Amino acid dipepetide frequency for Rhizopus stolonifer (Rhizopus nigricans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.897AlaAla: 4.897 ± 0.048	0.985AlaCys: 0.985 ± 0.014	3.02AlaAsp: 3.02 ± 0.021	3.772AlaGlu: 3.772 ± 0.034	2.715AlaPhe: 2.715 ± 0.024	3.188AlaGly: 3.188 ± 0.025	1.48AlaHis: 1.48 ± 0.016	4.283AlaIle: 4.283 ± 0.03	3.978AlaLys: 3.978 ± 0.031	6.449AlaLeu: 6.449 ± 0.037	1.659AlaMet: 1.659 ± 0.017	2.817AlaAsn: 2.817 ± 0.026	2.578AlaPro: 2.578 ± 0.024	2.74AlaGln: 2.74 ± 0.027	2.901AlaArg: 2.901 ± 0.023	5.294AlaSer: 5.294 ± 0.04	3.978AlaThr: 3.978 ± 0.031	4.016AlaVal: 4.016 ± 0.03	0.712AlaTrp: 0.712 ± 0.01	2.146AlaTyr: 2.146 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.78CysAla: 0.78 ± 0.012	0.275CysCys: 0.275 ± 0.008	0.695CysAsp: 0.695 ± 0.011	0.688CysGlu: 0.688 ± 0.012	0.683CysPhe: 0.683 ± 0.011	0.836CysGly: 0.836 ± 0.015	0.411CysHis: 0.411 ± 0.008	0.976CysIle: 0.976 ± 0.014	0.758CysLys: 0.758 ± 0.012	1.542CysLeu: 1.542 ± 0.016	0.33CysMet: 0.33 ± 0.008	0.567CysAsn: 0.567 ± 0.01	0.623CysPro: 0.623 ± 0.012	0.629CysGln: 0.629 ± 0.01	0.643CysArg: 0.643 ± 0.011	1.068CysSer: 1.068 ± 0.015	0.746CysThr: 0.746 ± 0.012	0.886CysVal: 0.886 ± 0.013	0.182CysTrp: 0.182 ± 0.006	0.51CysTyr: 0.51 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.407AspAla: 3.407 ± 0.028	0.709AspCys: 0.709 ± 0.012	3.877AspAsp: 3.877 ± 0.036	4.342AspGlu: 4.342 ± 0.036	2.331AspPhe: 2.331 ± 0.02	2.617AspGly: 2.617 ± 0.024	1.44AspHis: 1.44 ± 0.02	4.075AspIle: 4.075 ± 0.027	3.275AspLys: 3.275 ± 0.025	5.392AspLeu: 5.392 ± 0.032	1.559AspMet: 1.559 ± 0.018	2.559AspAsn: 2.559 ± 0.023	2.619AspPro: 2.619 ± 0.02	2.475AspGln: 2.475 ± 0.022	2.482AspArg: 2.482 ± 0.021	3.889AspSer: 3.889 ± 0.029	3.352AspThr: 3.352 ± 0.025	3.321AspVal: 3.321 ± 0.029	0.759AspTrp: 0.759 ± 0.012	2.138AspTyr: 2.138 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	4.434GluAla: 4.434 ± 0.036	0.764GluCys: 0.764 ± 0.012	4.34GluAsp: 4.34 ± 0.037	7.055GluGlu: 7.055 ± 0.076	2.381GluPhe: 2.381 ± 0.023	2.944GluGly: 2.944 ± 0.022	1.609GluHis: 1.609 ± 0.02	3.908GluIle: 3.908 ± 0.027	5.392GluLys: 5.392 ± 0.044	5.957GluLeu: 5.957 ± 0.041	1.588GluMet: 1.588 ± 0.018	3.391GluAsn: 3.391 ± 0.028	2.465GluPro: 2.465 ± 0.024	3.405GluGln: 3.405 ± 0.037	3.469GluArg: 3.469 ± 0.03	4.623GluSer: 4.623 ± 0.031	3.768GluThr: 3.768 ± 0.029	3.153GluVal: 3.153 ± 0.031	0.76GluTrp: 0.76 ± 0.012	2.216GluTyr: 2.216 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.555PheAla: 2.555 ± 0.025	0.65PheCys: 0.65 ± 0.01	2.651PheAsp: 2.651 ± 0.022	2.688PheGlu: 2.688 ± 0.023	1.8PhePhe: 1.8 ± 0.024	2.65PheGly: 2.65 ± 0.027	0.939PheHis: 0.939 ± 0.014	2.516PheIle: 2.516 ± 0.023	2.309PheLys: 2.309 ± 0.022	3.697PheLeu: 3.697 ± 0.029	1.065PheMet: 1.065 ± 0.012	1.897PheAsn: 1.897 ± 0.018	1.602PhePro: 1.602 ± 0.013	1.582PheGln: 1.582 ± 0.016	1.714PheArg: 1.714 ± 0.018	3.33PheSer: 3.33 ± 0.026	2.262PheThr: 2.262 ± 0.02	2.733PheVal: 2.733 ± 0.025	0.555PheTrp: 0.555 ± 0.011	1.496PheTyr: 1.496 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	2.973GlyAla: 2.973 ± 0.029	0.774GlyCys: 0.774 ± 0.011	2.561GlyAsp: 2.561 ± 0.024	2.588GlyGlu: 2.588 ± 0.022	2.392GlyPhe: 2.392 ± 0.027	3.137GlyGly: 3.137 ± 0.035	1.403GlyHis: 1.403 ± 0.016	3.304GlyIle: 3.304 ± 0.027	3.134GlyLys: 3.134 ± 0.024	4.81GlyLeu: 4.81 ± 0.032	1.18GlyMet: 1.18 ± 0.015	2.225GlyAsn: 2.225 ± 0.023	1.788GlyPro: 1.788 ± 0.017	2.036GlyGln: 2.036 ± 0.022	2.368GlyArg: 2.368 ± 0.021	4.002GlySer: 4.002 ± 0.032	2.874GlyThr: 2.874 ± 0.027	3.183GlyVal: 3.183 ± 0.025	0.75GlyTrp: 0.75 ± 0.012	2.067GlyTyr: 2.067 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.527HisAla: 1.527 ± 0.019	0.397HisCys: 0.397 ± 0.008	1.322HisAsp: 1.322 ± 0.017	1.427HisGlu: 1.427 ± 0.017	1.072HisPhe: 1.072 ± 0.014	1.268HisGly: 1.268 ± 0.015	1.044HisHis: 1.044 ± 0.018	1.63HisIle: 1.63 ± 0.017	1.355HisLys: 1.355 ± 0.017	2.544HisLeu: 2.544 ± 0.022	0.608HisMet: 0.608 ± 0.011	1.032HisAsn: 1.032 ± 0.016	1.442HisPro: 1.442 ± 0.018	1.374HisGln: 1.374 ± 0.019	1.329HisArg: 1.329 ± 0.017	1.883HisSer: 1.883 ± 0.017	1.528HisThr: 1.528 ± 0.018	1.628HisVal: 1.628 ± 0.019	0.333HisTrp: 0.333 ± 0.008	0.981HisTyr: 0.981 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.032IleAla: 4.032 ± 0.028	0.899IleCys: 0.899 ± 0.013	3.591IleAsp: 3.591 ± 0.025	4.245IleGlu: 4.245 ± 0.032	2.301IlePhe: 2.301 ± 0.026	3.033IleGly: 3.033 ± 0.026	1.731IleHis: 1.731 ± 0.016	3.427IleIle: 3.427 ± 0.031	3.971IleLys: 3.971 ± 0.025	5.618IleLeu: 5.618 ± 0.038	1.463IleMet: 1.463 ± 0.014	2.728IleAsn: 2.728 ± 0.026	3.18IlePro: 3.18 ± 0.022	3.221IleGln: 3.221 ± 0.028	3.042IleArg: 3.042 ± 0.025	4.629IleSer: 4.629 ± 0.028	3.467IleThr: 3.467 ± 0.031	3.882IleVal: 3.882 ± 0.027	0.724IleTrp: 0.724 ± 0.01	2.041IleTyr: 2.041 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.188LysAla: 4.188 ± 0.03	0.688LysCys: 0.688 ± 0.011	3.656LysAsp: 3.656 ± 0.026	5.391LysGlu: 5.391 ± 0.044	1.958LysPhe: 1.958 ± 0.022	2.741LysGly: 2.741 ± 0.023	1.61LysHis: 1.61 ± 0.017	3.617LysIle: 3.617 ± 0.026	6.061LysLys: 6.061 ± 0.06	5.484LysLeu: 5.484 ± 0.036	1.567LysMet: 1.567 ± 0.017	3.213LysAsn: 3.213 ± 0.027	2.957LysPro: 2.957 ± 0.025	3.251LysGln: 3.251 ± 0.029	4.059LysArg: 4.059 ± 0.03	4.754LysSer: 4.754 ± 0.033	4.008LysThr: 4.008 ± 0.028	3.489LysVal: 3.489 ± 0.024	0.652LysTrp: 0.652 ± 0.011	2.147LysTyr: 2.147 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	6.274LeuAla: 6.274 ± 0.037	1.468LeuCys: 1.468 ± 0.016	5.653LeuAsp: 5.653 ± 0.036	6.349LeuGlu: 6.349 ± 0.041	4.006LeuPhe: 4.006 ± 0.034	4.837LeuGly: 4.837 ± 0.032	2.169LeuHis: 2.169 ± 0.019	5.179LeuIle: 5.179 ± 0.036	6.22LeuLys: 6.22 ± 0.041	9.145LeuLeu: 9.145 ± 0.057	2.234LeuMet: 2.234 ± 0.02	4.46LeuAsn: 4.46 ± 0.023	4.676LeuPro: 4.676 ± 0.034	4.218LeuGln: 4.218 ± 0.033	4.384LeuArg: 4.384 ± 0.03	7.862LeuSer: 7.862 ± 0.041	5.213LeuThr: 5.213 ± 0.034	5.786LeuVal: 5.786 ± 0.035	1.022LeuTrp: 1.022 ± 0.014	3.092LeuTyr: 3.092 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.832MetAla: 1.832 ± 0.021	0.311MetCys: 0.311 ± 0.007	1.635MetAsp: 1.635 ± 0.02	1.591MetGlu: 1.591 ± 0.018	0.945MetPhe: 0.945 ± 0.013	1.245MetGly: 1.245 ± 0.014	0.521MetHis: 0.521 ± 0.009	1.546MetIle: 1.546 ± 0.016	1.488MetLys: 1.488 ± 0.016	2.144MetLeu: 2.144 ± 0.021	0.793MetMet: 0.793 ± 0.011	1.313MetAsn: 1.313 ± 0.015	1.116MetPro: 1.116 ± 0.015	0.968MetGln: 0.968 ± 0.015	1.106MetArg: 1.106 ± 0.013	2.122MetSer: 2.122 ± 0.018	1.681MetThr: 1.681 ± 0.017	1.462MetVal: 1.462 ± 0.016	0.226MetTrp: 0.226 ± 0.006	0.763MetTyr: 0.763 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.984AsnAla: 2.984 ± 0.027	0.573AsnCys: 0.573 ± 0.011	2.7AsnAsp: 2.7 ± 0.025	3.136AsnGlu: 3.136 ± 0.029	1.646AsnPhe: 1.646 ± 0.018	2.379AsnGly: 2.379 ± 0.024	1.237AsnHis: 1.237 ± 0.013	2.942AsnIle: 2.942 ± 0.022	3.151AsnLys: 3.151 ± 0.025	3.943AsnLeu: 3.943 ± 0.026	1.316AsnMet: 1.316 ± 0.016	2.903AsnAsn: 2.903 ± 0.034	2.238AsnPro: 2.238 ± 0.02	2.264AsnGln: 2.264 ± 0.023	2.13AsnArg: 2.13 ± 0.02	3.446AsnSer: 3.446 ± 0.026	3.275AsnThr: 3.275 ± 0.029	2.766AsnVal: 2.766 ± 0.025	0.558AsnTrp: 0.558 ± 0.009	1.642AsnTyr: 1.642 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	2.679ProAla: 2.679 ± 0.023	0.503ProCys: 0.503 ± 0.012	2.318ProAsp: 2.318 ± 0.019	3.204ProGlu: 3.204 ± 0.029	1.977ProPhe: 1.977 ± 0.018	1.951ProGly: 1.951 ± 0.02	1.106ProHis: 1.106 ± 0.014	2.863ProIle: 2.863 ± 0.02	2.868ProLys: 2.868 ± 0.025	4.238ProLeu: 4.238 ± 0.027	1.034ProMet: 1.034 ± 0.016	2.216ProAsn: 2.216 ± 0.022	3.015ProPro: 3.015 ± 0.045	2.002ProGln: 2.002 ± 0.024	1.96ProArg: 1.96 ± 0.02	4.527ProSer: 4.527 ± 0.036	3.327ProThr: 3.327 ± 0.027	3.104ProVal: 3.104 ± 0.025	0.459ProTrp: 0.459 ± 0.009	1.535ProTyr: 1.535 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.842GlnAla: 2.842 ± 0.028	0.574GlnCys: 0.574 ± 0.011	2.63GlnAsp: 2.63 ± 0.024	3.462GlnGlu: 3.462 ± 0.031	1.734GlnPhe: 1.734 ± 0.019	1.958GlnGly: 1.958 ± 0.021	1.386GlnHis: 1.386 ± 0.018	2.504GlnIle: 2.504 ± 0.021	3.106GlnLys: 3.106 ± 0.028	4.578GlnLeu: 4.578 ± 0.038	1.137GlnMet: 1.137 ± 0.013	1.987GlnAsn: 1.987 ± 0.023	2.221GlnPro: 2.221 ± 0.028	3.875GlnGln: 3.875 ± 0.073	2.341GlnArg: 2.341 ± 0.024	3.303GlnSer: 3.303 ± 0.027	2.622GlnThr: 2.622 ± 0.025	2.807GlnVal: 2.807 ± 0.024	0.561GlnTrp: 0.561 ± 0.009	1.493GlnTyr: 1.493 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	2.904ArgAla: 2.904 ± 0.021	0.607ArgCys: 0.607 ± 0.01	2.466ArgAsp: 2.466 ± 0.022	3.055ArgGlu: 3.055 ± 0.027	2.027ArgPhe: 2.027 ± 0.019	2.172ArgGly: 2.172 ± 0.022	1.406ArgHis: 1.406 ± 0.018	3.013ArgIle: 3.013 ± 0.021	3.513ArgLys: 3.513 ± 0.029	4.963ArgLeu: 4.963 ± 0.033	1.233ArgMet: 1.233 ± 0.017	2.175ArgAsn: 2.175 ± 0.02	2.232ArgPro: 2.232 ± 0.021	2.411ArgGln: 2.411 ± 0.024	3.203ArgArg: 3.203 ± 0.032	3.566ArgSer: 3.566 ± 0.028	2.599ArgThr: 2.599 ± 0.019	2.738ArgVal: 2.738 ± 0.026	0.62ArgTrp: 0.62 ± 0.011	1.699ArgTyr: 1.699 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	4.689SerAla: 4.689 ± 0.034	1.017SerCys: 1.017 ± 0.014	4.161SerAsp: 4.161 ± 0.031	4.349SerGlu: 4.349 ± 0.031	3.482SerPhe: 3.482 ± 0.027	3.852SerGly: 3.852 ± 0.035	1.932SerHis: 1.932 ± 0.022	5.103SerIle: 5.103 ± 0.032	4.758SerLys: 4.758 ± 0.033	7.693SerLeu: 7.693 ± 0.04	1.901SerMet: 1.901 ± 0.018	3.942SerAsn: 3.942 ± 0.035	4.02SerPro: 4.02 ± 0.036	3.391SerGln: 3.391 ± 0.027	3.691SerArg: 3.691 ± 0.027	8.376SerSer: 8.376 ± 0.073	5.488SerThr: 5.488 ± 0.046	4.797SerVal: 4.797 ± 0.032	0.875SerTrp: 0.875 ± 0.012	2.349SerTyr: 2.349 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	3.888ThrAla: 3.888 ± 0.031	0.886ThrCys: 0.886 ± 0.014	2.98ThrAsp: 2.98 ± 0.027	3.747ThrGlu: 3.747 ± 0.033	2.485ThrPhe: 2.485 ± 0.02	3.182ThrGly: 3.182 ± 0.03	1.514ThrHis: 1.514 ± 0.015	3.878ThrIle: 3.878 ± 0.027	3.701ThrLys: 3.701 ± 0.032	5.836ThrLeu: 5.836 ± 0.035	1.473ThrMet: 1.473 ± 0.016	2.78ThrAsn: 2.78 ± 0.025	3.312ThrPro: 3.312 ± 0.029	2.534ThrGln: 2.534 ± 0.021	2.731ThrArg: 2.731 ± 0.018	5.108ThrSer: 5.108 ± 0.044	4.604ThrThr: 4.604 ± 0.069	3.798ThrVal: 3.798 ± 0.026	0.678ThrTrp: 0.678 ± 0.013	1.772ThrTyr: 1.772 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	3.953ValAla: 3.953 ± 0.032	0.969ValCys: 0.969 ± 0.013	3.655ValAsp: 3.655 ± 0.029	3.841ValGlu: 3.841 ± 0.033	2.648ValPhe: 2.648 ± 0.023	3.046ValGly: 3.046 ± 0.03	1.505ValHis: 1.505 ± 0.015	3.682ValIle: 3.682 ± 0.029	3.677ValLys: 3.677 ± 0.028	5.78ValLeu: 5.78 ± 0.034	1.488ValMet: 1.488 ± 0.017	2.746ValAsn: 2.746 ± 0.025	2.873ValPro: 2.873 ± 0.023	2.637ValGln: 2.637 ± 0.024	2.681ValArg: 2.681 ± 0.025	4.64ValSer: 4.64 ± 0.03	3.407ValThr: 3.407 ± 0.028	3.973ValVal: 3.973 ± 0.03	0.733ValTrp: 0.733 ± 0.013	2.187ValTyr: 2.187 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.677TrpAla: 0.677 ± 0.011	0.182TrpCys: 0.182 ± 0.005	0.73TrpAsp: 0.73 ± 0.013	0.657TrpGlu: 0.657 ± 0.013	0.553TrpPhe: 0.553 ± 0.01	0.575TrpGly: 0.575 ± 0.01	0.287TrpHis: 0.287 ± 0.008	0.817TrpIle: 0.817 ± 0.012	0.836TrpLys: 0.836 ± 0.013	1.084TrpLeu: 1.084 ± 0.016	0.332TrpMet: 0.332 ± 0.008	0.639TrpAsn: 0.639 ± 0.011	0.394TrpPro: 0.394 ± 0.008	0.467TrpGln: 0.467 ± 0.009	0.616TrpArg: 0.616 ± 0.011	0.962TrpSer: 0.962 ± 0.014	0.737TrpThr: 0.737 ± 0.012	0.665TrpVal: 0.665 ± 0.011	0.189TrpTrp: 0.189 ± 0.006	0.393TrpTyr: 0.393 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.092TyrAla: 2.092 ± 0.02	0.596TyrCys: 0.596 ± 0.01	1.98TyrAsp: 1.98 ± 0.022	2.035TyrGlu: 2.035 ± 0.021	1.555TyrPhe: 1.555 ± 0.018	1.938TyrGly: 1.938 ± 0.021	0.992TyrHis: 0.992 ± 0.014	1.961TyrIle: 1.961 ± 0.02	1.941TyrLys: 1.941 ± 0.019	3.35TyrLeu: 3.35 ± 0.029	0.847TyrMet: 0.847 ± 0.012	1.642TyrAsn: 1.642 ± 0.018	1.535TyrPro: 1.535 ± 0.018	1.641TyrGln: 1.641 ± 0.017	1.751TyrArg: 1.751 ± 0.019	2.48TyrSer: 2.48 ± 0.024	1.951TyrThr: 1.951 ± 0.021	1.932TyrVal: 1.932 ± 0.019	0.445TyrTrp: 0.445 ± 0.009	1.42TyrTyr: 1.42 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13951 proteins (5779670 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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