Amino acid dipepetide frequency for Mycoplasma edwardii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.254AlaAla: 3.254 ± 0.194
0.261AlaCys: 0.261 ± 0.035
2.478AlaAsp: 2.478 ± 0.124
3.132AlaGlu: 3.132 ± 0.172
2.472AlaPhe: 2.472 ± 0.125
2.688AlaGly: 2.688 ± 0.143
0.87AlaHis: 0.87 ± 0.07
5.182AlaIle: 5.182 ± 0.189
6.152AlaLys: 6.152 ± 0.283
5.836AlaLeu: 5.836 ± 0.213
0.959AlaMet: 0.959 ± 0.087
3.841AlaAsn: 3.841 ± 0.127
1.38AlaPro: 1.38 ± 0.095
1.912AlaGln: 1.912 ± 0.127
2.078AlaArg: 2.078 ± 0.114
4.007AlaSer: 4.007 ± 0.177
2.965AlaThr: 2.965 ± 0.138
2.893AlaVal: 2.893 ± 0.129
0.261AlaTrp: 0.261 ± 0.037
1.796AlaTyr: 1.796 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.227CysAla: 0.227 ± 0.036
0.055CysCys: 0.055 ± 0.017
0.222CysAsp: 0.222 ± 0.036
0.216CysGlu: 0.216 ± 0.036
0.283CysPhe: 0.283 ± 0.041
0.31CysGly: 0.31 ± 0.043
0.072CysHis: 0.072 ± 0.022
0.299CysIle: 0.299 ± 0.043
0.238CysLys: 0.238 ± 0.038
0.388CysLeu: 0.388 ± 0.047
0.05CysMet: 0.05 ± 0.014
0.233CysAsn: 0.233 ± 0.034
0.083CysPro: 0.083 ± 0.023
0.133CysGln: 0.133 ± 0.025
0.111CysArg: 0.111 ± 0.024
0.416CysSer: 0.416 ± 0.049
0.161CysThr: 0.161 ± 0.031
0.188CysVal: 0.188 ± 0.043
0.017CysTrp: 0.017 ± 0.009
0.111CysTyr: 0.111 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.087AspAla: 3.087 ± 0.147
0.205AspCys: 0.205 ± 0.033
2.915AspAsp: 2.915 ± 0.137
4.783AspGlu: 4.783 ± 0.153
3.481AspPhe: 3.481 ± 0.129
2.866AspGly: 2.866 ± 0.125
0.881AspHis: 0.881 ± 0.077
4.911AspIle: 4.911 ± 0.172
5.969AspLys: 5.969 ± 0.198
5.881AspLeu: 5.881 ± 0.196
0.637AspMet: 0.637 ± 0.061
3.564AspAsn: 3.564 ± 0.149
1.524AspPro: 1.524 ± 0.094
1.873AspGln: 1.873 ± 0.109
1.63AspArg: 1.63 ± 0.099
3.32AspSer: 3.32 ± 0.129
2.339AspThr: 2.339 ± 0.101
3.47AspVal: 3.47 ± 0.148
0.338AspTrp: 0.338 ± 0.04
2.561AspTyr: 2.561 ± 0.116
0.0AspXaa: 0.0 ± 0.0
Glu
4.09GluAla: 4.09 ± 0.196
0.127GluCys: 0.127 ± 0.03
3.281GluAsp: 3.281 ± 0.132
5.071GluGlu: 5.071 ± 0.192
4.329GluPhe: 4.329 ± 0.193
2.954GluGly: 2.954 ± 0.128
0.959GluHis: 0.959 ± 0.078
7.804GluIle: 7.804 ± 0.214
7.505GluLys: 7.505 ± 0.253
7.682GluLeu: 7.682 ± 0.225
1.352GluMet: 1.352 ± 0.105
5.892GluAsn: 5.892 ± 0.182
1.591GluPro: 1.591 ± 0.145
2.228GluGln: 2.228 ± 0.098
2.345GluArg: 2.345 ± 0.107
3.835GluSer: 3.835 ± 0.153
3.847GluThr: 3.847 ± 0.131
4.6GluVal: 4.6 ± 0.185
0.41GluTrp: 0.41 ± 0.048
3.093GluTyr: 3.093 ± 0.137
0.0GluXaa: 0.0 ± 0.0
Phe
2.943PheAla: 2.943 ± 0.137
0.238PheCys: 0.238 ± 0.031
4.09PheAsp: 4.09 ± 0.148
4.107PheGlu: 4.107 ± 0.157
2.577PhePhe: 2.577 ± 0.138
2.644PheGly: 2.644 ± 0.131
0.615PheHis: 0.615 ± 0.059
4.55PheIle: 4.55 ± 0.147
5.299PheLys: 5.299 ± 0.175
4.75PheLeu: 4.75 ± 0.181
0.964PheMet: 0.964 ± 0.076
4.14PheAsn: 4.14 ± 0.168
1.258PhePro: 1.258 ± 0.078
1.28PheGln: 1.28 ± 0.089
1.408PheArg: 1.408 ± 0.097
3.93PheSer: 3.93 ± 0.147
2.433PheThr: 2.433 ± 0.107
3.558PheVal: 3.558 ± 0.141
0.449PheTrp: 0.449 ± 0.049
2.106PheTyr: 2.106 ± 0.112
0.0PheXaa: 0.0 ± 0.0
Gly
2.799GlyAla: 2.799 ± 0.136
0.222GlyCys: 0.222 ± 0.037
2.539GlyAsp: 2.539 ± 0.106
2.755GlyGlu: 2.755 ± 0.105
2.888GlyPhe: 2.888 ± 0.146
3.043GlyGly: 3.043 ± 0.168
0.953GlyHis: 0.953 ± 0.08
4.478GlyIle: 4.478 ± 0.156
4.562GlyLys: 4.562 ± 0.164
4.212GlyLeu: 4.212 ± 0.153
0.915GlyMet: 0.915 ± 0.074
2.699GlyAsn: 2.699 ± 0.123
0.854GlyPro: 0.854 ± 0.075
1.419GlyGln: 1.419 ± 0.102
1.746GlyArg: 1.746 ± 0.114
3.348GlySer: 3.348 ± 0.135
2.688GlyThr: 2.688 ± 0.143
2.877GlyVal: 2.877 ± 0.14
0.216GlyTrp: 0.216 ± 0.035
1.934GlyTyr: 1.934 ± 0.107
0.0GlyXaa: 0.0 ± 0.0
His
0.743HisAla: 0.743 ± 0.071
0.061HisCys: 0.061 ± 0.018
0.77HisAsp: 0.77 ± 0.056
1.097HisGlu: 1.097 ± 0.084
0.887HisPhe: 0.887 ± 0.069
0.826HisGly: 0.826 ± 0.073
0.31HisHis: 0.31 ± 0.04
1.325HisIle: 1.325 ± 0.094
1.253HisLys: 1.253 ± 0.089
1.347HisLeu: 1.347 ± 0.075
0.211HisMet: 0.211 ± 0.031
1.059HisAsn: 1.059 ± 0.066
0.571HisPro: 0.571 ± 0.058
0.421HisGln: 0.421 ± 0.048
0.388HisArg: 0.388 ± 0.051
1.003HisSer: 1.003 ± 0.065
0.693HisThr: 0.693 ± 0.062
0.848HisVal: 0.848 ± 0.075
0.072HisTrp: 0.072 ± 0.018
0.427HisTyr: 0.427 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.299IleAla: 5.299 ± 0.181
0.449IleCys: 0.449 ± 0.046
6.086IleAsp: 6.086 ± 0.166
6.54IleGlu: 6.54 ± 0.175
4.922IlePhe: 4.922 ± 0.196
4.079IleGly: 4.079 ± 0.167
1.081IleHis: 1.081 ± 0.08
7.992IleIle: 7.992 ± 0.256
9.356IleLys: 9.356 ± 0.215
8.026IleLeu: 8.026 ± 0.251
1.363IleMet: 1.363 ± 0.097
7.621IleAsn: 7.621 ± 0.244
2.677IlePro: 2.677 ± 0.133
2.599IleGln: 2.599 ± 0.111
2.45IleArg: 2.45 ± 0.103
7.1IleSer: 7.1 ± 0.22
4.667IleThr: 4.667 ± 0.18
5.099IleVal: 5.099 ± 0.174
0.477IleTrp: 0.477 ± 0.063
3.364IleTyr: 3.364 ± 0.125
0.0IleXaa: 0.0 ± 0.0
Lys
5.338LysAla: 5.338 ± 0.221
0.321LysCys: 0.321 ± 0.041
5.964LysAsp: 5.964 ± 0.185
9.095LysGlu: 9.095 ± 0.232
4.373LysPhe: 4.373 ± 0.157
3.725LysGly: 3.725 ± 0.152
1.43LysHis: 1.43 ± 0.086
9.378LysIle: 9.378 ± 0.224
9.212LysLys: 9.212 ± 0.249
9.245LysLeu: 9.245 ± 0.215
2.3LysMet: 2.3 ± 0.116
8.658LysAsn: 8.658 ± 0.212
2.605LysPro: 2.605 ± 0.132
3.281LysGln: 3.281 ± 0.126
3.281LysArg: 3.281 ± 0.134
5.809LysSer: 5.809 ± 0.202
5.354LysThr: 5.354 ± 0.165
6.352LysVal: 6.352 ± 0.203
0.571LysTrp: 0.571 ± 0.059
4.506LysTyr: 4.506 ± 0.163
0.0LysXaa: 0.0 ± 0.0
Leu
5.41LeuAla: 5.41 ± 0.184
0.338LeuCys: 0.338 ± 0.042
5.509LeuAsp: 5.509 ± 0.182
6.768LeuGlu: 6.768 ± 0.22
4.933LeuPhe: 4.933 ± 0.206
4.523LeuGly: 4.523 ± 0.141
1.28LeuHis: 1.28 ± 0.084
8.408LeuIle: 8.408 ± 0.287
9.899LeuLys: 9.899 ± 0.282
8.214LeuLeu: 8.214 ± 0.25
1.641LeuMet: 1.641 ± 0.104
8.137LeuAsn: 8.137 ± 0.235
2.827LeuPro: 2.827 ± 0.125
2.361LeuGln: 2.361 ± 0.125
2.976LeuArg: 2.976 ± 0.132
7.483LeuSer: 7.483 ± 0.175
4.966LeuThr: 4.966 ± 0.173
5.515LeuVal: 5.515 ± 0.162
0.394LeuTrp: 0.394 ± 0.047
3.115LeuTyr: 3.115 ± 0.135
0.0LeuXaa: 0.0 ± 0.0
Met
1.042MetAla: 1.042 ± 0.079
0.139MetCys: 0.139 ± 0.028
1.014MetAsp: 1.014 ± 0.07
1.031MetGlu: 1.031 ± 0.064
1.303MetPhe: 1.303 ± 0.087
0.942MetGly: 0.942 ± 0.08
0.371MetHis: 0.371 ± 0.043
2.09MetIle: 2.09 ± 0.095
2.378MetLys: 2.378 ± 0.115
2.345MetLeu: 2.345 ± 0.121
0.56MetMet: 0.56 ± 0.06
1.718MetAsn: 1.718 ± 0.107
0.698MetPro: 0.698 ± 0.072
0.826MetGln: 0.826 ± 0.063
0.693MetArg: 0.693 ± 0.066
1.785MetSer: 1.785 ± 0.104
1.092MetThr: 1.092 ± 0.085
1.153MetVal: 1.153 ± 0.085
0.083MetTrp: 0.083 ± 0.02
0.815MetTyr: 0.815 ± 0.062
0.0MetXaa: 0.0 ± 0.0
Asn
3.83AsnAla: 3.83 ± 0.173
0.133AsnCys: 0.133 ± 0.029
4.678AsnAsp: 4.678 ± 0.186
6.452AsnGlu: 6.452 ± 0.201
3.902AsnPhe: 3.902 ± 0.164
3.387AsnGly: 3.387 ± 0.149
1.031AsnHis: 1.031 ± 0.079
7.438AsnIle: 7.438 ± 0.216
8.353AsnLys: 8.353 ± 0.23
7.399AsnLeu: 7.399 ± 0.214
0.964AsnMet: 0.964 ± 0.067
6.878AsnAsn: 6.878 ± 0.279
2.317AsnPro: 2.317 ± 0.112
2.788AsnGln: 2.788 ± 0.127
1.785AsnArg: 1.785 ± 0.105
5.326AsnSer: 5.326 ± 0.18
3.181AsnThr: 3.181 ± 0.143
4.029AsnVal: 4.029 ± 0.145
0.427AsnTrp: 0.427 ± 0.05
2.993AsnTyr: 2.993 ± 0.126
0.0AsnXaa: 0.0 ± 0.0
Pro
1.436ProAla: 1.436 ± 0.098
0.072ProCys: 0.072 ± 0.021
1.43ProAsp: 1.43 ± 0.105
2.516ProGlu: 2.516 ± 0.144
1.397ProPhe: 1.397 ± 0.084
1.541ProGly: 1.541 ± 0.093
0.493ProHis: 0.493 ± 0.054
2.533ProIle: 2.533 ± 0.133
2.516ProLys: 2.516 ± 0.143
2.101ProLeu: 2.101 ± 0.11
0.371ProMet: 0.371 ± 0.046
1.957ProAsn: 1.957 ± 0.109
0.366ProPro: 0.366 ± 0.045
0.959ProGln: 0.959 ± 0.089
0.676ProArg: 0.676 ± 0.065
2.018ProSer: 2.018 ± 0.125
1.702ProThr: 1.702 ± 0.101
1.469ProVal: 1.469 ± 0.09
0.15ProTrp: 0.15 ± 0.03
1.109ProTyr: 1.109 ± 0.084
0.0ProXaa: 0.0 ± 0.0
Gln
1.774GlnAla: 1.774 ± 0.101
0.072GlnCys: 0.072 ± 0.019
1.48GlnAsp: 1.48 ± 0.102
2.733GlnGlu: 2.733 ± 0.143
1.352GlnPhe: 1.352 ± 0.093
1.214GlnGly: 1.214 ± 0.085
0.338GlnHis: 0.338 ± 0.04
3.048GlnIle: 3.048 ± 0.134
3.42GlnLys: 3.42 ± 0.141
2.594GlnLeu: 2.594 ± 0.132
0.576GlnMet: 0.576 ± 0.06
2.638GlnAsn: 2.638 ± 0.117
0.892GlnPro: 0.892 ± 0.098
0.859GlnGln: 0.859 ± 0.071
1.247GlnArg: 1.247 ± 0.082
1.779GlnSer: 1.779 ± 0.113
1.757GlnThr: 1.757 ± 0.1
1.873GlnVal: 1.873 ± 0.094
0.139GlnTrp: 0.139 ± 0.027
1.02GlnTyr: 1.02 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
1.751ArgAla: 1.751 ± 0.108
0.105ArgCys: 0.105 ± 0.023
1.546ArgAsp: 1.546 ± 0.099
2.284ArgGlu: 2.284 ± 0.11
1.491ArgPhe: 1.491 ± 0.085
1.419ArgGly: 1.419 ± 0.112
0.466ArgHis: 0.466 ± 0.054
2.949ArgIle: 2.949 ± 0.121
3.032ArgLys: 3.032 ± 0.133
2.782ArgLeu: 2.782 ± 0.123
0.687ArgMet: 0.687 ± 0.059
2.073ArgAsn: 2.073 ± 0.102
0.881ArgPro: 0.881 ± 0.073
0.953ArgGln: 0.953 ± 0.069
1.197ArgArg: 1.197 ± 0.095
1.934ArgSer: 1.934 ± 0.106
1.685ArgThr: 1.685 ± 0.099
1.951ArgVal: 1.951 ± 0.101
0.188ArgTrp: 0.188 ± 0.035
1.33ArgTyr: 1.33 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
3.137SerAla: 3.137 ± 0.136
0.449SerCys: 0.449 ± 0.05
3.858SerAsp: 3.858 ± 0.151
4.445SerGlu: 4.445 ± 0.178
4.229SerPhe: 4.229 ± 0.186
3.691SerGly: 3.691 ± 0.161
0.964SerHis: 0.964 ± 0.08
6.053SerIle: 6.053 ± 0.2
7.15SerLys: 7.15 ± 0.217
7.106SerLeu: 7.106 ± 0.227
1.053SerMet: 1.053 ± 0.082
5.299SerAsn: 5.299 ± 0.196
1.557SerPro: 1.557 ± 0.09
2.394SerGln: 2.394 ± 0.094
2.101SerArg: 2.101 ± 0.108
5.227SerSer: 5.227 ± 0.209
3.481SerThr: 3.481 ± 0.132
3.708SerVal: 3.708 ± 0.146
0.504SerTrp: 0.504 ± 0.05
2.938SerTyr: 2.938 ± 0.135
0.0SerXaa: 0.0 ± 0.0
Thr
2.328ThrAla: 2.328 ± 0.114
0.188ThrCys: 0.188 ± 0.036
2.428ThrAsp: 2.428 ± 0.121
3.176ThrGlu: 3.176 ± 0.125
3.082ThrPhe: 3.082 ± 0.153
2.561ThrGly: 2.561 ± 0.121
0.782ThrHis: 0.782 ± 0.073
4.634ThrIle: 4.634 ± 0.163
5.022ThrLys: 5.022 ± 0.169
5.16ThrLeu: 5.16 ± 0.187
0.754ThrMet: 0.754 ± 0.066
3.952ThrAsn: 3.952 ± 0.155
1.796ThrPro: 1.796 ± 0.088
1.63ThrGln: 1.63 ± 0.106
1.53ThrArg: 1.53 ± 0.102
3.752ThrSer: 3.752 ± 0.13
3.06ThrThr: 3.06 ± 0.133
2.827ThrVal: 2.827 ± 0.155
0.355ThrTrp: 0.355 ± 0.045
2.006ThrTyr: 2.006 ± 0.095
0.0ThrXaa: 0.0 ± 0.0
Val
3.736ValAla: 3.736 ± 0.156
0.255ValCys: 0.255 ± 0.045
3.508ValAsp: 3.508 ± 0.143
4.063ValGlu: 4.063 ± 0.162
3.093ValPhe: 3.093 ± 0.151
2.871ValGly: 2.871 ± 0.149
0.859ValHis: 0.859 ± 0.072
4.972ValIle: 4.972 ± 0.167
5.459ValLys: 5.459 ± 0.203
5.57ValLeu: 5.57 ± 0.158
0.953ValMet: 0.953 ± 0.069
4.035ValAsn: 4.035 ± 0.151
1.713ValPro: 1.713 ± 0.105
1.635ValGln: 1.635 ± 0.103
1.79ValArg: 1.79 ± 0.11
4.462ValSer: 4.462 ± 0.154
3.054ValThr: 3.054 ± 0.124
4.135ValVal: 4.135 ± 0.189
0.305ValTrp: 0.305 ± 0.04
2.106ValTyr: 2.106 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.028TrpAla: 0.028 ± 0.01
0.006TrpCys: 0.006 ± 0.006
0.006TrpAsp: 0.006 ± 0.006
0.017TrpGlu: 0.017 ± 0.01
0.061TrpPhe: 0.061 ± 0.017
0.017TrpGly: 0.017 ± 0.01
0.006TrpHis: 0.006 ± 0.006
0.028TrpIle: 0.028 ± 0.012
0.028TrpLys: 0.028 ± 0.012
0.05TrpLeu: 0.05 ± 0.018
5.171TrpMet: 5.171 ± 0.159
0.039TrpAsn: 0.039 ± 0.017
0.017TrpPro: 0.017 ± 0.009
0.022TrpGln: 0.022 ± 0.01
0.011TrpArg: 0.011 ± 0.008
0.028TrpSer: 0.028 ± 0.012
0.017TrpThr: 0.017 ± 0.01
0.044TrpVal: 0.044 ± 0.026
0.0TrpTrp: 0.0 ± 0.0
0.022TrpTyr: 0.022 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.167TyrAla: 2.167 ± 0.141
0.116TyrCys: 0.116 ± 0.028
2.433TyrAsp: 2.433 ± 0.112
2.716TyrGlu: 2.716 ± 0.137
2.289TyrPhe: 2.289 ± 0.122
1.846TyrGly: 1.846 ± 0.101
0.549TyrHis: 0.549 ± 0.051
3.176TyrIle: 3.176 ± 0.14
3.996TyrLys: 3.996 ± 0.154
4.007TyrLeu: 4.007 ± 0.145
0.588TyrMet: 0.588 ± 0.06
2.86TyrAsn: 2.86 ± 0.114
1.203TyrPro: 1.203 ± 0.087
1.23TyrGln: 1.23 ± 0.078
1.264TyrArg: 1.264 ± 0.084
2.782TyrSer: 2.782 ± 0.12
1.879TyrThr: 1.879 ± 0.114
1.984TyrVal: 1.984 ± 0.104
0.266TyrTrp: 0.266 ± 0.036
1.402TyrTyr: 1.402 ± 0.09
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1362 proteins (180421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski