.911GlnPhe: 0.911 ± 0.015	1.866GlnGly: 1.866 ± 0.021	1.593GlnHis: 1.593 ± 0.027	0.928GlnIle: 0.928 ± 0.019	1.35GlnLys: 1.35 ± 0.022	4.841GlnLeu: 4.841 ± 0.043	0.882GlnMet: 0.882 ± 0.014	0.913GlnAsn: 0.913 ± 0.014	2.365GlnPro: 2.365 ± 0.032	4.04GlnGln: 4.04 ± 0.072	4.542GlnArg: 4.542 ± 0.047	2.675GlnSer: 2.675 ± 0.029	1.785GlnThr: 1.785 ± 0.021	2.324GlnVal: 2.324 ± 0.023	0.585GlnTrp: 0.585 ± 0.011	1.026GlnTyr: 1.026 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	6.977ArgAla: 6.977 ± 0.058	1.675ArgCys: 1.675 ± 0.022	3.439ArgAsp: 3.439 ± 0.028	4.411ArgGlu: 4.411 ± 0.041	1.981ArgPhe: 1.981 ± 0.022	4.649ArgGly: 4.649 ± 0.048	2.39ArgHis: 2.39 ± 0.025	2.254ArgIle: 2.254 ± 0.026	2.536ArgLys: 2.536 ± 0.031	6.896ArgLeu: 6.896 ± 0.05	1.533ArgMet: 1.533 ± 0.018	1.893ArgAsn: 1.893 ± 0.026	3.215ArgPro: 3.215 ± 0.032	3.559ArgGln: 3.559 ± 0.034	7.214ArgArg: 7.214 ± 0.066	5.707ArgSer: 5.707 ± 0.05	3.791ArgThr: 3.791 ± 0.034	4.86ArgVal: 4.86 ± 0.044	0.966ArgTrp: 0.966 ± 0.016	1.906ArgTyr: 1.906 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	11.875SerAla: 11.875 ± 0.553	1.561SerCys: 1.561 ± 0.02	3.743SerAsp: 3.743 ± 0.028	3.87SerGlu: 3.87 ± 0.036	2.615SerPhe: 2.615 ± 0.028	6.243SerGly: 6.243 ± 0.053	1.99SerHis: 1.99 ± 0.024	2.623SerIle: 2.623 ± 0.027	2.355SerLys: 2.355 ± 0.026	7.681SerLeu: 7.681 ± 0.052	1.841SerMet: 1.841 ± 0.023	2.176SerAsn: 2.176 ± 0.025	6.043SerPro: 6.043 ± 0.07	2.569SerGln: 2.569 ± 0.024	5.437SerArg: 5.437 ± 0.047	13.323SerSer: 13.323 ± 1.502	6.11SerThr: 6.11 ± 0.054	5.88SerVal: 5.88 ± 0.043	0.839SerTrp: 0.839 ± 0.013	1.683SerTyr: 1.683 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.281ThrAla: 8.281 ± 0.065	0.969ThrCys: 0.969 ± 0.022	2.542ThrAsp: 2.542 ± 0.025	3.158ThrGlu: 3.158 ± 0.035	1.709ThrPhe: 1.709 ± 0.024	3.692ThrGly: 3.692 ± 0.033	1.552ThrHis: 1.552 ± 0.042	1.783ThrIle: 1.783 ± 0.021	1.768ThrLys: 1.768 ± 0.025	5.417ThrLeu: 5.417 ± 0.047	1.228ThrMet: 1.228 ± 0.015	1.497ThrAsn: 1.497 ± 0.02	4.329ThrPro: 4.329 ± 0.047	2.056ThrGln: 2.056 ± 0.023	3.537ThrArg: 3.537 ± 0.037	5.78ThrSer: 5.78 ± 0.057	4.618ThrThr: 4.618 ± 0.064	4.39ThrVal: 4.39 ± 0.046	0.577ThrTrp: 0.577 ± 0.012	1.309ThrTyr: 1.309 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	8.139ValAla: 8.139 ± 0.057	1.554ValCys: 1.554 ± 0.021	3.71ValAsp: 3.71 ± 0.032	4.43ValGlu: 4.43 ± 0.049	2.304ValPhe: 2.304 ± 0.026	4.035ValGly: 4.035 ± 0.033	1.919ValHis: 1.919 ± 0.019	2.048ValIle: 2.048 ± 0.023	2.321ValLys: 2.321 ± 0.029	7.119ValLeu: 7.119 ± 0.052	1.678ValMet: 1.678 ± 0.022	1.853ValAsn: 1.853 ± 0.02	4.268ValPro: 4.268 ± 0.037	2.958ValGln: 2.958 ± 0.034	4.889ValArg: 4.889 ± 0.041	5.842ValSer: 5.842 ± 0.046	4.089ValThr: 4.089 ± 0.034	5.715ValVal: 5.715 ± 0.052	0.792ValTrp: 0.792 ± 0.014	1.852ValTyr: 1.852 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.944TrpAla: 0.944 ± 0.018	0.317TrpCys: 0.317 ± 0.008	0.482TrpAsp: 0.482 ± 0.011	0.578TrpGlu: 0.578 ± 0.012	0.295TrpPhe: 0.295 ± 0.007	0.617TrpGly: 0.617 ± 0.014	0.291TrpHis: 0.291 ± 0.008	0.349TrpIle: 0.349 ± 0.009	0.449TrpLys: 0.449 ± 0.011	1.026TrpLeu: 1.026 ± 0.019	0.355TrpMet: 0.355 ± 0.008	0.363TrpAsn: 0.363 ± 0.008	0.435TrpPro: 0.435 ± 0.009	0.47TrpGln: 0.47 ± 0.011	1.07TrpArg: 1.07 ± 0.017	0.894TrpSer: 0.894 ± 0.016	0.597TrpThr: 0.597 ± 0.012	0.722TrpVal: 0.722 ± 0.015	0.228TrpTrp: 0.228 ± 0.007	0.314TrpTyr: 0.314 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.379TyrAla: 2.379 ± 0.029	0.504TyrCys: 0.504 ± 0.011	1.284TyrAsp: 1.284 ± 0.022	1.393TyrGlu: 1.393 ± 0.027	0.919TyrPhe: 0.919 ± 0.025	1.625TyrGly: 1.625 ± 0.025	0.687TyrHis: 0.687 ± 0.011	0.895TyrIle: 0.895 ± 0.023	0.725TyrLys: 0.725 ± 0.016	2.236TyrLeu: 2.236 ± 0.026	0.627TyrMet: 0.627 ± 0.018	0.809TyrAsn: 0.809 ± 0.019	1.123TyrPro: 1.123 ± 0.017	0.838TyrGln: 0.838 ± 0.015	1.7TyrArg: 1.7 ± 0.023	1.646TyrSer: 1.646 ± 0.025	1.47TyrThr: 1.47 ± 0.021	1.991TyrVal: 1.991 ± 0.025	0.279TyrTrp: 0.279 ± 0.008	0.869TyrTyr: 0.869 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8038 proteins (5143074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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