Amino acid dipepetide frequency for Rhodococcus sp. 1168

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.916AlaAla: 16.916 ± 0.166	0.852AlaCys: 0.852 ± 0.023	7.629AlaAsp: 7.629 ± 0.078	7.57AlaGlu: 7.57 ± 0.088	3.469AlaPhe: 3.469 ± 0.05	10.502AlaGly: 10.502 ± 0.104	2.441AlaHis: 2.441 ± 0.043	5.408AlaIle: 5.408 ± 0.072	3.094AlaLys: 3.094 ± 0.053	12.954AlaLeu: 12.954 ± 0.102	2.621AlaMet: 2.621 ± 0.04	2.299AlaAsn: 2.299 ± 0.04	5.413AlaPro: 5.413 ± 0.081	3.68AlaGln: 3.68 ± 0.057	7.873AlaArg: 7.873 ± 0.081	7.14AlaSer: 7.14 ± 0.08	6.882AlaThr: 6.882 ± 0.07	11.286AlaVal: 11.286 ± 0.101	1.522AlaTrp: 1.522 ± 0.037	2.174AlaTyr: 2.174 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.03	0.098CysCys: 0.098 ± 0.009	0.444CysAsp: 0.444 ± 0.018	0.395CysGlu: 0.395 ± 0.017	0.208CysPhe: 0.208 ± 0.012	0.777CysGly: 0.777 ± 0.023	0.15CysHis: 0.15 ± 0.011	0.29CysIle: 0.29 ± 0.014	0.146CysLys: 0.146 ± 0.011	0.535CysLeu: 0.535 ± 0.017	0.122CysMet: 0.122 ± 0.009	0.164CysAsn: 0.164 ± 0.012	0.396CysPro: 0.396 ± 0.018	0.166CysGln: 0.166 ± 0.01	0.461CysArg: 0.461 ± 0.021	0.554CysSer: 0.554 ± 0.021	0.466CysThr: 0.466 ± 0.018	0.586CysVal: 0.586 ± 0.019	0.1CysTrp: 0.1 ± 0.008	0.139CysTyr: 0.139 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.789AspAla: 7.789 ± 0.08	0.381AspCys: 0.381 ± 0.016	3.767AspAsp: 3.767 ± 0.054	3.865AspGlu: 3.865 ± 0.055	1.785AspPhe: 1.785 ± 0.039	5.832AspGly: 5.832 ± 0.06	1.347AspHis: 1.347 ± 0.035	2.973AspIle: 2.973 ± 0.052	1.484AspLys: 1.484 ± 0.032	6.407AspLeu: 6.407 ± 0.068	0.995AspMet: 0.995 ± 0.025	1.378AspAsn: 1.378 ± 0.033	4.154AspPro: 4.154 ± 0.05	1.702AspGln: 1.702 ± 0.039	4.611AspArg: 4.611 ± 0.065	3.866AspSer: 3.866 ± 0.053	3.4AspThr: 3.4 ± 0.048	5.398AspVal: 5.398 ± 0.067	0.874AspTrp: 0.874 ± 0.027	1.307AspTyr: 1.307 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.926GluAla: 5.926 ± 0.078	0.374GluCys: 0.374 ± 0.017	2.986GluAsp: 2.986 ± 0.05	2.955GluGlu: 2.955 ± 0.05	1.995GluPhe: 1.995 ± 0.038	3.756GluGly: 3.756 ± 0.059	1.496GluHis: 1.496 ± 0.03	2.976GluIle: 2.976 ± 0.042	1.732GluLys: 1.732 ± 0.041	6.787GluLeu: 6.787 ± 0.079	1.142GluMet: 1.142 ± 0.029	1.511GluAsn: 1.511 ± 0.034	2.822GluPro: 2.822 ± 0.054	2.274GluGln: 2.274 ± 0.041	4.399GluArg: 4.399 ± 0.064	3.692GluSer: 3.692 ± 0.055	2.88GluThr: 2.88 ± 0.042	4.713GluVal: 4.713 ± 0.069	0.853GluTrp: 0.853 ± 0.024	1.214GluTyr: 1.214 ± 0.029	0.001GluXaa: 0.001 ± 0.001
Phe	4.045PheAla: 4.045 ± 0.055	0.256PheCys: 0.256 ± 0.013	2.684PheAsp: 2.684 ± 0.051	1.795PheGlu: 1.795 ± 0.042	1.017PhePhe: 1.017 ± 0.029	3.553PheGly: 3.553 ± 0.057	0.665PheHis: 0.665 ± 0.021	1.059PheIle: 1.059 ± 0.029	0.545PheLys: 0.545 ± 0.021	2.631PheLeu: 2.631 ± 0.05	0.462PheMet: 0.462 ± 0.018	0.624PheAsn: 0.624 ± 0.022	1.384PhePro: 1.384 ± 0.03	0.71PheGln: 0.71 ± 0.023	1.659PheArg: 1.659 ± 0.037	1.895PheSer: 1.895 ± 0.037	2.039PheThr: 2.039 ± 0.042	2.865PheVal: 2.865 ± 0.049	0.389PheTrp: 0.389 ± 0.014	0.675PheTyr: 0.675 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.261GlyAla: 9.261 ± 0.103	0.712GlyCys: 0.712 ± 0.024	4.749GlyAsp: 4.749 ± 0.061	4.515GlyGlu: 4.515 ± 0.058	3.09GlyPhe: 3.09 ± 0.048	7.491GlyGly: 7.491 ± 0.1	1.92GlyHis: 1.92 ± 0.04	4.578GlyIle: 4.578 ± 0.064	2.743GlyLys: 2.743 ± 0.049	8.335GlyLeu: 8.335 ± 0.084	1.921GlyMet: 1.921 ± 0.04	2.044GlyAsn: 2.044 ± 0.04	3.955GlyPro: 3.955 ± 0.053	2.46GlyGln: 2.46 ± 0.048	5.925GlyArg: 5.925 ± 0.074	6.0GlySer: 6.0 ± 0.071	5.639GlyThr: 5.639 ± 0.071	7.563GlyVal: 7.563 ± 0.075	1.474GlyTrp: 1.474 ± 0.035	2.221GlyTyr: 2.221 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.273HisAla: 2.273 ± 0.042	0.193HisCys: 0.193 ± 0.012	1.248HisAsp: 1.248 ± 0.031	1.112HisGlu: 1.112 ± 0.027	0.625HisPhe: 0.625 ± 0.023	1.938HisGly: 1.938 ± 0.04	0.597HisHis: 0.597 ± 0.023	0.884HisIle: 0.884 ± 0.023	0.4HisLys: 0.4 ± 0.016	2.068HisLeu: 2.068 ± 0.037	0.351HisMet: 0.351 ± 0.015	0.443HisAsn: 0.443 ± 0.02	1.486HisPro: 1.486 ± 0.032	0.573HisGln: 0.573 ± 0.022	1.714HisArg: 1.714 ± 0.036	1.336HisSer: 1.336 ± 0.036	1.149HisThr: 1.149 ± 0.029	1.641HisVal: 1.641 ± 0.036	0.327HisTrp: 0.327 ± 0.017	0.492HisTyr: 0.492 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.72IleAla: 6.72 ± 0.077	0.351IleCys: 0.351 ± 0.016	3.926IleAsp: 3.926 ± 0.058	3.274IleGlu: 3.274 ± 0.048	1.194IlePhe: 1.194 ± 0.031	4.824IleGly: 4.824 ± 0.061	0.796IleHis: 0.796 ± 0.022	1.696IleIle: 1.696 ± 0.038	0.897IleLys: 0.897 ± 0.027	3.796IleLeu: 3.796 ± 0.067	0.671IleMet: 0.671 ± 0.021	1.043IleAsn: 1.043 ± 0.031	2.496IlePro: 2.496 ± 0.046	0.891IleGln: 0.891 ± 0.026	2.776IleArg: 2.776 ± 0.049	2.847IleSer: 2.847 ± 0.044	2.904IleThr: 2.904 ± 0.048	4.373IleVal: 4.373 ± 0.063	0.47IleTrp: 0.47 ± 0.019	0.855IleTyr: 0.855 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.863LysAla: 2.863 ± 0.05	0.131LysCys: 0.131 ± 0.01	1.328LysAsp: 1.328 ± 0.034	1.124LysGlu: 1.124 ± 0.03	0.825LysPhe: 0.825 ± 0.029	1.737LysGly: 1.737 ± 0.04	0.499LysHis: 0.499 ± 0.02	1.338LysIle: 1.338 ± 0.03	0.998LysLys: 0.998 ± 0.035	2.434LysLeu: 2.434 ± 0.042	0.581LysMet: 0.581 ± 0.022	0.741LysAsn: 0.741 ± 0.026	1.431LysPro: 1.431 ± 0.035	0.791LysGln: 0.791 ± 0.024	1.648LysArg: 1.648 ± 0.035	1.631LysSer: 1.631 ± 0.034	1.651LysThr: 1.651 ± 0.035	2.142LysVal: 2.142 ± 0.043	0.368LysTrp: 0.368 ± 0.016	0.627LysTyr: 0.627 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.167LeuAla: 13.167 ± 0.1	0.723LeuCys: 0.723 ± 0.024	7.236LeuAsp: 7.236 ± 0.078	5.021LeuGlu: 5.021 ± 0.062	2.854LeuPhe: 2.854 ± 0.047	8.953LeuGly: 8.953 ± 0.086	1.982LeuHis: 1.982 ± 0.037	4.428LeuIle: 4.428 ± 0.059	1.879LeuLys: 1.879 ± 0.041	9.597LeuLeu: 9.597 ± 0.108	1.709LeuMet: 1.709 ± 0.035	2.011LeuAsn: 2.011 ± 0.044	5.381LeuPro: 5.381 ± 0.064	2.476LeuGln: 2.476 ± 0.047	7.189LeuArg: 7.189 ± 0.088	6.375LeuSer: 6.375 ± 0.064	6.435LeuThr: 6.435 ± 0.074	8.79LeuVal: 8.79 ± 0.086	1.206LeuTrp: 1.206 ± 0.031	1.692LeuTyr: 1.692 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.254MetAla: 2.254 ± 0.044	0.164MetCys: 0.164 ± 0.011	0.939MetAsp: 0.939 ± 0.026	0.729MetGlu: 0.729 ± 0.023	0.625MetPhe: 0.625 ± 0.022	1.347MetGly: 1.347 ± 0.028	0.433MetHis: 0.433 ± 0.018	0.995MetIle: 0.995 ± 0.03	0.529MetLys: 0.529 ± 0.02	1.995MetLeu: 1.995 ± 0.04	0.39MetMet: 0.39 ± 0.018	0.581MetAsn: 0.581 ± 0.022	1.099MetPro: 1.099 ± 0.028	0.559MetGln: 0.559 ± 0.019	1.451MetArg: 1.451 ± 0.037	1.725MetSer: 1.725 ± 0.038	1.802MetThr: 1.802 ± 0.034	1.555MetVal: 1.555 ± 0.038	0.261MetTrp: 0.261 ± 0.014	0.359MetTyr: 0.359 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.586AsnAla: 2.586 ± 0.045	0.172AsnCys: 0.172 ± 0.012	1.283AsnAsp: 1.283 ± 0.033	1.137AsnGlu: 1.137 ± 0.032	0.723AsnPhe: 0.723 ± 0.023	2.059AsnGly: 2.059 ± 0.044	0.427AsnHis: 0.427 ± 0.018	1.064AsnIle: 1.064 ± 0.028	0.625AsnLys: 0.625 ± 0.019	2.122AsnLeu: 2.122 ± 0.04	0.421AsnMet: 0.421 ± 0.018	0.57AsnAsn: 0.57 ± 0.019	1.643AsnPro: 1.643 ± 0.035	0.64AsnGln: 0.64 ± 0.024	1.508AsnArg: 1.508 ± 0.031	1.48AsnSer: 1.48 ± 0.035	1.441AsnThr: 1.441 ± 0.034	1.764AsnVal: 1.764 ± 0.033	0.337AsnTrp: 0.337 ± 0.016	0.559AsnTyr: 0.559 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.978ProAla: 5.978 ± 0.076	0.244ProCys: 0.244 ± 0.014	3.819ProAsp: 3.819 ± 0.06	3.642ProGlu: 3.642 ± 0.059	1.548ProPhe: 1.548 ± 0.034	4.669ProGly: 4.669 ± 0.064	1.038ProHis: 1.038 ± 0.028	2.417ProIle: 2.417 ± 0.045	1.414ProLys: 1.414 ± 0.031	4.653ProLeu: 4.653 ± 0.06	1.031ProMet: 1.031 ± 0.026	1.26ProAsn: 1.26 ± 0.032	2.589ProPro: 2.589 ± 0.054	1.482ProGln: 1.482 ± 0.035	3.142ProArg: 3.142 ± 0.05	3.575ProSer: 3.575 ± 0.052	3.536ProThr: 3.536 ± 0.052	4.623ProVal: 4.623 ± 0.067	0.745ProTrp: 0.745 ± 0.024	1.028ProTyr: 1.028 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.195GlnAla: 3.195 ± 0.051	0.198GlnCys: 0.198 ± 0.012	1.273GlnAsp: 1.273 ± 0.03	1.195GlnGlu: 1.195 ± 0.027	0.992GlnPhe: 0.992 ± 0.029	2.004GlnGly: 2.004 ± 0.038	0.634GlnHis: 0.634 ± 0.023	1.541GlnIle: 1.541 ± 0.039	0.715GlnLys: 0.715 ± 0.021	3.289GlnLeu: 3.289 ± 0.053	0.642GlnMet: 0.642 ± 0.023	0.698GlnAsn: 0.698 ± 0.023	1.451GlnPro: 1.451 ± 0.036	1.25GlnGln: 1.25 ± 0.037	2.274GlnArg: 2.274 ± 0.04	1.742GlnSer: 1.742 ± 0.042	1.449GlnThr: 1.449 ± 0.036	2.413GlnVal: 2.413 ± 0.05	0.563GlnTrp: 0.563 ± 0.021	0.65GlnTyr: 0.65 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.587ArgAla: 7.587 ± 0.084	0.49ArgCys: 0.49 ± 0.02	3.729ArgAsp: 3.729 ± 0.055	4.045ArgGlu: 4.045 ± 0.047	2.254ArgPhe: 2.254 ± 0.038	4.895ArgGly: 4.895 ± 0.059	1.497ArgHis: 1.497 ± 0.038	3.649ArgIle: 3.649 ± 0.056	1.887ArgLys: 1.887 ± 0.037	6.546ArgLeu: 6.546 ± 0.082	1.7ArgMet: 1.7 ± 0.034	1.611ArgAsn: 1.611 ± 0.033	3.344ArgPro: 3.344 ± 0.057	2.012ArgGln: 2.012 ± 0.036	5.705ArgArg: 5.705 ± 0.098	4.753ArgSer: 4.753 ± 0.067	4.688ArgThr: 4.688 ± 0.063	5.399ArgVal: 5.399 ± 0.067	1.206ArgTrp: 1.206 ± 0.025	1.669ArgTyr: 1.669 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.926SerAla: 7.926 ± 0.079	0.404SerCys: 0.404 ± 0.017	3.922SerAsp: 3.922 ± 0.056	3.598SerGlu: 3.598 ± 0.055	1.916SerPhe: 1.916 ± 0.038	6.39SerGly: 6.39 ± 0.065	1.134SerHis: 1.134 ± 0.029	3.19SerIle: 3.19 ± 0.04	1.678SerLys: 1.678 ± 0.038	5.756SerLeu: 5.756 ± 0.064	1.668SerMet: 1.668 ± 0.035	1.544SerAsn: 1.544 ± 0.033	3.209SerPro: 3.209 ± 0.054	1.633SerGln: 1.633 ± 0.035	4.099SerArg: 4.099 ± 0.054	4.421SerSer: 4.421 ± 0.077	4.498SerThr: 4.498 ± 0.062	5.605SerVal: 5.605 ± 0.065	0.964SerTrp: 0.964 ± 0.026	1.354SerTyr: 1.354 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.757ThrAla: 7.757 ± 0.071	0.402ThrCys: 0.402 ± 0.015	3.957ThrAsp: 3.957 ± 0.053	3.6ThrGlu: 3.6 ± 0.054	1.932ThrPhe: 1.932 ± 0.035	5.726ThrGly: 5.726 ± 0.066	1.232ThrHis: 1.232 ± 0.032	2.863ThrIle: 2.863 ± 0.05	1.454ThrLys: 1.454 ± 0.032	5.91ThrLeu: 5.91 ± 0.06	1.185ThrMet: 1.185 ± 0.029	1.3ThrAsn: 1.3 ± 0.034	3.633ThrPro: 3.633 ± 0.052	1.537ThrGln: 1.537 ± 0.035	3.681ThrArg: 3.681 ± 0.058	4.046ThrSer: 4.046 ± 0.056	4.146ThrThr: 4.146 ± 0.069	6.182ThrVal: 6.182 ± 0.077	0.825ThrTrp: 0.825 ± 0.022	1.262ThrTyr: 1.262 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.824ValAla: 10.824 ± 0.112	0.672ValCys: 0.672 ± 0.019	6.33ValAsp: 6.33 ± 0.07	5.128ValGlu: 5.128 ± 0.063	2.625ValPhe: 2.625 ± 0.047	7.284ValGly: 7.284 ± 0.077	1.911ValHis: 1.911 ± 0.037	3.913ValIle: 3.913 ± 0.063	1.836ValLys: 1.836 ± 0.04	9.435ValLeu: 9.435 ± 0.101	1.555ValMet: 1.555 ± 0.034	1.822ValAsn: 1.822 ± 0.032	4.714ValPro: 4.714 ± 0.061	2.195ValGln: 2.195 ± 0.04	5.912ValArg: 5.912 ± 0.069	5.432ValSer: 5.432 ± 0.064	5.507ValThr: 5.507 ± 0.075	8.912ValVal: 8.912 ± 0.082	0.965ValTrp: 0.965 ± 0.028	1.461ValTyr: 1.461 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.471TrpAla: 1.471 ± 0.035	0.129TrpCys: 0.129 ± 0.01	0.753TrpAsp: 0.753 ± 0.025	0.601TrpGlu: 0.601 ± 0.022	0.518TrpPhe: 0.518 ± 0.019	0.938TrpGly: 0.938 ± 0.03	0.289TrpHis: 0.289 ± 0.016	0.762TrpIle: 0.762 ± 0.022	0.407TrpLys: 0.407 ± 0.018	1.584TrpLeu: 1.584 ± 0.036	0.318TrpMet: 0.318 ± 0.016	0.461TrpAsn: 0.461 ± 0.019	0.693TrpPro: 0.693 ± 0.02	0.543TrpGln: 0.543 ± 0.021	1.037TrpArg: 1.037 ± 0.031	1.035TrpSer: 1.035 ± 0.032	0.934TrpThr: 0.934 ± 0.026	1.057TrpVal: 1.057 ± 0.029	0.325TrpTrp: 0.325 ± 0.017	0.263TrpTyr: 0.263 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.255TyrAla: 2.255 ± 0.037	0.181TyrCys: 0.181 ± 0.012	1.312TyrAsp: 1.312 ± 0.032	1.181TyrGlu: 1.181 ± 0.028	0.757TyrPhe: 0.757 ± 0.022	1.921TyrGly: 1.921 ± 0.039	0.362TyrHis: 0.362 ± 0.016	0.775TyrIle: 0.775 ± 0.025	0.427TyrLys: 0.427 ± 0.019	2.271TyrLeu: 2.271 ± 0.044	0.308TyrMet: 0.308 ± 0.014	0.457TyrAsn: 0.457 ± 0.017	1.141TyrPro: 1.141 ± 0.034	0.59TyrGln: 0.59 ± 0.023	1.603TyrArg: 1.603 ± 0.037	1.366TyrSer: 1.366 ± 0.031	1.184TyrThr: 1.184 ± 0.03	1.567TyrVal: 1.567 ± 0.037	0.344TyrTrp: 0.344 ± 0.014	0.453TyrTyr: 0.453 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4386 proteins (1423437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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