Amino acid dipepetide frequency for Shewanella loihica (strain ATCC BAA-1088 / PV-4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.261AlaAla: 9.261 ± 0.11	1.167AlaCys: 1.167 ± 0.034	5.252AlaAsp: 5.252 ± 0.073	6.074AlaGlu: 6.074 ± 0.072	3.546AlaPhe: 3.546 ± 0.056	6.666AlaGly: 6.666 ± 0.083	1.905AlaHis: 1.905 ± 0.042	6.328AlaIle: 6.328 ± 0.078	5.692AlaLys: 5.692 ± 0.078	11.45AlaLeu: 11.45 ± 0.125	3.034AlaMet: 3.034 ± 0.051	3.727AlaAsn: 3.727 ± 0.063	3.616AlaPro: 3.616 ± 0.06	4.768AlaGln: 4.768 ± 0.07	4.28AlaArg: 4.28 ± 0.07	6.379AlaSer: 6.379 ± 0.086	4.478AlaThr: 4.478 ± 0.069	5.932AlaVal: 5.932 ± 0.077	1.054AlaTrp: 1.054 ± 0.03	2.627AlaTyr: 2.627 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.903CysAla: 0.903 ± 0.029	0.176CysCys: 0.176 ± 0.014	0.667CysAsp: 0.667 ± 0.026	0.656CysGlu: 0.656 ± 0.028	0.425CysPhe: 0.425 ± 0.019	0.878CysGly: 0.878 ± 0.027	0.483CysHis: 0.483 ± 0.032	0.561CysIle: 0.561 ± 0.024	0.362CysLys: 0.362 ± 0.016	1.039CysLeu: 1.039 ± 0.03	0.21CysMet: 0.21 ± 0.014	0.33CysAsn: 0.33 ± 0.018	0.482CysPro: 0.482 ± 0.023	0.55CysGln: 0.55 ± 0.021	0.528CysArg: 0.528 ± 0.022	0.673CysSer: 0.673 ± 0.022	0.434CysThr: 0.434 ± 0.02	0.673CysVal: 0.673 ± 0.023	0.118CysTrp: 0.118 ± 0.01	0.36CysTyr: 0.36 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.307AspAla: 5.307 ± 0.08	0.57AspCys: 0.57 ± 0.02	3.184AspAsp: 3.184 ± 0.069	4.067AspGlu: 4.067 ± 0.061	2.374AspPhe: 2.374 ± 0.044	4.201AspGly: 4.201 ± 0.121	1.095AspHis: 1.095 ± 0.03	3.435AspIle: 3.435 ± 0.054	3.546AspLys: 3.546 ± 0.06	5.333AspLeu: 5.333 ± 0.068	1.391AspMet: 1.391 ± 0.03	2.469AspAsn: 2.469 ± 0.055	2.278AspPro: 2.278 ± 0.044	1.973AspGln: 1.973 ± 0.045	2.49AspArg: 2.49 ± 0.046	3.39AspSer: 3.39 ± 0.061	2.824AspThr: 2.824 ± 0.066	3.26AspVal: 3.26 ± 0.056	0.845AspTrp: 0.845 ± 0.026	2.048AspTyr: 2.048 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.35GluAla: 6.35 ± 0.08	0.492GluCys: 0.492 ± 0.021	2.7GluAsp: 2.7 ± 0.048	3.459GluGlu: 3.459 ± 0.065	2.2GluPhe: 2.2 ± 0.044	3.729GluGly: 3.729 ± 0.051	1.525GluHis: 1.525 ± 0.037	3.603GluIle: 3.603 ± 0.058	2.914GluLys: 2.914 ± 0.041	7.179GluLeu: 7.179 ± 0.092	1.758GluMet: 1.758 ± 0.036	1.967GluAsn: 1.967 ± 0.04	2.087GluPro: 2.087 ± 0.047	4.252GluGln: 4.252 ± 0.062	3.519GluArg: 3.519 ± 0.064	3.451GluSer: 3.451 ± 0.055	3.097GluThr: 3.097 ± 0.049	4.531GluVal: 4.531 ± 0.058	0.641GluTrp: 0.641 ± 0.024	1.653GluTyr: 1.653 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.734PheAla: 3.734 ± 0.058	0.47PheCys: 0.47 ± 0.019	2.81PheAsp: 2.81 ± 0.054	2.438PheGlu: 2.438 ± 0.047	1.438PhePhe: 1.438 ± 0.034	3.081PheGly: 3.081 ± 0.051	0.786PheHis: 0.786 ± 0.025	2.562PheIle: 2.562 ± 0.049	1.835PheLys: 1.835 ± 0.036	2.978PheLeu: 2.978 ± 0.053	0.985PheMet: 0.985 ± 0.032	1.89PheAsn: 1.89 ± 0.043	1.312PhePro: 1.312 ± 0.03	1.068PheGln: 1.068 ± 0.027	1.376PheArg: 1.376 ± 0.036	3.058PheSer: 3.058 ± 0.055	2.206PheThr: 2.206 ± 0.081	2.554PheVal: 2.554 ± 0.049	0.494PheTrp: 0.494 ± 0.023	1.317PheTyr: 1.317 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.234GlyAla: 6.234 ± 0.083	0.902GlyCys: 0.902 ± 0.028	4.105GlyAsp: 4.105 ± 0.061	5.175GlyGlu: 5.175 ± 0.062	3.282GlyPhe: 3.282 ± 0.053	5.144GlyGly: 5.144 ± 0.079	1.721GlyHis: 1.721 ± 0.038	4.62GlyIle: 4.62 ± 0.067	3.93GlyLys: 3.93 ± 0.06	7.612GlyLeu: 7.612 ± 0.086	2.133GlyMet: 2.133 ± 0.039	2.578GlyAsn: 2.578 ± 0.069	1.87GlyPro: 1.87 ± 0.045	3.287GlyGln: 3.287 ± 0.06	3.455GlyArg: 3.455 ± 0.054	4.216GlySer: 4.216 ± 0.101	3.389GlyThr: 3.389 ± 0.084	5.491GlyVal: 5.491 ± 0.076	0.933GlyTrp: 0.933 ± 0.029	2.654GlyTyr: 2.654 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.623HisAla: 1.623 ± 0.034	0.326HisCys: 0.326 ± 0.016	1.073HisAsp: 1.073 ± 0.034	1.18HisGlu: 1.18 ± 0.034	1.076HisPhe: 1.076 ± 0.03	1.81HisGly: 1.81 ± 0.042	0.721HisHis: 0.721 ± 0.031	1.196HisIle: 1.196 ± 0.032	1.071HisLys: 1.071 ± 0.03	2.52HisLeu: 2.52 ± 0.051	0.515HisMet: 0.515 ± 0.018	0.805HisAsn: 0.805 ± 0.025	1.17HisPro: 1.17 ± 0.028	1.289HisGln: 1.289 ± 0.033	1.108HisArg: 1.108 ± 0.028	1.373HisSer: 1.373 ± 0.034	1.051HisThr: 1.051 ± 0.029	1.131HisVal: 1.131 ± 0.033	0.388HisTrp: 0.388 ± 0.017	0.953HisTyr: 0.953 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.677IleAla: 6.677 ± 0.096	0.666IleCys: 0.666 ± 0.023	4.203IleAsp: 4.203 ± 0.062	4.088IleGlu: 4.088 ± 0.07	1.899IlePhe: 1.899 ± 0.041	4.511IleGly: 4.511 ± 0.073	1.128IleHis: 1.128 ± 0.03	3.068IleIle: 3.068 ± 0.053	2.936IleLys: 2.936 ± 0.053	4.913IleLeu: 4.913 ± 0.064	1.164IleMet: 1.164 ± 0.037	2.574IleAsn: 2.574 ± 0.063	2.374IlePro: 2.374 ± 0.051	1.945IleGln: 1.945 ± 0.036	2.544IleArg: 2.544 ± 0.048	3.936IleSer: 3.936 ± 0.053	3.122IleThr: 3.122 ± 0.057	3.539IleVal: 3.539 ± 0.057	0.649IleTrp: 0.649 ± 0.022	1.656IleTyr: 1.656 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.511LysAla: 5.511 ± 0.085	0.299LysCys: 0.299 ± 0.019	2.479LysAsp: 2.479 ± 0.05	2.705LysGlu: 2.705 ± 0.056	1.457LysPhe: 1.457 ± 0.036	3.487LysGly: 3.487 ± 0.061	1.151LysHis: 1.151 ± 0.031	2.49LysIle: 2.49 ± 0.05	2.063LysLys: 2.063 ± 0.048	5.471LysLeu: 5.471 ± 0.08	1.317LysMet: 1.317 ± 0.031	1.402LysAsn: 1.402 ± 0.034	2.341LysPro: 2.341 ± 0.044	3.149LysGln: 3.149 ± 0.065	2.818LysArg: 2.818 ± 0.047	2.684LysSer: 2.684 ± 0.043	2.384LysThr: 2.384 ± 0.046	3.791LysVal: 3.791 ± 0.056	0.498LysTrp: 0.498 ± 0.02	1.221LysTyr: 1.221 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.925LeuAla: 11.925 ± 0.116	1.218LeuCys: 1.218 ± 0.037	6.185LeuAsp: 6.185 ± 0.071	6.208LeuGlu: 6.208 ± 0.081	4.255LeuPhe: 4.255 ± 0.07	7.945LeuGly: 7.945 ± 0.096	2.035LeuHis: 2.035 ± 0.052	5.947LeuIle: 5.947 ± 0.078	5.443LeuLys: 5.443 ± 0.07	11.848LeuLeu: 11.848 ± 0.15	2.894LeuMet: 2.894 ± 0.054	4.204LeuAsn: 4.204 ± 0.061	5.063LeuPro: 5.063 ± 0.07	3.715LeuGln: 3.715 ± 0.056	4.522LeuArg: 4.522 ± 0.081	8.404LeuSer: 8.404 ± 0.093	6.403LeuThr: 6.403 ± 0.077	7.557LeuVal: 7.557 ± 0.093	1.166LeuTrp: 1.166 ± 0.033	2.906LeuTyr: 2.906 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.977MetAla: 2.977 ± 0.053	0.191MetCys: 0.191 ± 0.013	1.25MetAsp: 1.25 ± 0.032	1.294MetGlu: 1.294 ± 0.034	0.793MetPhe: 0.793 ± 0.024	1.873MetGly: 1.873 ± 0.041	0.495MetHis: 0.495 ± 0.02	1.305MetIle: 1.305 ± 0.032	1.392MetLys: 1.392 ± 0.035	2.976MetLeu: 2.976 ± 0.048	0.825MetMet: 0.825 ± 0.026	0.929MetAsn: 0.929 ± 0.025	1.317MetPro: 1.317 ± 0.031	1.31MetGln: 1.31 ± 0.031	1.267MetArg: 1.267 ± 0.034	1.895MetSer: 1.895 ± 0.038	1.652MetThr: 1.652 ± 0.038	1.83MetVal: 1.83 ± 0.042	0.216MetTrp: 0.216 ± 0.012	0.47MetTyr: 0.47 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.294AsnAla: 3.294 ± 0.055	0.379AsnCys: 0.379 ± 0.02	1.98AsnAsp: 1.98 ± 0.058	2.004AsnGlu: 2.004 ± 0.049	1.36AsnPhe: 1.36 ± 0.034	2.781AsnGly: 2.781 ± 0.073	0.844AsnHis: 0.844 ± 0.026	2.199AsnIle: 2.199 ± 0.047	1.784AsnLys: 1.784 ± 0.037	3.895AsnLeu: 3.895 ± 0.054	0.921AsnMet: 0.921 ± 0.026	1.445AsnAsn: 1.445 ± 0.04	1.915AsnPro: 1.915 ± 0.041	2.019AsnGln: 2.019 ± 0.045	1.986AsnArg: 1.986 ± 0.038	2.166AsnSer: 2.166 ± 0.044	1.877AsnThr: 1.877 ± 0.048	2.121AsnVal: 2.121 ± 0.063	0.567AsnTrp: 0.567 ± 0.024	1.264AsnTyr: 1.264 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.503ProAla: 3.503 ± 0.058	0.324ProCys: 0.324 ± 0.016	2.383ProAsp: 2.383 ± 0.046	3.335ProGlu: 3.335 ± 0.054	1.657ProPhe: 1.657 ± 0.039	2.841ProGly: 2.841 ± 0.044	0.876ProHis: 0.876 ± 0.028	2.315ProIle: 2.315 ± 0.039	2.251ProLys: 2.251 ± 0.046	4.658ProLeu: 4.658 ± 0.064	1.138ProMet: 1.138 ± 0.031	1.51ProAsn: 1.51 ± 0.035	1.194ProPro: 1.194 ± 0.029	1.973ProGln: 1.973 ± 0.041	1.515ProArg: 1.515 ± 0.039	2.617ProSer: 2.617 ± 0.048	1.898ProThr: 1.898 ± 0.039	3.056ProVal: 3.056 ± 0.066	0.551ProTrp: 0.551 ± 0.021	1.265ProTyr: 1.265 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.772GlnAla: 5.772 ± 0.074	0.399GlnCys: 0.399 ± 0.019	2.361GlnAsp: 2.361 ± 0.043	2.593GlnGlu: 2.593 ± 0.048	1.721GlnPhe: 1.721 ± 0.037	3.872GlnGly: 3.872 ± 0.064	1.194GlnHis: 1.194 ± 0.031	2.507GlnIle: 2.507 ± 0.044	1.82GlnLys: 1.82 ± 0.041	6.021GlnLeu: 6.021 ± 0.092	1.27GlnMet: 1.27 ± 0.032	1.285GlnAsn: 1.285 ± 0.033	1.783GlnPro: 1.783 ± 0.033	3.217GlnGln: 3.217 ± 0.067	2.464GlnArg: 2.464 ± 0.051	2.974GlnSer: 2.974 ± 0.055	2.363GlnThr: 2.363 ± 0.043	3.555GlnVal: 3.555 ± 0.058	0.635GlnTrp: 0.635 ± 0.022	1.46GlnTyr: 1.46 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.0ArgAla: 4.0 ± 0.07	0.495ArgCys: 0.495 ± 0.021	2.622ArgAsp: 2.622 ± 0.049	2.944ArgGlu: 2.944 ± 0.057	2.153ArgPhe: 2.153 ± 0.037	2.938ArgGly: 2.938 ± 0.054	1.285ArgHis: 1.285 ± 0.033	2.866ArgIle: 2.866 ± 0.051	1.961ArgLys: 1.961 ± 0.041	5.889ArgLeu: 5.889 ± 0.093	1.227ArgMet: 1.227 ± 0.031	1.585ArgAsn: 1.585 ± 0.038	1.85ArgPro: 1.85 ± 0.04	2.697ArgGln: 2.697 ± 0.051	2.758ArgArg: 2.758 ± 0.057	2.606ArgSer: 2.606 ± 0.049	1.938ArgThr: 1.938 ± 0.039	3.377ArgVal: 3.377 ± 0.058	0.673ArgTrp: 0.673 ± 0.022	1.891ArgTyr: 1.891 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.74SerAla: 5.74 ± 0.072	0.702SerCys: 0.702 ± 0.027	3.693SerAsp: 3.693 ± 0.059	3.835SerGlu: 3.835 ± 0.062	2.727SerPhe: 2.727 ± 0.077	5.047SerGly: 5.047 ± 0.08	1.603SerHis: 1.603 ± 0.038	3.413SerIle: 3.413 ± 0.051	2.683SerLys: 2.683 ± 0.048	7.781SerLeu: 7.781 ± 0.103	1.553SerMet: 1.553 ± 0.033	2.199SerAsn: 2.199 ± 0.04	2.693SerPro: 2.693 ± 0.05	3.596SerGln: 3.596 ± 0.058	3.124SerArg: 3.124 ± 0.046	3.924SerSer: 3.924 ± 0.077	2.796SerThr: 2.796 ± 0.068	4.246SerVal: 4.246 ± 0.08	0.841SerTrp: 0.841 ± 0.025	2.074SerTyr: 2.074 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.459ThrAla: 4.459 ± 0.062	0.486ThrCys: 0.486 ± 0.024	2.643ThrAsp: 2.643 ± 0.071	2.781ThrGlu: 2.781 ± 0.053	1.701ThrPhe: 1.701 ± 0.04	4.142ThrGly: 4.142 ± 0.084	1.125ThrHis: 1.125 ± 0.026	2.758ThrIle: 2.758 ± 0.061	2.039ThrLys: 2.039 ± 0.042	6.454ThrLeu: 6.454 ± 0.083	1.086ThrMet: 1.086 ± 0.033	1.683ThrAsn: 1.683 ± 0.042	2.97ThrPro: 2.97 ± 0.054	3.027ThrGln: 3.027 ± 0.047	2.273ThrArg: 2.273 ± 0.044	3.146ThrSer: 3.146 ± 0.067	2.477ThrThr: 2.477 ± 0.06	3.278ThrVal: 3.278 ± 0.071	0.542ThrTrp: 0.542 ± 0.022	1.344ThrTyr: 1.344 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	6.728ValAla: 6.728 ± 0.082	0.721ValCys: 0.721 ± 0.023	4.271ValAsp: 4.271 ± 0.081	4.333ValGlu: 4.333 ± 0.067	2.387ValPhe: 2.387 ± 0.049	4.614ValGly: 4.614 ± 0.069	1.186ValHis: 1.186 ± 0.038	4.386ValIle: 4.386 ± 0.082	3.423ValLys: 3.423 ± 0.054	6.449ValLeu: 6.449 ± 0.068	1.919ValMet: 1.919 ± 0.048	2.842ValAsn: 2.842 ± 0.075	2.635ValPro: 2.635 ± 0.052	2.272ValGln: 2.272 ± 0.041	2.884ValArg: 2.884 ± 0.047	4.771ValSer: 4.771 ± 0.071	4.167ValThr: 4.167 ± 0.076	4.93ValVal: 4.93 ± 0.075	0.672ValTrp: 0.672 ± 0.025	1.742ValTyr: 1.742 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.888TrpAla: 0.888 ± 0.025	0.146TrpCys: 0.146 ± 0.011	0.602TrpAsp: 0.602 ± 0.022	0.449TrpGlu: 0.449 ± 0.021	0.528TrpPhe: 0.528 ± 0.021	0.812TrpGly: 0.812 ± 0.027	0.377TrpHis: 0.377 ± 0.018	0.616TrpIle: 0.616 ± 0.019	0.373TrpLys: 0.373 ± 0.016	1.67TrpLeu: 1.67 ± 0.038	0.306TrpMet: 0.306 ± 0.016	0.371TrpAsn: 0.371 ± 0.02	0.519TrpPro: 0.519 ± 0.021	1.12TrpGln: 1.12 ± 0.028	0.77TrpArg: 0.77 ± 0.026	0.738TrpSer: 0.738 ± 0.026	0.503TrpThr: 0.503 ± 0.021	0.772TrpVal: 0.772 ± 0.025	0.186TrpTrp: 0.186 ± 0.012	0.376TrpTyr: 0.376 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.351TyrAla: 2.351 ± 0.049	0.377TyrCys: 0.377 ± 0.017	1.617TyrAsp: 1.617 ± 0.042	1.489TyrGlu: 1.489 ± 0.036	1.414TyrPhe: 1.414 ± 0.041	2.358TyrGly: 2.358 ± 0.042	0.844TyrHis: 0.844 ± 0.027	1.417TyrIle: 1.417 ± 0.036	1.199TyrLys: 1.199 ± 0.034	3.707TyrLeu: 3.707 ± 0.06	0.609TyrMet: 0.609 ± 0.025	1.007TyrAsn: 1.007 ± 0.031	1.393TyrPro: 1.393 ± 0.037	2.037TyrGln: 2.037 ± 0.042	2.075TyrArg: 2.075 ± 0.042	1.868TyrSer: 1.868 ± 0.042	1.355TyrThr: 1.355 ± 0.041	1.709TyrVal: 1.709 ± 0.043	0.451TyrTrp: 0.451 ± 0.019	1.046TyrTyr: 1.046 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3855 proteins (1309847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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