Amino acid dipepetide frequency for Desulforudis audaxviator (strain MP104C)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.41AlaAla: 13.41 ± 0.22	1.179AlaCys: 1.179 ± 0.052	4.961AlaAsp: 4.961 ± 0.09	7.358AlaGlu: 7.358 ± 0.117	3.467AlaPhe: 3.467 ± 0.076	10.988AlaGly: 10.988 ± 0.173	1.92AlaHis: 1.92 ± 0.057	3.933AlaIle: 3.933 ± 0.102	3.005AlaLys: 3.005 ± 0.08	11.516AlaLeu: 11.516 ± 0.18	1.964AlaMet: 1.964 ± 0.058	2.125AlaAsn: 2.125 ± 0.061	3.942AlaPro: 3.942 ± 0.108	2.921AlaGln: 2.921 ± 0.068	8.716AlaArg: 8.716 ± 0.129	3.528AlaSer: 3.528 ± 0.078	3.703AlaThr: 3.703 ± 0.093	10.604AlaVal: 10.604 ± 0.152	1.115AlaTrp: 1.115 ± 0.042	2.571AlaTyr: 2.571 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.089CysAla: 1.089 ± 0.038	0.228CysCys: 0.228 ± 0.022	0.481CysAsp: 0.481 ± 0.027	0.499CysGlu: 0.499 ± 0.031	0.455CysPhe: 0.455 ± 0.026	1.369CysGly: 1.369 ± 0.052	0.272CysHis: 0.272 ± 0.019	0.397CysIle: 0.397 ± 0.027	0.301CysLys: 0.301 ± 0.021	1.155CysLeu: 1.155 ± 0.04	0.198CysMet: 0.198 ± 0.017	0.298CysAsn: 0.298 ± 0.022	0.881CysPro: 0.881 ± 0.047	0.275CysGln: 0.275 ± 0.021	1.207CysArg: 1.207 ± 0.045	0.596CysSer: 0.596 ± 0.031	0.567CysThr: 0.567 ± 0.029	0.793CysVal: 0.793 ± 0.037	0.134CysTrp: 0.134 ± 0.015	0.354CysTyr: 0.354 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.185AspAla: 4.185 ± 0.088	0.563AspCys: 0.563 ± 0.033	1.941AspAsp: 1.941 ± 0.057	3.432AspGlu: 3.432 ± 0.09	2.087AspPhe: 2.087 ± 0.067	4.149AspGly: 4.149 ± 0.083	0.922AspHis: 0.922 ± 0.037	2.774AspIle: 2.774 ± 0.065	1.614AspLys: 1.614 ± 0.059	5.874AspLeu: 5.874 ± 0.099	0.866AspMet: 0.866 ± 0.036	1.117AspAsn: 1.117 ± 0.04	3.134AspPro: 3.134 ± 0.072	1.381AspGln: 1.381 ± 0.046	4.327AspArg: 4.327 ± 0.09	1.782AspSer: 1.782 ± 0.055	2.218AspThr: 2.218 ± 0.055	3.785AspVal: 3.785 ± 0.085	0.666AspTrp: 0.666 ± 0.035	1.541AspTyr: 1.541 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	7.737GluAla: 7.737 ± 0.116	0.598GluCys: 0.598 ± 0.034	3.0GluAsp: 3.0 ± 0.075	5.593GluGlu: 5.593 ± 0.133	2.32GluPhe: 2.32 ± 0.058	4.726GluGly: 4.726 ± 0.08	1.395GluHis: 1.395 ± 0.05	4.511GluIle: 4.511 ± 0.09	3.501GluLys: 3.501 ± 0.075	7.691GluLeu: 7.691 ± 0.112	1.95GluMet: 1.95 ± 0.055	1.915GluAsn: 1.915 ± 0.051	2.862GluPro: 2.862 ± 0.07	2.512GluGln: 2.512 ± 0.067	5.841GluArg: 5.841 ± 0.107	2.583GluSer: 2.583 ± 0.071	3.601GluThr: 3.601 ± 0.07	5.864GluVal: 5.864 ± 0.098	0.714GluTrp: 0.714 ± 0.03	1.88GluTyr: 1.88 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.406PheAla: 3.406 ± 0.076	0.507PheCys: 0.507 ± 0.027	1.877PheAsp: 1.877 ± 0.054	2.182PheGlu: 2.182 ± 0.051	1.623PhePhe: 1.623 ± 0.056	3.387PheGly: 3.387 ± 0.074	0.768PheHis: 0.768 ± 0.03	1.706PheIle: 1.706 ± 0.051	1.234PheLys: 1.234 ± 0.046	4.109PheLeu: 4.109 ± 0.09	0.794PheMet: 0.794 ± 0.033	1.01PheAsn: 1.01 ± 0.039	1.815PhePro: 1.815 ± 0.047	1.112PheGln: 1.112 ± 0.041	2.678PheArg: 2.678 ± 0.064	1.955PheSer: 1.955 ± 0.052	2.004PheThr: 2.004 ± 0.061	2.854PheVal: 2.854 ± 0.076	0.501PheTrp: 0.501 ± 0.031	1.021PheTyr: 1.021 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	8.045GlyAla: 8.045 ± 0.15	1.203GlyCys: 1.203 ± 0.046	3.983GlyAsp: 3.983 ± 0.071	5.62GlyGlu: 5.62 ± 0.091	3.572GlyPhe: 3.572 ± 0.075	7.163GlyGly: 7.163 ± 0.134	1.725GlyHis: 1.725 ± 0.049	4.788GlyIle: 4.788 ± 0.082	3.769GlyLys: 3.769 ± 0.079	9.765GlyLeu: 9.765 ± 0.137	2.037GlyMet: 2.037 ± 0.062	2.055GlyAsn: 2.055 ± 0.065	3.522GlyPro: 3.522 ± 0.084	2.526GlyGln: 2.526 ± 0.067	7.46GlyArg: 7.46 ± 0.117	3.849GlySer: 3.849 ± 0.083	4.7GlyThr: 4.7 ± 0.09	7.346GlyVal: 7.346 ± 0.111	1.022GlyTrp: 1.022 ± 0.044	2.576GlyTyr: 2.576 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.626HisAla: 1.626 ± 0.053	0.335HisCys: 0.335 ± 0.024	0.785HisAsp: 0.785 ± 0.035	0.959HisGlu: 0.959 ± 0.047	0.796HisPhe: 0.796 ± 0.039	1.693HisGly: 1.693 ± 0.048	0.613HisHis: 0.613 ± 0.033	0.984HisIle: 0.984 ± 0.036	0.606HisLys: 0.606 ± 0.029	2.448HisLeu: 2.448 ± 0.076	0.339HisMet: 0.339 ± 0.021	0.545HisAsn: 0.545 ± 0.029	1.526HisPro: 1.526 ± 0.049	0.672HisGln: 0.672 ± 0.029	1.675HisArg: 1.675 ± 0.054	0.879HisSer: 0.879 ± 0.035	1.007HisThr: 1.007 ± 0.044	1.356HisVal: 1.356 ± 0.041	0.281HisTrp: 0.281 ± 0.021	0.672HisTyr: 0.672 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	4.878IleAla: 4.878 ± 0.099	0.595IleCys: 0.595 ± 0.03	2.576IleAsp: 2.576 ± 0.061	3.242IleGlu: 3.242 ± 0.073	1.576IlePhe: 1.576 ± 0.05	4.131IleGly: 4.131 ± 0.084	0.902IleHis: 0.902 ± 0.044	2.869IleIle: 2.869 ± 0.074	1.998IleLys: 1.998 ± 0.064	5.368IleLeu: 5.368 ± 0.095	1.009IleMet: 1.009 ± 0.038	1.48IleAsn: 1.48 ± 0.046	2.816IlePro: 2.816 ± 0.062	1.476IleGln: 1.476 ± 0.057	3.898IleArg: 3.898 ± 0.074	2.628IleSer: 2.628 ± 0.063	2.977IleThr: 2.977 ± 0.073	3.977IleVal: 3.977 ± 0.084	0.409IleTrp: 0.409 ± 0.027	1.245IleTyr: 1.245 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.519LysAla: 3.519 ± 0.068	0.386LysCys: 0.386 ± 0.023	1.827LysAsp: 1.827 ± 0.061	2.929LysGlu: 2.929 ± 0.073	0.933LysPhe: 0.933 ± 0.038	2.743LysGly: 2.743 ± 0.074	0.779LysHis: 0.779 ± 0.035	2.001LysIle: 2.001 ± 0.065	2.104LysLys: 2.104 ± 0.067	3.521LysLeu: 3.521 ± 0.082	0.914LysMet: 0.914 ± 0.036	1.225LysAsn: 1.225 ± 0.048	1.882LysPro: 1.882 ± 0.057	1.19LysGln: 1.19 ± 0.039	2.769LysArg: 2.769 ± 0.07	1.678LysSer: 1.678 ± 0.053	2.162LysThr: 2.162 ± 0.055	3.157LysVal: 3.157 ± 0.083	0.362LysTrp: 0.362 ± 0.022	1.079LysTyr: 1.079 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	12.876LeuAla: 12.876 ± 0.179	1.191LeuCys: 1.191 ± 0.044	6.008LeuAsp: 6.008 ± 0.107	8.172LeuGlu: 8.172 ± 0.136	3.875LeuPhe: 3.875 ± 0.077	9.154LeuGly: 9.154 ± 0.146	1.99LeuHis: 1.99 ± 0.057	4.948LeuIle: 4.948 ± 0.091	4.619LeuLys: 4.619 ± 0.084	11.05LeuLeu: 11.05 ± 0.161	2.028LeuMet: 2.028 ± 0.064	2.904LeuAsn: 2.904 ± 0.063	5.559LeuPro: 5.559 ± 0.103	3.204LeuGln: 3.204 ± 0.08	7.945LeuArg: 7.945 ± 0.137	5.097LeuSer: 5.097 ± 0.1	5.616LeuThr: 5.616 ± 0.096	9.734LeuVal: 9.734 ± 0.145	1.12LeuTrp: 1.12 ± 0.05	2.497LeuTyr: 2.497 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	2.268MetAla: 2.268 ± 0.062	0.186MetCys: 0.186 ± 0.016	0.989MetAsp: 0.989 ± 0.043	1.345MetGlu: 1.345 ± 0.043	0.686MetPhe: 0.686 ± 0.036	1.712MetGly: 1.712 ± 0.059	0.44MetHis: 0.44 ± 0.027	1.05MetIle: 1.05 ± 0.041	0.846MetLys: 0.846 ± 0.036	2.081MetLeu: 2.081 ± 0.058	0.428MetMet: 0.428 ± 0.025	0.65MetAsn: 0.65 ± 0.031	1.103MetPro: 1.103 ± 0.04	0.656MetGln: 0.656 ± 0.03	1.661MetArg: 1.661 ± 0.052	1.106MetSer: 1.106 ± 0.042	1.07MetThr: 1.07 ± 0.046	1.912MetVal: 1.912 ± 0.052	0.149MetTrp: 0.149 ± 0.014	0.402MetTyr: 0.402 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.221AsnAla: 2.221 ± 0.064	0.321AsnCys: 0.321 ± 0.023	1.01AsnAsp: 1.01 ± 0.042	1.465AsnGlu: 1.465 ± 0.05	0.889AsnPhe: 0.889 ± 0.038	2.043AsnGly: 2.043 ± 0.062	0.504AsnHis: 0.504 ± 0.03	1.629AsnIle: 1.629 ± 0.055	0.867AsnLys: 0.867 ± 0.036	3.146AsnLeu: 3.146 ± 0.064	0.536AsnMet: 0.536 ± 0.026	0.68AsnAsn: 0.68 ± 0.034	2.019AsnPro: 2.019 ± 0.06	0.815AsnGln: 0.815 ± 0.036	2.233AsnArg: 2.233 ± 0.06	0.914AsnSer: 0.914 ± 0.037	1.287AsnThr: 1.287 ± 0.05	2.031AsnVal: 2.031 ± 0.057	0.351AsnTrp: 0.351 ± 0.025	0.806AsnTyr: 0.806 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.369ProAla: 5.369 ± 0.108	0.499ProCys: 0.499 ± 0.026	3.192ProAsp: 3.192 ± 0.073	4.957ProGlu: 4.957 ± 0.081	1.824ProPhe: 1.824 ± 0.06	5.611ProGly: 5.611 ± 0.108	0.989ProHis: 0.989 ± 0.041	1.541ProIle: 1.541 ± 0.058	1.479ProLys: 1.479 ± 0.056	4.703ProLeu: 4.703 ± 0.093	0.815ProMet: 0.815 ± 0.038	1.126ProAsn: 1.126 ± 0.038	2.679ProPro: 2.679 ± 0.087	1.412ProGln: 1.412 ± 0.042	3.274ProArg: 3.274 ± 0.066	2.022ProSer: 2.022 ± 0.065	2.083ProThr: 2.083 ± 0.059	5.302ProVal: 5.302 ± 0.078	0.578ProTrp: 0.578 ± 0.031	1.311ProTyr: 1.311 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.604GlnAla: 3.604 ± 0.088	0.271GlnCys: 0.271 ± 0.023	1.296GlnAsp: 1.296 ± 0.045	2.314GlnGlu: 2.314 ± 0.06	0.93GlnPhe: 0.93 ± 0.041	2.387GlnGly: 2.387 ± 0.058	0.528GlnHis: 0.528 ± 0.03	1.625GlnIle: 1.625 ± 0.058	1.395GlnLys: 1.395 ± 0.046	2.944GlnLeu: 2.944 ± 0.065	0.726GlnMet: 0.726 ± 0.033	0.892GlnAsn: 0.892 ± 0.038	1.383GlnPro: 1.383 ± 0.05	1.115GlnGln: 1.115 ± 0.046	2.2GlnArg: 2.2 ± 0.056	1.208GlnSer: 1.208 ± 0.043	1.401GlnThr: 1.401 ± 0.04	2.898GlnVal: 2.898 ± 0.074	0.283GlnTrp: 0.283 ± 0.024	0.73GlnTyr: 0.73 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.364ArgAla: 7.364 ± 0.127	0.902ArgCys: 0.902 ± 0.047	3.88ArgAsp: 3.88 ± 0.083	7.245ArgGlu: 7.245 ± 0.118	2.985ArgPhe: 2.985 ± 0.069	5.693ArgGly: 5.693 ± 0.111	1.76ArgHis: 1.76 ± 0.051	4.196ArgIle: 4.196 ± 0.1	3.032ArgLys: 3.032 ± 0.066	9.238ArgLeu: 9.238 ± 0.138	1.989ArgMet: 1.989 ± 0.057	2.055ArgAsn: 2.055 ± 0.057	3.714ArgPro: 3.714 ± 0.096	2.739ArgGln: 2.739 ± 0.072	6.941ArgArg: 6.941 ± 0.136	3.151ArgSer: 3.151 ± 0.067	3.691ArgThr: 3.691 ± 0.078	6.994ArgVal: 6.994 ± 0.11	0.939ArgTrp: 0.939 ± 0.034	2.329ArgTyr: 2.329 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	4.109SerAla: 4.109 ± 0.09	0.543SerCys: 0.543 ± 0.034	1.815SerAsp: 1.815 ± 0.058	2.474SerGlu: 2.474 ± 0.053	1.835SerPhe: 1.835 ± 0.05	4.535SerGly: 4.535 ± 0.101	0.849SerHis: 0.849 ± 0.041	2.066SerIle: 2.066 ± 0.061	1.319SerLys: 1.319 ± 0.044	4.983SerLeu: 4.983 ± 0.106	0.849SerMet: 0.849 ± 0.036	0.919SerAsn: 0.919 ± 0.042	2.466SerPro: 2.466 ± 0.064	1.188SerGln: 1.188 ± 0.05	3.837SerArg: 3.837 ± 0.074	1.938SerSer: 1.938 ± 0.058	2.112SerThr: 2.112 ± 0.058	3.434SerVal: 3.434 ± 0.074	0.548SerTrp: 0.548 ± 0.029	1.165SerTyr: 1.165 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.381ThrAla: 5.381 ± 0.09	0.49ThrCys: 0.49 ± 0.03	2.287ThrAsp: 2.287 ± 0.056	2.822ThrGlu: 2.822 ± 0.07	1.646ThrPhe: 1.646 ± 0.05	5.649ThrGly: 5.649 ± 0.092	0.907ThrHis: 0.907 ± 0.041	2.402ThrIle: 2.402 ± 0.066	1.426ThrLys: 1.426 ± 0.051	5.282ThrLeu: 5.282 ± 0.084	0.902ThrMet: 0.902 ± 0.036	1.281ThrAsn: 1.281 ± 0.05	2.787ThrPro: 2.787 ± 0.056	1.144ThrGln: 1.144 ± 0.046	3.466ThrArg: 3.466 ± 0.072	1.905ThrSer: 1.905 ± 0.048	2.402ThrThr: 2.402 ± 0.061	5.139ThrVal: 5.139 ± 0.09	0.531ThrTrp: 0.531 ± 0.033	1.238ThrTyr: 1.238 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.563ValAla: 8.563 ± 0.133	1.033ValCys: 1.033 ± 0.039	4.488ValAsp: 4.488 ± 0.084	5.826ValGlu: 5.826 ± 0.095	3.499ValPhe: 3.499 ± 0.083	6.413ValGly: 6.413 ± 0.106	1.636ValHis: 1.636 ± 0.054	4.89ValIle: 4.89 ± 0.102	2.982ValLys: 2.982 ± 0.077	10.028ValLeu: 10.028 ± 0.136	1.771ValMet: 1.771 ± 0.051	2.456ValAsn: 2.456 ± 0.064	4.656ValPro: 4.656 ± 0.1	2.501ValGln: 2.501 ± 0.062	7.096ValArg: 7.096 ± 0.104	4.385ValSer: 4.385 ± 0.083	4.685ValThr: 4.685 ± 0.087	8.239ValVal: 8.239 ± 0.148	0.892ValTrp: 0.892 ± 0.043	2.183ValTyr: 2.183 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.989TrpAla: 0.989 ± 0.04	0.157TrpCys: 0.157 ± 0.016	0.584TrpAsp: 0.584 ± 0.028	0.857TrpGlu: 0.857 ± 0.033	0.424TrpPhe: 0.424 ± 0.028	0.825TrpGly: 0.825 ± 0.038	0.218TrpHis: 0.218 ± 0.02	0.52TrpIle: 0.52 ± 0.027	0.368TrpLys: 0.368 ± 0.024	1.284TrpLeu: 1.284 ± 0.053	0.248TrpMet: 0.248 ± 0.021	0.344TrpAsn: 0.344 ± 0.022	0.514TrpPro: 0.514 ± 0.028	0.388TrpGln: 0.388 ± 0.025	0.922TrpArg: 0.922 ± 0.044	0.612TrpSer: 0.612 ± 0.036	0.485TrpThr: 0.485 ± 0.031	0.866TrpVal: 0.866 ± 0.044	0.208TrpTrp: 0.208 ± 0.018	0.321TrpTyr: 0.321 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.287TyrAla: 2.287 ± 0.06	0.364TyrCys: 0.364 ± 0.021	1.378TyrAsp: 1.378 ± 0.05	1.505TyrGlu: 1.505 ± 0.047	1.12TyrPhe: 1.12 ± 0.043	2.355TyrGly: 2.355 ± 0.065	0.682TyrHis: 0.682 ± 0.036	1.219TyrIle: 1.219 ± 0.044	0.695TyrLys: 0.695 ± 0.03	3.402TyrLeu: 3.402 ± 0.083	0.374TyrMet: 0.374 ± 0.025	0.692TyrAsn: 0.692 ± 0.033	1.506TyrPro: 1.506 ± 0.048	0.902TyrGln: 0.902 ± 0.037	2.693TyrArg: 2.693 ± 0.07	1.168TyrSer: 1.168 ± 0.047	1.318TyrThr: 1.318 ± 0.042	1.934TyrVal: 1.934 ± 0.052	0.33TyrTrp: 0.33 ± 0.023	0.907TyrTyr: 0.907 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2136 proteins (657274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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