Amino acid dipepetide frequency for Hubei sobemo-like virus 31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.01AlaAla: 5.01 ± 3.006
0.0AlaCys: 0.0 ± 0.0
6.012AlaAsp: 6.012 ± 0.626
7.014AlaGlu: 7.014 ± 2.718
4.008AlaPhe: 4.008 ± 2.405
4.008AlaGly: 4.008 ± 2.405
1.002AlaHis: 1.002 ± 0.601
5.01AlaIle: 5.01 ± 0.025
6.012AlaLys: 6.012 ± 0.865
6.012AlaLeu: 6.012 ± 0.626
5.01AlaMet: 5.01 ± 0.025
3.006AlaAsn: 3.006 ± 0.313
1.002AlaPro: 1.002 ± 0.601
1.002AlaGln: 1.002 ± 0.89
2.004AlaArg: 2.004 ± 1.203
2.004AlaSer: 2.004 ± 0.288
2.004AlaThr: 2.004 ± 1.203
2.004AlaVal: 2.004 ± 1.203
1.002AlaTrp: 1.002 ± 0.89
4.008AlaTyr: 4.008 ± 0.914
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
2.004CysAsp: 2.004 ± 1.203
1.002CysGlu: 1.002 ± 0.89
0.0CysPhe: 0.0 ± 0.0
1.002CysGly: 1.002 ± 0.89
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.002CysLys: 1.002 ± 0.89
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
4.008CysAsn: 4.008 ± 0.577
2.004CysPro: 2.004 ± 1.203
2.004CysGln: 2.004 ± 0.288
3.006CysArg: 3.006 ± 0.313
0.0CysSer: 0.0 ± 0.0
1.002CysThr: 1.002 ± 0.601
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.002CysTyr: 1.002 ± 0.89
0.0CysXaa: 0.0 ± 0.0
Asp
5.01AspAla: 5.01 ± 1.466
0.0AspCys: 0.0 ± 0.0
5.01AspAsp: 5.01 ± 1.466
3.006AspGlu: 3.006 ± 0.313
3.006AspPhe: 3.006 ± 0.313
2.004AspGly: 2.004 ± 0.288
0.0AspHis: 0.0 ± 0.0
1.002AspIle: 1.002 ± 0.601
4.008AspLys: 4.008 ± 0.914
4.008AspLeu: 4.008 ± 2.067
3.006AspMet: 3.006 ± 0.313
2.004AspAsn: 2.004 ± 0.288
1.002AspPro: 1.002 ± 0.89
4.008AspGln: 4.008 ± 0.577
3.006AspArg: 3.006 ± 0.313
5.01AspSer: 5.01 ± 2.957
2.004AspThr: 2.004 ± 0.288
2.004AspVal: 2.004 ± 0.288
5.01AspTrp: 5.01 ± 0.025
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
6.012GluAla: 6.012 ± 3.608
2.004GluCys: 2.004 ± 1.203
3.006GluAsp: 3.006 ± 1.804
8.016GluGlu: 8.016 ± 1.828
1.002GluPhe: 1.002 ± 0.89
4.008GluGly: 4.008 ± 0.914
1.002GluHis: 1.002 ± 0.89
5.01GluIle: 5.01 ± 0.025
7.014GluLys: 7.014 ± 2.718
6.012GluLeu: 6.012 ± 0.865
2.004GluMet: 2.004 ± 1.779
3.006GluAsn: 3.006 ± 0.313
2.004GluPro: 2.004 ± 1.779
0.0GluGln: 0.0 ± 0.0
12.024GluArg: 12.024 ± 1.73
3.006GluSer: 3.006 ± 1.804
2.004GluThr: 2.004 ± 1.203
4.008GluVal: 4.008 ± 0.914
1.002GluTrp: 1.002 ± 0.601
2.004GluTyr: 2.004 ± 0.288
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.002PheCys: 1.002 ± 0.89
1.002PheAsp: 1.002 ± 0.89
1.002PheGlu: 1.002 ± 0.601
2.004PhePhe: 2.004 ± 0.288
4.008PheGly: 4.008 ± 3.558
1.002PheHis: 1.002 ± 0.601
0.0PheIle: 0.0 ± 0.0
0.0PheLys: 0.0 ± 0.0
4.008PheLeu: 4.008 ± 0.914
1.002PheMet: 1.002 ± 0.89
3.006PheAsn: 3.006 ± 1.178
1.002PhePro: 1.002 ± 0.601
0.0PheGln: 0.0 ± 0.0
4.008PheArg: 4.008 ± 0.577
0.0PheSer: 0.0 ± 0.0
1.002PheThr: 1.002 ± 0.601
2.004PheVal: 2.004 ± 0.288
0.0PheTrp: 0.0 ± 0.0
1.002PheTyr: 1.002 ± 0.601
0.0PheXaa: 0.0 ± 0.0
Gly
2.004GlyAla: 2.004 ± 1.203
2.004GlyCys: 2.004 ± 1.779
2.004GlyAsp: 2.004 ± 0.288
6.012GlyGlu: 6.012 ± 0.865
1.002GlyPhe: 1.002 ± 0.601
2.004GlyGly: 2.004 ± 1.779
0.0GlyHis: 0.0 ± 0.0
2.004GlyIle: 2.004 ± 0.288
3.006GlyLys: 3.006 ± 1.804
6.012GlyLeu: 6.012 ± 2.117
3.006GlyMet: 3.006 ± 0.378
1.002GlyAsn: 1.002 ± 0.89
1.002GlyPro: 1.002 ± 0.601
2.004GlyGln: 2.004 ± 1.203
6.012GlyArg: 6.012 ± 0.626
5.01GlySer: 5.01 ± 1.515
1.002GlyThr: 1.002 ± 0.601
4.008GlyVal: 4.008 ± 0.577
3.006GlyTrp: 3.006 ± 2.669
5.01GlyTyr: 5.01 ± 1.515
0.0GlyXaa: 0.0 ± 0.0
His
3.006HisAla: 3.006 ± 2.669
0.0HisCys: 0.0 ± 0.0
1.002HisAsp: 1.002 ± 0.89
2.004HisGlu: 2.004 ± 0.288
3.006HisPhe: 3.006 ± 1.178
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
2.004HisIle: 2.004 ± 1.203
1.002HisLys: 1.002 ± 0.601
0.0HisLeu: 0.0 ± 0.0
1.002HisMet: 1.002 ± 0.601
3.006HisAsn: 3.006 ± 1.178
1.002HisPro: 1.002 ± 0.601
1.002HisGln: 1.002 ± 0.601
1.002HisArg: 1.002 ± 0.601
0.0HisSer: 0.0 ± 0.0
3.006HisThr: 3.006 ± 0.313
1.002HisVal: 1.002 ± 0.601
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.004IleAla: 2.004 ± 0.288
0.0IleCys: 0.0 ± 0.0
10.02IleAsp: 10.02 ± 4.423
3.006IleGlu: 3.006 ± 0.313
1.002IlePhe: 1.002 ± 0.89
3.006IleGly: 3.006 ± 0.313
1.002IleHis: 1.002 ± 0.89
6.012IleIle: 6.012 ± 2.356
5.01IleLys: 5.01 ± 3.006
4.008IleLeu: 4.008 ± 0.577
3.006IleMet: 3.006 ± 1.178
2.004IleAsn: 2.004 ± 1.203
6.012IlePro: 6.012 ± 0.626
1.002IleGln: 1.002 ± 0.601
2.004IleArg: 2.004 ± 0.288
4.008IleSer: 4.008 ± 0.577
1.002IleThr: 1.002 ± 0.89
2.004IleVal: 2.004 ± 1.779
2.004IleTrp: 2.004 ± 0.288
1.002IleTyr: 1.002 ± 0.601
0.0IleXaa: 0.0 ± 0.0
Lys
6.012LysAla: 6.012 ± 2.117
0.0LysCys: 0.0 ± 0.0
2.004LysAsp: 2.004 ± 0.288
5.01LysGlu: 5.01 ± 1.515
0.0LysPhe: 0.0 ± 0.0
2.004LysGly: 2.004 ± 0.288
4.008LysHis: 4.008 ± 0.914
3.006LysIle: 3.006 ± 0.313
10.02LysLys: 10.02 ± 6.013
7.014LysLeu: 7.014 ± 1.227
2.004LysMet: 2.004 ± 1.779
2.004LysAsn: 2.004 ± 0.288
5.01LysPro: 5.01 ± 1.515
2.004LysGln: 2.004 ± 1.779
4.008LysArg: 4.008 ± 0.577
5.01LysSer: 5.01 ± 0.025
3.006LysThr: 3.006 ± 1.178
2.004LysVal: 2.004 ± 0.288
2.004LysTrp: 2.004 ± 0.288
4.008LysTyr: 4.008 ± 2.405
0.0LysXaa: 0.0 ± 0.0
Leu
9.018LeuAla: 9.018 ± 3.921
3.006LeuCys: 3.006 ± 0.313
2.004LeuAsp: 2.004 ± 0.288
10.02LeuGlu: 10.02 ± 1.54
8.016LeuPhe: 8.016 ± 4.135
4.008LeuGly: 4.008 ± 2.405
1.002LeuHis: 1.002 ± 0.89
3.006LeuIle: 3.006 ± 1.178
5.01LeuLys: 5.01 ± 0.025
7.014LeuLeu: 7.014 ± 0.264
4.008LeuMet: 4.008 ± 0.914
3.006LeuAsn: 3.006 ± 1.178
2.004LeuPro: 2.004 ± 1.779
2.004LeuGln: 2.004 ± 0.288
4.008LeuArg: 4.008 ± 2.067
6.012LeuSer: 6.012 ± 0.626
6.012LeuThr: 6.012 ± 0.626
11.022LeuVal: 11.022 ± 0.651
0.0LeuTrp: 0.0 ± 0.0
4.008LeuTyr: 4.008 ± 0.577
0.0LeuXaa: 0.0 ± 0.0
Met
4.008MetAla: 4.008 ± 0.577
0.0MetCys: 0.0 ± 0.0
1.002MetAsp: 1.002 ± 0.89
1.002MetGlu: 1.002 ± 0.601
0.0MetPhe: 0.0 ± 0.0
3.006MetGly: 3.006 ± 1.178
2.004MetHis: 2.004 ± 0.288
4.008MetIle: 4.008 ± 0.914
2.004MetLys: 2.004 ± 1.779
4.008MetLeu: 4.008 ± 0.577
2.004MetMet: 2.004 ± 1.203
2.004MetAsn: 2.004 ± 0.288
1.002MetPro: 1.002 ± 0.89
4.008MetGln: 4.008 ± 0.577
3.006MetArg: 3.006 ± 1.178
1.002MetSer: 1.002 ± 0.601
1.002MetThr: 1.002 ± 0.89
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
2.004MetTyr: 2.004 ± 0.288
0.0MetXaa: 0.0 ± 0.0
Asn
2.004AsnAla: 2.004 ± 0.288
1.002AsnCys: 1.002 ± 0.89
3.006AsnAsp: 3.006 ± 1.804
3.006AsnGlu: 3.006 ± 2.669
0.0AsnPhe: 0.0 ± 0.0
4.008AsnGly: 4.008 ± 2.405
3.006AsnHis: 3.006 ± 1.804
3.006AsnIle: 3.006 ± 2.669
2.004AsnLys: 2.004 ± 1.779
2.004AsnLeu: 2.004 ± 0.288
1.002AsnMet: 1.002 ± 0.601
1.002AsnAsn: 1.002 ± 0.89
1.002AsnPro: 1.002 ± 0.89
1.002AsnGln: 1.002 ± 0.601
3.006AsnArg: 3.006 ± 0.313
3.006AsnSer: 3.006 ± 1.178
2.004AsnThr: 2.004 ± 0.288
6.012AsnVal: 6.012 ± 0.626
2.004AsnTrp: 2.004 ± 1.779
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
1.002ProCys: 1.002 ± 0.601
0.0ProAsp: 0.0 ± 0.0
4.008ProGlu: 4.008 ± 0.577
0.0ProPhe: 0.0 ± 0.0
4.008ProGly: 4.008 ± 0.914
1.002ProHis: 1.002 ± 0.89
2.004ProIle: 2.004 ± 1.779
4.008ProLys: 4.008 ± 2.405
3.006ProLeu: 3.006 ± 1.804
1.002ProMet: 1.002 ± 0.89
0.0ProAsn: 0.0 ± 0.0
1.002ProPro: 1.002 ± 0.601
1.002ProGln: 1.002 ± 0.601
1.002ProArg: 1.002 ± 0.601
4.008ProSer: 4.008 ± 0.914
3.006ProThr: 3.006 ± 1.178
1.002ProVal: 1.002 ± 0.89
0.0ProTrp: 0.0 ± 0.0
4.008ProTyr: 4.008 ± 2.067
0.0ProXaa: 0.0 ± 0.0
Gln
4.008GlnAla: 4.008 ± 2.405
1.002GlnCys: 1.002 ± 0.601
2.004GlnAsp: 2.004 ± 0.288
0.0GlnGlu: 0.0 ± 0.0
1.002GlnPhe: 1.002 ± 0.89
1.002GlnGly: 1.002 ± 0.89
1.002GlnHis: 1.002 ± 0.601
3.006GlnIle: 3.006 ± 2.669
1.002GlnLys: 1.002 ± 0.89
4.008GlnLeu: 4.008 ± 0.914
3.006GlnMet: 3.006 ± 1.52
0.0GlnAsn: 0.0 ± 0.0
2.004GlnPro: 2.004 ± 1.203
0.0GlnGln: 0.0 ± 0.0
2.004GlnArg: 2.004 ± 1.203
3.006GlnSer: 3.006 ± 0.313
1.002GlnThr: 1.002 ± 0.89
2.004GlnVal: 2.004 ± 1.203
0.0GlnTrp: 0.0 ± 0.0
1.002GlnTyr: 1.002 ± 0.601
0.0GlnXaa: 0.0 ± 0.0
Arg
4.008ArgAla: 4.008 ± 2.067
1.002ArgCys: 1.002 ± 0.601
3.006ArgAsp: 3.006 ± 1.178
5.01ArgGlu: 5.01 ± 1.515
1.002ArgPhe: 1.002 ± 0.601
4.008ArgGly: 4.008 ± 0.914
2.004ArgHis: 2.004 ± 0.288
2.004ArgIle: 2.004 ± 1.203
4.008ArgLys: 4.008 ± 2.067
12.024ArgLeu: 12.024 ± 0.239
0.0ArgMet: 0.0 ± 0.0
2.004ArgAsn: 2.004 ± 0.288
1.002ArgPro: 1.002 ± 0.601
4.008ArgGln: 4.008 ± 0.914
3.006ArgArg: 3.006 ± 1.804
7.014ArgSer: 7.014 ± 1.755
2.004ArgThr: 2.004 ± 1.203
6.012ArgVal: 6.012 ± 2.356
0.0ArgTrp: 0.0 ± 0.0
5.01ArgTyr: 5.01 ± 2.957
0.0ArgXaa: 0.0 ± 0.0
Ser
2.004SerAla: 2.004 ± 1.203
2.004SerCys: 2.004 ± 1.203
7.014SerAsp: 7.014 ± 3.245
3.006SerGlu: 3.006 ± 1.804
2.004SerPhe: 2.004 ± 0.288
7.014SerGly: 7.014 ± 1.755
2.004SerHis: 2.004 ± 0.288
8.016SerIle: 8.016 ± 2.644
3.006SerLys: 3.006 ± 1.804
4.008SerLeu: 4.008 ± 0.577
2.004SerMet: 2.004 ± 0.288
4.008SerAsn: 4.008 ± 0.914
3.006SerPro: 3.006 ± 1.178
1.002SerGln: 1.002 ± 0.601
3.006SerArg: 3.006 ± 1.178
8.016SerSer: 8.016 ± 1.828
5.01SerThr: 5.01 ± 3.006
4.008SerVal: 4.008 ± 0.577
2.004SerTrp: 2.004 ± 1.203
3.006SerTyr: 3.006 ± 1.178
0.0SerXaa: 0.0 ± 0.0
Thr
4.008ThrAla: 4.008 ± 0.914
0.0ThrCys: 0.0 ± 0.0
2.004ThrAsp: 2.004 ± 1.203
2.004ThrGlu: 2.004 ± 0.288
0.0ThrPhe: 0.0 ± 0.0
2.004ThrGly: 2.004 ± 1.203
0.0ThrHis: 0.0 ± 0.0
6.012ThrIle: 6.012 ± 0.626
4.008ThrLys: 4.008 ± 2.405
4.008ThrLeu: 4.008 ± 3.558
0.0ThrMet: 0.0 ± 0.0
2.004ThrAsn: 2.004 ± 0.288
0.0ThrPro: 0.0 ± 0.0
3.006ThrGln: 3.006 ± 0.313
2.004ThrArg: 2.004 ± 0.288
8.016ThrSer: 8.016 ± 1.153
2.004ThrThr: 2.004 ± 1.203
4.008ThrVal: 4.008 ± 2.405
0.0ThrTrp: 0.0 ± 0.0
1.002ThrTyr: 1.002 ± 0.601
0.0ThrXaa: 0.0 ± 0.0
Val
4.008ValAla: 4.008 ± 2.405
3.006ValCys: 3.006 ± 1.178
1.002ValAsp: 1.002 ± 0.601
7.014ValGlu: 7.014 ± 1.227
0.0ValPhe: 0.0 ± 0.0
4.008ValGly: 4.008 ± 0.914
2.004ValHis: 2.004 ± 0.288
2.004ValIle: 2.004 ± 1.203
4.008ValLys: 4.008 ± 2.067
9.018ValLeu: 9.018 ± 0.552
2.004ValMet: 2.004 ± 0.288
2.004ValAsn: 2.004 ± 0.288
1.002ValPro: 1.002 ± 0.601
2.004ValGln: 2.004 ± 0.288
1.002ValArg: 1.002 ± 0.89
5.01ValSer: 5.01 ± 0.025
2.004ValThr: 2.004 ± 0.288
4.008ValVal: 4.008 ± 2.405
1.002ValTrp: 1.002 ± 0.601
2.004ValTyr: 2.004 ± 0.288
0.0ValXaa: 0.0 ± 0.0
Trp
1.002TrpAla: 1.002 ± 0.601
0.0TrpCys: 0.0 ± 0.0
1.002TrpAsp: 1.002 ± 0.89
1.002TrpGlu: 1.002 ± 0.89
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
2.004TrpLys: 2.004 ± 0.288
2.004TrpLeu: 2.004 ± 0.288
0.0TrpMet: 0.0 ± 0.0
2.004TrpAsn: 2.004 ± 0.288
1.002TrpPro: 1.002 ± 0.89
0.0TrpGln: 0.0 ± 0.0
2.004TrpArg: 2.004 ± 0.288
5.01TrpSer: 5.01 ± 0.025
2.004TrpThr: 2.004 ± 0.288
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.008TyrAla: 4.008 ± 0.914
1.002TyrCys: 1.002 ± 0.89
0.0TyrAsp: 0.0 ± 0.0
2.004TyrGlu: 2.004 ± 1.203
0.0TyrPhe: 0.0 ± 0.0
3.006TyrGly: 3.006 ± 0.313
1.002TyrHis: 1.002 ± 0.89
2.004TyrIle: 2.004 ± 0.288
2.004TyrLys: 2.004 ± 1.779
6.012TyrLeu: 6.012 ± 0.626
1.002TyrMet: 1.002 ± 0.89
2.004TyrAsn: 2.004 ± 0.288
2.004TyrPro: 2.004 ± 0.288
1.002TyrGln: 1.002 ± 0.601
7.014TyrArg: 7.014 ± 1.755
1.002TyrSer: 1.002 ± 0.601
4.008TyrThr: 4.008 ± 0.914
1.002TyrVal: 1.002 ± 0.601
0.0TyrTrp: 0.0 ± 0.0
2.004TyrTyr: 2.004 ± 1.779
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (999 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski