Amino acid dipepetide frequency for Salipiger profundus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.748AlaAla: 16.748 ± 0.171	1.169AlaCys: 1.169 ± 0.03	6.797AlaAsp: 6.797 ± 0.079	8.896AlaGlu: 8.896 ± 0.101	4.227AlaPhe: 4.227 ± 0.055	10.931AlaGly: 10.931 ± 0.105	2.338AlaHis: 2.338 ± 0.037	5.47AlaIle: 5.47 ± 0.075	3.169AlaLys: 3.169 ± 0.051	14.513AlaLeu: 14.513 ± 0.132	4.021AlaMet: 4.021 ± 0.058	2.411AlaAsn: 2.411 ± 0.04	6.331AlaPro: 6.331 ± 0.085	4.374AlaGln: 4.374 ± 0.056	9.648AlaArg: 9.648 ± 0.099	5.751AlaSer: 5.751 ± 0.059	5.983AlaThr: 5.983 ± 0.067	8.441AlaVal: 8.441 ± 0.086	1.603AlaTrp: 1.603 ± 0.035	2.442AlaTyr: 2.442 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.109CysAla: 1.109 ± 0.025	0.121CysCys: 0.121 ± 0.01	0.594CysAsp: 0.594 ± 0.022	0.498CysGlu: 0.498 ± 0.018	0.316CysPhe: 0.316 ± 0.013	0.974CysGly: 0.974 ± 0.03	0.27CysHis: 0.27 ± 0.014	0.387CysIle: 0.387 ± 0.014	0.187CysLys: 0.187 ± 0.011	0.855CysLeu: 0.855 ± 0.024	0.182CysMet: 0.182 ± 0.011	0.218CysAsn: 0.218 ± 0.012	0.542CysPro: 0.542 ± 0.02	0.224CysGln: 0.224 ± 0.012	0.598CysArg: 0.598 ± 0.022	0.442CysSer: 0.442 ± 0.02	0.468CysThr: 0.468 ± 0.019	0.616CysVal: 0.616 ± 0.021	0.136CysTrp: 0.136 ± 0.01	0.194CysTyr: 0.194 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.594AspAla: 7.594 ± 0.08	0.517AspCys: 0.517 ± 0.022	3.653AspAsp: 3.653 ± 0.072	3.896AspGlu: 3.896 ± 0.05	2.246AspPhe: 2.246 ± 0.042	5.865AspGly: 5.865 ± 0.092	1.325AspHis: 1.325 ± 0.027	2.848AspIle: 2.848 ± 0.049	1.484AspLys: 1.484 ± 0.034	6.137AspLeu: 6.137 ± 0.065	1.682AspMet: 1.682 ± 0.034	1.215AspAsn: 1.215 ± 0.031	3.827AspPro: 3.827 ± 0.047	1.562AspGln: 1.562 ± 0.031	4.723AspArg: 4.723 ± 0.059	2.29AspSer: 2.29 ± 0.043	3.17AspThr: 3.17 ± 0.068	4.166AspVal: 4.166 ± 0.066	1.261AspTrp: 1.261 ± 0.031	1.607AspTyr: 1.607 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	9.03GluAla: 9.03 ± 0.102	0.352GluCys: 0.352 ± 0.017	3.725GluAsp: 3.725 ± 0.048	3.937GluGlu: 3.937 ± 0.063	1.672GluPhe: 1.672 ± 0.036	5.395GluGly: 5.395 ± 0.067	1.22GluHis: 1.22 ± 0.027	3.861GluIle: 3.861 ± 0.049	2.069GluLys: 2.069 ± 0.042	5.519GluLeu: 5.519 ± 0.076	2.02GluMet: 2.02 ± 0.034	1.672GluAsn: 1.672 ± 0.036	2.854GluPro: 2.854 ± 0.049	2.006GluGln: 2.006 ± 0.037	4.732GluArg: 4.732 ± 0.06	2.382GluSer: 2.382 ± 0.035	4.466GluThr: 4.466 ± 0.058	4.57GluVal: 4.57 ± 0.064	0.705GluTrp: 0.705 ± 0.021	1.001GluTyr: 1.001 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.24PheAla: 4.24 ± 0.063	0.403PheCys: 0.403 ± 0.015	2.795PheAsp: 2.795 ± 0.047	2.323PheGlu: 2.323 ± 0.039	1.328PhePhe: 1.328 ± 0.032	3.643PheGly: 3.643 ± 0.052	0.739PheHis: 0.739 ± 0.021	1.483PheIle: 1.483 ± 0.035	0.73PheLys: 0.73 ± 0.024	3.357PheLeu: 3.357 ± 0.051	0.837PheMet: 0.837 ± 0.024	0.933PheAsn: 0.933 ± 0.024	1.556PhePro: 1.556 ± 0.034	0.912PheGln: 0.912 ± 0.021	2.344PheArg: 2.344 ± 0.042	2.028PheSer: 2.028 ± 0.038	2.063PheThr: 2.063 ± 0.039	2.611PheVal: 2.611 ± 0.047	0.559PheTrp: 0.559 ± 0.021	0.897PheTyr: 0.897 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.549GlyAla: 10.549 ± 0.109	0.913GlyCys: 0.913 ± 0.026	5.034GlyAsp: 5.034 ± 0.09	5.189GlyGlu: 5.189 ± 0.061	3.597GlyPhe: 3.597 ± 0.056	7.963GlyGly: 7.963 ± 0.136	2.042GlyHis: 2.042 ± 0.037	4.531GlyIle: 4.531 ± 0.066	2.774GlyLys: 2.774 ± 0.046	9.593GlyLeu: 9.593 ± 0.101	2.636GlyMet: 2.636 ± 0.041	2.081GlyAsn: 2.081 ± 0.061	3.847GlyPro: 3.847 ± 0.052	2.971GlyGln: 2.971 ± 0.049	6.278GlyArg: 6.278 ± 0.07	4.411GlySer: 4.411 ± 0.064	5.008GlyThr: 5.008 ± 0.06	6.417GlyVal: 6.417 ± 0.07	1.564GlyTrp: 1.564 ± 0.032	2.317GlyTyr: 2.317 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.412HisAla: 2.412 ± 0.045	0.231HisCys: 0.231 ± 0.012	1.351HisAsp: 1.351 ± 0.029	1.182HisGlu: 1.182 ± 0.029	0.829HisPhe: 0.829 ± 0.021	2.076HisGly: 2.076 ± 0.042	0.551HisHis: 0.551 ± 0.021	0.846HisIle: 0.846 ± 0.027	0.442HisLys: 0.442 ± 0.016	2.05HisLeu: 2.05 ± 0.044	0.563HisMet: 0.563 ± 0.018	0.387HisAsn: 0.387 ± 0.016	1.391HisPro: 1.391 ± 0.028	0.489HisGln: 0.489 ± 0.017	1.45HisArg: 1.45 ± 0.03	0.856HisSer: 0.856 ± 0.025	0.786HisThr: 0.786 ± 0.023	1.589HisVal: 1.589 ± 0.037	0.351HisTrp: 0.351 ± 0.014	0.517HisTyr: 0.517 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.675IleAla: 6.675 ± 0.063	0.56IleCys: 0.56 ± 0.02	3.398IleAsp: 3.398 ± 0.046	3.486IleGlu: 3.486 ± 0.048	1.719IlePhe: 1.719 ± 0.037	4.625IleGly: 4.625 ± 0.063	0.859IleHis: 0.859 ± 0.023	1.893IleIle: 1.893 ± 0.042	1.087IleLys: 1.087 ± 0.034	4.503IleLeu: 4.503 ± 0.058	0.983IleMet: 0.983 ± 0.026	1.115IleAsn: 1.115 ± 0.033	2.253IlePro: 2.253 ± 0.038	1.022IleGln: 1.022 ± 0.022	3.116IleArg: 3.116 ± 0.044	2.72IleSer: 2.72 ± 0.043	2.667IleThr: 2.667 ± 0.046	3.676IleVal: 3.676 ± 0.052	0.68IleTrp: 0.68 ± 0.024	1.072IleTyr: 1.072 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.39LysAla: 3.39 ± 0.059	0.169LysCys: 0.169 ± 0.011	1.457LysAsp: 1.457 ± 0.038	1.321LysGlu: 1.321 ± 0.034	0.726LysPhe: 0.726 ± 0.022	2.38LysGly: 2.38 ± 0.044	0.533LysHis: 0.533 ± 0.019	1.359LysIle: 1.359 ± 0.032	0.988LysLys: 0.988 ± 0.037	2.69LysLeu: 2.69 ± 0.049	0.757LysMet: 0.757 ± 0.023	0.604LysAsn: 0.604 ± 0.022	1.644LysPro: 1.644 ± 0.034	0.813LysGln: 0.813 ± 0.023	2.139LysArg: 2.139 ± 0.041	1.533LysSer: 1.533 ± 0.034	1.762LysThr: 1.762 ± 0.035	2.015LysVal: 2.015 ± 0.039	0.343LysTrp: 0.343 ± 0.013	0.532LysTyr: 0.532 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.254LeuAla: 13.254 ± 0.12	0.972LeuCys: 0.972 ± 0.029	6.314LeuAsp: 6.314 ± 0.055	5.849LeuGlu: 5.849 ± 0.071	3.56LeuPhe: 3.56 ± 0.057	8.819LeuGly: 8.819 ± 0.085	1.941LeuHis: 1.941 ± 0.039	4.557LeuIle: 4.557 ± 0.062	2.81LeuLys: 2.81 ± 0.044	9.413LeuLeu: 9.413 ± 0.101	2.635LeuMet: 2.635 ± 0.04	2.355LeuAsn: 2.355 ± 0.039	5.77LeuPro: 5.77 ± 0.07	2.652LeuGln: 2.652 ± 0.044	7.582LeuArg: 7.582 ± 0.084	6.631LeuSer: 6.631 ± 0.076	5.923LeuThr: 5.923 ± 0.068	7.206LeuVal: 7.206 ± 0.076	1.356LeuTrp: 1.356 ± 0.03	1.987LeuTyr: 1.987 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.506MetAla: 3.506 ± 0.051	0.196MetCys: 0.196 ± 0.01	1.379MetAsp: 1.379 ± 0.032	1.341MetGlu: 1.341 ± 0.032	0.76MetPhe: 0.76 ± 0.024	2.283MetGly: 2.283 ± 0.042	0.458MetHis: 0.458 ± 0.017	1.524MetIle: 1.524 ± 0.032	0.992MetLys: 0.992 ± 0.027	2.67MetLeu: 2.67 ± 0.042	0.818MetMet: 0.818 ± 0.028	0.764MetAsn: 0.764 ± 0.02	1.633MetPro: 1.633 ± 0.034	0.997MetGln: 0.997 ± 0.026	2.04MetArg: 2.04 ± 0.04	1.783MetSer: 1.783 ± 0.035	2.179MetThr: 2.179 ± 0.04	1.929MetVal: 1.929 ± 0.033	0.24MetTrp: 0.24 ± 0.013	0.334MetTyr: 0.334 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.923AsnAla: 2.923 ± 0.04	0.246AsnCys: 0.246 ± 0.013	1.42AsnAsp: 1.42 ± 0.049	1.157AsnGlu: 1.157 ± 0.029	0.855AsnPhe: 0.855 ± 0.024	2.228AsnGly: 2.228 ± 0.038	0.468AsnHis: 0.468 ± 0.019	1.187AsnIle: 1.187 ± 0.029	0.522AsnLys: 0.522 ± 0.02	2.246AsnLeu: 2.246 ± 0.04	0.637AsnMet: 0.637 ± 0.022	0.546AsnAsn: 0.546 ± 0.019	1.631AsnPro: 1.631 ± 0.033	0.605AsnGln: 0.605 ± 0.023	1.607AsnArg: 1.607 ± 0.032	1.002AsnSer: 1.002 ± 0.028	1.18AsnThr: 1.18 ± 0.031	1.626AsnVal: 1.626 ± 0.035	0.409AsnTrp: 0.409 ± 0.015	0.577AsnTyr: 0.577 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.079ProAla: 6.079 ± 0.072	0.399ProCys: 0.399 ± 0.018	4.045ProAsp: 4.045 ± 0.052	4.861ProGlu: 4.861 ± 0.059	1.958ProPhe: 1.958 ± 0.033	4.91ProGly: 4.91 ± 0.06	1.049ProHis: 1.049 ± 0.025	2.003ProIle: 2.003 ± 0.042	1.396ProLys: 1.396 ± 0.035	4.931ProLeu: 4.931 ± 0.06	1.326ProMet: 1.326 ± 0.029	1.153ProAsn: 1.153 ± 0.026	2.464ProPro: 2.464 ± 0.05	1.674ProGln: 1.674 ± 0.034	3.173ProArg: 3.173 ± 0.049	2.59ProSer: 2.59 ± 0.053	2.287ProThr: 2.287 ± 0.039	4.413ProVal: 4.413 ± 0.055	0.741ProTrp: 0.741 ± 0.021	1.128ProTyr: 1.128 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.86GlnAla: 3.86 ± 0.059	0.202GlnCys: 0.202 ± 0.013	1.6GlnAsp: 1.6 ± 0.034	1.583GlnGlu: 1.583 ± 0.032	0.941GlnPhe: 0.941 ± 0.024	2.539GlnGly: 2.539 ± 0.038	0.54GlnHis: 0.54 ± 0.022	1.782GlnIle: 1.782 ± 0.038	0.915GlnLys: 0.915 ± 0.026	2.844GlnLeu: 2.844 ± 0.044	0.93GlnMet: 0.93 ± 0.025	0.725GlnAsn: 0.725 ± 0.024	1.586GlnPro: 1.586 ± 0.036	1.033GlnGln: 1.033 ± 0.032	2.187GlnArg: 2.187 ± 0.039	1.647GlnSer: 1.647 ± 0.036	1.676GlnThr: 1.676 ± 0.03	2.266GlnVal: 2.266 ± 0.037	0.368GlnTrp: 0.368 ± 0.017	0.566GlnTyr: 0.566 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.763ArgAla: 8.763 ± 0.088	0.538ArgCys: 0.538 ± 0.019	4.631ArgAsp: 4.631 ± 0.058	4.456ArgGlu: 4.456 ± 0.057	2.826ArgPhe: 2.826 ± 0.042	5.103ArgGly: 5.103 ± 0.064	1.707ArgHis: 1.707 ± 0.038	3.914ArgIle: 3.914 ± 0.044	2.197ArgLys: 2.197 ± 0.039	7.877ArgLeu: 7.877 ± 0.081	2.069ArgMet: 2.069 ± 0.037	1.734ArgAsn: 1.734 ± 0.036	3.627ArgPro: 3.627 ± 0.048	2.306ArgGln: 2.306 ± 0.042	5.755ArgArg: 5.755 ± 0.079	3.482ArgSer: 3.482 ± 0.054	3.077ArgThr: 3.077 ± 0.047	4.924ArgVal: 4.924 ± 0.065	0.981ArgTrp: 0.981 ± 0.025	1.579ArgTyr: 1.579 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.919SerAla: 5.919 ± 0.062	0.46SerCys: 0.46 ± 0.02	3.296SerAsp: 3.296 ± 0.048	3.218SerGlu: 3.218 ± 0.051	2.128SerPhe: 2.128 ± 0.037	5.604SerGly: 5.604 ± 0.075	1.06SerHis: 1.06 ± 0.027	2.286SerIle: 2.286 ± 0.04	1.319SerLys: 1.319 ± 0.03	4.879SerLeu: 4.879 ± 0.062	1.395SerMet: 1.395 ± 0.033	1.2SerAsn: 1.2 ± 0.029	2.541SerPro: 2.541 ± 0.044	1.442SerGln: 1.442 ± 0.031	3.351SerArg: 3.351 ± 0.047	2.605SerSer: 2.605 ± 0.049	2.465SerThr: 2.465 ± 0.04	3.735SerVal: 3.735 ± 0.046	0.75SerTrp: 0.75 ± 0.022	1.305SerTyr: 1.305 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.34ThrAla: 6.34 ± 0.071	0.464ThrCys: 0.464 ± 0.02	3.218ThrAsp: 3.218 ± 0.052	3.303ThrGlu: 3.303 ± 0.045	1.963ThrPhe: 1.963 ± 0.039	5.764ThrGly: 5.764 ± 0.081	1.047ThrHis: 1.047 ± 0.028	2.548ThrIle: 2.548 ± 0.042	1.212ThrLys: 1.212 ± 0.029	6.154ThrLeu: 6.154 ± 0.06	1.323ThrMet: 1.323 ± 0.032	1.147ThrAsn: 1.147 ± 0.032	3.487ThrPro: 3.487 ± 0.052	1.479ThrGln: 1.479 ± 0.032	3.765ThrArg: 3.765 ± 0.051	2.593ThrSer: 2.593 ± 0.046	2.809ThrThr: 2.809 ± 0.049	4.295ThrVal: 4.295 ± 0.057	0.674ThrTrp: 0.674 ± 0.022	1.173ThrTyr: 1.173 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	8.976ValAla: 8.976 ± 0.083	0.65ValCys: 0.65 ± 0.02	3.968ValAsp: 3.968 ± 0.054	4.627ValGlu: 4.627 ± 0.062	2.765ValPhe: 2.765 ± 0.041	5.429ValGly: 5.429 ± 0.071	1.343ValHis: 1.343 ± 0.033	4.022ValIle: 4.022 ± 0.059	1.914ValLys: 1.914 ± 0.041	7.487ValLeu: 7.487 ± 0.074	2.109ValMet: 2.109 ± 0.034	1.832ValAsn: 1.832 ± 0.034	3.772ValPro: 3.772 ± 0.055	2.024ValGln: 2.024 ± 0.038	4.341ValArg: 4.341 ± 0.055	4.39ValSer: 4.39 ± 0.055	4.868ValThr: 4.868 ± 0.062	5.615ValVal: 5.615 ± 0.059	0.975ValTrp: 0.975 ± 0.025	1.45ValTyr: 1.45 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.362TrpAla: 1.362 ± 0.034	0.137TrpCys: 0.137 ± 0.009	0.782TrpAsp: 0.782 ± 0.023	0.714TrpGlu: 0.714 ± 0.023	0.535TrpPhe: 0.535 ± 0.02	1.063TrpGly: 1.063 ± 0.027	0.386TrpHis: 0.386 ± 0.017	0.703TrpIle: 0.703 ± 0.02	0.464TrpLys: 0.464 ± 0.019	1.733TrpLeu: 1.733 ± 0.036	0.442TrpMet: 0.442 ± 0.017	0.423TrpAsn: 0.423 ± 0.018	0.751TrpPro: 0.751 ± 0.023	0.612TrpGln: 0.612 ± 0.02	1.162TrpArg: 1.162 ± 0.029	0.823TrpSer: 0.823 ± 0.028	0.816TrpThr: 0.816 ± 0.024	0.884TrpVal: 0.884 ± 0.027	0.209TrpTrp: 0.209 ± 0.011	0.262TrpTyr: 0.262 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.534TyrAla: 2.534 ± 0.042	0.234TyrCys: 0.234 ± 0.013	1.611TyrAsp: 1.611 ± 0.033	1.35TyrGlu: 1.35 ± 0.036	0.829TyrPhe: 0.829 ± 0.023	2.119TyrGly: 2.119 ± 0.045	0.474TyrHis: 0.474 ± 0.016	0.906TyrIle: 0.906 ± 0.025	0.481TyrLys: 0.481 ± 0.021	2.135TyrLeu: 2.135 ± 0.038	0.46TyrMet: 0.46 ± 0.019	0.559TyrAsn: 0.559 ± 0.019	1.075TyrPro: 1.075 ± 0.028	0.592TyrGln: 0.592 ± 0.022	1.554TyrArg: 1.554 ± 0.033	0.999TyrSer: 0.999 ± 0.027	1.105TyrThr: 1.105 ± 0.027	1.564TyrVal: 1.564 ± 0.034	0.358TyrTrp: 0.358 ± 0.014	0.563TyrTyr: 0.563 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5105 proteins (1558204 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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