Amino acid dipepetide frequency for Cedratvirus Zaza IHUMI

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.267AlaAla: 4.267 ± 0.268
1.414AlaCys: 1.414 ± 0.097
2.286AlaAsp: 2.286 ± 0.115
3.051AlaGlu: 3.051 ± 0.125
2.49AlaPhe: 2.49 ± 0.125
2.834AlaGly: 2.834 ± 0.211
1.013AlaHis: 1.013 ± 0.077
3.044AlaIle: 3.044 ± 0.14
3.082AlaLys: 3.082 ± 0.115
6.165AlaLeu: 6.165 ± 0.202
1.083AlaMet: 1.083 ± 0.094
2.624AlaAsn: 2.624 ± 0.156
1.783AlaPro: 1.783 ± 0.107
2.401AlaGln: 2.401 ± 0.177
3.643AlaArg: 3.643 ± 0.197
4.152AlaSer: 4.152 ± 0.155
3.051AlaThr: 3.051 ± 0.357
2.987AlaVal: 2.987 ± 0.152
0.681AlaTrp: 0.681 ± 0.075
2.77AlaTyr: 2.77 ± 0.134
0.0AlaXaa: 0.0 ± 0.0
Cys
1.274CysAla: 1.274 ± 0.104
0.465CysCys: 0.465 ± 0.059
1.204CysAsp: 1.204 ± 0.092
1.083CysGlu: 1.083 ± 0.086
1.006CysPhe: 1.006 ± 0.091
0.974CysGly: 0.974 ± 0.102
0.446CysHis: 0.446 ± 0.053
1.095CysIle: 1.095 ± 0.097
1.732CysLys: 1.732 ± 0.116
2.318CysLeu: 2.318 ± 0.136
0.459CysMet: 0.459 ± 0.055
0.898CysAsn: 0.898 ± 0.089
2.254CysPro: 2.254 ± 0.196
0.56CysGln: 0.56 ± 0.066
1.229CysArg: 1.229 ± 0.101
2.961CysSer: 2.961 ± 0.155
1.178CysThr: 1.178 ± 0.09
1.42CysVal: 1.42 ± 0.107
0.21CysTrp: 0.21 ± 0.045
1.095CysTyr: 1.095 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
2.356AspAla: 2.356 ± 0.109
1.235AspCys: 1.235 ± 0.094
2.707AspAsp: 2.707 ± 0.149
4.197AspGlu: 4.197 ± 0.164
2.809AspPhe: 2.809 ± 0.141
2.567AspGly: 2.567 ± 0.164
0.885AspHis: 0.885 ± 0.083
3.528AspIle: 3.528 ± 0.15
3.993AspLys: 3.993 ± 0.183
6.33AspLeu: 6.33 ± 0.244
1.337AspMet: 1.337 ± 0.091
2.248AspAsn: 2.248 ± 0.093
1.675AspPro: 1.675 ± 0.102
1.165AspGln: 1.165 ± 0.098
2.484AspArg: 2.484 ± 0.123
2.592AspSer: 2.592 ± 0.142
2.293AspThr: 2.293 ± 0.133
3.337AspVal: 3.337 ± 0.16
0.892AspTrp: 0.892 ± 0.07
2.898AspTyr: 2.898 ± 0.126
0.0AspXaa: 0.0 ± 0.0
Glu
3.706GluAla: 3.706 ± 0.156
0.962GluCys: 0.962 ± 0.086
4.471GluAsp: 4.471 ± 0.177
9.05GluGlu: 9.05 ± 0.332
3.057GluPhe: 3.057 ± 0.152
4.439GluGly: 4.439 ± 0.162
1.516GluHis: 1.516 ± 0.105
4.859GluIle: 4.859 ± 0.218
6.33GluLys: 6.33 ± 0.278
6.056GluLeu: 6.056 ± 0.211
1.726GluMet: 1.726 ± 0.104
3.91GluAsn: 3.91 ± 0.17
1.739GluPro: 1.739 ± 0.117
2.961GluGln: 2.961 ± 0.132
5.057GluArg: 5.057 ± 0.177
3.433GluSer: 3.433 ± 0.16
3.566GluThr: 3.566 ± 0.188
5.152GluVal: 5.152 ± 0.171
1.121GluTrp: 1.121 ± 0.115
2.923GluTyr: 2.923 ± 0.154
0.0GluXaa: 0.0 ± 0.0
Phe
3.165PheAla: 3.165 ± 0.146
1.146PheCys: 1.146 ± 0.095
1.949PheAsp: 1.949 ± 0.102
1.949PheGlu: 1.949 ± 0.117
2.541PhePhe: 2.541 ± 0.135
2.012PheGly: 2.012 ± 0.127
0.701PheHis: 0.701 ± 0.061
2.764PheIle: 2.764 ± 0.124
1.172PheLys: 1.172 ± 0.087
4.936PheLeu: 4.936 ± 0.205
1.019PheMet: 1.019 ± 0.087
1.84PheAsn: 1.84 ± 0.11
2.216PhePro: 2.216 ± 0.109
0.981PheGln: 0.981 ± 0.09
2.477PheArg: 2.477 ± 0.132
4.878PheSer: 4.878 ± 0.203
3.184PheThr: 3.184 ± 0.152
3.152PheVal: 3.152 ± 0.14
0.917PheTrp: 0.917 ± 0.087
2.649PheTyr: 2.649 ± 0.14
0.0PheXaa: 0.0 ± 0.0
Gly
3.687GlyAla: 3.687 ± 0.592
2.318GlyCys: 2.318 ± 0.192
2.815GlyAsp: 2.815 ± 0.131
4.7GlyGlu: 4.7 ± 0.286
2.426GlyPhe: 2.426 ± 0.12
3.375GlyGly: 3.375 ± 0.198
1.93GlyHis: 1.93 ± 0.173
3.076GlyIle: 3.076 ± 0.143
3.847GlyLys: 3.847 ± 0.231
4.649GlyLeu: 4.649 ± 0.195
0.993GlyMet: 0.993 ± 0.09
3.687GlyAsn: 3.687 ± 0.365
1.63GlyPro: 1.63 ± 0.127
1.936GlyGln: 1.936 ± 0.141
2.879GlyArg: 2.879 ± 0.14
3.617GlySer: 3.617 ± 0.194
2.643GlyThr: 2.643 ± 0.154
4.738GlyVal: 4.738 ± 0.577
0.605GlyTrp: 0.605 ± 0.063
3.242GlyTyr: 3.242 ± 0.145
0.0GlyXaa: 0.0 ± 0.0
His
0.974HisAla: 0.974 ± 0.088
0.535HisCys: 0.535 ± 0.062
1.14HisAsp: 1.14 ± 0.081
1.382HisGlu: 1.382 ± 0.087
0.63HisPhe: 0.63 ± 0.063
1.14HisGly: 1.14 ± 0.087
0.497HisHis: 0.497 ± 0.081
1.216HisIle: 1.216 ± 0.091
1.057HisLys: 1.057 ± 0.098
2.872HisLeu: 2.872 ± 0.173
0.433HisMet: 0.433 ± 0.061
0.847HisAsn: 0.847 ± 0.073
0.949HisPro: 0.949 ± 0.091
0.56HisGln: 0.56 ± 0.069
0.987HisArg: 0.987 ± 0.079
1.089HisSer: 1.089 ± 0.086
0.713HisThr: 0.713 ± 0.066
1.567HisVal: 1.567 ± 0.102
0.185HisTrp: 0.185 ± 0.034
0.841HisTyr: 0.841 ± 0.086
0.0HisXaa: 0.0 ± 0.0
Ile
3.057IleAla: 3.057 ± 0.139
1.363IleCys: 1.363 ± 0.088
3.025IleAsp: 3.025 ± 0.156
3.522IleGlu: 3.522 ± 0.182
3.006IlePhe: 3.006 ± 0.143
2.586IleGly: 2.586 ± 0.157
1.165IleHis: 1.165 ± 0.089
3.356IleIle: 3.356 ± 0.168
3.783IleLys: 3.783 ± 0.183
6.579IleLeu: 6.579 ± 0.257
1.121IleMet: 1.121 ± 0.081
2.395IleAsn: 2.395 ± 0.131
2.611IlePro: 2.611 ± 0.121
1.446IleGln: 1.446 ± 0.091
2.993IleArg: 2.993 ± 0.142
4.21IleSer: 4.21 ± 0.181
2.738IleThr: 2.738 ± 0.17
3.343IleVal: 3.343 ± 0.172
0.535IleTrp: 0.535 ± 0.059
2.745IleTyr: 2.745 ± 0.147
0.0IleXaa: 0.0 ± 0.0
Lys
3.14LysAla: 3.14 ± 0.146
0.751LysCys: 0.751 ± 0.092
4.095LysAsp: 4.095 ± 0.22
6.056LysGlu: 6.056 ± 0.225
2.14LysPhe: 2.14 ± 0.123
3.847LysGly: 3.847 ± 0.174
1.554LysHis: 1.554 ± 0.107
4.133LysIle: 4.133 ± 0.171
5.057LysLys: 5.057 ± 0.283
5.26LysLeu: 5.26 ± 0.234
1.095LysMet: 1.095 ± 0.075
2.809LysAsn: 2.809 ± 0.138
2.312LysPro: 2.312 ± 0.129
2.019LysGln: 2.019 ± 0.132
3.541LysArg: 3.541 ± 0.174
3.299LysSer: 3.299 ± 0.151
2.961LysThr: 2.961 ± 0.147
4.483LysVal: 4.483 ± 0.217
1.089LysTrp: 1.089 ± 0.125
2.35LysTyr: 2.35 ± 0.129
0.0LysXaa: 0.0 ± 0.0
Leu
5.967LeuAla: 5.967 ± 0.203
2.751LeuCys: 2.751 ± 0.147
5.719LeuAsp: 5.719 ± 0.208
9.222LeuGlu: 9.222 ± 0.314
4.853LeuPhe: 4.853 ± 0.189
5.127LeuGly: 5.127 ± 0.184
2.184LeuHis: 2.184 ± 0.127
4.541LeuIle: 4.541 ± 0.178
5.343LeuLys: 5.343 ± 0.239
11.865LeuLeu: 11.865 ± 0.329
1.548LeuMet: 1.548 ± 0.093
3.777LeuAsn: 3.777 ± 0.178
5.884LeuPro: 5.884 ± 0.23
5.534LeuGln: 5.534 ± 0.23
5.133LeuArg: 5.133 ± 0.182
9.515LeuSer: 9.515 ± 0.31
5.063LeuThr: 5.063 ± 0.208
7.018LeuVal: 7.018 ± 0.235
1.197LeuTrp: 1.197 ± 0.088
5.139LeuTyr: 5.139 ± 0.203
0.0LeuXaa: 0.0 ± 0.0
Met
1.197MetAla: 1.197 ± 0.085
0.395MetCys: 0.395 ± 0.054
1.376MetAsp: 1.376 ± 0.098
1.917MetGlu: 1.917 ± 0.114
0.783MetPhe: 0.783 ± 0.074
0.936MetGly: 0.936 ± 0.081
0.503MetHis: 0.503 ± 0.062
0.974MetIle: 0.974 ± 0.075
0.987MetLys: 0.987 ± 0.08
1.949MetLeu: 1.949 ± 0.111
0.369MetMet: 0.369 ± 0.05
0.707MetAsn: 0.707 ± 0.072
0.471MetPro: 0.471 ± 0.056
1.407MetGln: 1.407 ± 0.091
0.955MetArg: 0.955 ± 0.093
1.624MetSer: 1.624 ± 0.089
0.618MetThr: 0.618 ± 0.079
1.261MetVal: 1.261 ± 0.085
0.261MetTrp: 0.261 ± 0.039
0.751MetTyr: 0.751 ± 0.077
0.0MetXaa: 0.0 ± 0.0
Asn
1.961AsnAla: 1.961 ± 0.113
0.586AsnCys: 0.586 ± 0.064
1.235AsnAsp: 1.235 ± 0.088
1.751AsnGlu: 1.751 ± 0.097
2.446AsnPhe: 2.446 ± 0.118
3.375AsnGly: 3.375 ± 0.287
0.745AsnHis: 0.745 ± 0.074
3.114AsnIle: 3.114 ± 0.142
3.165AsnLys: 3.165 ± 0.176
6.063AsnLeu: 6.063 ± 0.224
1.14AsnMet: 1.14 ± 0.074
2.006AsnAsn: 2.006 ± 0.136
2.159AsnPro: 2.159 ± 0.121
1.681AsnGln: 1.681 ± 0.127
2.165AsnArg: 2.165 ± 0.119
2.63AsnSer: 2.63 ± 0.144
2.758AsnThr: 2.758 ± 0.312
2.764AsnVal: 2.764 ± 0.146
0.446AsnTrp: 0.446 ± 0.053
2.159AsnTyr: 2.159 ± 0.12
0.0AsnXaa: 0.0 ± 0.0
Pro
1.446ProAla: 1.446 ± 0.103
1.057ProCys: 1.057 ± 0.092
2.082ProAsp: 2.082 ± 0.106
4.14ProGlu: 4.14 ± 0.172
1.968ProPhe: 1.968 ± 0.111
2.42ProGly: 2.42 ± 0.171
0.732ProHis: 0.732 ± 0.071
1.535ProIle: 1.535 ± 0.105
2.063ProLys: 2.063 ± 0.109
5.108ProLeu: 5.108 ± 0.197
0.535ProMet: 0.535 ± 0.059
1.624ProAsn: 1.624 ± 0.105
2.0ProPro: 2.0 ± 0.155
1.796ProGln: 1.796 ± 0.143
2.089ProArg: 2.089 ± 0.142
3.515ProSer: 3.515 ± 0.171
1.707ProThr: 1.707 ± 0.113
2.91ProVal: 2.91 ± 0.152
1.331ProTrp: 1.331 ± 0.167
1.707ProTyr: 1.707 ± 0.112
0.0ProXaa: 0.0 ± 0.0
Gln
2.344GlnAla: 2.344 ± 0.118
0.541GlnCys: 0.541 ± 0.06
1.993GlnAsp: 1.993 ± 0.108
3.356GlnGlu: 3.356 ± 0.171
0.751GlnPhe: 0.751 ± 0.056
3.948GlnGly: 3.948 ± 0.339
0.554GlnHis: 0.554 ± 0.065
1.79GlnIle: 1.79 ± 0.099
1.713GlnLys: 1.713 ± 0.12
2.56GlnLeu: 2.56 ± 0.124
0.592GlnMet: 0.592 ± 0.062
1.439GlnAsn: 1.439 ± 0.141
1.286GlnPro: 1.286 ± 0.107
0.968GlnGln: 0.968 ± 0.117
2.153GlnArg: 2.153 ± 0.121
1.79GlnSer: 1.79 ± 0.1
2.102GlnThr: 2.102 ± 0.129
3.076GlnVal: 3.076 ± 0.164
1.509GlnTrp: 1.509 ± 0.179
0.802GlnTyr: 0.802 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
2.987ArgAla: 2.987 ± 0.144
1.108ArgCys: 1.108 ± 0.104
3.363ArgAsp: 3.363 ± 0.15
5.732ArgGlu: 5.732 ± 0.202
2.274ArgPhe: 2.274 ± 0.11
3.407ArgGly: 3.407 ± 0.161
0.771ArgHis: 0.771 ± 0.067
3.178ArgIle: 3.178 ± 0.162
3.968ArgLys: 3.968 ± 0.198
4.592ArgLeu: 4.592 ± 0.17
1.172ArgMet: 1.172 ± 0.081
2.516ArgAsn: 2.516 ± 0.117
1.688ArgPro: 1.688 ± 0.115
1.853ArgGln: 1.853 ± 0.094
3.216ArgArg: 3.216 ± 0.157
3.458ArgSer: 3.458 ± 0.175
2.242ArgThr: 2.242 ± 0.145
3.439ArgVal: 3.439 ± 0.139
0.592ArgTrp: 0.592 ± 0.061
2.203ArgTyr: 2.203 ± 0.137
0.0ArgXaa: 0.0 ± 0.0
Ser
3.719SerAla: 3.719 ± 0.171
1.745SerCys: 1.745 ± 0.131
3.197SerAsp: 3.197 ± 0.159
4.031SerGlu: 4.031 ± 0.17
4.292SerPhe: 4.292 ± 0.155
4.388SerGly: 4.388 ± 0.185
1.165SerHis: 1.165 ± 0.091
3.732SerIle: 3.732 ± 0.179
4.127SerLys: 4.127 ± 0.159
9.298SerLeu: 9.298 ± 0.327
1.376SerMet: 1.376 ± 0.093
2.859SerAsn: 2.859 ± 0.158
3.452SerPro: 3.452 ± 0.202
2.274SerGln: 2.274 ± 0.14
3.56SerArg: 3.56 ± 0.163
7.98SerSer: 7.98 ± 0.726
3.77SerThr: 3.77 ± 0.18
4.458SerVal: 4.458 ± 0.185
1.134SerTrp: 1.134 ± 0.085
3.585SerTyr: 3.585 ± 0.152
0.0SerXaa: 0.0 ± 0.0
Thr
1.923ThrAla: 1.923 ± 0.132
1.866ThrCys: 1.866 ± 0.15
2.114ThrAsp: 2.114 ± 0.115
2.853ThrGlu: 2.853 ± 0.147
2.547ThrPhe: 2.547 ± 0.14
6.114ThrGly: 6.114 ± 1.332
0.675ThrHis: 0.675 ± 0.075
2.98ThrIle: 2.98 ± 0.157
2.605ThrLys: 2.605 ± 0.122
5.42ThrLeu: 5.42 ± 0.191
0.758ThrMet: 0.758 ± 0.079
2.051ThrAsn: 2.051 ± 0.121
2.471ThrPro: 2.471 ± 0.127
1.35ThrGln: 1.35 ± 0.105
2.726ThrArg: 2.726 ± 0.157
3.847ThrSer: 3.847 ± 0.181
2.305ThrThr: 2.305 ± 0.162
2.535ThrVal: 2.535 ± 0.165
0.847ThrTrp: 0.847 ± 0.063
2.133ThrTyr: 2.133 ± 0.126
0.0ThrXaa: 0.0 ± 0.0
Val
3.49ValAla: 3.49 ± 0.175
2.496ValCys: 2.496 ± 0.156
3.394ValAsp: 3.394 ± 0.133
4.624ValGlu: 4.624 ± 0.17
2.56ValPhe: 2.56 ± 0.141
2.605ValGly: 2.605 ± 0.175
1.312ValHis: 1.312 ± 0.1
3.184ValIle: 3.184 ± 0.164
4.025ValLys: 4.025 ± 0.162
7.636ValLeu: 7.636 ± 0.253
1.261ValMet: 1.261 ± 0.093
2.745ValAsn: 2.745 ± 0.142
2.745ValPro: 2.745 ± 0.157
2.312ValGln: 2.312 ± 0.145
3.433ValArg: 3.433 ± 0.14
4.63ValSer: 4.63 ± 0.187
4.101ValThr: 4.101 ± 0.491
3.738ValVal: 3.738 ± 0.188
0.777ValTrp: 0.777 ± 0.072
3.433ValTyr: 3.433 ± 0.151
0.0ValXaa: 0.0 ± 0.0
Trp
1.719TrpAla: 1.719 ± 0.18
0.42TrpCys: 0.42 ± 0.065
1.255TrpAsp: 1.255 ± 0.139
0.63TrpGlu: 0.63 ± 0.061
0.611TrpPhe: 0.611 ± 0.067
0.541TrpGly: 0.541 ± 0.06
0.242TrpHis: 0.242 ± 0.038
0.713TrpIle: 0.713 ± 0.062
1.044TrpLys: 1.044 ± 0.081
2.044TrpLeu: 2.044 ± 0.181
0.344TrpMet: 0.344 ± 0.049
1.044TrpAsn: 1.044 ± 0.106
0.242TrpPro: 0.242 ± 0.051
0.401TrpGln: 0.401 ± 0.05
0.637TrpArg: 0.637 ± 0.068
1.019TrpSer: 1.019 ± 0.088
0.618TrpThr: 0.618 ± 0.068
0.739TrpVal: 0.739 ± 0.073
0.121TrpTrp: 0.121 ± 0.031
0.478TrpTyr: 0.478 ± 0.057
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.439TyrAla: 2.439 ± 0.124
0.707TyrCys: 0.707 ± 0.078
2.108TyrAsp: 2.108 ± 0.128
2.789TyrGlu: 2.789 ± 0.137
2.458TyrPhe: 2.458 ± 0.113
2.159TyrGly: 2.159 ± 0.12
1.025TyrHis: 1.025 ± 0.081
2.764TyrIle: 2.764 ± 0.15
2.898TyrLys: 2.898 ± 0.161
5.687TyrLeu: 5.687 ± 0.205
1.076TyrMet: 1.076 ± 0.089
2.325TyrAsn: 2.325 ± 0.138
2.197TyrPro: 2.197 ± 0.129
1.662TyrGln: 1.662 ± 0.105
2.401TyrArg: 2.401 ± 0.152
3.904TyrSer: 3.904 ± 0.158
2.509TyrThr: 2.509 ± 0.139
2.382TyrVal: 2.382 ± 0.125
0.414TyrTrp: 0.414 ± 0.051
2.637TyrTyr: 2.637 ± 0.132
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 636 proteins (157024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski