Amino acid dipepetide frequency for Methylophaga aminisulfidivorans MP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.645AlaAla: 7.645 ± 0.119	0.875AlaCys: 0.875 ± 0.032	5.472AlaAsp: 5.472 ± 0.078	6.331AlaGlu: 6.331 ± 0.099	3.241AlaPhe: 3.241 ± 0.06	6.108AlaGly: 6.108 ± 0.086	1.653AlaHis: 1.653 ± 0.039	6.11AlaIle: 6.11 ± 0.093	4.482AlaLys: 4.482 ± 0.066	9.197AlaLeu: 9.197 ± 0.097	2.68AlaMet: 2.68 ± 0.058	3.343AlaAsn: 3.343 ± 0.066	2.624AlaPro: 2.624 ± 0.066	3.29AlaGln: 3.29 ± 0.059	3.81AlaArg: 3.81 ± 0.067	5.135AlaSer: 5.135 ± 0.069	4.208AlaThr: 4.208 ± 0.066	5.948AlaVal: 5.948 ± 0.076	1.064AlaTrp: 1.064 ± 0.032	2.409AlaTyr: 2.409 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.642CysAla: 0.642 ± 0.024	0.147CysCys: 0.147 ± 0.012	0.526CysAsp: 0.526 ± 0.023	0.507CysGlu: 0.507 ± 0.023	0.41CysPhe: 0.41 ± 0.021	0.76CysGly: 0.76 ± 0.03	0.308CysHis: 0.308 ± 0.017	0.525CysIle: 0.525 ± 0.026	0.317CysLys: 0.317 ± 0.02	0.977CysLeu: 0.977 ± 0.034	0.176CysMet: 0.176 ± 0.014	0.279CysAsn: 0.279 ± 0.017	0.476CysPro: 0.476 ± 0.024	0.438CysGln: 0.438 ± 0.025	0.463CysArg: 0.463 ± 0.021	0.551CysSer: 0.551 ± 0.023	0.332CysThr: 0.332 ± 0.019	0.518CysVal: 0.518 ± 0.026	0.112CysTrp: 0.112 ± 0.011	0.288CysTyr: 0.288 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.743AspAla: 4.743 ± 0.073	0.478AspCys: 0.478 ± 0.02	3.727AspAsp: 3.727 ± 0.088	4.318AspGlu: 4.318 ± 0.099	2.42AspPhe: 2.42 ± 0.054	3.917AspGly: 3.917 ± 0.087	1.108AspHis: 1.108 ± 0.029	4.663AspIle: 4.663 ± 0.065	3.469AspLys: 3.469 ± 0.066	5.419AspLeu: 5.419 ± 0.077	1.665AspMet: 1.665 ± 0.042	2.777AspAsn: 2.777 ± 0.057	2.192AspPro: 2.192 ± 0.056	1.819AspGln: 1.819 ± 0.045	2.553AspArg: 2.553 ± 0.052	3.308AspSer: 3.308 ± 0.059	3.05AspThr: 3.05 ± 0.055	4.063AspVal: 4.063 ± 0.058	1.013AspTrp: 1.013 ± 0.032	2.152AspTyr: 2.152 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.395GluAla: 5.395 ± 0.087	0.442GluCys: 0.442 ± 0.021	3.017GluAsp: 3.017 ± 0.068	3.588GluGlu: 3.588 ± 0.087	2.346GluPhe: 2.346 ± 0.058	3.412GluGly: 3.412 ± 0.064	1.576GluHis: 1.576 ± 0.038	4.006GluIle: 4.006 ± 0.074	4.002GluLys: 4.002 ± 0.073	6.697GluLeu: 6.697 ± 0.099	1.806GluMet: 1.806 ± 0.046	2.76GluAsn: 2.76 ± 0.056	2.333GluPro: 2.333 ± 0.187	4.054GluGln: 4.054 ± 0.079	3.34GluArg: 3.34 ± 0.068	3.707GluSer: 3.707 ± 0.069	3.541GluThr: 3.541 ± 0.057	4.257GluVal: 4.257 ± 0.076	0.766GluTrp: 0.766 ± 0.029	1.673GluTyr: 1.673 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.164PheAla: 3.164 ± 0.056	0.424PheCys: 0.424 ± 0.02	2.756PheAsp: 2.756 ± 0.059	2.37PheGlu: 2.37 ± 0.048	1.865PhePhe: 1.865 ± 0.051	2.85PheGly: 2.85 ± 0.055	0.821PheHis: 0.821 ± 0.028	2.995PheIle: 2.995 ± 0.061	1.791PheLys: 1.791 ± 0.042	3.722PheLeu: 3.722 ± 0.081	1.01PheMet: 1.01 ± 0.032	1.933PheAsn: 1.933 ± 0.051	1.451PhePro: 1.451 ± 0.041	1.24PheGln: 1.24 ± 0.035	1.604PheArg: 1.604 ± 0.04	3.242PheSer: 3.242 ± 0.061	2.244PheThr: 2.244 ± 0.044	2.566PheVal: 2.566 ± 0.053	0.522PheTrp: 0.522 ± 0.026	1.447PheTyr: 1.447 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.853GlyAla: 4.853 ± 0.088	0.69GlyCys: 0.69 ± 0.032	3.704GlyAsp: 3.704 ± 0.073	4.131GlyGlu: 4.131 ± 0.062	3.036GlyPhe: 3.036 ± 0.059	4.535GlyGly: 4.535 ± 0.102	1.639GlyHis: 1.639 ± 0.039	4.826GlyIle: 4.826 ± 0.077	3.707GlyLys: 3.707 ± 0.065	7.198GlyLeu: 7.198 ± 0.088	1.985GlyMet: 1.985 ± 0.049	2.524GlyAsn: 2.524 ± 0.078	1.721GlyPro: 1.721 ± 0.045	2.922GlyGln: 2.922 ± 0.063	3.229GlyArg: 3.229 ± 0.064	3.812GlySer: 3.812 ± 0.079	3.381GlyThr: 3.381 ± 0.09	4.695GlyVal: 4.695 ± 0.078	0.987GlyTrp: 0.987 ± 0.028	2.331GlyTyr: 2.331 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.785HisAla: 1.785 ± 0.045	0.291HisCys: 0.291 ± 0.017	1.297HisAsp: 1.297 ± 0.04	1.317HisGlu: 1.317 ± 0.04	1.029HisPhe: 1.029 ± 0.031	1.572HisGly: 1.572 ± 0.045	0.858HisHis: 0.858 ± 0.032	1.706HisIle: 1.706 ± 0.042	0.988HisLys: 0.988 ± 0.027	2.245HisLeu: 2.245 ± 0.058	0.56HisMet: 0.56 ± 0.025	0.908HisAsn: 0.908 ± 0.027	1.229HisPro: 1.229 ± 0.038	1.322HisGln: 1.322 ± 0.036	1.131HisArg: 1.131 ± 0.034	1.374HisSer: 1.374 ± 0.039	1.154HisThr: 1.154 ± 0.034	1.35HisVal: 1.35 ± 0.041	0.388HisTrp: 0.388 ± 0.018	0.962HisTyr: 0.962 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.307IleAla: 6.307 ± 0.092	0.615IleCys: 0.615 ± 0.027	4.698IleAsp: 4.698 ± 0.075	4.73IleGlu: 4.73 ± 0.077	2.314IlePhe: 2.314 ± 0.053	4.502IleGly: 4.502 ± 0.082	1.566IleHis: 1.566 ± 0.038	4.182IleIle: 4.182 ± 0.084	3.598IleLys: 3.598 ± 0.054	5.647IleLeu: 5.647 ± 0.079	1.369IleMet: 1.369 ± 0.036	3.293IleAsn: 3.293 ± 0.07	2.785IlePro: 2.785 ± 0.06	2.565IleGln: 2.565 ± 0.057	3.204IleArg: 3.204 ± 0.058	4.878IleSer: 4.878 ± 0.087	3.859IleThr: 3.859 ± 0.068	4.109IleVal: 4.109 ± 0.065	0.697IleTrp: 0.697 ± 0.027	1.759IleTyr: 1.759 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.706LysAla: 4.706 ± 0.095	0.242LysCys: 0.242 ± 0.019	2.597LysAsp: 2.597 ± 0.06	2.838LysGlu: 2.838 ± 0.06	1.373LysPhe: 1.373 ± 0.037	2.908LysGly: 2.908 ± 0.054	1.366LysHis: 1.366 ± 0.04	2.831LysIle: 2.831 ± 0.061	3.118LysLys: 3.118 ± 0.066	5.287LysLeu: 5.287 ± 0.084	1.365LysMet: 1.365 ± 0.034	2.277LysAsn: 2.277 ± 0.048	2.336LysPro: 2.336 ± 0.053	3.554LysGln: 3.554 ± 0.065	2.748LysArg: 2.748 ± 0.061	3.025LysSer: 3.025 ± 0.061	3.4LysThr: 3.4 ± 0.063	3.44LysVal: 3.44 ± 0.069	0.613LysTrp: 0.613 ± 0.027	1.243LysTyr: 1.243 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	9.688LeuAla: 9.688 ± 0.102	0.908LeuCys: 0.908 ± 0.036	5.961LeuAsp: 5.961 ± 0.082	5.882LeuGlu: 5.882 ± 0.086	4.527LeuPhe: 4.527 ± 0.087	6.555LeuGly: 6.555 ± 0.102	2.192LeuHis: 2.192 ± 0.047	6.938LeuIle: 6.938 ± 0.096	5.478LeuLys: 5.478 ± 0.084	10.936LeuLeu: 10.936 ± 0.139	2.781LeuMet: 2.781 ± 0.051	4.665LeuAsn: 4.665 ± 0.078	4.846LeuPro: 4.846 ± 0.082	4.045LeuGln: 4.045 ± 0.072	4.748LeuArg: 4.748 ± 0.075	8.243LeuSer: 8.243 ± 0.104	6.219LeuThr: 6.219 ± 0.077	6.627LeuVal: 6.627 ± 0.094	1.102LeuTrp: 1.102 ± 0.04	2.654LeuTyr: 2.654 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.673MetAla: 2.673 ± 0.063	0.168MetCys: 0.168 ± 0.013	1.4MetAsp: 1.4 ± 0.04	1.237MetGlu: 1.237 ± 0.034	0.871MetPhe: 0.871 ± 0.031	1.707MetGly: 1.707 ± 0.046	0.555MetHis: 0.555 ± 0.027	1.542MetIle: 1.542 ± 0.043	1.467MetLys: 1.467 ± 0.042	2.869MetLeu: 2.869 ± 0.053	0.841MetMet: 0.841 ± 0.033	1.183MetAsn: 1.183 ± 0.033	1.284MetPro: 1.284 ± 0.038	1.18MetGln: 1.18 ± 0.039	1.295MetArg: 1.295 ± 0.039	1.966MetSer: 1.966 ± 0.042	1.871MetThr: 1.871 ± 0.045	1.703MetVal: 1.703 ± 0.047	0.218MetTrp: 0.218 ± 0.015	0.472MetTyr: 0.472 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.48AsnAla: 3.48 ± 0.066	0.298AsnCys: 0.298 ± 0.018	2.606AsnAsp: 2.606 ± 0.069	2.524AsnGlu: 2.524 ± 0.059	1.393AsnPhe: 1.393 ± 0.039	2.801AsnGly: 2.801 ± 0.064	0.986AsnHis: 0.986 ± 0.035	2.908AsnIle: 2.908 ± 0.059	2.234AsnLys: 2.234 ± 0.05	3.943AsnLeu: 3.943 ± 0.068	1.005AsnMet: 1.005 ± 0.031	2.03AsnAsn: 2.03 ± 0.071	2.079AsnPro: 2.079 ± 0.051	2.002AsnGln: 2.002 ± 0.047	1.998AsnArg: 1.998 ± 0.041	2.493AsnSer: 2.493 ± 0.058	2.423AsnThr: 2.423 ± 0.06	2.617AsnVal: 2.617 ± 0.057	0.585AsnTrp: 0.585 ± 0.024	1.305AsnTyr: 1.305 ± 0.041	0.001AsnXaa: 0.001 ± 0.001
Pro	3.343ProAla: 3.343 ± 0.06	0.306ProCys: 0.306 ± 0.02	2.888ProAsp: 2.888 ± 0.057	3.519ProGlu: 3.519 ± 0.173	1.646ProPhe: 1.646 ± 0.044	2.527ProGly: 2.527 ± 0.058	0.842ProHis: 0.842 ± 0.029	2.464ProIle: 2.464 ± 0.049	1.849ProLys: 1.849 ± 0.049	4.019ProLeu: 4.019 ± 0.066	0.959ProMet: 0.959 ± 0.028	1.436ProAsn: 1.436 ± 0.044	1.212ProPro: 1.212 ± 0.038	1.568ProGln: 1.568 ± 0.037	1.485ProArg: 1.485 ± 0.035	2.386ProSer: 2.386 ± 0.05	1.954ProThr: 1.954 ± 0.04	3.381ProVal: 3.381 ± 0.07	0.527ProTrp: 0.527 ± 0.025	1.248ProTyr: 1.248 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.555GlnAla: 4.555 ± 0.079	0.375GlnCys: 0.375 ± 0.02	1.968GlnAsp: 1.968 ± 0.05	2.269GlnGlu: 2.269 ± 0.048	1.815GlnPhe: 1.815 ± 0.04	2.653GlnGly: 2.653 ± 0.054	1.41GlnHis: 1.41 ± 0.043	2.744GlnIle: 2.744 ± 0.052	2.279GlnLys: 2.279 ± 0.054	5.275GlnLeu: 5.275 ± 0.091	1.049GlnMet: 1.049 ± 0.031	1.693GlnAsn: 1.693 ± 0.045	1.778GlnPro: 1.778 ± 0.044	3.718GlnGln: 3.718 ± 0.104	2.716GlnArg: 2.716 ± 0.054	2.936GlnSer: 2.936 ± 0.062	2.532GlnThr: 2.532 ± 0.053	2.918GlnVal: 2.918 ± 0.055	0.701GlnTrp: 0.701 ± 0.028	1.344GlnTyr: 1.344 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.495ArgAla: 3.495 ± 0.064	0.43ArgCys: 0.43 ± 0.023	2.737ArgAsp: 2.737 ± 0.056	3.175ArgGlu: 3.175 ± 0.062	2.273ArgPhe: 2.273 ± 0.047	2.65ArgGly: 2.65 ± 0.07	1.306ArgHis: 1.306 ± 0.037	3.15ArgIle: 3.15 ± 0.063	2.248ArgLys: 2.248 ± 0.051	5.618ArgLeu: 5.618 ± 0.088	1.242ArgMet: 1.242 ± 0.037	1.824ArgAsn: 1.824 ± 0.042	1.704ArgPro: 1.704 ± 0.043	2.689ArgGln: 2.689 ± 0.053	2.601ArgArg: 2.601 ± 0.062	2.607ArgSer: 2.607 ± 0.049	2.086ArgThr: 2.086 ± 0.049	3.18ArgVal: 3.18 ± 0.057	0.708ArgTrp: 0.708 ± 0.029	1.933ArgTyr: 1.933 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.442SerAla: 5.442 ± 0.081	0.574SerCys: 0.574 ± 0.024	3.693SerAsp: 3.693 ± 0.07	3.946SerGlu: 3.946 ± 0.076	2.72SerPhe: 2.72 ± 0.051	4.994SerGly: 4.994 ± 0.092	1.637SerHis: 1.637 ± 0.043	3.988SerIle: 3.988 ± 0.077	2.746SerLys: 2.746 ± 0.056	7.443SerLeu: 7.443 ± 0.105	1.779SerMet: 1.779 ± 0.041	2.355SerAsn: 2.355 ± 0.052	2.601SerPro: 2.601 ± 0.051	2.945SerGln: 2.945 ± 0.058	3.046SerArg: 3.046 ± 0.063	4.381SerSer: 4.381 ± 0.085	3.207SerThr: 3.207 ± 0.06	4.513SerVal: 4.513 ± 0.066	0.95SerTrp: 0.95 ± 0.033	2.086SerTyr: 2.086 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.858ThrAla: 4.858 ± 0.067	0.379ThrCys: 0.379 ± 0.018	3.358ThrAsp: 3.358 ± 0.065	3.418ThrGlu: 3.418 ± 0.073	1.963ThrPhe: 1.963 ± 0.046	4.293ThrGly: 4.293 ± 0.084	1.289ThrHis: 1.289 ± 0.04	3.512ThrIle: 3.512 ± 0.067	2.209ThrLys: 2.209 ± 0.048	6.468ThrLeu: 6.468 ± 0.083	1.245ThrMet: 1.245 ± 0.041	1.986ThrAsn: 1.986 ± 0.047	2.579ThrPro: 2.579 ± 0.054	2.336ThrGln: 2.336 ± 0.05	2.307ThrArg: 2.307 ± 0.051	3.382ThrSer: 3.382 ± 0.058	2.956ThrThr: 2.956 ± 0.072	3.926ThrVal: 3.926 ± 0.059	0.547ThrTrp: 0.547 ± 0.024	1.368ThrTyr: 1.368 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.696ValAla: 5.696 ± 0.083	0.643ValCys: 0.643 ± 0.027	4.14ValAsp: 4.14 ± 0.07	4.303ValGlu: 4.303 ± 0.074	2.856ValPhe: 2.856 ± 0.055	4.321ValGly: 4.321 ± 0.077	1.229ValHis: 1.229 ± 0.03	5.099ValIle: 5.099 ± 0.082	3.448ValLys: 3.448 ± 0.061	6.74ValLeu: 6.74 ± 0.087	2.095ValMet: 2.095 ± 0.046	2.995ValAsn: 2.995 ± 0.059	2.425ValPro: 2.425 ± 0.054	2.101ValGln: 2.101 ± 0.052	2.92ValArg: 2.92 ± 0.06	4.825ValSer: 4.825 ± 0.071	3.927ValThr: 3.927 ± 0.072	4.838ValVal: 4.838 ± 0.09	0.833ValTrp: 0.833 ± 0.032	1.851ValTyr: 1.851 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.847TrpAla: 0.847 ± 0.026	0.158TrpCys: 0.158 ± 0.012	0.579TrpAsp: 0.579 ± 0.025	0.574TrpGlu: 0.574 ± 0.025	0.62TrpPhe: 0.62 ± 0.032	0.738TrpGly: 0.738 ± 0.031	0.358TrpHis: 0.358 ± 0.016	0.765TrpIle: 0.765 ± 0.025	0.544TrpLys: 0.544 ± 0.025	1.971TrpLeu: 1.971 ± 0.057	0.309TrpMet: 0.309 ± 0.019	0.457TrpAsn: 0.457 ± 0.024	0.53TrpPro: 0.53 ± 0.025	1.045TrpGln: 1.045 ± 0.035	0.699TrpArg: 0.699 ± 0.031	0.832TrpSer: 0.832 ± 0.032	0.546TrpThr: 0.546 ± 0.021	0.833TrpVal: 0.833 ± 0.03	0.177TrpTrp: 0.177 ± 0.015	0.395TrpTyr: 0.395 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.305TyrAla: 2.305 ± 0.044	0.313TyrCys: 0.313 ± 0.018	1.728TyrAsp: 1.728 ± 0.047	1.739TyrGlu: 1.739 ± 0.048	1.301TyrPhe: 1.301 ± 0.041	2.105TyrGly: 2.105 ± 0.048	0.766TyrHis: 0.766 ± 0.026	1.72TyrIle: 1.72 ± 0.048	1.288TyrLys: 1.288 ± 0.036	3.323TyrLeu: 3.323 ± 0.064	0.578TyrMet: 0.578 ± 0.023	0.994TyrAsn: 0.994 ± 0.037	1.376TyrPro: 1.376 ± 0.036	1.898TyrGln: 1.898 ± 0.048	1.76TyrArg: 1.76 ± 0.046	1.962TyrSer: 1.962 ± 0.047	1.489TyrThr: 1.489 ± 0.044	1.802TyrVal: 1.802 ± 0.041	0.469TyrTrp: 0.469 ± 0.025	0.96TyrTyr: 0.96 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3174 proteins (995886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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