Amino acid dipepetide frequency for Enorma massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.385AlaAla: 15.385 ± 0.27	2.107AlaCys: 2.107 ± 0.069	6.717AlaAsp: 6.717 ± 0.102	8.057AlaGlu: 8.057 ± 0.137	4.221AlaPhe: 4.221 ± 0.085	10.1AlaGly: 10.1 ± 0.145	2.381AlaHis: 2.381 ± 0.06	5.604AlaIle: 5.604 ± 0.103	3.58AlaLys: 3.58 ± 0.092	11.722AlaLeu: 11.722 ± 0.168	2.865AlaMet: 2.865 ± 0.064	2.9AlaAsn: 2.9 ± 0.075	4.985AlaPro: 4.985 ± 0.118	3.874AlaGln: 3.874 ± 0.091	8.165AlaArg: 8.165 ± 0.176	7.208AlaSer: 7.208 ± 0.145	5.837AlaThr: 5.837 ± 0.116	8.557AlaVal: 8.557 ± 0.137	1.332AlaTrp: 1.332 ± 0.051	3.121AlaTyr: 3.121 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.752CysAla: 1.752 ± 0.064	0.261CysCys: 0.261 ± 0.021	1.017CysAsp: 1.017 ± 0.035	0.999CysGlu: 0.999 ± 0.04	0.512CysPhe: 0.512 ± 0.03	1.634CysGly: 1.634 ± 0.052	0.325CysHis: 0.325 ± 0.027	0.767CysIle: 0.767 ± 0.038	0.363CysLys: 0.363 ± 0.024	1.13CysLeu: 1.13 ± 0.054	0.372CysMet: 0.372 ± 0.02	0.349CysAsn: 0.349 ± 0.021	0.831CysPro: 0.831 ± 0.043	0.36CysGln: 0.36 ± 0.023	0.87CysArg: 0.87 ± 0.04	0.97CysSer: 0.97 ± 0.045	0.899CysThr: 0.899 ± 0.033	1.127CysVal: 1.127 ± 0.048	0.136CysTrp: 0.136 ± 0.015	0.372CysTyr: 0.372 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	8.578AspAla: 8.578 ± 0.128	0.776AspCys: 0.776 ± 0.036	4.029AspAsp: 4.029 ± 0.096	5.314AspGlu: 5.314 ± 0.108	2.281AspPhe: 2.281 ± 0.066	5.596AspGly: 5.596 ± 0.132	1.133AspHis: 1.133 ± 0.043	3.27AspIle: 3.27 ± 0.073	1.582AspLys: 1.582 ± 0.051	5.456AspLeu: 5.456 ± 0.1	1.492AspMet: 1.492 ± 0.048	1.36AspAsn: 1.36 ± 0.064	3.046AspPro: 3.046 ± 0.086	1.407AspGln: 1.407 ± 0.053	3.744AspArg: 3.744 ± 0.101	2.883AspSer: 2.883 ± 0.065	3.003AspThr: 3.003 ± 0.076	4.779AspVal: 4.779 ± 0.102	0.669AspTrp: 0.669 ± 0.032	1.895AspTyr: 1.895 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	7.895GluAla: 7.895 ± 0.144	0.745GluCys: 0.745 ± 0.036	3.84GluAsp: 3.84 ± 0.083	4.88GluGlu: 4.88 ± 0.11	2.075GluPhe: 2.075 ± 0.051	5.391GluGly: 5.391 ± 0.096	1.935GluHis: 1.935 ± 0.064	2.993GluIle: 2.993 ± 0.077	2.374GluLys: 2.374 ± 0.073	7.493GluLeu: 7.493 ± 0.114	1.71GluMet: 1.71 ± 0.05	2.023GluAsn: 2.023 ± 0.059	2.871GluPro: 2.871 ± 0.077	2.724GluGln: 2.724 ± 0.064	6.179GluArg: 6.179 ± 0.119	3.177GluSer: 3.177 ± 0.077	3.169GluThr: 3.169 ± 0.073	4.994GluVal: 4.994 ± 0.099	0.55GluTrp: 0.55 ± 0.027	1.64GluTyr: 1.64 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.906PheAla: 3.906 ± 0.077	0.674PheCys: 0.674 ± 0.032	2.889PheAsp: 2.889 ± 0.071	2.476PheGlu: 2.476 ± 0.071	1.427PhePhe: 1.427 ± 0.052	3.291PheGly: 3.291 ± 0.078	0.61PheHis: 0.61 ± 0.033	1.771PheIle: 1.771 ± 0.06	1.098PheLys: 1.098 ± 0.046	2.796PheLeu: 2.796 ± 0.074	0.965PheMet: 0.965 ± 0.041	1.09PheAsn: 1.09 ± 0.047	1.294PhePro: 1.294 ± 0.041	0.864PheGln: 0.864 ± 0.039	1.721PheArg: 1.721 ± 0.053	2.583PheSer: 2.583 ± 0.063	2.122PheThr: 2.122 ± 0.07	2.799PheVal: 2.799 ± 0.079	0.419PheTrp: 0.419 ± 0.025	1.041PheTyr: 1.041 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	9.251GlyAla: 9.251 ± 0.153	1.52GlyCys: 1.52 ± 0.053	4.682GlyAsp: 4.682 ± 0.102	5.412GlyGlu: 5.412 ± 0.104	3.165GlyPhe: 3.165 ± 0.07	6.496GlyGly: 6.496 ± 0.127	1.613GlyHis: 1.613 ± 0.056	5.133GlyIle: 5.133 ± 0.089	3.205GlyLys: 3.205 ± 0.075	7.013GlyLeu: 7.013 ± 0.113	2.436GlyMet: 2.436 ± 0.065	2.239GlyAsn: 2.239 ± 0.07	2.429GlyPro: 2.429 ± 0.059	2.151GlyGln: 2.151 ± 0.067	5.214GlyArg: 5.214 ± 0.105	5.552GlySer: 5.552 ± 0.11	5.075GlyThr: 5.075 ± 0.103	6.56GlyVal: 6.56 ± 0.109	0.96GlyTrp: 0.96 ± 0.042	2.683GlyTyr: 2.683 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	2.386HisAla: 2.386 ± 0.06	0.248HisCys: 0.248 ± 0.023	1.366HisAsp: 1.366 ± 0.05	1.482HisGlu: 1.482 ± 0.051	0.657HisPhe: 0.657 ± 0.031	1.887HisGly: 1.887 ± 0.058	0.466HisHis: 0.466 ± 0.032	1.096HisIle: 1.096 ± 0.039	0.454HisLys: 0.454 ± 0.028	1.709HisLeu: 1.709 ± 0.055	0.486HisMet: 0.486 ± 0.026	0.521HisAsn: 0.521 ± 0.03	1.157HisPro: 1.157 ± 0.05	0.453HisGln: 0.453 ± 0.033	1.25HisArg: 1.25 ± 0.053	0.916HisSer: 0.916 ± 0.037	0.989HisThr: 0.989 ± 0.04	1.668HisVal: 1.668 ± 0.059	0.171HisTrp: 0.171 ± 0.017	0.573HisTyr: 0.573 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.464IleAla: 6.464 ± 0.116	0.854IleCys: 0.854 ± 0.039	4.256IleAsp: 4.256 ± 0.093	4.168IleGlu: 4.168 ± 0.085	1.592IlePhe: 1.592 ± 0.057	3.895IleGly: 3.895 ± 0.087	0.802IleHis: 0.802 ± 0.036	2.647IleIle: 2.647 ± 0.077	1.608IleLys: 1.608 ± 0.052	3.621IleLeu: 3.621 ± 0.089	1.363IleMet: 1.363 ± 0.052	1.433IleAsn: 1.433 ± 0.047	2.43IlePro: 2.43 ± 0.069	1.274IleGln: 1.274 ± 0.047	2.642IleArg: 2.642 ± 0.073	3.09IleSer: 3.09 ± 0.07	2.858IleThr: 2.858 ± 0.074	4.685IleVal: 4.685 ± 0.106	0.462IleTrp: 0.462 ± 0.025	1.221IleTyr: 1.221 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	3.455LysAla: 3.455 ± 0.087	0.288LysCys: 0.288 ± 0.021	1.636LysAsp: 1.636 ± 0.062	1.849LysGlu: 1.849 ± 0.057	0.828LysPhe: 0.828 ± 0.033	2.404LysGly: 2.404 ± 0.071	0.66LysHis: 0.66 ± 0.03	1.614LysIle: 1.614 ± 0.057	1.669LysLys: 1.669 ± 0.067	3.229LysLeu: 3.229 ± 0.086	0.861LysMet: 0.861 ± 0.038	1.136LysAsn: 1.136 ± 0.049	1.619LysPro: 1.619 ± 0.053	1.113LysGln: 1.113 ± 0.042	2.721LysArg: 2.721 ± 0.074	1.736LysSer: 1.736 ± 0.06	2.093LysThr: 2.093 ± 0.067	2.375LysVal: 2.375 ± 0.078	0.25LysTrp: 0.25 ± 0.021	0.861LysTyr: 0.861 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	11.656LeuAla: 11.656 ± 0.16	1.351LeuCys: 1.351 ± 0.046	6.403LeuAsp: 6.403 ± 0.107	5.866LeuGlu: 5.866 ± 0.1	3.323LeuPhe: 3.323 ± 0.078	7.592LeuGly: 7.592 ± 0.138	1.61LeuHis: 1.61 ± 0.048	4.366LeuIle: 4.366 ± 0.1	2.979LeuLys: 2.979 ± 0.076	7.901LeuLeu: 7.901 ± 0.144	2.526LeuMet: 2.526 ± 0.067	2.38LeuAsn: 2.38 ± 0.066	4.333LeuPro: 4.333 ± 0.092	2.096LeuGln: 2.096 ± 0.051	5.401LeuArg: 5.401 ± 0.106	6.115LeuSer: 6.115 ± 0.092	5.04LeuThr: 5.04 ± 0.103	7.312LeuVal: 7.312 ± 0.138	0.752LeuTrp: 0.752 ± 0.034	2.232LeuTyr: 2.232 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	3.029MetAla: 3.029 ± 0.074	0.32MetCys: 0.32 ± 0.025	1.489MetAsp: 1.489 ± 0.05	1.398MetGlu: 1.398 ± 0.045	0.796MetPhe: 0.796 ± 0.041	2.323MetGly: 2.323 ± 0.066	0.549MetHis: 0.549 ± 0.029	1.113MetIle: 1.113 ± 0.046	0.968MetLys: 0.968 ± 0.039	2.518MetLeu: 2.518 ± 0.07	0.636MetMet: 0.636 ± 0.035	0.805MetAsn: 0.805 ± 0.037	1.459MetPro: 1.459 ± 0.048	0.858MetGln: 0.858 ± 0.035	1.973MetArg: 1.973 ± 0.049	1.59MetSer: 1.59 ± 0.048	1.351MetThr: 1.351 ± 0.041	1.855MetVal: 1.855 ± 0.052	0.18MetTrp: 0.18 ± 0.018	0.529MetTyr: 0.529 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.089AsnAla: 3.089 ± 0.074	0.32AsnCys: 0.32 ± 0.026	1.686AsnAsp: 1.686 ± 0.059	1.842AsnGlu: 1.842 ± 0.064	0.814AsnPhe: 0.814 ± 0.039	2.381AsnGly: 2.381 ± 0.083	0.529AsnHis: 0.529 ± 0.026	1.546AsnIle: 1.546 ± 0.053	0.86AsnLys: 0.86 ± 0.039	2.564AsnLeu: 2.564 ± 0.07	0.739AsnMet: 0.739 ± 0.037	0.828AsnAsn: 0.828 ± 0.051	1.692AsnPro: 1.692 ± 0.055	0.776AsnGln: 0.776 ± 0.038	1.669AsnArg: 1.669 ± 0.05	1.276AsnSer: 1.276 ± 0.041	1.488AsnThr: 1.488 ± 0.078	2.212AsnVal: 2.212 ± 0.071	0.259AsnTrp: 0.259 ± 0.023	0.764AsnTyr: 0.764 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.366ProAla: 5.366 ± 0.115	0.578ProCys: 0.578 ± 0.036	2.793ProAsp: 2.793 ± 0.071	3.941ProGlu: 3.941 ± 0.077	1.709ProPhe: 1.709 ± 0.054	3.514ProGly: 3.514 ± 0.088	0.963ProHis: 0.963 ± 0.037	2.041ProIle: 2.041 ± 0.059	1.439ProLys: 1.439 ± 0.053	3.715ProLeu: 3.715 ± 0.073	0.864ProMet: 0.864 ± 0.038	1.171ProAsn: 1.171 ± 0.049	1.186ProPro: 1.186 ± 0.055	1.422ProGln: 1.422 ± 0.046	2.416ProArg: 2.416 ± 0.071	2.851ProSer: 2.851 ± 0.077	2.217ProThr: 2.217 ± 0.056	3.691ProVal: 3.691 ± 0.071	0.553ProTrp: 0.553 ± 0.029	1.305ProTyr: 1.305 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.483GlnAla: 3.483 ± 0.086	0.258GlnCys: 0.258 ± 0.02	1.451GlnAsp: 1.451 ± 0.049	1.909GlnGlu: 1.909 ± 0.055	0.927GlnPhe: 0.927 ± 0.041	2.395GlnGly: 2.395 ± 0.067	0.596GlnHis: 0.596 ± 0.03	1.634GlnIle: 1.634 ± 0.062	0.963GlnLys: 0.963 ± 0.041	2.878GlnLeu: 2.878 ± 0.074	0.808GlnMet: 0.808 ± 0.032	0.86GlnAsn: 0.86 ± 0.037	1.197GlnPro: 1.197 ± 0.047	1.22GlnGln: 1.22 ± 0.057	2.125GlnArg: 2.125 ± 0.061	1.447GlnSer: 1.447 ± 0.044	1.477GlnThr: 1.477 ± 0.048	2.264GlnVal: 2.264 ± 0.058	0.276GlnTrp: 0.276 ± 0.023	0.692GlnTyr: 0.692 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	7.665ArgAla: 7.665 ± 0.168	0.947ArgCys: 0.947 ± 0.045	3.81ArgAsp: 3.81 ± 0.081	4.921ArgGlu: 4.921 ± 0.101	2.415ArgPhe: 2.415 ± 0.066	4.636ArgGly: 4.636 ± 0.102	1.331ArgHis: 1.331 ± 0.046	3.618ArgIle: 3.618 ± 0.073	2.114ArgLys: 2.114 ± 0.068	5.872ArgLeu: 5.872 ± 0.11	1.968ArgMet: 1.968 ± 0.052	1.642ArgAsn: 1.642 ± 0.055	2.596ArgPro: 2.596 ± 0.07	1.857ArgGln: 1.857 ± 0.056	5.058ArgArg: 5.058 ± 0.129	3.852ArgSer: 3.852 ± 0.089	3.352ArgThr: 3.352 ± 0.068	5.09ArgVal: 5.09 ± 0.09	0.738ArgTrp: 0.738 ± 0.035	2.108ArgTyr: 2.108 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	6.757SerAla: 6.757 ± 0.145	0.974SerCys: 0.974 ± 0.044	3.423SerAsp: 3.423 ± 0.074	3.508SerGlu: 3.508 ± 0.076	2.583SerPhe: 2.583 ± 0.068	5.385SerGly: 5.385 ± 0.107	1.102SerHis: 1.102 ± 0.04	3.36SerIle: 3.36 ± 0.083	1.874SerLys: 1.874 ± 0.064	5.345SerLeu: 5.345 ± 0.101	1.645SerMet: 1.645 ± 0.044	1.726SerAsn: 1.726 ± 0.059	2.422SerPro: 2.422 ± 0.06	1.616SerGln: 1.616 ± 0.055	3.519SerArg: 3.519 ± 0.086	4.188SerSer: 4.188 ± 0.126	3.237SerThr: 3.237 ± 0.081	4.366SerVal: 4.366 ± 0.087	0.796SerTrp: 0.796 ± 0.037	2.002SerTyr: 2.002 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	5.696ThrAla: 5.696 ± 0.119	0.825ThrCys: 0.825 ± 0.034	3.125ThrAsp: 3.125 ± 0.095	3.009ThrGlu: 3.009 ± 0.088	2.197ThrPhe: 2.197 ± 0.074	5.025ThrGly: 5.025 ± 0.095	1.11ThrHis: 1.11 ± 0.041	2.968ThrIle: 2.968 ± 0.082	1.677ThrLys: 1.677 ± 0.063	4.888ThrLeu: 4.888 ± 0.089	1.232ThrMet: 1.232 ± 0.049	1.467ThrAsn: 1.467 ± 0.059	2.89ThrPro: 2.89 ± 0.06	1.43ThrGln: 1.43 ± 0.051	2.941ThrArg: 2.941 ± 0.073	3.169ThrSer: 3.169 ± 0.085	2.793ThrThr: 2.793 ± 0.091	4.807ThrVal: 4.807 ± 0.125	0.613ThrTrp: 0.613 ± 0.031	1.79ThrTyr: 1.79 ± 0.078	0.0ThrXaa: 0.0 ± 0.0
Val	8.985ValAla: 8.985 ± 0.146	1.39ValCys: 1.39 ± 0.046	4.977ValAsp: 4.977 ± 0.089	5.052ValGlu: 5.052 ± 0.09	2.924ValPhe: 2.924 ± 0.068	5.68ValGly: 5.68 ± 0.1	1.366ValHis: 1.366 ± 0.049	4.031ValIle: 4.031 ± 0.081	2.442ValLys: 2.442 ± 0.072	7.464ValLeu: 7.464 ± 0.114	1.89ValMet: 1.89 ± 0.057	2.224ValAsn: 2.224 ± 0.063	3.752ValPro: 3.752 ± 0.074	2.047ValGln: 2.047 ± 0.062	5.167ValArg: 5.167 ± 0.097	5.144ValSer: 5.144 ± 0.088	4.497ValThr: 4.497 ± 0.121	6.769ValVal: 6.769 ± 0.134	0.742ValTrp: 0.742 ± 0.038	2.058ValTyr: 2.058 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.941TrpAla: 0.941 ± 0.043	0.206TrpCys: 0.206 ± 0.017	0.657TrpAsp: 0.657 ± 0.03	0.669TrpGlu: 0.669 ± 0.036	0.43TrpPhe: 0.43 ± 0.026	0.837TrpGly: 0.837 ± 0.037	0.232TrpHis: 0.232 ± 0.02	0.506TrpIle: 0.506 ± 0.027	0.364TrpLys: 0.364 ± 0.026	1.023TrpLeu: 1.023 ± 0.043	0.3TrpMet: 0.3 ± 0.021	0.372TrpAsn: 0.372 ± 0.027	0.378TrpPro: 0.378 ± 0.025	0.39TrpGln: 0.39 ± 0.026	0.735TrpArg: 0.735 ± 0.034	0.614TrpSer: 0.614 ± 0.033	0.5TrpThr: 0.5 ± 0.026	0.652TrpVal: 0.652 ± 0.035	0.159TrpTrp: 0.159 ± 0.015	0.325TrpTyr: 0.325 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.98TyrAla: 2.98 ± 0.068	0.402TyrCys: 0.402 ± 0.028	2.049TyrAsp: 2.049 ± 0.067	1.907TyrGlu: 1.907 ± 0.057	0.962TyrPhe: 0.962 ± 0.038	2.325TyrGly: 2.325 ± 0.067	0.625TyrHis: 0.625 ± 0.036	1.287TyrIle: 1.287 ± 0.049	0.785TyrLys: 0.785 ± 0.036	2.897TyrLeu: 2.897 ± 0.072	0.578TyrMet: 0.578 ± 0.033	0.81TyrAsn: 0.81 ± 0.042	1.169TyrPro: 1.169 ± 0.047	0.927TyrGln: 0.927 ± 0.041	2.081TyrArg: 2.081 ± 0.053	1.464TyrSer: 1.464 ± 0.05	1.651TyrThr: 1.651 ± 0.058	2.041TyrVal: 2.041 ± 0.052	0.273TyrTrp: 0.273 ± 0.019	0.881TyrTyr: 0.881 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1937 proteins (655953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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