Amino acid dipepetide frequency for Hydrangea chlorotic mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.186AlaAla: 6.186 ± 2.912
1.82AlaCys: 1.82 ± 0.866
4.003AlaAsp: 4.003 ± 1.267
2.911AlaGlu: 2.911 ± 1.413
4.367AlaPhe: 4.367 ± 0.938
5.095AlaGly: 5.095 ± 1.063
1.456AlaHis: 1.456 ± 1.362
6.914AlaIle: 6.914 ± 2.401
7.278AlaLys: 7.278 ± 1.094
4.367AlaLeu: 4.367 ± 1.292
2.911AlaMet: 2.911 ± 1.139
3.639AlaAsn: 3.639 ± 1.462
1.456AlaPro: 1.456 ± 0.888
3.275AlaGln: 3.275 ± 0.575
1.82AlaArg: 1.82 ± 0.748
5.095AlaSer: 5.095 ± 1.096
2.547AlaThr: 2.547 ± 0.724
3.275AlaVal: 3.275 ± 1.281
0.728AlaTrp: 0.728 ± 0.389
1.456AlaTyr: 1.456 ± 0.546
0.0AlaXaa: 0.0 ± 0.0
Cys
1.456CysAla: 1.456 ± 0.52
0.0CysCys: 0.0 ± 0.0
0.364CysAsp: 0.364 ± 0.781
1.092CysGlu: 1.092 ± 1.162
2.183CysPhe: 2.183 ± 0.946
4.367CysGly: 4.367 ± 1.308
0.364CysHis: 0.364 ± 0.194
1.82CysIle: 1.82 ± 1.099
1.82CysLys: 1.82 ± 0.59
1.82CysLeu: 1.82 ± 0.912
0.364CysMet: 0.364 ± 0.194
1.092CysAsn: 1.092 ± 0.625
0.0CysPro: 0.0 ± 0.0
1.092CysGln: 1.092 ± 0.583
1.82CysArg: 1.82 ± 1.549
2.183CysSer: 2.183 ± 0.878
2.911CysThr: 2.911 ± 1.091
1.456CysVal: 1.456 ± 0.777
0.0CysTrp: 0.0 ± 0.0
2.183CysTyr: 2.183 ± 1.281
0.0CysXaa: 0.0 ± 0.0
Asp
3.275AspAla: 3.275 ± 1.142
0.728AspCys: 0.728 ± 0.389
1.456AspAsp: 1.456 ± 0.777
4.367AspGlu: 4.367 ± 1.092
1.456AspPhe: 1.456 ± 0.777
2.547AspGly: 2.547 ± 0.992
0.364AspHis: 0.364 ± 0.194
2.547AspIle: 2.547 ± 1.36
3.639AspLys: 3.639 ± 1.44
6.186AspLeu: 6.186 ± 2.698
1.82AspMet: 1.82 ± 0.642
1.456AspAsn: 1.456 ± 0.628
3.275AspPro: 3.275 ± 3.217
1.092AspGln: 1.092 ± 0.568
1.456AspArg: 1.456 ± 0.628
2.547AspSer: 2.547 ± 0.44
1.82AspThr: 1.82 ± 1.204
4.003AspVal: 4.003 ± 1.217
0.728AspTrp: 0.728 ± 0.522
2.911AspTyr: 2.911 ± 0.954
0.0AspXaa: 0.0 ± 0.0
Glu
3.275GluAla: 3.275 ± 2.324
0.728GluCys: 0.728 ± 0.651
3.639GluAsp: 3.639 ± 0.955
5.459GluGlu: 5.459 ± 2.378
2.911GluPhe: 2.911 ± 1.04
5.822GluGly: 5.822 ± 1.982
2.183GluHis: 2.183 ± 0.946
4.731GluIle: 4.731 ± 2.171
5.822GluLys: 5.822 ± 1.346
5.459GluLeu: 5.459 ± 1.073
1.456GluMet: 1.456 ± 1.044
2.547GluAsn: 2.547 ± 0.699
2.911GluPro: 2.911 ± 1.009
3.275GluGln: 3.275 ± 1.676
4.003GluArg: 4.003 ± 0.876
5.822GluSer: 5.822 ± 1.017
1.82GluThr: 1.82 ± 0.618
6.914GluVal: 6.914 ± 1.305
0.728GluTrp: 0.728 ± 0.389
1.82GluTyr: 1.82 ± 0.567
0.0GluXaa: 0.0 ± 0.0
Phe
3.639PheAla: 3.639 ± 2.679
0.728PheCys: 0.728 ± 0.389
4.367PheAsp: 4.367 ± 0.853
6.186PheGlu: 6.186 ± 1.457
1.82PhePhe: 1.82 ± 1.099
2.547PheGly: 2.547 ± 0.821
0.728PheHis: 0.728 ± 0.389
1.456PheIle: 1.456 ± 0.546
2.911PheLys: 2.911 ± 0.493
5.822PheLeu: 5.822 ± 1.176
1.092PheMet: 1.092 ± 0.59
2.183PheAsn: 2.183 ± 0.755
1.092PhePro: 1.092 ± 1.132
2.183PheGln: 2.183 ± 0.774
2.547PheArg: 2.547 ± 0.926
4.367PheSer: 4.367 ± 1.811
2.547PheThr: 2.547 ± 0.821
1.82PheVal: 1.82 ± 0.618
0.364PheTrp: 0.364 ± 0.194
1.456PheTyr: 1.456 ± 0.82
0.0PheXaa: 0.0 ± 0.0
Gly
4.003GlyAla: 4.003 ± 0.935
2.183GlyCys: 2.183 ± 0.946
3.639GlyAsp: 3.639 ± 1.363
5.459GlyGlu: 5.459 ± 1.914
4.003GlyPhe: 4.003 ± 0.503
3.275GlyGly: 3.275 ± 1.802
0.728GlyHis: 0.728 ± 0.389
2.183GlyIle: 2.183 ± 0.878
4.731GlyLys: 4.731 ± 1.27
6.186GlyLeu: 6.186 ± 2.395
1.092GlyMet: 1.092 ± 0.483
2.911GlyAsn: 2.911 ± 0.77
1.092GlyPro: 1.092 ± 0.583
1.092GlyGln: 1.092 ± 1.54
4.731GlyArg: 4.731 ± 2.191
3.275GlySer: 3.275 ± 1.45
2.547GlyThr: 2.547 ± 0.992
4.003GlyVal: 4.003 ± 1.238
1.092GlyTrp: 1.092 ± 0.583
1.456GlyTyr: 1.456 ± 0.628
0.0GlyXaa: 0.0 ± 0.0
His
1.82HisAla: 1.82 ± 0.971
0.364HisCys: 0.364 ± 0.194
0.728HisAsp: 0.728 ± 0.389
2.911HisGlu: 2.911 ± 1.464
1.456HisPhe: 1.456 ± 0.546
1.456HisGly: 1.456 ± 0.988
1.092HisHis: 1.092 ± 0.583
1.456HisIle: 1.456 ± 1.043
1.092HisLys: 1.092 ± 0.483
2.183HisLeu: 2.183 ± 0.688
1.092HisMet: 1.092 ± 0.651
1.092HisAsn: 1.092 ± 0.483
1.092HisPro: 1.092 ± 0.625
0.0HisGln: 0.0 ± 0.0
1.82HisArg: 1.82 ± 1.207
2.911HisSer: 2.911 ± 0.724
1.092HisThr: 1.092 ± 0.583
2.183HisVal: 2.183 ± 0.878
0.364HisTrp: 0.364 ± 0.622
0.728HisTyr: 0.728 ± 0.389
0.0HisXaa: 0.0 ± 0.0
Ile
4.367IleAla: 4.367 ± 1.534
2.183IleCys: 2.183 ± 1.249
2.911IleAsp: 2.911 ± 0.829
4.367IleGlu: 4.367 ± 0.799
2.911IlePhe: 2.911 ± 1.022
2.183IleGly: 2.183 ± 0.697
0.364IleHis: 0.364 ± 0.194
2.547IleIle: 2.547 ± 2.033
4.367IleLys: 4.367 ± 1.637
4.003IleLeu: 4.003 ± 1.355
2.547IleMet: 2.547 ± 0.985
1.82IleAsn: 1.82 ± 0.912
1.456IlePro: 1.456 ± 0.841
2.547IleGln: 2.547 ± 0.44
4.003IleArg: 4.003 ± 2.508
4.003IleSer: 4.003 ± 1.109
0.728IleThr: 0.728 ± 0.867
1.82IleVal: 1.82 ± 0.795
0.364IleTrp: 0.364 ± 0.911
0.728IleTyr: 0.728 ± 0.389
0.0IleXaa: 0.0 ± 0.0
Lys
4.003LysAla: 4.003 ± 1.495
2.183LysCys: 2.183 ± 0.792
2.911LysAsp: 2.911 ± 0.975
4.003LysGlu: 4.003 ± 1.536
4.003LysPhe: 4.003 ± 0.918
2.547LysGly: 2.547 ± 1.097
1.456LysHis: 1.456 ± 0.777
2.911LysIle: 2.911 ± 1.082
3.275LysLys: 3.275 ± 1.281
8.37LysLeu: 8.37 ± 2.731
1.092LysMet: 1.092 ± 1.132
1.092LysAsn: 1.092 ± 0.583
2.911LysPro: 2.911 ± 1.091
2.911LysGln: 2.911 ± 0.791
6.914LysArg: 6.914 ± 0.964
5.459LysSer: 5.459 ± 1.652
3.275LysThr: 3.275 ± 1.12
2.183LysVal: 2.183 ± 0.889
0.364LysTrp: 0.364 ± 0.194
1.82LysTyr: 1.82 ± 0.688
0.0LysXaa: 0.0 ± 0.0
Leu
5.459LeuAla: 5.459 ± 1.125
3.639LeuCys: 3.639 ± 1.498
3.639LeuAsp: 3.639 ± 1.44
8.006LeuGlu: 8.006 ± 1.555
4.003LeuPhe: 4.003 ± 1.625
5.822LeuGly: 5.822 ± 1.956
1.82LeuHis: 1.82 ± 0.688
3.639LeuIle: 3.639 ± 0.954
7.642LeuLys: 7.642 ± 2.19
12.737LeuLeu: 12.737 ± 2.619
1.092LeuMet: 1.092 ± 0.56
5.095LeuAsn: 5.095 ± 1.383
4.367LeuPro: 4.367 ± 1.265
3.275LeuGln: 3.275 ± 1.087
5.822LeuArg: 5.822 ± 1.117
6.914LeuSer: 6.914 ± 1.887
6.186LeuThr: 6.186 ± 2.675
6.914LeuVal: 6.914 ± 3.862
0.364LeuTrp: 0.364 ± 0.194
3.639LeuTyr: 3.639 ± 0.738
0.0LeuXaa: 0.0 ± 0.0
Met
3.639MetAla: 3.639 ± 1.462
1.456MetCys: 1.456 ± 0.52
0.728MetAsp: 0.728 ± 0.651
1.82MetGlu: 1.82 ± 0.688
0.728MetPhe: 0.728 ± 0.389
2.183MetGly: 2.183 ± 0.967
1.092MetHis: 1.092 ± 0.583
0.728MetIle: 0.728 ± 0.389
1.092MetLys: 1.092 ± 1.132
2.547MetLeu: 2.547 ± 0.913
0.728MetMet: 0.728 ± 0.389
0.0MetAsn: 0.0 ± 0.0
2.183MetPro: 2.183 ± 1.295
0.728MetGln: 0.728 ± 0.68
1.82MetArg: 1.82 ± 0.971
0.364MetSer: 0.364 ± 0.194
0.0MetThr: 0.0 ± 0.0
2.183MetVal: 2.183 ± 1.166
0.364MetTrp: 0.364 ± 0.951
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.275AsnAla: 3.275 ± 2.022
1.456AsnCys: 1.456 ± 0.754
0.728AsnAsp: 0.728 ± 0.389
2.547AsnGlu: 2.547 ± 0.93
3.275AsnPhe: 3.275 ± 0.927
1.092AsnGly: 1.092 ± 0.625
1.82AsnHis: 1.82 ± 0.618
1.82AsnIle: 1.82 ± 0.748
3.639AsnLys: 3.639 ± 1.326
4.731AsnLeu: 4.731 ± 1.336
0.728AsnMet: 0.728 ± 0.522
2.183AsnAsn: 2.183 ± 0.697
1.82AsnPro: 1.82 ± 1.931
0.364AsnGln: 0.364 ± 0.194
2.547AsnArg: 2.547 ± 0.699
1.82AsnSer: 1.82 ± 1.907
2.183AsnThr: 2.183 ± 0.755
3.639AsnVal: 3.639 ± 0.974
0.728AsnTrp: 0.728 ± 0.389
1.82AsnTyr: 1.82 ± 0.971
0.0AsnXaa: 0.0 ± 0.0
Pro
1.82ProAla: 1.82 ± 1.204
1.092ProCys: 1.092 ± 0.583
3.639ProAsp: 3.639 ± 1.18
2.547ProGlu: 2.547 ± 1.001
1.82ProPhe: 1.82 ± 0.567
2.547ProGly: 2.547 ± 1.755
2.183ProHis: 2.183 ± 2.815
2.183ProIle: 2.183 ± 1.844
1.092ProLys: 1.092 ± 1.725
3.275ProLeu: 3.275 ± 2.707
1.092ProMet: 1.092 ± 0.583
2.183ProAsn: 2.183 ± 1.175
2.911ProPro: 2.911 ± 2.884
1.456ProGln: 1.456 ± 0.777
2.183ProArg: 2.183 ± 1.006
2.183ProSer: 2.183 ± 1.827
2.183ProThr: 2.183 ± 0.967
4.003ProVal: 4.003 ± 2.609
0.728ProTrp: 0.728 ± 0.389
1.82ProTyr: 1.82 ± 0.618
0.0ProXaa: 0.0 ± 0.0
Gln
3.275GlnAla: 3.275 ± 0.73
2.911GlnCys: 2.911 ± 1.006
1.092GlnAsp: 1.092 ± 0.583
1.456GlnGlu: 1.456 ± 0.52
0.728GlnPhe: 0.728 ± 0.389
1.82GlnGly: 1.82 ± 1.179
1.456GlnHis: 1.456 ± 0.949
1.092GlnIle: 1.092 ± 0.568
2.183GlnLys: 2.183 ± 0.946
2.911GlnLeu: 2.911 ± 0.493
0.728GlnMet: 0.728 ± 0.389
0.728GlnAsn: 0.728 ± 0.522
2.183GlnPro: 2.183 ± 1.058
0.0GlnGln: 0.0 ± 0.0
1.82GlnArg: 1.82 ± 0.987
2.183GlnSer: 2.183 ± 1.166
1.82GlnThr: 1.82 ± 0.866
0.728GlnVal: 0.728 ± 0.389
0.364GlnTrp: 0.364 ± 0.911
1.092GlnTyr: 1.092 ± 0.583
0.0GlnXaa: 0.0 ± 0.0
Arg
5.095ArgAla: 5.095 ± 1.339
1.456ArgCys: 1.456 ± 2.743
1.82ArgAsp: 1.82 ± 0.858
3.639ArgGlu: 3.639 ± 1.244
4.731ArgPhe: 4.731 ± 0.974
3.275ArgGly: 3.275 ± 0.775
1.456ArgHis: 1.456 ± 0.546
1.82ArgIle: 1.82 ± 0.864
2.911ArgLys: 2.911 ± 0.954
6.186ArgLeu: 6.186 ± 1.636
1.82ArgMet: 1.82 ± 0.971
2.547ArgAsn: 2.547 ± 1.503
2.911ArgPro: 2.911 ± 1.952
0.728ArgGln: 0.728 ± 0.389
4.367ArgArg: 4.367 ± 3.717
5.459ArgSer: 5.459 ± 1.269
2.547ArgThr: 2.547 ± 0.926
3.275ArgVal: 3.275 ± 0.849
0.728ArgTrp: 0.728 ± 0.651
4.731ArgTyr: 4.731 ± 0.672
0.0ArgXaa: 0.0 ± 0.0
Ser
6.914SerAla: 6.914 ± 1.318
0.364SerCys: 0.364 ± 0.194
3.639SerAsp: 3.639 ± 1.44
4.003SerGlu: 4.003 ± 0.745
1.456SerPhe: 1.456 ± 0.52
4.367SerGly: 4.367 ± 1.421
1.82SerHis: 1.82 ± 0.567
3.275SerIle: 3.275 ± 0.73
4.003SerLys: 4.003 ± 1.175
5.459SerLeu: 5.459 ± 1.979
1.456SerMet: 1.456 ± 0.52
4.003SerAsn: 4.003 ± 2.235
3.275SerPro: 3.275 ± 0.972
3.275SerGln: 3.275 ± 1.259
3.275SerArg: 3.275 ± 1.259
5.822SerSer: 5.822 ± 1.594
4.003SerThr: 4.003 ± 1.652
6.186SerVal: 6.186 ± 2.318
1.456SerTrp: 1.456 ± 0.777
2.911SerTyr: 2.911 ± 0.809
0.0SerXaa: 0.0 ± 0.0
Thr
3.275ThrAla: 3.275 ± 1.125
0.728ThrCys: 0.728 ± 0.68
1.82ThrAsp: 1.82 ± 0.971
2.547ThrGlu: 2.547 ± 2.144
4.731ThrPhe: 4.731 ± 0.974
2.547ThrGly: 2.547 ± 0.743
3.639ThrHis: 3.639 ± 1.443
2.911ThrIle: 2.911 ± 0.975
1.456ThrLys: 1.456 ± 0.949
3.639ThrLeu: 3.639 ± 2.256
1.456ThrMet: 1.456 ± 0.777
2.183ThrAsn: 2.183 ± 0.755
1.456ThrPro: 1.456 ± 2.119
0.0ThrGln: 0.0 ± 0.0
1.82ThrArg: 1.82 ± 0.866
2.911ThrSer: 2.911 ± 0.975
1.092ThrThr: 1.092 ± 0.583
2.911ThrVal: 2.911 ± 1.082
0.364ThrTrp: 0.364 ± 0.194
2.183ThrTyr: 2.183 ± 0.774
0.0ThrXaa: 0.0 ± 0.0
Val
2.547ValAla: 2.547 ± 0.985
2.911ValCys: 2.911 ± 0.77
3.639ValAsp: 3.639 ± 2.145
5.095ValGlu: 5.095 ± 1.366
1.092ValPhe: 1.092 ± 0.583
3.639ValGly: 3.639 ± 3.263
2.183ValHis: 2.183 ± 0.469
3.275ValIle: 3.275 ± 2.038
4.003ValLys: 4.003 ± 2.137
8.37ValLeu: 8.37 ± 1.989
0.364ValMet: 0.364 ± 0.194
1.82ValAsn: 1.82 ± 0.688
2.547ValPro: 2.547 ± 0.44
2.183ValGln: 2.183 ± 0.688
5.095ValArg: 5.095 ± 1.457
5.459ValSer: 5.459 ± 1.389
3.275ValThr: 3.275 ± 1.378
6.186ValVal: 6.186 ± 1.701
0.728ValTrp: 0.728 ± 0.522
2.547ValTyr: 2.547 ± 1.237
0.0ValXaa: 0.0 ± 0.0
Trp
0.364TrpAla: 0.364 ± 0.194
0.364TrpCys: 0.364 ± 0.194
0.728TrpAsp: 0.728 ± 0.389
0.0TrpGlu: 0.0 ± 0.0
1.092TrpPhe: 1.092 ± 0.583
0.364TrpGly: 0.364 ± 0.951
0.728TrpHis: 0.728 ± 0.389
0.364TrpIle: 0.364 ± 0.775
0.0TrpLys: 0.0 ± 0.0
2.547TrpLeu: 2.547 ± 0.992
0.364TrpMet: 0.364 ± 0.194
0.728TrpAsn: 0.728 ± 0.522
0.728TrpPro: 0.728 ± 0.817
0.364TrpGln: 0.364 ± 0.622
0.728TrpArg: 0.728 ± 0.522
0.364TrpSer: 0.364 ± 0.194
0.0TrpThr: 0.0 ± 0.0
0.728TrpVal: 0.728 ± 0.389
0.0TrpTrp: 0.0 ± 0.0
0.364TrpTyr: 0.364 ± 0.194
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.911TyrAla: 2.911 ± 1.46
1.092TyrCys: 1.092 ± 1.13
2.183TyrAsp: 2.183 ± 0.792
2.911TyrGlu: 2.911 ± 0.975
1.456TyrPhe: 1.456 ± 1.193
2.183TyrGly: 2.183 ± 1.045
0.0TyrHis: 0.0 ± 0.0
2.547TyrIle: 2.547 ± 0.897
0.728TyrLys: 0.728 ± 0.389
3.275TyrLeu: 3.275 ± 0.775
0.728TyrMet: 0.728 ± 0.389
2.911TyrAsn: 2.911 ± 0.753
3.275TyrPro: 3.275 ± 0.953
0.728TyrGln: 0.728 ± 0.389
2.911TyrArg: 2.911 ± 0.916
1.82TyrSer: 1.82 ± 0.59
1.092TyrThr: 1.092 ± 0.583
2.547TyrVal: 2.547 ± 0.913
0.364TyrTrp: 0.364 ± 0.194
1.82TyrTyr: 1.82 ± 0.971
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski