Amino acid dipepetide frequency for Candidatus Frankia datiscae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.338AlaAla: 22.338 ± 0.209
1.094AlaCys: 1.094 ± 0.035
8.894AlaAsp: 8.894 ± 0.095
7.39AlaGlu: 7.39 ± 0.09
3.407AlaPhe: 3.407 ± 0.06
15.358AlaGly: 15.358 ± 0.165
2.735AlaHis: 2.735 ± 0.045
3.965AlaIle: 3.965 ± 0.053
1.829AlaLys: 1.829 ± 0.046
13.271AlaLeu: 13.271 ± 0.138
2.153AlaMet: 2.153 ± 0.041
2.023AlaAsn: 2.023 ± 0.037
7.051AlaPro: 7.051 ± 0.105
3.449AlaGln: 3.449 ± 0.053
11.496AlaArg: 11.496 ± 0.106
6.847AlaSer: 6.847 ± 0.084
7.935AlaThr: 7.935 ± 0.082
12.705AlaVal: 12.705 ± 0.114
1.637AlaTrp: 1.637 ± 0.036
2.238AlaTyr: 2.238 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.06CysAla: 1.06 ± 0.033
0.115CysCys: 0.115 ± 0.01
0.513CysAsp: 0.513 ± 0.018
0.368CysGlu: 0.368 ± 0.017
0.23CysPhe: 0.23 ± 0.013
0.967CysGly: 0.967 ± 0.03
0.23CysHis: 0.23 ± 0.014
0.171CysIle: 0.171 ± 0.011
0.08CysLys: 0.08 ± 0.007
0.799CysLeu: 0.799 ± 0.026
0.101CysMet: 0.101 ± 0.008
0.127CysAsn: 0.127 ± 0.01
0.568CysPro: 0.568 ± 0.022
0.23CysGln: 0.23 ± 0.013
0.733CysArg: 0.733 ± 0.026
0.446CysSer: 0.446 ± 0.019
0.413CysThr: 0.413 ± 0.017
0.657CysVal: 0.657 ± 0.022
0.143CysTrp: 0.143 ± 0.01
0.188CysTyr: 0.188 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
8.184AspAla: 8.184 ± 0.101
0.405AspCys: 0.405 ± 0.017
3.971AspAsp: 3.971 ± 0.062
3.453AspGlu: 3.453 ± 0.055
1.43AspPhe: 1.43 ± 0.035
6.43AspGly: 6.43 ± 0.078
1.463AspHis: 1.463 ± 0.036
2.23AspIle: 2.23 ± 0.045
0.726AspLys: 0.726 ± 0.024
6.379AspLeu: 6.379 ± 0.078
0.673AspMet: 0.673 ± 0.021
1.057AspAsn: 1.057 ± 0.032
4.656AspPro: 4.656 ± 0.072
1.654AspGln: 1.654 ± 0.041
5.091AspArg: 5.091 ± 0.068
2.692AspSer: 2.692 ± 0.045
3.339AspThr: 3.339 ± 0.046
5.391AspVal: 5.391 ± 0.071
0.776AspTrp: 0.776 ± 0.026
1.094AspTyr: 1.094 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
5.929GluAla: 5.929 ± 0.073
0.332GluCys: 0.332 ± 0.018
2.087GluAsp: 2.087 ± 0.037
2.489GluGlu: 2.489 ± 0.053
1.379GluPhe: 1.379 ± 0.036
3.076GluGly: 3.076 ± 0.05
1.426GluHis: 1.426 ± 0.034
2.54GluIle: 2.54 ± 0.043
1.094GluLys: 1.094 ± 0.033
6.111GluLeu: 6.111 ± 0.079
0.766GluMet: 0.766 ± 0.026
0.896GluAsn: 0.896 ± 0.028
3.181GluPro: 3.181 ± 0.058
1.993GluGln: 1.993 ± 0.043
5.209GluArg: 5.209 ± 0.082
2.154GluSer: 2.154 ± 0.047
2.713GluThr: 2.713 ± 0.045
4.052GluVal: 4.052 ± 0.065
0.608GluTrp: 0.608 ± 0.019
0.9GluTyr: 0.9 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.586PheAla: 3.586 ± 0.052
0.302PheCys: 0.302 ± 0.016
2.075PheAsp: 2.075 ± 0.04
1.241PheGlu: 1.241 ± 0.035
0.819PhePhe: 0.819 ± 0.026
2.956PheGly: 2.956 ± 0.048
0.671PheHis: 0.671 ± 0.023
0.735PheIle: 0.735 ± 0.024
0.299PheLys: 0.299 ± 0.015
2.445PheLeu: 2.445 ± 0.047
0.335PheMet: 0.335 ± 0.015
0.504PheAsn: 0.504 ± 0.019
1.396PhePro: 1.396 ± 0.037
0.632PheGln: 0.632 ± 0.021
1.887PheArg: 1.887 ± 0.04
1.39PheSer: 1.39 ± 0.034
1.91PheThr: 1.91 ± 0.04
2.468PheVal: 2.468 ± 0.043
0.347PheTrp: 0.347 ± 0.016
0.52PheTyr: 0.52 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
10.684GlyAla: 10.684 ± 0.134
0.868GlyCys: 0.868 ± 0.03
4.997GlyAsp: 4.997 ± 0.067
4.425GlyGlu: 4.425 ± 0.056
2.768GlyPhe: 2.768 ± 0.05
9.152GlyGly: 9.152 ± 0.147
2.329GlyHis: 2.329 ± 0.049
3.703GlyIle: 3.703 ± 0.053
1.676GlyLys: 1.676 ± 0.037
9.178GlyLeu: 9.178 ± 0.089
1.762GlyMet: 1.762 ± 0.035
1.682GlyAsn: 1.682 ± 0.044
6.043GlyPro: 6.043 ± 0.094
3.08GlyGln: 3.08 ± 0.051
9.26GlyArg: 9.26 ± 0.079
5.779GlySer: 5.779 ± 0.077
6.179GlyThr: 6.179 ± 0.083
7.762GlyVal: 7.762 ± 0.084
1.601GlyTrp: 1.601 ± 0.036
2.174GlyTyr: 2.174 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.699HisAla: 2.699 ± 0.047
0.188HisCys: 0.188 ± 0.012
1.505HisAsp: 1.505 ± 0.039
1.053HisGlu: 1.053 ± 0.03
0.555HisPhe: 0.555 ± 0.021
2.367HisGly: 2.367 ± 0.043
0.692HisHis: 0.692 ± 0.029
0.647HisIle: 0.647 ± 0.025
0.231HisLys: 0.231 ± 0.014
2.374HisLeu: 2.374 ± 0.052
0.29HisMet: 0.29 ± 0.016
0.425HisAsn: 0.425 ± 0.019
1.943HisPro: 1.943 ± 0.037
0.641HisGln: 0.641 ± 0.024
2.087HisArg: 2.087 ± 0.041
1.071HisSer: 1.071 ± 0.028
1.276HisThr: 1.276 ± 0.036
1.703HisVal: 1.703 ± 0.038
0.293HisTrp: 0.293 ± 0.015
0.428HisTyr: 0.428 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.935IleAla: 4.935 ± 0.05
0.35IleCys: 0.35 ± 0.015
2.63IleAsp: 2.63 ± 0.046
1.923IleGlu: 1.923 ± 0.04
0.865IlePhe: 0.865 ± 0.029
3.666IleGly: 3.666 ± 0.057
0.761IleHis: 0.761 ± 0.025
1.309IleIle: 1.309 ± 0.042
0.551IleLys: 0.551 ± 0.023
2.799IleLeu: 2.799 ± 0.052
0.518IleMet: 0.518 ± 0.022
0.725IleAsn: 0.725 ± 0.027
2.068IlePro: 2.068 ± 0.039
0.774IleGln: 0.774 ± 0.025
2.958IleArg: 2.958 ± 0.054
1.932IleSer: 1.932 ± 0.045
2.323IleThr: 2.323 ± 0.044
3.346IleVal: 3.346 ± 0.054
0.355IleTrp: 0.355 ± 0.019
0.631IleTyr: 0.631 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
1.751LysAla: 1.751 ± 0.045
0.078LysCys: 0.078 ± 0.008
0.701LysAsp: 0.701 ± 0.025
0.71LysGlu: 0.71 ± 0.026
0.36LysPhe: 0.36 ± 0.016
1.107LysGly: 1.107 ± 0.037
0.298LysHis: 0.298 ± 0.016
0.956LysIle: 0.956 ± 0.03
0.584LysLys: 0.584 ± 0.036
1.49LysLeu: 1.49 ± 0.037
0.257LysMet: 0.257 ± 0.014
0.383LysAsn: 0.383 ± 0.019
0.951LysPro: 0.951 ± 0.03
0.446LysGln: 0.446 ± 0.019
1.059LysArg: 1.059 ± 0.031
0.83LysSer: 0.83 ± 0.026
0.967LysThr: 0.967 ± 0.028
1.421LysVal: 1.421 ± 0.038
0.153LysTrp: 0.153 ± 0.01
0.305LysTyr: 0.305 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
15.677LeuAla: 15.677 ± 0.133
0.815LeuCys: 0.815 ± 0.028
6.603LeuAsp: 6.603 ± 0.075
4.365LeuGlu: 4.365 ± 0.06
2.563LeuPhe: 2.563 ± 0.049
8.486LeuGly: 8.486 ± 0.085
2.012LeuHis: 2.012 ± 0.046
3.12LeuIle: 3.12 ± 0.053
1.253LeuLys: 1.253 ± 0.034
11.031LeuLeu: 11.031 ± 0.145
1.271LeuMet: 1.271 ± 0.027
1.439LeuAsn: 1.439 ± 0.037
6.634LeuPro: 6.634 ± 0.079
1.803LeuGln: 1.803 ± 0.039
9.326LeuArg: 9.326 ± 0.082
5.348LeuSer: 5.348 ± 0.061
6.563LeuThr: 6.563 ± 0.084
9.232LeuVal: 9.232 ± 0.098
1.199LeuTrp: 1.199 ± 0.039
1.595LeuTyr: 1.595 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.023MetAla: 2.023 ± 0.039
0.17MetCys: 0.17 ± 0.012
0.732MetAsp: 0.732 ± 0.023
0.584MetGlu: 0.584 ± 0.02
0.448MetPhe: 0.448 ± 0.016
1.032MetGly: 1.032 ± 0.027
0.266MetHis: 0.266 ± 0.015
0.827MetIle: 0.827 ± 0.028
0.271MetLys: 0.271 ± 0.014
1.547MetLeu: 1.547 ± 0.034
0.255MetMet: 0.255 ± 0.014
0.357MetAsn: 0.357 ± 0.016
0.976MetPro: 0.976 ± 0.03
0.311MetGln: 0.311 ± 0.017
1.276MetArg: 1.276 ± 0.033
1.203MetSer: 1.203 ± 0.032
1.462MetThr: 1.462 ± 0.033
1.189MetVal: 1.189 ± 0.035
0.184MetTrp: 0.184 ± 0.011
0.237MetTyr: 0.237 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.099AsnAla: 2.099 ± 0.045
0.149AsnCys: 0.149 ± 0.009
0.928AsnAsp: 0.928 ± 0.026
0.726AsnGlu: 0.726 ± 0.026
0.443AsnPhe: 0.443 ± 0.017
1.721AsnGly: 1.721 ± 0.042
0.414AsnHis: 0.414 ± 0.022
0.791AsnIle: 0.791 ± 0.026
0.286AsnLys: 0.286 ± 0.017
1.66AsnLeu: 1.66 ± 0.035
0.267AsnMet: 0.267 ± 0.014
0.416AsnAsn: 0.416 ± 0.019
1.358AsnPro: 1.358 ± 0.032
0.511AsnGln: 0.511 ± 0.019
1.417AsnArg: 1.417 ± 0.033
0.884AsnSer: 0.884 ± 0.024
1.109AsnThr: 1.109 ± 0.035
1.397AsnVal: 1.397 ± 0.04
0.279AsnTrp: 0.279 ± 0.017
0.357AsnTyr: 0.357 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
10.607ProAla: 10.607 ± 0.119
0.378ProCys: 0.378 ± 0.018
4.892ProAsp: 4.892 ± 0.068
3.282ProGlu: 3.282 ± 0.056
1.586ProPhe: 1.586 ± 0.03
7.241ProGly: 7.241 ± 0.088
1.271ProHis: 1.271 ± 0.033
1.574ProIle: 1.574 ± 0.034
0.829ProLys: 0.829 ± 0.029
5.323ProLeu: 5.323 ± 0.073
0.88ProMet: 0.88 ± 0.025
1.01ProAsn: 1.01 ± 0.029
4.863ProPro: 4.863 ± 0.094
1.482ProGln: 1.482 ± 0.036
4.712ProArg: 4.712 ± 0.063
3.75ProSer: 3.75 ± 0.064
3.964ProThr: 3.964 ± 0.063
6.017ProVal: 6.017 ± 0.072
0.886ProTrp: 0.886 ± 0.025
1.167ProTyr: 1.167 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.809GlnAla: 3.809 ± 0.058
0.154GlnCys: 0.154 ± 0.011
1.139GlnAsp: 1.139 ± 0.034
1.222GlnGlu: 1.222 ± 0.032
0.639GlnPhe: 0.639 ± 0.026
1.839GlnGly: 1.839 ± 0.042
0.632GlnHis: 0.632 ± 0.02
1.193GlnIle: 1.193 ± 0.029
0.425GlnLys: 0.425 ± 0.022
2.899GlnLeu: 2.899 ± 0.053
0.476GlnMet: 0.476 ± 0.019
0.473GlnAsn: 0.473 ± 0.022
2.153GlnPro: 2.153 ± 0.051
1.043GlnGln: 1.043 ± 0.041
2.731GlnArg: 2.731 ± 0.044
1.116GlnSer: 1.116 ± 0.031
1.399GlnThr: 1.399 ± 0.032
2.483GlnVal: 2.483 ± 0.049
0.35GlnTrp: 0.35 ± 0.017
0.479GlnTyr: 0.479 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
10.92ArgAla: 10.92 ± 0.117
0.734ArgCys: 0.734 ± 0.026
4.914ArgAsp: 4.914 ± 0.064
4.394ArgGlu: 4.394 ± 0.07
2.504ArgPhe: 2.504 ± 0.037
6.563ArgGly: 6.563 ± 0.079
2.333ArgHis: 2.333 ± 0.042
3.418ArgIle: 3.418 ± 0.048
1.313ArgLys: 1.313 ± 0.04
9.325ArgLeu: 9.325 ± 0.084
1.751ArgMet: 1.751 ± 0.036
1.48ArgAsn: 1.48 ± 0.032
6.479ArgPro: 6.479 ± 0.076
2.919ArgGln: 2.919 ± 0.057
9.346ArgArg: 9.346 ± 0.113
4.635ArgSer: 4.635 ± 0.058
5.331ArgThr: 5.331 ± 0.065
6.594ArgVal: 6.594 ± 0.076
1.507ArgTrp: 1.507 ± 0.04
1.895ArgTyr: 1.895 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.107SerAla: 7.107 ± 0.089
0.463SerCys: 0.463 ± 0.02
2.934SerAsp: 2.934 ± 0.052
2.25SerGlu: 2.25 ± 0.044
1.501SerPhe: 1.501 ± 0.035
6.1SerGly: 6.1 ± 0.07
1.06SerHis: 1.06 ± 0.032
1.668SerIle: 1.668 ± 0.035
0.752SerLys: 0.752 ± 0.024
4.727SerLeu: 4.727 ± 0.06
1.007SerMet: 1.007 ± 0.029
0.899SerAsn: 0.899 ± 0.03
3.758SerPro: 3.758 ± 0.065
1.36SerGln: 1.36 ± 0.037
4.635SerArg: 4.635 ± 0.063
3.307SerSer: 3.307 ± 0.065
3.36SerThr: 3.36 ± 0.057
4.537SerVal: 4.537 ± 0.065
0.879SerTrp: 0.879 ± 0.025
1.109SerTyr: 1.109 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.884ThrAla: 8.884 ± 0.11
0.434ThrCys: 0.434 ± 0.019
3.744ThrAsp: 3.744 ± 0.051
2.805ThrGlu: 2.805 ± 0.05
1.63ThrPhe: 1.63 ± 0.036
6.952ThrGly: 6.952 ± 0.089
1.184ThrHis: 1.184 ± 0.03
2.196ThrIle: 2.196 ± 0.042
0.85ThrLys: 0.85 ± 0.026
5.781ThrLeu: 5.781 ± 0.065
0.907ThrMet: 0.907 ± 0.026
1.076ThrAsn: 1.076 ± 0.031
4.266ThrPro: 4.266 ± 0.057
1.292ThrGln: 1.292 ± 0.036
4.563ThrArg: 4.563 ± 0.063
3.557ThrSer: 3.557 ± 0.055
4.014ThrThr: 4.014 ± 0.075
6.094ThrVal: 6.094 ± 0.068
0.852ThrTrp: 0.852 ± 0.027
1.122ThrTyr: 1.122 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
11.804ValAla: 11.804 ± 0.108
0.763ValCys: 0.763 ± 0.025
5.842ValAsp: 5.842 ± 0.063
4.611ValGlu: 4.611 ± 0.067
2.414ValPhe: 2.414 ± 0.041
7.392ValGly: 7.392 ± 0.086
1.937ValHis: 1.937 ± 0.047
3.339ValIle: 3.339 ± 0.05
1.184ValLys: 1.184 ± 0.035
9.365ValLeu: 9.365 ± 0.098
1.219ValMet: 1.219 ± 0.031
1.587ValAsn: 1.587 ± 0.037
5.409ValPro: 5.409 ± 0.064
1.856ValGln: 1.856 ± 0.037
7.452ValArg: 7.452 ± 0.086
4.743ValSer: 4.743 ± 0.065
6.052ValThr: 6.052 ± 0.079
8.729ValVal: 8.729 ± 0.108
1.034ValTrp: 1.034 ± 0.028
1.454ValTyr: 1.454 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.492TrpAla: 1.492 ± 0.037
0.151TrpCys: 0.151 ± 0.01
0.751TrpAsp: 0.751 ± 0.031
0.67TrpGlu: 0.67 ± 0.026
0.413TrpPhe: 0.413 ± 0.018
0.869TrpGly: 0.869 ± 0.029
0.343TrpHis: 0.343 ± 0.015
0.532TrpIle: 0.532 ± 0.019
0.28TrpLys: 0.28 ± 0.016
1.661TrpLeu: 1.661 ± 0.035
0.239TrpMet: 0.239 ± 0.013
0.309TrpAsn: 0.309 ± 0.014
0.83TrpPro: 0.83 ± 0.03
0.539TrpGln: 0.539 ± 0.02
1.363TrpArg: 1.363 ± 0.033
0.857TrpSer: 0.857 ± 0.026
0.823TrpThr: 0.823 ± 0.026
0.947TrpVal: 0.947 ± 0.031
0.314TrpTrp: 0.314 ± 0.017
0.296TrpTyr: 0.296 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.228TyrAla: 2.228 ± 0.04
0.194TyrCys: 0.194 ± 0.013
1.241TyrAsp: 1.241 ± 0.032
0.971TyrGlu: 0.971 ± 0.029
0.568TyrPhe: 0.568 ± 0.019
1.827TyrGly: 1.827 ± 0.038
0.413TyrHis: 0.413 ± 0.019
0.506TyrIle: 0.506 ± 0.021
0.293TyrLys: 0.293 ± 0.017
2.172TyrLeu: 2.172 ± 0.043
0.223TyrMet: 0.223 ± 0.014
0.345TyrAsn: 0.345 ± 0.017
1.13TyrPro: 1.13 ± 0.031
0.637TyrGln: 0.637 ± 0.025
1.756TyrArg: 1.756 ± 0.044
0.872TyrSer: 0.872 ± 0.028
1.07TyrThr: 1.07 ± 0.031
1.463TyrVal: 1.463 ± 0.032
0.281TyrTrp: 0.281 ± 0.014
0.428TyrTyr: 0.428 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4063 proteins (1333214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski