Amino acid dipepetide frequency for Mycobacterium phage DrDrey

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.621AlaAla: 12.621 ± 1.297
1.128AlaCys: 1.128 ± 0.249
6.394AlaAsp: 6.394 ± 0.469
8.442AlaGlu: 8.442 ± 0.759
2.842AlaPhe: 2.842 ± 0.407
8.526AlaGly: 8.526 ± 0.636
2.34AlaHis: 2.34 ± 0.383
3.845AlaIle: 3.845 ± 0.418
5.099AlaLys: 5.099 ± 0.437
8.191AlaLeu: 8.191 ± 0.705
3.009AlaMet: 3.009 ± 0.37
3.009AlaAsn: 3.009 ± 0.507
4.639AlaPro: 4.639 ± 0.381
3.427AlaGln: 3.427 ± 0.35
6.143AlaArg: 6.143 ± 0.698
5.767AlaSer: 5.767 ± 0.579
6.436AlaThr: 6.436 ± 0.508
6.018AlaVal: 6.018 ± 0.446
1.839AlaTrp: 1.839 ± 0.29
2.758AlaTyr: 2.758 ± 0.331
0.0AlaXaa: 0.0 ± 0.0
Cys
1.045CysAla: 1.045 ± 0.187
0.167CysCys: 0.167 ± 0.084
0.543CysAsp: 0.543 ± 0.187
0.585CysGlu: 0.585 ± 0.187
0.334CysPhe: 0.334 ± 0.126
1.881CysGly: 1.881 ± 0.33
0.251CysHis: 0.251 ± 0.117
0.543CysIle: 0.543 ± 0.137
0.46CysLys: 0.46 ± 0.129
1.128CysLeu: 1.128 ± 0.245
0.125CysMet: 0.125 ± 0.066
0.418CysAsn: 0.418 ± 0.147
0.71CysPro: 0.71 ± 0.212
0.502CysGln: 0.502 ± 0.171
0.669CysArg: 0.669 ± 0.215
0.71CysSer: 0.71 ± 0.203
0.334CysThr: 0.334 ± 0.119
0.627CysVal: 0.627 ± 0.186
0.209CysTrp: 0.209 ± 0.102
0.376CysTyr: 0.376 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
6.227AspAla: 6.227 ± 0.579
1.087AspCys: 1.087 ± 0.215
4.305AspAsp: 4.305 ± 0.553
4.472AspGlu: 4.472 ± 0.504
1.379AspPhe: 1.379 ± 0.246
6.896AspGly: 6.896 ± 0.56
1.672AspHis: 1.672 ± 0.338
3.176AspIle: 3.176 ± 0.479
2.633AspLys: 2.633 ± 0.336
4.764AspLeu: 4.764 ± 0.419
1.588AspMet: 1.588 ± 0.255
1.797AspAsn: 1.797 ± 0.283
3.887AspPro: 3.887 ± 0.35
1.672AspGln: 1.672 ± 0.307
4.054AspArg: 4.054 ± 0.511
3.009AspSer: 3.009 ± 0.348
3.552AspThr: 3.552 ± 0.321
4.305AspVal: 4.305 ± 0.406
1.463AspTrp: 1.463 ± 0.215
2.466AspTyr: 2.466 ± 0.407
0.0AspXaa: 0.0 ± 0.0
Glu
6.854GluAla: 6.854 ± 0.626
1.128GluCys: 1.128 ± 0.248
4.89GluAsp: 4.89 ± 0.513
4.931GluGlu: 4.931 ± 0.603
2.758GluPhe: 2.758 ± 0.367
4.472GluGly: 4.472 ± 0.425
1.463GluHis: 1.463 ± 0.236
2.842GluIle: 2.842 ± 0.366
2.299GluLys: 2.299 ± 0.378
7.481GluLeu: 7.481 ± 0.62
1.17GluMet: 1.17 ± 0.216
2.215GluAsn: 2.215 ± 0.283
2.758GluPro: 2.758 ± 0.331
2.34GluGln: 2.34 ± 0.311
4.179GluArg: 4.179 ± 0.485
2.591GluSer: 2.591 ± 0.31
4.012GluThr: 4.012 ± 0.381
4.514GluVal: 4.514 ± 0.432
1.254GluTrp: 1.254 ± 0.232
2.34GluTyr: 2.34 ± 0.313
0.0GluXaa: 0.0 ± 0.0
Phe
2.675PheAla: 2.675 ± 0.373
0.627PheCys: 0.627 ± 0.158
2.591PheAsp: 2.591 ± 0.327
1.964PheGlu: 1.964 ± 0.236
0.961PhePhe: 0.961 ± 0.188
2.675PheGly: 2.675 ± 0.368
0.878PheHis: 0.878 ± 0.196
1.421PheIle: 1.421 ± 0.244
1.212PheLys: 1.212 ± 0.242
1.881PheLeu: 1.881 ± 0.322
0.543PheMet: 0.543 ± 0.132
1.087PheAsn: 1.087 ± 0.245
1.296PhePro: 1.296 ± 0.213
0.794PheGln: 0.794 ± 0.17
1.128PheArg: 1.128 ± 0.198
1.964PheSer: 1.964 ± 0.307
2.173PheThr: 2.173 ± 0.344
2.048PheVal: 2.048 ± 0.378
0.418PheTrp: 0.418 ± 0.117
0.961PheTyr: 0.961 ± 0.191
0.0PheXaa: 0.0 ± 0.0
Gly
8.024GlyAla: 8.024 ± 0.708
0.669GlyCys: 0.669 ± 0.151
5.684GlyAsp: 5.684 ± 0.468
5.517GlyGlu: 5.517 ± 0.478
2.09GlyPhe: 2.09 ± 0.266
9.487GlyGly: 9.487 ± 1.815
2.173GlyHis: 2.173 ± 0.289
4.263GlyIle: 4.263 ± 0.493
4.012GlyLys: 4.012 ± 0.358
6.185GlyLeu: 6.185 ± 0.408
2.215GlyMet: 2.215 ± 0.317
3.385GlyAsn: 3.385 ± 0.35
3.719GlyPro: 3.719 ± 0.416
2.424GlyGln: 2.424 ± 0.397
4.221GlyArg: 4.221 ± 0.363
5.182GlySer: 5.182 ± 0.712
6.645GlyThr: 6.645 ± 0.635
6.311GlyVal: 6.311 ± 0.594
1.797GlyTrp: 1.797 ± 0.247
3.594GlyTyr: 3.594 ± 0.405
0.0GlyXaa: 0.0 ± 0.0
His
1.964HisAla: 1.964 ± 0.294
0.502HisCys: 0.502 ± 0.149
1.505HisAsp: 1.505 ± 0.274
1.254HisGlu: 1.254 ± 0.281
0.669HisPhe: 0.669 ± 0.137
2.173HisGly: 2.173 ± 0.279
1.045HisHis: 1.045 ± 0.238
1.128HisIle: 1.128 ± 0.215
1.087HisLys: 1.087 ± 0.207
2.591HisLeu: 2.591 ± 0.377
0.46HisMet: 0.46 ± 0.122
0.961HisAsn: 0.961 ± 0.19
1.546HisPro: 1.546 ± 0.252
0.878HisGln: 0.878 ± 0.229
1.421HisArg: 1.421 ± 0.244
1.296HisSer: 1.296 ± 0.189
1.337HisThr: 1.337 ± 0.274
1.379HisVal: 1.379 ± 0.241
0.46HisTrp: 0.46 ± 0.142
1.003HisTyr: 1.003 ± 0.235
0.0HisXaa: 0.0 ± 0.0
Ile
5.14IleAla: 5.14 ± 0.424
0.46IleCys: 0.46 ± 0.132
3.218IleAsp: 3.218 ± 0.326
3.719IleGlu: 3.719 ± 0.412
1.045IlePhe: 1.045 ± 0.244
3.218IleGly: 3.218 ± 0.449
1.296IleHis: 1.296 ± 0.244
1.839IleIle: 1.839 ± 0.323
2.006IleLys: 2.006 ± 0.267
3.343IleLeu: 3.343 ± 0.384
0.878IleMet: 0.878 ± 0.187
1.839IleAsn: 1.839 ± 0.314
2.716IlePro: 2.716 ± 0.308
1.672IleGln: 1.672 ± 0.293
2.633IleArg: 2.633 ± 0.298
2.549IleSer: 2.549 ± 0.351
2.758IleThr: 2.758 ± 0.441
3.26IleVal: 3.26 ± 0.342
0.502IleTrp: 0.502 ± 0.143
1.212IleTyr: 1.212 ± 0.25
0.0IleXaa: 0.0 ± 0.0
Lys
4.848LysAla: 4.848 ± 0.525
0.627LysCys: 0.627 ± 0.16
2.675LysAsp: 2.675 ± 0.336
2.382LysGlu: 2.382 ± 0.317
1.254LysPhe: 1.254 ± 0.235
3.511LysGly: 3.511 ± 0.385
1.296LysHis: 1.296 ± 0.243
1.713LysIle: 1.713 ± 0.249
2.215LysLys: 2.215 ± 0.297
3.636LysLeu: 3.636 ± 0.396
1.128LysMet: 1.128 ± 0.221
1.546LysAsn: 1.546 ± 0.282
2.424LysPro: 2.424 ± 0.381
1.588LysGln: 1.588 ± 0.217
3.051LysArg: 3.051 ± 0.421
2.967LysSer: 2.967 ± 0.438
2.048LysThr: 2.048 ± 0.268
3.302LysVal: 3.302 ± 0.277
1.296LysTrp: 1.296 ± 0.224
1.128LysTyr: 1.128 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
8.902LeuAla: 8.902 ± 0.643
0.585LeuCys: 0.585 ± 0.143
4.639LeuAsp: 4.639 ± 0.45
4.931LeuGlu: 4.931 ± 0.506
2.131LeuPhe: 2.131 ± 0.356
5.851LeuGly: 5.851 ± 0.466
1.672LeuHis: 1.672 ± 0.292
4.137LeuIle: 4.137 ± 0.368
3.97LeuLys: 3.97 ± 0.408
6.854LeuLeu: 6.854 ± 0.579
2.299LeuMet: 2.299 ± 0.278
3.385LeuAsn: 3.385 ± 0.389
4.054LeuPro: 4.054 ± 0.388
3.134LeuGln: 3.134 ± 0.356
5.6LeuArg: 5.6 ± 0.497
4.848LeuSer: 4.848 ± 0.432
6.102LeuThr: 6.102 ± 0.552
5.182LeuVal: 5.182 ± 0.374
1.421LeuTrp: 1.421 ± 0.251
1.839LeuTyr: 1.839 ± 0.271
0.0LeuXaa: 0.0 ± 0.0
Met
2.591MetAla: 2.591 ± 0.336
0.209MetCys: 0.209 ± 0.094
1.379MetAsp: 1.379 ± 0.235
1.463MetGlu: 1.463 ± 0.25
0.627MetPhe: 0.627 ± 0.153
1.505MetGly: 1.505 ± 0.273
0.502MetHis: 0.502 ± 0.134
1.045MetIle: 1.045 ± 0.188
1.672MetLys: 1.672 ± 0.316
1.505MetLeu: 1.505 ± 0.214
0.376MetMet: 0.376 ± 0.13
1.003MetAsn: 1.003 ± 0.187
1.003MetPro: 1.003 ± 0.167
0.502MetGln: 0.502 ± 0.194
1.296MetArg: 1.296 ± 0.192
2.508MetSer: 2.508 ± 0.396
2.006MetThr: 2.006 ± 0.252
1.379MetVal: 1.379 ± 0.253
0.627MetTrp: 0.627 ± 0.172
0.251MetTyr: 0.251 ± 0.091
0.0MetXaa: 0.0 ± 0.0
Asn
2.8AsnAla: 2.8 ± 0.371
0.209AsnCys: 0.209 ± 0.09
1.964AsnAsp: 1.964 ± 0.246
1.964AsnGlu: 1.964 ± 0.234
0.878AsnPhe: 0.878 ± 0.212
4.806AsnGly: 4.806 ± 0.494
0.669AsnHis: 0.669 ± 0.199
1.421AsnIle: 1.421 ± 0.291
0.919AsnLys: 0.919 ± 0.183
3.469AsnLeu: 3.469 ± 0.512
0.293AsnMet: 0.293 ± 0.133
1.045AsnAsn: 1.045 ± 0.209
2.967AsnPro: 2.967 ± 0.342
1.212AsnGln: 1.212 ± 0.185
2.173AsnArg: 2.173 ± 0.305
1.755AsnSer: 1.755 ± 0.283
1.755AsnThr: 1.755 ± 0.318
2.215AsnVal: 2.215 ± 0.382
0.627AsnTrp: 0.627 ± 0.158
0.669AsnTyr: 0.669 ± 0.188
0.0AsnXaa: 0.0 ± 0.0
Pro
5.308ProAla: 5.308 ± 0.482
0.585ProCys: 0.585 ± 0.158
3.761ProAsp: 3.761 ± 0.367
3.469ProGlu: 3.469 ± 0.367
1.797ProPhe: 1.797 ± 0.305
5.015ProGly: 5.015 ± 0.636
1.546ProHis: 1.546 ± 0.282
2.424ProIle: 2.424 ± 0.29
2.508ProLys: 2.508 ± 0.382
3.845ProLeu: 3.845 ± 0.339
1.337ProMet: 1.337 ± 0.211
1.755ProAsn: 1.755 ± 0.24
3.093ProPro: 3.093 ± 0.431
1.839ProGln: 1.839 ± 0.258
2.382ProArg: 2.382 ± 0.325
2.967ProSer: 2.967 ± 0.365
3.302ProThr: 3.302 ± 0.293
3.469ProVal: 3.469 ± 0.36
1.17ProTrp: 1.17 ± 0.222
1.672ProTyr: 1.672 ± 0.216
0.0ProXaa: 0.0 ± 0.0
Gln
3.97GlnAla: 3.97 ± 0.381
0.376GlnCys: 0.376 ± 0.138
1.797GlnAsp: 1.797 ± 0.256
2.048GlnGlu: 2.048 ± 0.315
0.794GlnPhe: 0.794 ± 0.165
2.299GlnGly: 2.299 ± 0.351
0.46GlnHis: 0.46 ± 0.135
1.588GlnIle: 1.588 ± 0.242
1.588GlnLys: 1.588 ± 0.3
3.552GlnLeu: 3.552 ± 0.53
1.003GlnMet: 1.003 ± 0.227
0.836GlnAsn: 0.836 ± 0.198
1.672GlnPro: 1.672 ± 0.268
0.919GlnGln: 0.919 ± 0.217
2.34GlnArg: 2.34 ± 0.231
1.964GlnSer: 1.964 ± 0.244
1.588GlnThr: 1.588 ± 0.227
2.299GlnVal: 2.299 ± 0.297
1.003GlnTrp: 1.003 ± 0.215
0.836GlnTyr: 0.836 ± 0.158
0.0GlnXaa: 0.0 ± 0.0
Arg
6.561ArgAla: 6.561 ± 0.765
0.752ArgCys: 0.752 ± 0.197
3.845ArgAsp: 3.845 ± 0.477
3.385ArgGlu: 3.385 ± 0.402
1.839ArgPhe: 1.839 ± 0.299
3.761ArgGly: 3.761 ± 0.388
1.797ArgHis: 1.797 ± 0.284
2.591ArgIle: 2.591 ± 0.35
3.093ArgLys: 3.093 ± 0.376
4.723ArgLeu: 4.723 ± 0.531
1.922ArgMet: 1.922 ± 0.293
1.546ArgAsn: 1.546 ± 0.202
2.842ArgPro: 2.842 ± 0.392
2.299ArgGln: 2.299 ± 0.275
3.636ArgArg: 3.636 ± 0.487
3.051ArgSer: 3.051 ± 0.361
2.842ArgThr: 2.842 ± 0.371
4.221ArgVal: 4.221 ± 0.456
1.546ArgTrp: 1.546 ± 0.266
2.382ArgTyr: 2.382 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
4.89SerAla: 4.89 ± 0.45
0.46SerCys: 0.46 ± 0.143
3.343SerAsp: 3.343 ± 0.357
3.636SerGlu: 3.636 ± 0.482
2.006SerPhe: 2.006 ± 0.26
6.143SerGly: 6.143 ± 0.913
1.463SerHis: 1.463 ± 0.246
2.09SerIle: 2.09 ± 0.294
2.131SerLys: 2.131 ± 0.311
5.14SerLeu: 5.14 ± 0.471
1.17SerMet: 1.17 ± 0.202
1.964SerAsn: 1.964 ± 0.308
2.716SerPro: 2.716 ± 0.318
1.421SerGln: 1.421 ± 0.279
3.469SerArg: 3.469 ± 0.466
3.511SerSer: 3.511 ± 0.445
3.678SerThr: 3.678 ± 0.511
3.719SerVal: 3.719 ± 0.353
1.588SerTrp: 1.588 ± 0.257
1.588SerTyr: 1.588 ± 0.288
0.0SerXaa: 0.0 ± 0.0
Thr
6.603ThrAla: 6.603 ± 0.537
0.502ThrCys: 0.502 ± 0.14
3.678ThrAsp: 3.678 ± 0.412
4.012ThrGlu: 4.012 ± 0.388
2.131ThrPhe: 2.131 ± 0.281
5.684ThrGly: 5.684 ± 0.496
1.128ThrHis: 1.128 ± 0.193
3.218ThrIle: 3.218 ± 0.337
2.508ThrLys: 2.508 ± 0.389
4.89ThrLeu: 4.89 ± 0.38
1.421ThrMet: 1.421 ± 0.308
1.964ThrAsn: 1.964 ± 0.297
5.224ThrPro: 5.224 ± 0.526
1.964ThrGln: 1.964 ± 0.309
2.842ThrArg: 2.842 ± 0.376
2.967ThrSer: 2.967 ± 0.347
3.302ThrThr: 3.302 ± 0.423
5.517ThrVal: 5.517 ± 0.457
1.379ThrTrp: 1.379 ± 0.331
2.048ThrTyr: 2.048 ± 0.266
0.0ThrXaa: 0.0 ± 0.0
Val
7.23ValAla: 7.23 ± 0.503
0.752ValCys: 0.752 ± 0.188
4.597ValAsp: 4.597 ± 0.444
5.684ValGlu: 5.684 ± 0.55
2.173ValPhe: 2.173 ± 0.332
5.099ValGly: 5.099 ± 0.47
1.672ValHis: 1.672 ± 0.245
3.761ValIle: 3.761 ± 0.421
3.385ValLys: 3.385 ± 0.44
4.096ValLeu: 4.096 ± 0.442
1.505ValMet: 1.505 ± 0.215
2.549ValAsn: 2.549 ± 0.309
3.427ValPro: 3.427 ± 0.397
2.257ValGln: 2.257 ± 0.316
4.096ValArg: 4.096 ± 0.472
3.97ValSer: 3.97 ± 0.335
5.308ValThr: 5.308 ± 0.592
5.684ValVal: 5.684 ± 0.645
0.836ValTrp: 0.836 ± 0.223
1.881ValTyr: 1.881 ± 0.285
0.0ValXaa: 0.0 ± 0.0
Trp
1.797TrpAla: 1.797 ± 0.275
0.334TrpCys: 0.334 ± 0.132
1.797TrpAsp: 1.797 ± 0.282
0.794TrpGlu: 0.794 ± 0.175
0.836TrpPhe: 0.836 ± 0.212
1.17TrpGly: 1.17 ± 0.237
0.71TrpHis: 0.71 ± 0.149
1.003TrpIle: 1.003 ± 0.184
0.669TrpLys: 0.669 ± 0.15
1.797TrpLeu: 1.797 ± 0.315
0.376TrpMet: 0.376 ± 0.144
0.669TrpAsn: 0.669 ± 0.151
0.919TrpPro: 0.919 ± 0.196
0.961TrpGln: 0.961 ± 0.215
1.045TrpArg: 1.045 ± 0.227
1.087TrpSer: 1.087 ± 0.218
1.296TrpThr: 1.296 ± 0.234
2.048TrpVal: 2.048 ± 0.305
0.376TrpTrp: 0.376 ± 0.134
0.71TrpTyr: 0.71 ± 0.198
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.424TyrAla: 2.424 ± 0.28
0.46TyrCys: 0.46 ± 0.154
1.797TyrAsp: 1.797 ± 0.355
1.839TyrGlu: 1.839 ± 0.27
0.794TyrPhe: 0.794 ± 0.205
3.427TyrGly: 3.427 ± 0.446
0.627TyrHis: 0.627 ± 0.168
1.254TyrIle: 1.254 ± 0.201
1.17TyrLys: 1.17 ± 0.235
2.466TyrLeu: 2.466 ± 0.286
0.585TyrMet: 0.585 ± 0.161
0.836TyrAsn: 0.836 ± 0.165
1.63TyrPro: 1.63 ± 0.283
1.128TyrGln: 1.128 ± 0.226
2.257TyrArg: 2.257 ± 0.304
1.463TyrSer: 1.463 ± 0.225
2.508TyrThr: 2.508 ± 0.332
2.466TyrVal: 2.466 ± 0.31
0.585TyrTrp: 0.585 ± 0.177
0.752TyrTyr: 0.752 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 144 proteins (23929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski