Amino acid dipepetide frequency for Microviridae sp. ctjWc39

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.144AlaAla: 4.144 ± 1.317
0.691AlaCys: 0.691 ± 0.569
5.525AlaAsp: 5.525 ± 1.63
3.453AlaGlu: 3.453 ± 1.402
4.834AlaPhe: 4.834 ± 1.673
4.144AlaGly: 4.144 ± 0.654
0.0AlaHis: 0.0 ± 0.0
2.072AlaIle: 2.072 ± 0.999
2.762AlaLys: 2.762 ± 0.806
7.597AlaLeu: 7.597 ± 2.508
2.762AlaMet: 2.762 ± 1.705
2.072AlaAsn: 2.072 ± 1.651
4.834AlaPro: 4.834 ± 2.107
2.762AlaGln: 2.762 ± 1.125
6.215AlaArg: 6.215 ± 1.37
11.74AlaSer: 11.74 ± 3.416
3.453AlaThr: 3.453 ± 1.61
2.072AlaVal: 2.072 ± 0.77
0.0AlaTrp: 0.0 ± 0.0
6.215AlaTyr: 6.215 ± 1.779
0.0AlaXaa: 0.0 ± 0.0
Cys
0.691CysAla: 0.691 ± 0.423
0.0CysCys: 0.0 ± 0.0
0.691CysAsp: 0.691 ± 0.653
0.0CysGlu: 0.0 ± 0.0
2.072CysPhe: 2.072 ± 0.85
1.381CysGly: 1.381 ± 1.138
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.381CysLys: 1.381 ± 0.952
3.453CysLeu: 3.453 ± 1.001
0.691CysMet: 0.691 ± 0.569
0.0CysAsn: 0.0 ± 0.0
0.691CysPro: 0.691 ± 0.569
1.381CysGln: 1.381 ± 1.138
1.381CysArg: 1.381 ± 1.138
0.0CysSer: 0.0 ± 0.0
1.381CysThr: 1.381 ± 0.844
2.072CysVal: 2.072 ± 0.907
0.0CysTrp: 0.0 ± 0.0
0.691CysTyr: 0.691 ± 0.569
0.0CysXaa: 0.0 ± 0.0
Asp
3.453AspAla: 3.453 ± 1.371
0.691AspCys: 0.691 ± 0.423
5.525AspAsp: 5.525 ± 1.569
4.144AspGlu: 4.144 ± 1.067
6.906AspPhe: 6.906 ± 2.048
2.072AspGly: 2.072 ± 0.61
2.072AspHis: 2.072 ± 0.768
4.144AspIle: 4.144 ± 1.44
3.453AspLys: 3.453 ± 2.278
4.144AspLeu: 4.144 ± 1.443
0.691AspMet: 0.691 ± 0.423
3.453AspAsn: 3.453 ± 1.514
3.453AspPro: 3.453 ± 1.127
0.691AspGln: 0.691 ± 0.653
2.072AspArg: 2.072 ± 1.707
4.834AspSer: 4.834 ± 1.487
4.834AspThr: 4.834 ± 1.524
4.834AspVal: 4.834 ± 1.313
0.691AspTrp: 0.691 ± 0.423
3.453AspTyr: 3.453 ± 1.61
0.0AspXaa: 0.0 ± 0.0
Glu
4.144GluAla: 4.144 ± 2.223
0.691GluCys: 0.691 ± 0.653
3.453GluAsp: 3.453 ± 2.357
2.072GluGlu: 2.072 ± 0.891
3.453GluPhe: 3.453 ± 0.877
1.381GluGly: 1.381 ± 0.998
0.691GluHis: 0.691 ± 0.423
2.072GluIle: 2.072 ± 0.968
2.072GluLys: 2.072 ± 1.014
4.144GluLeu: 4.144 ± 2.4
1.381GluMet: 1.381 ± 0.846
2.762GluAsn: 2.762 ± 1.4
0.0GluPro: 0.0 ± 0.0
2.072GluGln: 2.072 ± 1.339
6.215GluArg: 6.215 ± 1.836
1.381GluSer: 1.381 ± 0.846
0.0GluThr: 0.0 ± 0.0
1.381GluVal: 1.381 ± 0.786
0.0GluTrp: 0.0 ± 0.0
2.072GluTyr: 2.072 ± 0.77
0.0GluXaa: 0.0 ± 0.0
Phe
4.834PheAla: 4.834 ± 2.301
2.762PheCys: 2.762 ± 0.929
3.453PheAsp: 3.453 ± 1.044
2.762PheGlu: 2.762 ± 1.85
4.144PhePhe: 4.144 ± 1.342
7.597PheGly: 7.597 ± 1.155
0.691PheHis: 0.691 ± 0.569
2.762PheIle: 2.762 ± 1.589
2.072PheLys: 2.072 ± 0.893
5.525PheLeu: 5.525 ± 1.439
0.691PheMet: 0.691 ± 0.418
3.453PheAsn: 3.453 ± 1.515
2.762PhePro: 2.762 ± 0.623
1.381PheGln: 1.381 ± 0.7
4.834PheArg: 4.834 ± 1.673
4.834PheSer: 4.834 ± 1.083
3.453PheThr: 3.453 ± 1.674
0.691PheVal: 0.691 ± 0.423
0.691PheTrp: 0.691 ± 0.569
1.381PheTyr: 1.381 ± 0.529
0.0PheXaa: 0.0 ± 0.0
Gly
7.597GlyAla: 7.597 ± 4.284
1.381GlyCys: 1.381 ± 1.138
6.215GlyAsp: 6.215 ± 1.855
2.072GlyGlu: 2.072 ± 0.768
1.381GlyPhe: 1.381 ± 0.793
6.906GlyGly: 6.906 ± 2.134
1.381GlyHis: 1.381 ± 0.529
2.762GlyIle: 2.762 ± 0.852
3.453GlyLys: 3.453 ± 1.411
6.906GlyLeu: 6.906 ± 3.068
0.0GlyMet: 0.0 ± 0.0
2.762GlyAsn: 2.762 ± 1.869
1.381GlyPro: 1.381 ± 0.846
0.691GlyGln: 0.691 ± 0.653
2.762GlyArg: 2.762 ± 1.557
8.287GlySer: 8.287 ± 2.036
4.144GlyThr: 4.144 ± 1.434
3.453GlyVal: 3.453 ± 1.016
2.072GlyTrp: 2.072 ± 1.058
2.072GlyTyr: 2.072 ± 0.891
0.0GlyXaa: 0.0 ± 0.0
His
2.762HisAla: 2.762 ± 0.967
1.381HisCys: 1.381 ± 0.846
0.0HisAsp: 0.0 ± 0.0
1.381HisGlu: 1.381 ± 1.138
3.453HisPhe: 3.453 ± 1.515
2.072HisGly: 2.072 ± 1.269
0.0HisHis: 0.0 ± 0.0
0.691HisIle: 0.691 ± 0.423
0.0HisLys: 0.0 ± 0.0
1.381HisLeu: 1.381 ± 0.629
0.691HisMet: 0.691 ± 0.569
0.691HisAsn: 0.691 ± 0.806
0.691HisPro: 0.691 ± 0.569
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.381HisSer: 1.381 ± 0.952
2.072HisThr: 2.072 ± 0.797
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.381HisTyr: 1.381 ± 1.138
0.0HisXaa: 0.0 ± 0.0
Ile
1.381IleAla: 1.381 ± 0.786
0.691IleCys: 0.691 ± 0.824
3.453IleAsp: 3.453 ± 2.259
1.381IleGlu: 1.381 ± 0.952
1.381IlePhe: 1.381 ± 1.035
2.072IleGly: 2.072 ± 0.77
0.691IleHis: 0.691 ± 0.423
1.381IleIle: 1.381 ± 0.7
1.381IleLys: 1.381 ± 0.629
1.381IleLeu: 1.381 ± 0.7
4.144IleMet: 4.144 ± 0.813
4.144IleAsn: 4.144 ± 1.582
3.453IlePro: 3.453 ± 1.718
0.0IleGln: 0.0 ± 0.0
3.453IleArg: 3.453 ± 1.613
0.0IleSer: 0.0 ± 0.0
1.381IleThr: 1.381 ± 0.529
2.762IleVal: 2.762 ± 1.336
0.691IleTrp: 0.691 ± 0.423
2.072IleTyr: 2.072 ± 1.014
0.0IleXaa: 0.0 ± 0.0
Lys
4.834LysAla: 4.834 ± 2.105
0.691LysCys: 0.691 ± 0.569
1.381LysAsp: 1.381 ± 1.138
3.453LysGlu: 3.453 ± 1.236
4.834LysPhe: 4.834 ± 0.826
3.453LysGly: 3.453 ± 1.366
1.381LysHis: 1.381 ± 0.786
2.072LysIle: 2.072 ± 0.623
6.215LysLys: 6.215 ± 2.792
5.525LysLeu: 5.525 ± 2.482
2.072LysMet: 2.072 ± 0.601
2.762LysAsn: 2.762 ± 1.086
4.144LysPro: 4.144 ± 1.011
2.072LysGln: 2.072 ± 1.281
5.525LysArg: 5.525 ± 0.906
4.144LysSer: 4.144 ± 1.499
2.072LysThr: 2.072 ± 0.906
4.144LysVal: 4.144 ± 1.909
0.0LysTrp: 0.0 ± 0.0
0.691LysTyr: 0.691 ± 0.806
0.0LysXaa: 0.0 ± 0.0
Leu
6.215LeuAla: 6.215 ± 1.46
0.0LeuCys: 0.0 ± 0.0
8.287LeuAsp: 8.287 ± 1.778
4.144LeuGlu: 4.144 ± 2.028
5.525LeuPhe: 5.525 ± 1.398
6.215LeuGly: 6.215 ± 1.212
3.453LeuHis: 3.453 ± 0.874
6.906LeuIle: 6.906 ± 1.709
8.978LeuLys: 8.978 ± 2.574
4.144LeuLeu: 4.144 ± 1.554
1.381LeuMet: 1.381 ± 1.313
4.144LeuAsn: 4.144 ± 2.679
6.906LeuPro: 6.906 ± 0.796
2.762LeuGln: 2.762 ± 0.795
4.144LeuArg: 4.144 ± 1.587
4.834LeuSer: 4.834 ± 1.367
6.215LeuThr: 6.215 ± 3.025
6.215LeuVal: 6.215 ± 1.849
0.0LeuTrp: 0.0 ± 0.0
3.453LeuTyr: 3.453 ± 1.016
0.0LeuXaa: 0.0 ± 0.0
Met
2.762MetAla: 2.762 ± 1.496
0.691MetCys: 0.691 ± 0.569
0.691MetAsp: 0.691 ± 0.423
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
3.453MetGly: 3.453 ± 1.127
1.381MetHis: 1.381 ± 0.529
0.0MetIle: 0.0 ± 0.0
2.072MetLys: 2.072 ± 1.501
2.762MetLeu: 2.762 ± 1.112
0.0MetMet: 0.0 ± 0.0
1.381MetAsn: 1.381 ± 0.7
1.381MetPro: 1.381 ± 0.529
0.691MetGln: 0.691 ± 0.569
1.381MetArg: 1.381 ± 0.657
1.381MetSer: 1.381 ± 1.06
2.072MetThr: 2.072 ± 0.905
2.762MetVal: 2.762 ± 0.978
0.691MetTrp: 0.691 ± 0.423
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.072AsnAla: 2.072 ± 1.339
0.691AsnCys: 0.691 ± 0.569
2.762AsnAsp: 2.762 ± 1.231
2.762AsnGlu: 2.762 ± 2.158
1.381AsnPhe: 1.381 ± 0.952
3.453AsnGly: 3.453 ± 1.252
0.0AsnHis: 0.0 ± 0.0
0.691AsnIle: 0.691 ± 0.717
2.762AsnLys: 2.762 ± 1.44
8.287AsnLeu: 8.287 ± 1.156
0.691AsnMet: 0.691 ± 0.705
0.691AsnAsn: 0.691 ± 0.705
4.834AsnPro: 4.834 ± 1.708
0.691AsnGln: 0.691 ± 0.423
2.072AsnArg: 2.072 ± 1.269
4.144AsnSer: 4.144 ± 1.445
2.762AsnThr: 2.762 ± 1.221
1.381AsnVal: 1.381 ± 1.434
1.381AsnTrp: 1.381 ± 0.793
2.072AsnTyr: 2.072 ± 0.814
0.0AsnXaa: 0.0 ± 0.0
Pro
4.144ProAla: 4.144 ± 1.065
1.381ProCys: 1.381 ± 1.138
3.453ProAsp: 3.453 ± 1.557
2.072ProGlu: 2.072 ± 0.768
2.072ProPhe: 2.072 ± 0.905
5.525ProGly: 5.525 ± 1.226
2.072ProHis: 2.072 ± 0.768
4.144ProIle: 4.144 ± 0.784
0.691ProLys: 0.691 ± 0.653
4.834ProLeu: 4.834 ± 1.124
0.691ProMet: 0.691 ± 0.423
2.072ProAsn: 2.072 ± 1.459
2.762ProPro: 2.762 ± 0.711
2.072ProGln: 2.072 ± 1.269
1.381ProArg: 1.381 ± 0.529
4.144ProSer: 4.144 ± 2.044
2.072ProThr: 2.072 ± 0.917
4.834ProVal: 4.834 ± 1.797
0.691ProTrp: 0.691 ± 0.423
0.691ProTyr: 0.691 ± 0.423
0.0ProXaa: 0.0 ± 0.0
Gln
4.834GlnAla: 4.834 ± 1.361
0.0GlnCys: 0.0 ± 0.0
2.762GlnAsp: 2.762 ± 1.374
1.381GlnGlu: 1.381 ± 0.7
0.691GlnPhe: 0.691 ± 0.653
1.381GlnGly: 1.381 ± 0.7
0.0GlnHis: 0.0 ± 0.0
1.381GlnIle: 1.381 ± 0.7
3.453GlnLys: 3.453 ± 0.874
1.381GlnLeu: 1.381 ± 0.529
2.072GlnMet: 2.072 ± 0.81
2.762GlnAsn: 2.762 ± 1.221
1.381GlnPro: 1.381 ± 1.124
0.691GlnGln: 0.691 ± 0.569
1.381GlnArg: 1.381 ± 0.7
1.381GlnSer: 1.381 ± 1.054
2.762GlnThr: 2.762 ± 1.692
1.381GlnVal: 1.381 ± 1.306
0.691GlnTrp: 0.691 ± 0.569
0.691GlnTyr: 0.691 ± 0.717
0.0GlnXaa: 0.0 ± 0.0
Arg
6.215ArgAla: 6.215 ± 1.864
1.381ArgCys: 1.381 ± 1.138
3.453ArgAsp: 3.453 ± 0.929
2.762ArgGlu: 2.762 ± 1.374
3.453ArgPhe: 3.453 ± 1.173
4.144ArgGly: 4.144 ± 1.359
0.0ArgHis: 0.0 ± 0.0
1.381ArgIle: 1.381 ± 0.998
4.144ArgLys: 4.144 ± 2.046
7.597ArgLeu: 7.597 ± 2.776
2.762ArgMet: 2.762 ± 1.4
0.0ArgAsn: 0.0 ± 0.0
2.072ArgPro: 2.072 ± 0.77
2.762ArgGln: 2.762 ± 1.058
1.381ArgArg: 1.381 ± 0.793
7.597ArgSer: 7.597 ± 1.449
1.381ArgThr: 1.381 ± 1.138
1.381ArgVal: 1.381 ± 0.657
0.0ArgTrp: 0.0 ± 0.0
5.525ArgTyr: 5.525 ± 1.527
0.0ArgXaa: 0.0 ± 0.0
Ser
6.215SerAla: 6.215 ± 1.22
1.381SerCys: 1.381 ± 0.629
1.381SerAsp: 1.381 ± 1.138
0.691SerGlu: 0.691 ± 0.569
4.834SerPhe: 4.834 ± 1.4
4.144SerGly: 4.144 ± 1.017
2.072SerHis: 2.072 ± 1.269
1.381SerIle: 1.381 ± 1.054
6.906SerLys: 6.906 ± 2.833
9.669SerLeu: 9.669 ± 1.896
2.762SerMet: 2.762 ± 1.545
3.453SerAsn: 3.453 ± 1.134
2.072SerPro: 2.072 ± 0.906
4.144SerGln: 4.144 ± 2.152
4.144SerArg: 4.144 ± 1.011
6.215SerSer: 6.215 ± 2.555
6.906SerThr: 6.906 ± 1.749
7.597SerVal: 7.597 ± 1.487
0.691SerTrp: 0.691 ± 0.423
2.072SerTyr: 2.072 ± 1.269
0.0SerXaa: 0.0 ± 0.0
Thr
4.144ThrAla: 4.144 ± 1.834
0.0ThrCys: 0.0 ± 0.0
4.834ThrAsp: 4.834 ± 1.705
2.072ThrGlu: 2.072 ± 1.269
6.215ThrPhe: 6.215 ± 1.575
4.834ThrGly: 4.834 ± 0.665
1.381ThrHis: 1.381 ± 0.844
2.072ThrIle: 2.072 ± 1.014
3.453ThrLys: 3.453 ± 1.311
5.525ThrLeu: 5.525 ± 1.255
0.0ThrMet: 0.0 ± 0.0
3.453ThrAsn: 3.453 ± 1.392
3.453ThrPro: 3.453 ± 1.63
1.381ThrGln: 1.381 ± 0.629
1.381ThrArg: 1.381 ± 0.846
6.215ThrSer: 6.215 ± 1.212
2.762ThrThr: 2.762 ± 1.11
0.691ThrVal: 0.691 ± 0.423
0.691ThrTrp: 0.691 ± 0.717
1.381ThrTyr: 1.381 ± 0.629
0.0ThrXaa: 0.0 ± 0.0
Val
3.453ValAla: 3.453 ± 0.825
2.072ValCys: 2.072 ± 0.907
4.834ValAsp: 4.834 ± 2.274
0.691ValGlu: 0.691 ± 0.705
2.762ValPhe: 2.762 ± 1.484
2.072ValGly: 2.072 ± 0.604
0.0ValHis: 0.0 ± 0.0
0.0ValIle: 0.0 ± 0.0
3.453ValLys: 3.453 ± 1.557
4.834ValLeu: 4.834 ± 1.407
0.691ValMet: 0.691 ± 0.653
2.762ValAsn: 2.762 ± 0.711
4.144ValPro: 4.144 ± 1.871
2.762ValGln: 2.762 ± 2.158
6.906ValArg: 6.906 ± 2.198
0.691ValSer: 0.691 ± 0.653
3.453ValThr: 3.453 ± 1.016
4.834ValVal: 4.834 ± 1.578
1.381ValTrp: 1.381 ± 0.529
2.762ValTyr: 2.762 ± 1.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.691TrpAla: 0.691 ± 0.569
0.0TrpCys: 0.0 ± 0.0
0.691TrpAsp: 0.691 ± 0.423
2.072TrpGlu: 2.072 ± 0.797
0.691TrpPhe: 0.691 ± 0.423
0.0TrpGly: 0.0 ± 0.0
0.691TrpHis: 0.691 ± 0.423
0.691TrpIle: 0.691 ± 0.705
0.691TrpLys: 0.691 ± 0.569
1.381TrpLeu: 1.381 ± 0.844
0.0TrpMet: 0.0 ± 0.0
0.691TrpAsn: 0.691 ± 0.423
0.691TrpPro: 0.691 ± 0.423
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.381TrpSer: 1.381 ± 0.629
0.691TrpThr: 0.691 ± 0.569
0.691TrpVal: 0.691 ± 0.824
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.453TyrAla: 3.453 ± 1.285
1.381TyrCys: 1.381 ± 1.138
2.762TyrAsp: 2.762 ± 1.484
2.072TyrGlu: 2.072 ± 0.85
0.691TyrPhe: 0.691 ± 0.423
1.381TyrGly: 1.381 ± 0.529
2.072TyrHis: 2.072 ± 1.014
0.691TyrIle: 0.691 ± 0.423
2.072TyrLys: 2.072 ± 0.623
3.453TyrLeu: 3.453 ± 1.089
0.691TyrMet: 0.691 ± 0.423
2.072TyrAsn: 2.072 ± 0.797
0.691TyrPro: 0.691 ± 0.806
3.453TyrGln: 3.453 ± 1.134
2.762TyrArg: 2.762 ± 1.231
4.144TyrSer: 4.144 ± 0.813
2.072TyrThr: 2.072 ± 0.77
1.381TyrVal: 1.381 ± 0.764
1.381TyrTrp: 1.381 ± 0.629
2.072TyrTyr: 2.072 ± 1.707
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski