Amino acid dipepetide frequency for Streptococcus satellite phage Javan646

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.404AlaAla: 0.404 ± 0.347
0.0AlaCys: 0.0 ± 0.0
2.826AlaAsp: 2.826 ± 1.561
4.845AlaGlu: 4.845 ± 1.99
2.422AlaPhe: 2.422 ± 0.916
2.422AlaGly: 2.422 ± 1.246
0.807AlaHis: 0.807 ± 0.384
4.441AlaIle: 4.441 ± 2.106
4.441AlaLys: 4.441 ± 0.954
6.056AlaLeu: 6.056 ± 2.224
1.211AlaMet: 1.211 ± 0.551
2.019AlaAsn: 2.019 ± 0.929
3.633AlaPro: 3.633 ± 1.071
2.826AlaGln: 2.826 ± 1.231
3.23AlaArg: 3.23 ± 0.691
3.23AlaSer: 3.23 ± 1.34
5.652AlaThr: 5.652 ± 1.15
1.615AlaVal: 1.615 ± 0.589
1.211AlaTrp: 1.211 ± 0.678
4.037AlaTyr: 4.037 ± 1.027
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.807CysAsp: 0.807 ± 0.609
0.404CysGlu: 0.404 ± 0.372
1.211CysPhe: 1.211 ± 0.694
0.404CysGly: 0.404 ± 0.337
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.807CysLys: 0.807 ± 0.462
0.807CysLeu: 0.807 ± 0.545
0.0CysMet: 0.0 ± 0.0
0.404CysAsn: 0.404 ± 0.337
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.404CysArg: 0.404 ± 0.347
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.404CysTrp: 0.404 ± 0.328
0.807CysTyr: 0.807 ± 0.513
0.0CysXaa: 0.0 ± 0.0
Asp
1.211AspAla: 1.211 ± 0.624
1.211AspCys: 1.211 ± 0.899
3.633AspAsp: 3.633 ± 1.28
3.633AspGlu: 3.633 ± 0.979
3.23AspPhe: 3.23 ± 0.495
1.211AspGly: 1.211 ± 0.617
0.0AspHis: 0.0 ± 0.0
5.652AspIle: 5.652 ± 1.534
8.074AspLys: 8.074 ± 1.541
5.248AspLeu: 5.248 ± 1.306
3.23AspMet: 3.23 ± 0.81
6.056AspAsn: 6.056 ± 1.735
0.404AspPro: 0.404 ± 0.337
0.404AspGln: 0.404 ± 0.408
2.826AspArg: 2.826 ± 0.94
1.615AspSer: 1.615 ± 0.8
3.23AspThr: 3.23 ± 1.375
3.633AspVal: 3.633 ± 1.345
1.211AspTrp: 1.211 ± 0.738
3.633AspTyr: 3.633 ± 0.834
0.0AspXaa: 0.0 ± 0.0
Glu
2.826GluAla: 2.826 ± 1.134
0.404GluCys: 0.404 ± 0.494
6.863GluAsp: 6.863 ± 1.691
6.459GluGlu: 6.459 ± 2.481
3.633GluPhe: 3.633 ± 1.275
2.019GluGly: 2.019 ± 0.736
2.019GluHis: 2.019 ± 1.074
6.863GluIle: 6.863 ± 2.364
7.267GluLys: 7.267 ± 1.965
10.093GluLeu: 10.093 ± 2.621
1.211GluMet: 1.211 ± 0.719
4.037GluAsn: 4.037 ± 1.178
2.019GluPro: 2.019 ± 0.753
6.459GluGln: 6.459 ± 2.104
6.056GluArg: 6.056 ± 1.806
1.615GluSer: 1.615 ± 1.136
4.441GluThr: 4.441 ± 1.124
6.056GluVal: 6.056 ± 1.561
0.404GluTrp: 0.404 ± 0.347
6.056GluTyr: 6.056 ± 2.057
0.0GluXaa: 0.0 ± 0.0
Phe
0.807PheAla: 0.807 ± 0.758
0.0PheCys: 0.0 ± 0.0
4.441PheAsp: 4.441 ± 1.355
2.019PheGlu: 2.019 ± 0.797
0.404PhePhe: 0.404 ± 0.337
2.422PheGly: 2.422 ± 1.056
0.404PheHis: 0.404 ± 0.347
2.826PheIle: 2.826 ± 0.879
3.633PheLys: 3.633 ± 1.062
3.23PheLeu: 3.23 ± 0.96
1.211PheMet: 1.211 ± 0.491
4.441PheAsn: 4.441 ± 1.222
0.404PhePro: 0.404 ± 0.328
0.807PheGln: 0.807 ± 0.445
2.422PheArg: 2.422 ± 1.277
4.037PheSer: 4.037 ± 0.88
1.211PheThr: 1.211 ± 0.624
0.807PheVal: 0.807 ± 0.542
0.807PheTrp: 0.807 ± 0.445
2.826PheTyr: 2.826 ± 1.062
0.0PheXaa: 0.0 ± 0.0
Gly
3.23GlyAla: 3.23 ± 1.42
0.404GlyCys: 0.404 ± 0.347
2.422GlyAsp: 2.422 ± 1.218
3.23GlyGlu: 3.23 ± 1.011
2.019GlyPhe: 2.019 ± 0.633
2.019GlyGly: 2.019 ± 1.178
0.807GlyHis: 0.807 ± 0.549
5.248GlyIle: 5.248 ± 1.397
3.633GlyLys: 3.633 ± 1.217
3.23GlyLeu: 3.23 ± 1.137
0.807GlyMet: 0.807 ± 0.528
0.0GlyAsn: 0.0 ± 0.0
0.0GlyPro: 0.0 ± 0.0
1.211GlyGln: 1.211 ± 0.638
2.422GlyArg: 2.422 ± 1.016
0.807GlySer: 0.807 ± 0.51
2.019GlyThr: 2.019 ± 0.77
3.23GlyVal: 3.23 ± 1.142
0.807GlyTrp: 0.807 ± 0.542
3.23GlyTyr: 3.23 ± 0.83
0.0GlyXaa: 0.0 ± 0.0
His
1.211HisAla: 1.211 ± 1.041
0.0HisCys: 0.0 ± 0.0
0.404HisAsp: 0.404 ± 0.45
1.211HisGlu: 1.211 ± 0.545
0.404HisPhe: 0.404 ± 0.328
0.404HisGly: 0.404 ± 0.408
0.404HisHis: 0.404 ± 0.45
2.019HisIle: 2.019 ± 1.129
1.211HisLys: 1.211 ± 0.751
2.019HisLeu: 2.019 ± 0.626
0.0HisMet: 0.0 ± 0.0
1.211HisAsn: 1.211 ± 1.077
1.211HisPro: 1.211 ± 0.643
0.807HisGln: 0.807 ± 0.384
1.211HisArg: 1.211 ± 0.655
0.404HisSer: 0.404 ± 0.429
0.404HisThr: 0.404 ± 0.347
0.404HisVal: 0.404 ± 0.476
0.0HisTrp: 0.0 ± 0.0
1.211HisTyr: 1.211 ± 0.913
0.0HisXaa: 0.0 ± 0.0
Ile
6.863IleAla: 6.863 ± 2.121
0.807IleCys: 0.807 ± 0.559
6.056IleAsp: 6.056 ± 1.526
6.863IleGlu: 6.863 ± 2.291
2.019IlePhe: 2.019 ± 0.726
2.422IleGly: 2.422 ± 0.847
2.019IleHis: 2.019 ± 0.653
3.633IleIle: 3.633 ± 1.091
9.689IleLys: 9.689 ± 2.282
7.267IleLeu: 7.267 ± 1.522
2.826IleMet: 2.826 ± 0.952
7.267IleAsn: 7.267 ± 1.497
4.441IlePro: 4.441 ± 1.255
3.23IleGln: 3.23 ± 1.166
1.615IleArg: 1.615 ± 0.513
3.633IleSer: 3.633 ± 1.551
2.826IleThr: 2.826 ± 0.974
2.019IleVal: 2.019 ± 0.737
0.807IleTrp: 0.807 ± 0.525
2.422IleTyr: 2.422 ± 0.781
0.0IleXaa: 0.0 ± 0.0
Lys
5.248LysAla: 5.248 ± 1.417
0.404LysCys: 0.404 ± 0.337
4.037LysAsp: 4.037 ± 1.549
13.323LysGlu: 13.323 ± 2.006
3.23LysPhe: 3.23 ± 1.238
4.037LysGly: 4.037 ± 1.67
2.422LysHis: 2.422 ± 0.811
7.671LysIle: 7.671 ± 1.655
6.863LysLys: 6.863 ± 2.1
7.267LysLeu: 7.267 ± 2.157
1.211LysMet: 1.211 ± 0.52
3.23LysAsn: 3.23 ± 0.888
2.422LysPro: 2.422 ± 0.911
5.652LysGln: 5.652 ± 1.204
5.248LysArg: 5.248 ± 1.608
5.652LysSer: 5.652 ± 1.368
6.459LysThr: 6.459 ± 1.546
4.845LysVal: 4.845 ± 1.07
0.404LysTrp: 0.404 ± 0.45
1.211LysTyr: 1.211 ± 0.466
0.0LysXaa: 0.0 ± 0.0
Leu
8.882LeuAla: 8.882 ± 1.103
0.404LeuCys: 0.404 ± 0.337
6.863LeuAsp: 6.863 ± 1.491
14.13LeuGlu: 14.13 ± 2.803
4.037LeuPhe: 4.037 ± 1.368
2.826LeuGly: 2.826 ± 0.966
1.211LeuHis: 1.211 ± 0.649
6.056LeuIle: 6.056 ± 1.395
7.267LeuLys: 7.267 ± 2.076
9.285LeuLeu: 9.285 ± 1.658
2.422LeuMet: 2.422 ± 0.961
8.478LeuAsn: 8.478 ± 2.712
4.037LeuPro: 4.037 ± 1.085
5.248LeuGln: 5.248 ± 1.19
2.826LeuArg: 2.826 ± 0.909
4.441LeuSer: 4.441 ± 1.32
4.845LeuThr: 4.845 ± 1.15
6.056LeuVal: 6.056 ± 1.324
0.404LeuTrp: 0.404 ± 0.347
4.441LeuTyr: 4.441 ± 1.305
0.0LeuXaa: 0.0 ± 0.0
Met
1.211MetAla: 1.211 ± 0.907
0.0MetCys: 0.0 ± 0.0
0.807MetAsp: 0.807 ± 0.496
1.211MetGlu: 1.211 ± 0.789
0.404MetPhe: 0.404 ± 0.328
0.807MetGly: 0.807 ± 0.644
0.0MetHis: 0.0 ± 0.0
2.019MetIle: 2.019 ± 0.957
2.019MetLys: 2.019 ± 0.845
2.826MetLeu: 2.826 ± 0.965
0.807MetMet: 0.807 ± 0.551
2.019MetAsn: 2.019 ± 0.64
1.211MetPro: 1.211 ± 0.762
1.211MetGln: 1.211 ± 0.793
0.0MetArg: 0.0 ± 0.0
0.404MetSer: 0.404 ± 0.328
4.441MetThr: 4.441 ± 1.066
0.807MetVal: 0.807 ± 0.545
0.404MetTrp: 0.404 ± 0.382
0.807MetTyr: 0.807 ± 0.659
0.0MetXaa: 0.0 ± 0.0
Asn
5.248AsnAla: 5.248 ± 1.175
0.807AsnCys: 0.807 ± 0.745
2.422AsnAsp: 2.422 ± 0.924
4.037AsnGlu: 4.037 ± 1.244
2.422AsnPhe: 2.422 ± 1.025
3.23AsnGly: 3.23 ± 1.193
1.211AsnHis: 1.211 ± 0.67
3.23AsnIle: 3.23 ± 0.841
6.056AsnLys: 6.056 ± 1.531
6.056AsnLeu: 6.056 ± 1.649
2.019AsnMet: 2.019 ± 0.794
6.056AsnAsn: 6.056 ± 1.945
4.037AsnPro: 4.037 ± 1.347
2.826AsnGln: 2.826 ± 0.875
4.441AsnArg: 4.441 ± 1.004
2.019AsnSer: 2.019 ± 1.04
3.23AsnThr: 3.23 ± 1.304
1.615AsnVal: 1.615 ± 0.566
0.0AsnTrp: 0.0 ± 0.0
2.826AsnTyr: 2.826 ± 1.152
0.0AsnXaa: 0.0 ± 0.0
Pro
2.422ProAla: 2.422 ± 1.062
0.404ProCys: 0.404 ± 0.337
3.23ProAsp: 3.23 ± 1.251
2.826ProGlu: 2.826 ± 0.934
1.211ProPhe: 1.211 ± 0.497
0.0ProGly: 0.0 ± 0.0
0.404ProHis: 0.404 ± 0.429
2.826ProIle: 2.826 ± 0.844
2.826ProLys: 2.826 ± 0.927
3.23ProLeu: 3.23 ± 1.423
0.807ProMet: 0.807 ± 0.745
1.615ProAsn: 1.615 ± 0.92
0.807ProPro: 0.807 ± 0.542
2.019ProGln: 2.019 ± 1.09
1.211ProArg: 1.211 ± 0.509
0.807ProSer: 0.807 ± 0.445
2.826ProThr: 2.826 ± 0.984
1.615ProVal: 1.615 ± 0.563
0.0ProTrp: 0.0 ± 0.0
1.211ProTyr: 1.211 ± 0.983
0.0ProXaa: 0.0 ± 0.0
Gln
2.826GlnAla: 2.826 ± 0.885
0.0GlnCys: 0.0 ± 0.0
2.422GlnAsp: 2.422 ± 0.821
4.037GlnGlu: 4.037 ± 1.3
1.615GlnPhe: 1.615 ± 0.791
2.826GlnGly: 2.826 ± 1.005
0.404GlnHis: 0.404 ± 0.347
5.248GlnIle: 5.248 ± 1.647
4.037GlnLys: 4.037 ± 1.047
8.478GlnLeu: 8.478 ± 1.104
0.404GlnMet: 0.404 ± 0.347
2.826GlnAsn: 2.826 ± 1.052
0.807GlnPro: 0.807 ± 0.551
1.211GlnGln: 1.211 ± 0.54
2.422GlnArg: 2.422 ± 0.934
3.23GlnSer: 3.23 ± 1.19
2.422GlnThr: 2.422 ± 0.543
1.615GlnVal: 1.615 ± 0.944
0.0GlnTrp: 0.0 ± 0.0
2.019GlnTyr: 2.019 ± 0.718
0.0GlnXaa: 0.0 ± 0.0
Arg
2.422ArgAla: 2.422 ± 0.924
0.404ArgCys: 0.404 ± 0.347
1.211ArgAsp: 1.211 ± 0.759
2.826ArgGlu: 2.826 ± 0.756
0.807ArgPhe: 0.807 ± 0.656
3.633ArgGly: 3.633 ± 1.17
2.019ArgHis: 2.019 ± 1.199
3.633ArgIle: 3.633 ± 0.88
2.826ArgLys: 2.826 ± 1.337
5.248ArgLeu: 5.248 ± 1.711
0.807ArgMet: 0.807 ± 0.469
2.019ArgAsn: 2.019 ± 0.879
1.211ArgPro: 1.211 ± 0.687
3.633ArgGln: 3.633 ± 0.684
1.615ArgArg: 1.615 ± 1.291
1.211ArgSer: 1.211 ± 0.6
4.037ArgThr: 4.037 ± 1.013
2.019ArgVal: 2.019 ± 0.651
0.404ArgTrp: 0.404 ± 0.429
2.422ArgTyr: 2.422 ± 1.168
0.0ArgXaa: 0.0 ± 0.0
Ser
2.019SerAla: 2.019 ± 0.946
0.0SerCys: 0.0 ± 0.0
3.633SerAsp: 3.633 ± 1.151
4.037SerGlu: 4.037 ± 1.635
1.211SerPhe: 1.211 ± 0.766
0.0SerGly: 0.0 ± 0.0
0.404SerHis: 0.404 ± 0.347
3.23SerIle: 3.23 ± 0.999
3.633SerLys: 3.633 ± 0.93
6.056SerLeu: 6.056 ± 1.725
0.807SerMet: 0.807 ± 0.622
2.826SerAsn: 2.826 ± 0.677
1.615SerPro: 1.615 ± 0.659
2.019SerGln: 2.019 ± 0.761
1.211SerArg: 1.211 ± 0.54
1.211SerSer: 1.211 ± 0.649
3.23SerThr: 3.23 ± 0.747
3.23SerVal: 3.23 ± 0.637
0.404SerTrp: 0.404 ± 0.347
2.422SerTyr: 2.422 ± 1.419
0.0SerXaa: 0.0 ± 0.0
Thr
4.037ThrAla: 4.037 ± 1.286
0.404ThrCys: 0.404 ± 0.372
3.633ThrAsp: 3.633 ± 1.046
3.633ThrGlu: 3.633 ± 1.321
4.441ThrPhe: 4.441 ± 1.22
5.248ThrGly: 5.248 ± 1.264
0.807ThrHis: 0.807 ± 0.694
7.267ThrIle: 7.267 ± 1.309
3.633ThrLys: 3.633 ± 1.651
5.248ThrLeu: 5.248 ± 1.518
1.211ThrMet: 1.211 ± 0.6
2.019ThrAsn: 2.019 ± 1.554
1.615ThrPro: 1.615 ± 0.92
1.615ThrGln: 1.615 ± 0.889
2.826ThrArg: 2.826 ± 0.964
2.826ThrSer: 2.826 ± 0.961
4.037ThrThr: 4.037 ± 0.843
3.633ThrVal: 3.633 ± 1.222
0.0ThrTrp: 0.0 ± 0.0
2.826ThrTyr: 2.826 ± 0.893
0.0ThrXaa: 0.0 ± 0.0
Val
3.23ValAla: 3.23 ± 0.876
0.404ValCys: 0.404 ± 0.372
1.211ValAsp: 1.211 ± 0.712
3.633ValGlu: 3.633 ± 0.934
3.23ValPhe: 3.23 ± 1.19
2.019ValGly: 2.019 ± 0.841
0.0ValHis: 0.0 ± 0.0
2.422ValIle: 2.422 ± 0.923
6.056ValLys: 6.056 ± 1.2
5.248ValLeu: 5.248 ± 1.324
0.807ValMet: 0.807 ± 0.628
2.422ValAsn: 2.422 ± 1.18
1.211ValPro: 1.211 ± 0.544
1.615ValGln: 1.615 ± 0.767
1.615ValArg: 1.615 ± 0.64
2.826ValSer: 2.826 ± 0.787
4.845ValThr: 4.845 ± 0.945
0.807ValVal: 0.807 ± 0.384
0.404ValTrp: 0.404 ± 0.337
1.211ValTyr: 1.211 ± 0.793
0.0ValXaa: 0.0 ± 0.0
Trp
1.211TrpAla: 1.211 ± 0.632
0.0TrpCys: 0.0 ± 0.0
0.404TrpAsp: 0.404 ± 0.382
0.807TrpGlu: 0.807 ± 0.528
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.807TrpIle: 0.807 ± 0.548
1.211TrpLys: 1.211 ± 0.705
1.615TrpLeu: 1.615 ± 0.669
0.0TrpMet: 0.0 ± 0.0
0.404TrpAsn: 0.404 ± 0.328
0.0TrpPro: 0.0 ± 0.0
0.404TrpGln: 0.404 ± 0.476
0.0TrpArg: 0.0 ± 0.0
0.404TrpSer: 0.404 ± 0.347
0.0TrpThr: 0.0 ± 0.0
1.211TrpVal: 1.211 ± 0.6
0.0TrpTrp: 0.0 ± 0.0
0.404TrpTyr: 0.404 ± 0.328
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.019TyrAla: 2.019 ± 0.964
0.404TyrCys: 0.404 ± 0.328
2.019TyrAsp: 2.019 ± 0.776
3.633TyrGlu: 3.633 ± 1.329
1.211TyrPhe: 1.211 ± 0.668
2.826TyrGly: 2.826 ± 0.987
0.807TyrHis: 0.807 ± 0.506
3.633TyrIle: 3.633 ± 1.082
5.652TyrLys: 5.652 ± 1.335
5.652TyrLeu: 5.652 ± 1.688
1.211TyrMet: 1.211 ± 0.534
4.441TyrAsn: 4.441 ± 1.115
1.211TyrPro: 1.211 ± 0.509
5.652TyrGln: 5.652 ± 1.511
0.807TyrArg: 0.807 ± 0.694
3.23TyrSer: 3.23 ± 0.815
0.807TyrThr: 0.807 ± 0.656
0.0TyrVal: 0.0 ± 0.0
0.807TyrTrp: 0.807 ± 0.445
3.23TyrTyr: 3.23 ± 1.141
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski