Amino acid dipepetide frequency for Burkholderia sp. (strain CCGE1003)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.883AlaAla: 18.883 ± 0.151	1.336AlaCys: 1.336 ± 0.031	6.618AlaAsp: 6.618 ± 0.067	6.061AlaGlu: 6.061 ± 0.071	4.288AlaPhe: 4.288 ± 0.053	10.636AlaGly: 10.636 ± 0.096	2.984AlaHis: 2.984 ± 0.043	5.568AlaIle: 5.568 ± 0.055	3.629AlaLys: 3.629 ± 0.056	14.777AlaLeu: 14.777 ± 0.109	3.239AlaMet: 3.239 ± 0.041	3.498AlaAsn: 3.498 ± 0.052	6.245AlaPro: 6.245 ± 0.075	5.813AlaGln: 5.813 ± 0.064	9.408AlaArg: 9.408 ± 0.102	8.133AlaSer: 8.133 ± 0.077	6.491AlaThr: 6.491 ± 0.071	8.932AlaVal: 8.932 ± 0.07	1.682AlaTrp: 1.682 ± 0.035	2.75AlaTyr: 2.75 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.304CysAla: 1.304 ± 0.025	0.121CysCys: 0.121 ± 0.009	0.525CysAsp: 0.525 ± 0.017	0.504CysGlu: 0.504 ± 0.017	0.322CysPhe: 0.322 ± 0.014	1.018CysGly: 1.018 ± 0.023	0.251CysHis: 0.251 ± 0.012	0.386CysIle: 0.386 ± 0.015	0.219CysLys: 0.219 ± 0.01	0.772CysLeu: 0.772 ± 0.017	0.21CysMet: 0.21 ± 0.01	0.256CysAsn: 0.256 ± 0.013	0.421CysPro: 0.421 ± 0.016	0.191CysGln: 0.191 ± 0.01	0.592CysArg: 0.592 ± 0.018	0.524CysSer: 0.524 ± 0.017	0.475CysThr: 0.475 ± 0.019	0.807CysVal: 0.807 ± 0.02	0.128CysTrp: 0.128 ± 0.01	0.215CysTyr: 0.215 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.488AspAla: 7.488 ± 0.08	0.448AspCys: 0.448 ± 0.015	2.951AspAsp: 2.951 ± 0.048	3.418AspGlu: 3.418 ± 0.048	1.841AspPhe: 1.841 ± 0.032	4.281AspGly: 4.281 ± 0.054	1.082AspHis: 1.082 ± 0.026	2.44AspIle: 2.44 ± 0.041	1.499AspLys: 1.499 ± 0.03	4.985AspLeu: 4.985 ± 0.052	1.215AspMet: 1.215 ± 0.023	1.336AspAsn: 1.336 ± 0.033	2.794AspPro: 2.794 ± 0.036	1.529AspGln: 1.529 ± 0.027	3.146AspArg: 3.146 ± 0.045	2.56AspSer: 2.56 ± 0.037	2.771AspThr: 2.771 ± 0.039	4.163AspVal: 4.163 ± 0.054	0.877AspTrp: 0.877 ± 0.02	1.478AspTyr: 1.478 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.711GluAla: 6.711 ± 0.07	0.4GluCys: 0.4 ± 0.015	1.998GluAsp: 1.998 ± 0.038	2.433GluGlu: 2.433 ± 0.04	1.731GluPhe: 1.731 ± 0.028	3.387GluGly: 3.387 ± 0.041	1.429GluHis: 1.429 ± 0.026	2.625GluIle: 2.625 ± 0.037	1.784GluLys: 1.784 ± 0.032	5.502GluLeu: 5.502 ± 0.058	1.158GluMet: 1.158 ± 0.023	1.376GluAsn: 1.376 ± 0.031	2.629GluPro: 2.629 ± 0.046	2.434GluGln: 2.434 ± 0.04	4.978GluArg: 4.978 ± 0.057	2.652GluSer: 2.652 ± 0.036	2.758GluThr: 2.758 ± 0.039	3.593GluVal: 3.593 ± 0.047	0.69GluTrp: 0.69 ± 0.021	1.118GluTyr: 1.118 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.844PheAla: 4.844 ± 0.061	0.428PheCys: 0.428 ± 0.016	2.579PheAsp: 2.579 ± 0.044	2.03PheGlu: 2.03 ± 0.036	1.45PhePhe: 1.45 ± 0.036	3.657PheGly: 3.657 ± 0.047	0.729PheHis: 0.729 ± 0.022	1.576PheIle: 1.576 ± 0.03	0.957PheLys: 0.957 ± 0.023	2.907PheLeu: 2.907 ± 0.045	0.801PheMet: 0.801 ± 0.021	1.192PheAsn: 1.192 ± 0.023	1.528PhePro: 1.528 ± 0.03	0.96PheGln: 0.96 ± 0.023	1.987PheArg: 1.987 ± 0.035	2.303PheSer: 2.303 ± 0.036	1.906PheThr: 1.906 ± 0.037	3.126PheVal: 3.126 ± 0.044	0.49PheTrp: 0.49 ± 0.018	0.949PheTyr: 0.949 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.817GlyAla: 9.817 ± 0.096	0.829GlyCys: 0.829 ± 0.024	3.807GlyAsp: 3.807 ± 0.041	4.322GlyGlu: 4.322 ± 0.046	3.392GlyPhe: 3.392 ± 0.05	6.842GlyGly: 6.842 ± 0.096	1.892GlyHis: 1.892 ± 0.033	4.149GlyIle: 4.149 ± 0.047	3.178GlyLys: 3.178 ± 0.045	7.857GlyLeu: 7.857 ± 0.068	2.227GlyMet: 2.227 ± 0.033	2.49GlyAsn: 2.49 ± 0.052	2.908GlyPro: 2.908 ± 0.044	2.69GlyGln: 2.69 ± 0.046	5.106GlyArg: 5.106 ± 0.047	4.861GlySer: 4.861 ± 0.074	4.71GlyThr: 4.71 ± 0.082	6.817GlyVal: 6.817 ± 0.061	1.34GlyTrp: 1.34 ± 0.029	2.359GlyTyr: 2.359 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.21HisAla: 3.21 ± 0.051	0.256HisCys: 0.256 ± 0.011	1.371HisAsp: 1.371 ± 0.028	1.271HisGlu: 1.271 ± 0.032	0.944HisPhe: 0.944 ± 0.023	2.167HisGly: 2.167 ± 0.037	0.603HisHis: 0.603 ± 0.02	0.931HisIle: 0.931 ± 0.021	0.535HisLys: 0.535 ± 0.018	2.112HisLeu: 2.112 ± 0.03	0.513HisMet: 0.513 ± 0.017	0.564HisAsn: 0.564 ± 0.017	1.362HisPro: 1.362 ± 0.027	0.653HisGln: 0.653 ± 0.02	1.514HisArg: 1.514 ± 0.028	1.136HisSer: 1.136 ± 0.024	1.127HisThr: 1.127 ± 0.027	1.76HisVal: 1.76 ± 0.029	0.385HisTrp: 0.385 ± 0.014	0.686HisTyr: 0.686 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.028IleAla: 7.028 ± 0.063	0.446IleCys: 0.446 ± 0.014	3.282IleAsp: 3.282 ± 0.043	3.124IleGlu: 3.124 ± 0.037	1.423IlePhe: 1.423 ± 0.029	4.673IleGly: 4.673 ± 0.057	0.854IleHis: 0.854 ± 0.022	1.571IleIle: 1.571 ± 0.032	1.307IleLys: 1.307 ± 0.029	3.219IleLeu: 3.219 ± 0.052	0.766IleMet: 0.766 ± 0.022	1.435IleAsn: 1.435 ± 0.04	1.991IlePro: 1.991 ± 0.033	1.226IleGln: 1.226 ± 0.023	2.682IleArg: 2.682 ± 0.033	2.478IleSer: 2.478 ± 0.044	2.314IleThr: 2.314 ± 0.039	4.348IleVal: 4.348 ± 0.046	0.466IleTrp: 0.466 ± 0.015	1.03IleTyr: 1.03 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.551LysAla: 3.551 ± 0.052	0.163LysCys: 0.163 ± 0.01	1.407LysAsp: 1.407 ± 0.029	1.436LysGlu: 1.436 ± 0.031	0.836LysPhe: 0.836 ± 0.019	2.082LysGly: 2.082 ± 0.041	0.682LysHis: 0.682 ± 0.02	1.515LysIle: 1.515 ± 0.027	1.206LysLys: 1.206 ± 0.036	3.382LysLeu: 3.382 ± 0.042	0.777LysMet: 0.777 ± 0.023	0.854LysAsn: 0.854 ± 0.023	1.971LysPro: 1.971 ± 0.034	1.251LysGln: 1.251 ± 0.023	2.297LysArg: 2.297 ± 0.031	1.688LysSer: 1.688 ± 0.032	1.768LysThr: 1.768 ± 0.031	2.267LysVal: 2.267 ± 0.033	0.372LysTrp: 0.372 ± 0.015	0.659LysTyr: 0.659 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.31LeuAla: 14.31 ± 0.104	1.037LeuCys: 1.037 ± 0.023	5.766LeuAsp: 5.766 ± 0.058	5.057LeuGlu: 5.057 ± 0.057	3.665LeuPhe: 3.665 ± 0.048	8.069LeuGly: 8.069 ± 0.075	2.268LeuHis: 2.268 ± 0.035	4.619LeuIle: 4.619 ± 0.056	3.292LeuLys: 3.292 ± 0.043	10.243LeuLeu: 10.243 ± 0.111	2.246LeuMet: 2.246 ± 0.038	2.888LeuAsn: 2.888 ± 0.041	5.787LeuPro: 5.787 ± 0.058	3.546LeuGln: 3.546 ± 0.046	7.166LeuArg: 7.166 ± 0.062	6.428LeuSer: 6.428 ± 0.056	5.597LeuThr: 5.597 ± 0.057	7.402LeuVal: 7.402 ± 0.081	1.1LeuTrp: 1.1 ± 0.026	2.168LeuTyr: 2.168 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.426MetAla: 2.426 ± 0.04	0.18MetCys: 0.18 ± 0.01	0.927MetAsp: 0.927 ± 0.019	0.889MetGlu: 0.889 ± 0.021	0.759MetPhe: 0.759 ± 0.019	1.525MetGly: 1.525 ± 0.032	0.595MetHis: 0.595 ± 0.016	1.095MetIle: 1.095 ± 0.025	1.017MetLys: 1.017 ± 0.022	2.672MetLeu: 2.672 ± 0.04	0.573MetMet: 0.573 ± 0.018	0.951MetAsn: 0.951 ± 0.021	1.48MetPro: 1.48 ± 0.027	1.051MetGln: 1.051 ± 0.024	1.773MetArg: 1.773 ± 0.028	1.794MetSer: 1.794 ± 0.027	1.612MetThr: 1.612 ± 0.032	1.483MetVal: 1.483 ± 0.032	0.22MetTrp: 0.22 ± 0.011	0.43MetTyr: 0.43 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.857AsnAla: 3.857 ± 0.054	0.26AsnCys: 0.26 ± 0.01	1.469AsnAsp: 1.469 ± 0.027	1.398AsnGlu: 1.398 ± 0.027	0.992AsnPhe: 0.992 ± 0.024	2.801AsnGly: 2.801 ± 0.081	0.553AsnHis: 0.553 ± 0.018	1.22AsnIle: 1.22 ± 0.034	0.669AsnLys: 0.669 ± 0.02	2.823AsnLeu: 2.823 ± 0.042	0.585AsnMet: 0.585 ± 0.018	0.836AsnAsn: 0.836 ± 0.027	1.816AsnPro: 1.816 ± 0.033	0.914AsnGln: 0.914 ± 0.026	1.822AsnArg: 1.822 ± 0.031	1.528AsnSer: 1.528 ± 0.038	1.553AsnThr: 1.553 ± 0.039	2.407AsnVal: 2.407 ± 0.047	0.422AsnTrp: 0.422 ± 0.016	0.731AsnTyr: 0.731 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.808ProAla: 6.808 ± 0.076	0.339ProCys: 0.339 ± 0.013	3.03ProAsp: 3.03 ± 0.043	2.945ProGlu: 2.945 ± 0.041	1.935ProPhe: 1.935 ± 0.035	4.104ProGly: 4.104 ± 0.054	1.302ProHis: 1.302 ± 0.026	1.911ProIle: 1.911 ± 0.033	1.371ProLys: 1.371 ± 0.025	5.366ProLeu: 5.366 ± 0.059	1.077ProMet: 1.077 ± 0.024	1.469ProAsn: 1.469 ± 0.03	2.448ProPro: 2.448 ± 0.046	2.051ProGln: 2.051 ± 0.035	3.008ProArg: 3.008 ± 0.039	2.85ProSer: 2.85 ± 0.045	2.61ProThr: 2.61 ± 0.04	4.285ProVal: 4.285 ± 0.044	0.628ProTrp: 0.628 ± 0.02	1.242ProTyr: 1.242 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.689GlnAla: 4.689 ± 0.064	0.31GlnCys: 0.31 ± 0.013	1.286GlnAsp: 1.286 ± 0.03	1.346GlnGlu: 1.346 ± 0.027	1.305GlnPhe: 1.305 ± 0.025	2.501GlnGly: 2.501 ± 0.036	0.974GlnHis: 0.974 ± 0.021	1.989GlnIle: 1.989 ± 0.031	1.158GlnLys: 1.158 ± 0.027	3.934GlnLeu: 3.934 ± 0.052	1.065GlnMet: 1.065 ± 0.023	0.96GlnAsn: 0.96 ± 0.025	2.087GlnPro: 2.087 ± 0.037	2.048GlnGln: 2.048 ± 0.038	3.017GlnArg: 3.017 ± 0.042	2.144GlnSer: 2.144 ± 0.039	2.128GlnThr: 2.128 ± 0.034	2.538GlnVal: 2.538 ± 0.034	0.585GlnTrp: 0.585 ± 0.017	0.931GlnTyr: 0.931 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.505ArgAla: 8.505 ± 0.089	0.607ArgCys: 0.607 ± 0.019	3.743ArgAsp: 3.743 ± 0.046	4.398ArgGlu: 4.398 ± 0.06	2.992ArgPhe: 2.992 ± 0.041	4.643ArgGly: 4.643 ± 0.048	1.851ArgHis: 1.851 ± 0.028	3.551ArgIle: 3.551 ± 0.041	2.087ArgLys: 2.087 ± 0.036	7.273ArgLeu: 7.273 ± 0.077	1.84ArgMet: 1.84 ± 0.034	2.014ArgAsn: 2.014 ± 0.034	2.985ArgPro: 2.985 ± 0.046	2.482ArgGln: 2.482 ± 0.036	5.327ArgArg: 5.327 ± 0.063	3.613ArgSer: 3.613 ± 0.042	3.357ArgThr: 3.357 ± 0.039	5.279ArgVal: 5.279 ± 0.058	1.028ArgTrp: 1.028 ± 0.025	1.945ArgTyr: 1.945 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.672SerAla: 7.672 ± 0.087	0.465SerCys: 0.465 ± 0.016	2.758SerAsp: 2.758 ± 0.037	2.616SerGlu: 2.616 ± 0.035	2.207SerPhe: 2.207 ± 0.03	5.706SerGly: 5.706 ± 0.099	1.271SerHis: 1.271 ± 0.024	2.737SerIle: 2.737 ± 0.038	1.585SerLys: 1.585 ± 0.031	5.916SerLeu: 5.916 ± 0.054	1.409SerMet: 1.409 ± 0.027	1.747SerAsn: 1.747 ± 0.04	2.894SerPro: 2.894 ± 0.039	1.963SerGln: 1.963 ± 0.03	3.857SerArg: 3.857 ± 0.043	3.707SerSer: 3.707 ± 0.057	3.289SerThr: 3.289 ± 0.051	4.651SerVal: 4.651 ± 0.053	0.69SerTrp: 0.69 ± 0.02	1.381SerTyr: 1.381 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.149ThrAla: 6.149 ± 0.072	0.409ThrCys: 0.409 ± 0.015	2.586ThrAsp: 2.586 ± 0.046	2.315ThrGlu: 2.315 ± 0.037	1.935ThrPhe: 1.935 ± 0.031	4.819ThrGly: 4.819 ± 0.078	1.291ThrHis: 1.291 ± 0.028	2.53ThrIle: 2.53 ± 0.039	1.188ThrLys: 1.188 ± 0.029	6.543ThrLeu: 6.543 ± 0.058	1.128ThrMet: 1.128 ± 0.022	1.43ThrAsn: 1.43 ± 0.047	3.51ThrPro: 3.51 ± 0.04	2.037ThrGln: 2.037 ± 0.033	3.58ThrArg: 3.58 ± 0.042	3.15ThrSer: 3.15 ± 0.046	2.88ThrThr: 2.88 ± 0.054	4.398ThrVal: 4.398 ± 0.056	0.68ThrTrp: 0.68 ± 0.019	1.256ThrTyr: 1.256 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.782ValAla: 9.782 ± 0.075	0.802ValCys: 0.802 ± 0.019	4.236ValAsp: 4.236 ± 0.046	4.123ValGlu: 4.123 ± 0.051	2.821ValPhe: 2.821 ± 0.037	5.682ValGly: 5.682 ± 0.064	1.561ValHis: 1.561 ± 0.029	3.784ValIle: 3.784 ± 0.055	2.461ValLys: 2.461 ± 0.038	7.981ValLeu: 7.981 ± 0.08	1.816ValMet: 1.816 ± 0.03	2.274ValAsn: 2.274 ± 0.037	4.002ValPro: 4.002 ± 0.049	2.597ValGln: 2.597 ± 0.037	5.12ValArg: 5.12 ± 0.059	4.862ValSer: 4.862 ± 0.055	4.505ValThr: 4.505 ± 0.055	6.353ValVal: 6.353 ± 0.064	0.957ValTrp: 0.957 ± 0.021	1.713ValTyr: 1.713 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.14TrpAla: 1.14 ± 0.028	0.143TrpCys: 0.143 ± 0.008	0.602TrpAsp: 0.602 ± 0.019	0.472TrpGlu: 0.472 ± 0.015	0.552TrpPhe: 0.552 ± 0.016	0.827TrpGly: 0.827 ± 0.023	0.413TrpHis: 0.413 ± 0.015	0.654TrpIle: 0.654 ± 0.017	0.398TrpLys: 0.398 ± 0.013	1.913TrpLeu: 1.913 ± 0.037	0.351TrpMet: 0.351 ± 0.015	0.469TrpAsn: 0.469 ± 0.016	0.674TrpPro: 0.674 ± 0.019	0.69TrpGln: 0.69 ± 0.021	1.192TrpArg: 1.192 ± 0.031	0.792TrpSer: 0.792 ± 0.022	0.686TrpThr: 0.686 ± 0.022	0.883TrpVal: 0.883 ± 0.02	0.224TrpTrp: 0.224 ± 0.012	0.291TrpTyr: 0.291 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.798TyrAla: 2.798 ± 0.034	0.264TyrCys: 0.264 ± 0.01	1.363TyrAsp: 1.363 ± 0.027	1.228TyrGlu: 1.228 ± 0.027	1.007TyrPhe: 1.007 ± 0.024	2.176TyrGly: 2.176 ± 0.038	0.514TyrHis: 0.514 ± 0.017	0.812TyrIle: 0.812 ± 0.019	0.621TyrLys: 0.621 ± 0.02	2.477TyrLeu: 2.477 ± 0.036	0.455TyrMet: 0.455 ± 0.016	0.618TyrAsn: 0.618 ± 0.018	1.248TyrPro: 1.248 ± 0.023	0.869TyrGln: 0.869 ± 0.022	1.946TyrArg: 1.946 ± 0.031	1.318TyrSer: 1.318 ± 0.026	1.277TyrThr: 1.277 ± 0.028	1.941TyrVal: 1.941 ± 0.034	0.402TyrTrp: 0.402 ± 0.013	0.665TyrTyr: 0.665 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5983 proteins (1998914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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