Amino acid dipepetide frequency for Salinicoccus roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.188AlaAla: 6.188 ± 0.128
0.53AlaCys: 0.53 ± 0.029
4.08AlaAsp: 4.08 ± 0.078
5.479AlaGlu: 5.479 ± 0.101
3.433AlaPhe: 3.433 ± 0.084
5.905AlaGly: 5.905 ± 0.097
1.596AlaHis: 1.596 ± 0.053
5.534AlaIle: 5.534 ± 0.088
3.607AlaLys: 3.607 ± 0.077
7.997AlaLeu: 7.997 ± 0.113
2.336AlaMet: 2.336 ± 0.063
2.319AlaAsn: 2.319 ± 0.064
2.403AlaPro: 2.403 ± 0.065
2.268AlaGln: 2.268 ± 0.053
3.183AlaArg: 3.183 ± 0.074
4.264AlaSer: 4.264 ± 0.081
3.44AlaThr: 3.44 ± 0.079
5.945AlaVal: 5.945 ± 0.098
0.549AlaTrp: 0.549 ± 0.031
2.388AlaTyr: 2.388 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.329CysAla: 0.329 ± 0.026
0.05CysCys: 0.05 ± 0.009
0.364CysAsp: 0.364 ± 0.025
0.366CysGlu: 0.366 ± 0.023
0.171CysPhe: 0.171 ± 0.015
0.69CysGly: 0.69 ± 0.035
0.175CysHis: 0.175 ± 0.016
0.375CysIle: 0.375 ± 0.024
0.198CysLys: 0.198 ± 0.02
0.428CysLeu: 0.428 ± 0.022
0.145CysMet: 0.145 ± 0.015
0.192CysAsn: 0.192 ± 0.016
0.306CysPro: 0.306 ± 0.023
0.154CysGln: 0.154 ± 0.016
0.31CysArg: 0.31 ± 0.02
0.36CysSer: 0.36 ± 0.022
0.338CysThr: 0.338 ± 0.023
0.298CysVal: 0.298 ± 0.023
0.033CysTrp: 0.033 ± 0.006
0.193CysTyr: 0.193 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.677AspAla: 4.677 ± 0.096
0.289AspCys: 0.289 ± 0.022
3.835AspAsp: 3.835 ± 0.078
5.587AspGlu: 5.587 ± 0.099
2.847AspPhe: 2.847 ± 0.065
4.423AspGly: 4.423 ± 0.081
1.479AspHis: 1.479 ± 0.044
5.128AspIle: 5.128 ± 0.089
3.024AspLys: 3.024 ± 0.069
4.887AspLeu: 4.887 ± 0.084
2.045AspMet: 2.045 ± 0.054
2.092AspAsn: 2.092 ± 0.059
2.139AspPro: 2.139 ± 0.062
1.867AspGln: 1.867 ± 0.055
3.216AspArg: 3.216 ± 0.069
2.974AspSer: 2.974 ± 0.063
3.048AspThr: 3.048 ± 0.061
4.384AspVal: 4.384 ± 0.093
0.508AspTrp: 0.508 ± 0.028
2.682AspTyr: 2.682 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
7.131GluAla: 7.131 ± 0.13
0.364GluCys: 0.364 ± 0.025
5.257GluAsp: 5.257 ± 0.106
7.895GluGlu: 7.895 ± 0.175
2.44GluPhe: 2.44 ± 0.066
5.623GluGly: 5.623 ± 0.101
1.683GluHis: 1.683 ± 0.048
5.647GluIle: 5.647 ± 0.086
5.525GluLys: 5.525 ± 0.086
6.328GluLeu: 6.328 ± 0.104
2.991GluMet: 2.991 ± 0.068
3.496GluAsn: 3.496 ± 0.075
2.192GluPro: 2.192 ± 0.062
2.826GluGln: 2.826 ± 0.074
4.015GluArg: 4.015 ± 0.089
4.367GluSer: 4.367 ± 0.095
4.452GluThr: 4.452 ± 0.097
5.904GluVal: 5.904 ± 0.115
0.811GluTrp: 0.811 ± 0.038
2.739GluTyr: 2.739 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.766PheAla: 2.766 ± 0.063
0.249PheCys: 0.249 ± 0.017
2.835PheAsp: 2.835 ± 0.063
3.198PheGlu: 3.198 ± 0.07
2.097PhePhe: 2.097 ± 0.074
3.599PheGly: 3.599 ± 0.073
0.927PheHis: 0.927 ± 0.038
3.95PheIle: 3.95 ± 0.095
2.287PheLys: 2.287 ± 0.068
4.009PheLeu: 4.009 ± 0.099
1.392PheMet: 1.392 ± 0.045
2.085PheAsn: 2.085 ± 0.054
1.389PhePro: 1.389 ± 0.041
1.153PheGln: 1.153 ± 0.039
1.855PheArg: 1.855 ± 0.044
2.972PheSer: 2.972 ± 0.073
2.571PheThr: 2.571 ± 0.063
2.709PheVal: 2.709 ± 0.061
0.381PheTrp: 0.381 ± 0.023
1.491PheTyr: 1.491 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.575GlyAla: 5.575 ± 0.105
0.522GlyCys: 0.522 ± 0.029
3.816GlyAsp: 3.816 ± 0.088
5.371GlyGlu: 5.371 ± 0.089
3.418GlyPhe: 3.418 ± 0.076
5.536GlyGly: 5.536 ± 0.124
1.745GlyHis: 1.745 ± 0.052
6.058GlyIle: 6.058 ± 0.104
4.004GlyLys: 4.004 ± 0.079
6.858GlyLeu: 6.858 ± 0.102
2.586GlyMet: 2.586 ± 0.055
2.671GlyAsn: 2.671 ± 0.064
1.949GlyPro: 1.949 ± 0.055
2.097GlyGln: 2.097 ± 0.057
3.69GlyArg: 3.69 ± 0.077
4.143GlySer: 4.143 ± 0.087
4.306GlyThr: 4.306 ± 0.073
5.619GlyVal: 5.619 ± 0.094
0.716GlyTrp: 0.716 ± 0.029
2.959GlyTyr: 2.959 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.549HisAla: 1.549 ± 0.047
0.167HisCys: 0.167 ± 0.018
1.426HisAsp: 1.426 ± 0.045
1.776HisGlu: 1.776 ± 0.049
1.108HisPhe: 1.108 ± 0.039
1.657HisGly: 1.657 ± 0.052
0.82HisHis: 0.82 ± 0.037
1.805HisIle: 1.805 ± 0.045
0.958HisLys: 0.958 ± 0.034
2.251HisLeu: 2.251 ± 0.061
0.705HisMet: 0.705 ± 0.033
0.799HisAsn: 0.799 ± 0.035
1.303HisPro: 1.303 ± 0.042
0.796HisGln: 0.796 ± 0.038
1.041HisArg: 1.041 ± 0.036
1.174HisSer: 1.174 ± 0.042
1.185HisThr: 1.185 ± 0.038
1.578HisVal: 1.578 ± 0.054
0.213HisTrp: 0.213 ± 0.018
0.912HisTyr: 0.912 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.837IleAla: 5.837 ± 0.102
0.431IleCys: 0.431 ± 0.024
4.954IleAsp: 4.954 ± 0.094
6.006IleGlu: 6.006 ± 0.099
3.407IlePhe: 3.407 ± 0.084
5.983IleGly: 5.983 ± 0.106
1.759IleHis: 1.759 ± 0.05
6.361IleIle: 6.361 ± 0.128
3.546IleLys: 3.546 ± 0.078
6.777IleLeu: 6.777 ± 0.139
2.138IleMet: 2.138 ± 0.065
3.138IleAsn: 3.138 ± 0.055
2.937IlePro: 2.937 ± 0.076
2.176IleGln: 2.176 ± 0.062
3.585IleArg: 3.585 ± 0.068
4.893IleSer: 4.893 ± 0.081
4.242IleThr: 4.242 ± 0.071
5.222IleVal: 5.222 ± 0.091
0.574IleTrp: 0.574 ± 0.033
2.438IleTyr: 2.438 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
3.864LysAla: 3.864 ± 0.079
0.253LysCys: 0.253 ± 0.023
3.68LysAsp: 3.68 ± 0.083
5.517LysGlu: 5.517 ± 0.111
1.801LysPhe: 1.801 ± 0.057
3.71LysGly: 3.71 ± 0.073
1.279LysHis: 1.279 ± 0.046
3.362LysIle: 3.362 ± 0.067
3.956LysLys: 3.956 ± 0.093
4.344LysLeu: 4.344 ± 0.079
2.035LysMet: 2.035 ± 0.047
2.402LysAsn: 2.402 ± 0.063
1.776LysPro: 1.776 ± 0.057
1.908LysGln: 1.908 ± 0.054
3.039LysArg: 3.039 ± 0.063
3.082LysSer: 3.082 ± 0.069
2.706LysThr: 2.706 ± 0.055
4.306LysVal: 4.306 ± 0.079
0.506LysTrp: 0.506 ± 0.029
2.229LysTyr: 2.229 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
6.842LeuAla: 6.842 ± 0.124
0.443LeuCys: 0.443 ± 0.027
5.714LeuAsp: 5.714 ± 0.086
7.294LeuGlu: 7.294 ± 0.127
4.265LeuPhe: 4.265 ± 0.102
6.789LeuGly: 6.789 ± 0.096
1.786LeuHis: 1.786 ± 0.059
6.869LeuIle: 6.869 ± 0.138
5.746LeuLys: 5.746 ± 0.104
8.977LeuLeu: 8.977 ± 0.173
3.025LeuMet: 3.025 ± 0.068
3.922LeuAsn: 3.922 ± 0.076
3.629LeuPro: 3.629 ± 0.079
2.514LeuGln: 2.514 ± 0.063
3.399LeuArg: 3.399 ± 0.074
6.361LeuSer: 6.361 ± 0.096
4.953LeuThr: 4.953 ± 0.091
6.083LeuVal: 6.083 ± 0.116
0.667LeuTrp: 0.667 ± 0.032
3.171LeuTyr: 3.171 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.521MetAla: 2.521 ± 0.057
0.135MetCys: 0.135 ± 0.014
2.185MetAsp: 2.185 ± 0.056
2.634MetGlu: 2.634 ± 0.061
1.233MetPhe: 1.233 ± 0.043
2.052MetGly: 2.052 ± 0.057
0.655MetHis: 0.655 ± 0.034
2.349MetIle: 2.349 ± 0.062
2.58MetLys: 2.58 ± 0.058
3.103MetLeu: 3.103 ± 0.069
1.252MetMet: 1.252 ± 0.047
1.707MetAsn: 1.707 ± 0.051
1.201MetPro: 1.201 ± 0.048
1.022MetGln: 1.022 ± 0.043
1.253MetArg: 1.253 ± 0.047
1.854MetSer: 1.854 ± 0.049
2.062MetThr: 2.062 ± 0.055
2.04MetVal: 2.04 ± 0.056
0.204MetTrp: 0.204 ± 0.016
0.858MetTyr: 0.858 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.845AsnAla: 2.845 ± 0.059
0.207AsnCys: 0.207 ± 0.017
2.397AsnAsp: 2.397 ± 0.056
3.093AsnGlu: 3.093 ± 0.065
1.635AsnPhe: 1.635 ± 0.043
2.864AsnGly: 2.864 ± 0.063
1.067AsnHis: 1.067 ± 0.037
3.368AsnIle: 3.368 ± 0.064
1.916AsnLys: 1.916 ± 0.05
3.391AsnLeu: 3.391 ± 0.061
1.331AsnMet: 1.331 ± 0.041
1.57AsnAsn: 1.57 ± 0.049
1.839AsnPro: 1.839 ± 0.046
1.449AsnGln: 1.449 ± 0.045
2.287AsnArg: 2.287 ± 0.053
1.969AsnSer: 1.969 ± 0.045
2.06AsnThr: 2.06 ± 0.06
2.934AsnVal: 2.934 ± 0.066
0.309AsnTrp: 0.309 ± 0.023
1.503AsnTyr: 1.503 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
2.372ProAla: 2.372 ± 0.055
0.175ProCys: 0.175 ± 0.014
2.332ProAsp: 2.332 ± 0.06
3.576ProGlu: 3.576 ± 0.075
1.851ProPhe: 1.851 ± 0.049
2.535ProGly: 2.535 ± 0.063
0.942ProHis: 0.942 ± 0.035
2.512ProIle: 2.512 ± 0.058
1.859ProLys: 1.859 ± 0.052
3.395ProLeu: 3.395 ± 0.07
1.038ProMet: 1.038 ± 0.032
1.207ProAsn: 1.207 ± 0.041
0.928ProPro: 0.928 ± 0.031
0.92ProGln: 0.92 ± 0.037
1.143ProArg: 1.143 ± 0.042
2.081ProSer: 2.081 ± 0.055
1.674ProThr: 1.674 ± 0.054
3.044ProVal: 3.044 ± 0.072
0.336ProTrp: 0.336 ± 0.025
1.305ProTyr: 1.305 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.238GlnAla: 2.238 ± 0.057
0.132GlnCys: 0.132 ± 0.014
1.67GlnAsp: 1.67 ± 0.045
2.539GlnGlu: 2.539 ± 0.065
1.476GlnPhe: 1.476 ± 0.041
1.895GlnGly: 1.895 ± 0.053
0.768GlnHis: 0.768 ± 0.036
2.043GlnIle: 2.043 ± 0.051
1.958GlnLys: 1.958 ± 0.059
3.082GlnLeu: 3.082 ± 0.078
1.147GlnMet: 1.147 ± 0.041
1.331GlnAsn: 1.331 ± 0.043
1.013GlnPro: 1.013 ± 0.039
1.135GlnGln: 1.135 ± 0.04
1.322GlnArg: 1.322 ± 0.053
1.889GlnSer: 1.889 ± 0.056
1.64GlnThr: 1.64 ± 0.048
1.953GlnVal: 1.953 ± 0.049
0.296GlnTrp: 0.296 ± 0.019
1.226GlnTyr: 1.226 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.805ArgAla: 2.805 ± 0.067
0.217ArgCys: 0.217 ± 0.02
2.536ArgAsp: 2.536 ± 0.072
3.875ArgGlu: 3.875 ± 0.087
2.131ArgPhe: 2.131 ± 0.052
2.716ArgGly: 2.716 ± 0.065
1.188ArgHis: 1.188 ± 0.04
3.459ArgIle: 3.459 ± 0.082
3.157ArgLys: 3.157 ± 0.059
4.387ArgLeu: 4.387 ± 0.081
1.742ArgMet: 1.742 ± 0.054
2.204ArgAsn: 2.204 ± 0.056
1.541ArgPro: 1.541 ± 0.046
1.753ArgGln: 1.753 ± 0.052
2.622ArgArg: 2.622 ± 0.075
2.529ArgSer: 2.529 ± 0.066
2.642ArgThr: 2.642 ± 0.068
2.928ArgVal: 2.928 ± 0.062
0.314ArgTrp: 0.314 ± 0.024
1.767ArgTyr: 1.767 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.011SerAla: 4.011 ± 0.086
0.257SerCys: 0.257 ± 0.021
3.403SerAsp: 3.403 ± 0.077
4.348SerGlu: 4.348 ± 0.078
2.857SerPhe: 2.857 ± 0.061
5.004SerGly: 5.004 ± 0.08
1.4SerHis: 1.4 ± 0.038
4.534SerIle: 4.534 ± 0.089
3.031SerLys: 3.031 ± 0.065
5.489SerLeu: 5.489 ± 0.093
1.828SerMet: 1.828 ± 0.058
2.274SerAsn: 2.274 ± 0.057
1.942SerPro: 1.942 ± 0.053
1.748SerGln: 1.748 ± 0.053
2.981SerArg: 2.981 ± 0.066
3.386SerSer: 3.386 ± 0.072
3.131SerThr: 3.131 ± 0.07
4.005SerVal: 4.005 ± 0.07
0.488SerTrp: 0.488 ± 0.027
2.16SerTyr: 2.16 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.047ThrAla: 4.047 ± 0.076
0.306ThrCys: 0.306 ± 0.021
3.172ThrAsp: 3.172 ± 0.068
4.138ThrGlu: 4.138 ± 0.083
2.498ThrPhe: 2.498 ± 0.062
4.469ThrGly: 4.469 ± 0.086
1.248ThrHis: 1.248 ± 0.042
3.944ThrIle: 3.944 ± 0.076
2.429ThrLys: 2.429 ± 0.062
5.441ThrLeu: 5.441 ± 0.099
1.529ThrMet: 1.529 ± 0.04
1.843ThrAsn: 1.843 ± 0.048
2.393ThrPro: 2.393 ± 0.063
1.403ThrGln: 1.403 ± 0.047
2.183ThrArg: 2.183 ± 0.058
3.088ThrSer: 3.088 ± 0.066
2.789ThrThr: 2.789 ± 0.063
4.497ThrVal: 4.497 ± 0.085
0.42ThrTrp: 0.42 ± 0.024
1.884ThrTyr: 1.884 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.128ValAla: 5.128 ± 0.097
0.461ValCys: 0.461 ± 0.029
4.524ValAsp: 4.524 ± 0.083
5.688ValGlu: 5.688 ± 0.097
3.077ValPhe: 3.077 ± 0.074
4.894ValGly: 4.894 ± 0.095
1.59ValHis: 1.59 ± 0.048
5.814ValIle: 5.814 ± 0.108
3.841ValLys: 3.841 ± 0.087
7.116ValLeu: 7.116 ± 0.103
2.217ValMet: 2.217 ± 0.062
2.88ValAsn: 2.88 ± 0.065
2.743ValPro: 2.743 ± 0.06
2.003ValGln: 2.003 ± 0.055
2.917ValArg: 2.917 ± 0.067
4.323ValSer: 4.323 ± 0.074
4.091ValThr: 4.091 ± 0.07
5.144ValVal: 5.144 ± 0.095
0.578ValTrp: 0.578 ± 0.026
2.229ValTyr: 2.229 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.531TrpAla: 0.531 ± 0.028
0.067TrpCys: 0.067 ± 0.01
0.397TrpAsp: 0.397 ± 0.026
0.514TrpGlu: 0.514 ± 0.025
0.457TrpPhe: 0.457 ± 0.026
0.584TrpGly: 0.584 ± 0.03
0.197TrpHis: 0.197 ± 0.017
0.617TrpIle: 0.617 ± 0.031
0.424TrpLys: 0.424 ± 0.026
0.931TrpLeu: 0.931 ± 0.04
0.344TrpMet: 0.344 ± 0.025
0.389TrpAsn: 0.389 ± 0.026
0.25TrpPro: 0.25 ± 0.018
0.362TrpGln: 0.362 ± 0.025
0.336TrpArg: 0.336 ± 0.024
0.457TrpSer: 0.457 ± 0.025
0.469TrpThr: 0.469 ± 0.03
0.56TrpVal: 0.56 ± 0.028
0.101TrpTrp: 0.101 ± 0.014
0.322TrpTyr: 0.322 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.187TyrAla: 2.187 ± 0.054
0.222TyrCys: 0.222 ± 0.018
2.552TyrAsp: 2.552 ± 0.058
2.792TyrGlu: 2.792 ± 0.07
1.712TyrPhe: 1.712 ± 0.051
2.711TyrGly: 2.711 ± 0.056
0.923TyrHis: 0.923 ± 0.038
2.675TyrIle: 2.675 ± 0.06
1.707TyrLys: 1.707 ± 0.05
3.258TyrLeu: 3.258 ± 0.077
1.07TyrMet: 1.07 ± 0.043
1.515TyrAsn: 1.515 ± 0.05
1.351TyrPro: 1.351 ± 0.05
1.2TyrGln: 1.2 ± 0.04
2.139TyrArg: 2.139 ± 0.056
2.111TyrSer: 2.111 ± 0.057
1.919TyrThr: 1.919 ± 0.05
2.105TyrVal: 2.105 ± 0.058
0.304TyrTrp: 0.304 ± 0.02
1.437TyrTyr: 1.437 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2412 proteins (735775 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski