Amino acid dipepetide frequency for Brachybacterium sp. UMB0905

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.374AlaAla: 19.374 ± 0.227	0.754AlaCys: 0.754 ± 0.033	8.484AlaAsp: 8.484 ± 0.095	8.773AlaGlu: 8.773 ± 0.132	3.119AlaPhe: 3.119 ± 0.064	11.153AlaGly: 11.153 ± 0.116	2.696AlaHis: 2.696 ± 0.059	5.035AlaIle: 5.035 ± 0.082	2.324AlaLys: 2.324 ± 0.063	14.331AlaLeu: 14.331 ± 0.169	2.868AlaMet: 2.868 ± 0.056	1.765AlaAsn: 1.765 ± 0.04	7.195AlaPro: 7.195 ± 0.112	4.977AlaGln: 4.977 ± 0.088	9.602AlaArg: 9.602 ± 0.145	6.183AlaSer: 6.183 ± 0.088	6.64AlaThr: 6.64 ± 0.102	10.571AlaVal: 10.571 ± 0.131	1.813AlaTrp: 1.813 ± 0.046	1.994AlaTyr: 1.994 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.762CysAla: 0.762 ± 0.03	0.051CysCys: 0.051 ± 0.008	0.308CysAsp: 0.308 ± 0.019	0.362CysGlu: 0.362 ± 0.021	0.148CysPhe: 0.148 ± 0.012	0.63CysGly: 0.63 ± 0.027	0.133CysHis: 0.133 ± 0.012	0.19CysIle: 0.19 ± 0.014	0.071CysLys: 0.071 ± 0.009	0.511CysLeu: 0.511 ± 0.026	0.091CysMet: 0.091 ± 0.009	0.119CysAsn: 0.119 ± 0.013	0.357CysPro: 0.357 ± 0.021	0.163CysGln: 0.163 ± 0.013	0.417CysArg: 0.417 ± 0.022	0.33CysSer: 0.33 ± 0.02	0.402CysThr: 0.402 ± 0.023	0.4CysVal: 0.4 ± 0.021	0.091CysTrp: 0.091 ± 0.009	0.106CysTyr: 0.106 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.311AspAla: 8.311 ± 0.098	0.286AspCys: 0.286 ± 0.019	3.553AspAsp: 3.553 ± 0.08	4.275AspGlu: 4.275 ± 0.081	1.518AspPhe: 1.518 ± 0.042	6.447AspGly: 6.447 ± 0.109	1.421AspHis: 1.421 ± 0.045	2.131AspIle: 2.131 ± 0.059	0.892AspLys: 0.892 ± 0.036	7.103AspLeu: 7.103 ± 0.101	0.983AspMet: 0.983 ± 0.035	0.791AspAsn: 0.791 ± 0.032	4.988AspPro: 4.988 ± 0.083	1.849AspGln: 1.849 ± 0.052	4.251AspArg: 4.251 ± 0.07	2.539AspSer: 2.539 ± 0.053	2.934AspThr: 2.934 ± 0.061	5.175AspVal: 5.175 ± 0.084	0.838AspTrp: 0.838 ± 0.03	1.114AspTyr: 1.114 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.385GluAla: 7.385 ± 0.115	0.274GluCys: 0.274 ± 0.018	4.391GluAsp: 4.391 ± 0.076	4.346GluGlu: 4.346 ± 0.086	1.507GluPhe: 1.507 ± 0.046	4.875GluGly: 4.875 ± 0.083	2.169GluHis: 2.169 ± 0.048	2.936GluIle: 2.936 ± 0.067	1.507GluLys: 1.507 ± 0.049	6.929GluLeu: 6.929 ± 0.102	1.094GluMet: 1.094 ± 0.036	1.282GluAsn: 1.282 ± 0.042	3.31GluPro: 3.31 ± 0.066	3.669GluGln: 3.669 ± 0.065	5.722GluArg: 5.722 ± 0.104	2.735GluSer: 2.735 ± 0.064	3.005GluThr: 3.005 ± 0.066	5.209GluVal: 5.209 ± 0.087	0.681GluTrp: 0.681 ± 0.026	1.11GluTyr: 1.11 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.366PheAla: 3.366 ± 0.058	0.192PheCys: 0.192 ± 0.017	1.839PheAsp: 1.839 ± 0.054	1.601PheGlu: 1.601 ± 0.05	0.885PhePhe: 0.885 ± 0.035	2.616PheGly: 2.616 ± 0.063	0.608PheHis: 0.608 ± 0.027	0.994PheIle: 0.994 ± 0.031	0.364PheLys: 0.364 ± 0.025	2.557PheLeu: 2.557 ± 0.06	0.484PheMet: 0.484 ± 0.023	0.5PheAsn: 0.5 ± 0.023	1.3PhePro: 1.3 ± 0.041	0.712PheGln: 0.712 ± 0.027	1.607PheArg: 1.607 ± 0.049	1.641PheSer: 1.641 ± 0.045	2.131PheThr: 2.131 ± 0.054	2.173PheVal: 2.173 ± 0.048	0.426PheTrp: 0.426 ± 0.024	0.572PheTyr: 0.572 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.881GlyAla: 10.881 ± 0.133	0.586GlyCys: 0.586 ± 0.027	4.782GlyAsp: 4.782 ± 0.072	5.865GlyGlu: 5.865 ± 0.088	2.635GlyPhe: 2.635 ± 0.064	7.94GlyGly: 7.94 ± 0.136	1.95GlyHis: 1.95 ± 0.05	4.371GlyIle: 4.371 ± 0.074	2.122GlyLys: 2.122 ± 0.063	8.467GlyLeu: 8.467 ± 0.107	2.248GlyMet: 2.248 ± 0.05	1.522GlyAsn: 1.522 ± 0.047	4.486GlyPro: 4.486 ± 0.089	3.012GlyGln: 3.012 ± 0.059	6.507GlyArg: 6.507 ± 0.097	5.23GlySer: 5.23 ± 0.091	6.074GlyThr: 6.074 ± 0.105	6.862GlyVal: 6.862 ± 0.086	1.457GlyTrp: 1.457 ± 0.041	1.96GlyTyr: 1.96 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.541HisAla: 2.541 ± 0.054	0.125HisCys: 0.125 ± 0.013	1.465HisAsp: 1.465 ± 0.052	1.455HisGlu: 1.455 ± 0.047	0.538HisPhe: 0.538 ± 0.022	2.216HisGly: 2.216 ± 0.056	0.708HisHis: 0.708 ± 0.028	0.704HisIle: 0.704 ± 0.027	0.274HisLys: 0.274 ± 0.018	2.736HisLeu: 2.736 ± 0.056	0.335HisMet: 0.335 ± 0.017	0.317HisAsn: 0.317 ± 0.017	1.696HisPro: 1.696 ± 0.043	0.678HisGln: 0.678 ± 0.026	2.132HisArg: 2.132 ± 0.051	0.991HisSer: 0.991 ± 0.032	1.176HisThr: 1.176 ± 0.04	1.812HisVal: 1.812 ± 0.042	0.322HisTrp: 0.322 ± 0.021	0.413HisTyr: 0.413 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.392IleAla: 6.392 ± 0.085	0.279IleCys: 0.279 ± 0.016	3.162IleAsp: 3.162 ± 0.069	2.7IleGlu: 2.7 ± 0.059	0.97IlePhe: 0.97 ± 0.041	4.276IleGly: 4.276 ± 0.072	0.822IleHis: 0.822 ± 0.029	1.828IleIle: 1.828 ± 0.052	0.632IleLys: 0.632 ± 0.031	3.629IleLeu: 3.629 ± 0.07	0.699IleMet: 0.699 ± 0.032	0.766IleAsn: 0.766 ± 0.025	2.648IlePro: 2.648 ± 0.057	1.013IleGln: 1.013 ± 0.03	2.475IleArg: 2.475 ± 0.052	2.458IleSer: 2.458 ± 0.059	3.21IleThr: 3.21 ± 0.065	3.49IleVal: 3.49 ± 0.065	0.494IleTrp: 0.494 ± 0.025	0.715IleTyr: 0.715 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.056LysAla: 2.056 ± 0.066	0.064LysCys: 0.064 ± 0.008	1.248LysAsp: 1.248 ± 0.045	1.093LysGlu: 1.093 ± 0.042	0.415LysPhe: 0.415 ± 0.019	1.543LysGly: 1.543 ± 0.053	0.449LysHis: 0.449 ± 0.025	0.859LysIle: 0.859 ± 0.03	0.707LysLys: 0.707 ± 0.034	1.613LysLeu: 1.613 ± 0.047	0.369LysMet: 0.369 ± 0.023	0.547LysAsn: 0.547 ± 0.027	1.055LysPro: 1.055 ± 0.042	0.714LysGln: 0.714 ± 0.031	1.296LysArg: 1.296 ± 0.041	0.968LysSer: 0.968 ± 0.041	1.097LysThr: 1.097 ± 0.047	1.439LysVal: 1.439 ± 0.04	0.187LysTrp: 0.187 ± 0.013	0.397LysTyr: 0.397 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.701LeuAla: 14.701 ± 0.185	0.539LeuCys: 0.539 ± 0.023	6.51LeuAsp: 6.51 ± 0.092	6.442LeuGlu: 6.442 ± 0.089	2.579LeuPhe: 2.579 ± 0.06	9.376LeuGly: 9.376 ± 0.127	2.249LeuHis: 2.249 ± 0.051	4.234LeuIle: 4.234 ± 0.08	1.575LeuLys: 1.575 ± 0.048	11.945LeuLeu: 11.945 ± 0.187	1.964LeuMet: 1.964 ± 0.045	1.644LeuAsn: 1.644 ± 0.047	6.189LeuPro: 6.189 ± 0.099	3.024LeuGln: 3.024 ± 0.058	8.276LeuArg: 8.276 ± 0.119	5.539LeuSer: 5.539 ± 0.08	6.738LeuThr: 6.738 ± 0.091	8.825LeuVal: 8.825 ± 0.121	1.306LeuTrp: 1.306 ± 0.043	1.615LeuTyr: 1.615 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.289MetAla: 2.289 ± 0.053	0.121MetCys: 0.121 ± 0.012	1.084MetAsp: 1.084 ± 0.037	0.877MetGlu: 0.877 ± 0.036	0.584MetPhe: 0.584 ± 0.026	1.539MetGly: 1.539 ± 0.043	0.433MetHis: 0.433 ± 0.022	1.002MetIle: 1.002 ± 0.035	0.41MetLys: 0.41 ± 0.023	2.327MetLeu: 2.327 ± 0.046	0.414MetMet: 0.414 ± 0.024	0.518MetAsn: 0.518 ± 0.024	1.22MetPro: 1.22 ± 0.037	0.592MetGln: 0.592 ± 0.025	1.509MetArg: 1.509 ± 0.043	1.498MetSer: 1.498 ± 0.035	1.752MetThr: 1.752 ± 0.048	1.587MetVal: 1.587 ± 0.039	0.232MetTrp: 0.232 ± 0.019	0.317MetTyr: 0.317 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.068AsnAla: 2.068 ± 0.05	0.097AsnCys: 0.097 ± 0.01	0.878AsnAsp: 0.878 ± 0.035	0.813AsnGlu: 0.813 ± 0.036	0.494AsnPhe: 0.494 ± 0.025	1.514AsnGly: 1.514 ± 0.046	0.393AsnHis: 0.393 ± 0.022	0.807AsnIle: 0.807 ± 0.031	0.308AsnLys: 0.308 ± 0.02	1.803AsnLeu: 1.803 ± 0.047	0.333AsnMet: 0.333 ± 0.02	0.398AsnAsn: 0.398 ± 0.021	1.404AsnPro: 1.404 ± 0.041	0.541AsnGln: 0.541 ± 0.029	1.204AsnArg: 1.204 ± 0.04	0.906AsnSer: 0.906 ± 0.033	1.019AsnThr: 1.019 ± 0.038	1.283AsnVal: 1.283 ± 0.036	0.274AsnTrp: 0.274 ± 0.018	0.399AsnTyr: 0.399 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.129ProAla: 8.129 ± 0.112	0.228ProCys: 0.228 ± 0.014	3.821ProAsp: 3.821 ± 0.081	4.686ProGlu: 4.686 ± 0.07	1.589ProPhe: 1.589 ± 0.042	5.73ProGly: 5.73 ± 0.099	1.326ProHis: 1.326 ± 0.034	1.924ProIle: 1.924 ± 0.048	0.844ProLys: 0.844 ± 0.035	5.463ProLeu: 5.463 ± 0.09	1.138ProMet: 1.138 ± 0.032	0.875ProAsn: 0.875 ± 0.031	2.777ProPro: 2.777 ± 0.07	2.082ProGln: 2.082 ± 0.054	3.949ProArg: 3.949 ± 0.075	3.434ProSer: 3.434 ± 0.07	3.812ProThr: 3.812 ± 0.067	4.796ProVal: 4.796 ± 0.071	0.857ProTrp: 0.857 ± 0.033	1.063ProTyr: 1.063 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.099GlnAla: 4.099 ± 0.067	0.156GlnCys: 0.156 ± 0.012	1.917GlnAsp: 1.917 ± 0.05	2.183GlnGlu: 2.183 ± 0.059	0.803GlnPhe: 0.803 ± 0.029	2.455GlnGly: 2.455 ± 0.063	0.83GlnHis: 0.83 ± 0.028	1.756GlnIle: 1.756 ± 0.046	0.743GlnLys: 0.743 ± 0.034	3.849GlnLeu: 3.849 ± 0.072	0.728GlnMet: 0.728 ± 0.031	0.671GlnAsn: 0.671 ± 0.028	1.697GlnPro: 1.697 ± 0.055	1.754GlnGln: 1.754 ± 0.053	2.931GlnArg: 2.931 ± 0.06	1.441GlnSer: 1.441 ± 0.039	1.522GlnThr: 1.522 ± 0.043	3.168GlnVal: 3.168 ± 0.055	0.523GlnTrp: 0.523 ± 0.021	0.609GlnTyr: 0.609 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.135ArgAla: 9.135 ± 0.134	0.454ArgCys: 0.454 ± 0.025	4.325ArgAsp: 4.325 ± 0.071	5.696ArgGlu: 5.696 ± 0.091	2.149ArgPhe: 2.149 ± 0.056	5.927ArgGly: 5.927 ± 0.091	1.749ArgHis: 1.749 ± 0.044	3.66ArgIle: 3.66 ± 0.055	1.359ArgLys: 1.359 ± 0.042	7.286ArgLeu: 7.286 ± 0.117	1.831ArgMet: 1.831 ± 0.04	1.124ArgAsn: 1.124 ± 0.03	4.288ArgPro: 4.288 ± 0.087	2.167ArgGln: 2.167 ± 0.045	7.604ArgArg: 7.604 ± 0.131	4.426ArgSer: 4.426 ± 0.08	5.123ArgThr: 5.123 ± 0.084	5.126ArgVal: 5.126 ± 0.084	1.175ArgTrp: 1.175 ± 0.033	1.494ArgTyr: 1.494 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	7.067SerAla: 7.067 ± 0.098	0.299SerCys: 0.299 ± 0.019	2.925SerAsp: 2.925 ± 0.062	2.668SerGlu: 2.668 ± 0.062	1.636SerPhe: 1.636 ± 0.044	5.513SerGly: 5.513 ± 0.088	1.082SerHis: 1.082 ± 0.034	2.173SerIle: 2.173 ± 0.054	0.941SerLys: 0.941 ± 0.038	5.018SerLeu: 5.018 ± 0.072	1.218SerMet: 1.218 ± 0.037	0.853SerAsn: 0.853 ± 0.038	3.453SerPro: 3.453 ± 0.066	1.524SerGln: 1.524 ± 0.041	3.926SerArg: 3.926 ± 0.075	3.316SerSer: 3.316 ± 0.079	3.799SerThr: 3.799 ± 0.064	4.023SerVal: 4.023 ± 0.07	0.881SerTrp: 0.881 ± 0.034	1.058SerTyr: 1.058 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.447ThrAla: 8.447 ± 0.11	0.363ThrCys: 0.363 ± 0.02	3.63ThrAsp: 3.63 ± 0.062	3.445ThrGlu: 3.445 ± 0.067	1.721ThrPhe: 1.721 ± 0.044	5.87ThrGly: 5.87 ± 0.081	1.177ThrHis: 1.177 ± 0.034	2.619ThrIle: 2.619 ± 0.06	1.02ThrLys: 1.02 ± 0.036	6.148ThrLeu: 6.148 ± 0.075	1.143ThrMet: 1.143 ± 0.034	0.973ThrAsn: 0.973 ± 0.032	4.11ThrPro: 4.11 ± 0.078	1.67ThrGln: 1.67 ± 0.04	3.991ThrArg: 3.991 ± 0.064	3.635ThrSer: 3.635 ± 0.07	4.046ThrThr: 4.046 ± 0.073	5.713ThrVal: 5.713 ± 0.083	1.02ThrTrp: 1.02 ± 0.035	1.233ThrTyr: 1.233 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.042ValAla: 9.042 ± 0.105	0.52ValCys: 0.52 ± 0.026	5.091ValAsp: 5.091 ± 0.088	4.892ValGlu: 4.892 ± 0.08	2.203ValPhe: 2.203 ± 0.057	6.537ValGly: 6.537 ± 0.093	1.798ValHis: 1.798 ± 0.051	4.193ValIle: 4.193 ± 0.072	1.416ValLys: 1.416 ± 0.041	10.116ValLeu: 10.116 ± 0.129	1.677ValMet: 1.677 ± 0.045	1.499ValAsn: 1.499 ± 0.041	4.708ValPro: 4.708 ± 0.08	2.492ValGln: 2.492 ± 0.051	5.997ValArg: 5.997 ± 0.086	4.217ValSer: 4.217 ± 0.072	5.486ValThr: 5.486 ± 0.087	7.316ValVal: 7.316 ± 0.106	1.045ValTrp: 1.045 ± 0.037	1.264ValTyr: 1.264 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.51TrpAla: 1.51 ± 0.044	0.106TrpCys: 0.106 ± 0.011	0.788TrpAsp: 0.788 ± 0.031	0.859TrpGlu: 0.859 ± 0.028	0.496TrpPhe: 0.496 ± 0.026	1.064TrpGly: 1.064 ± 0.033	0.311TrpHis: 0.311 ± 0.02	0.645TrpIle: 0.645 ± 0.028	0.311TrpLys: 0.311 ± 0.02	1.454TrpLeu: 1.454 ± 0.045	0.379TrpMet: 0.379 ± 0.019	0.404TrpAsn: 0.404 ± 0.02	0.674TrpPro: 0.674 ± 0.028	0.618TrpGln: 0.618 ± 0.027	1.143TrpArg: 1.143 ± 0.036	0.891TrpSer: 0.891 ± 0.033	0.872TrpThr: 0.872 ± 0.033	1.102TrpVal: 1.102 ± 0.039	0.332TrpTrp: 0.332 ± 0.02	0.301TrpTyr: 0.301 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.096TyrAla: 2.096 ± 0.044	0.145TyrCys: 0.145 ± 0.012	1.199TyrAsp: 1.199 ± 0.04	1.107TyrGlu: 1.107 ± 0.037	0.578TyrPhe: 0.578 ± 0.026	1.735TyrGly: 1.735 ± 0.053	0.331TyrHis: 0.331 ± 0.02	0.596TyrIle: 0.596 ± 0.027	0.297TyrLys: 0.297 ± 0.016	1.985TyrLeu: 1.985 ± 0.049	0.307TyrMet: 0.307 ± 0.017	0.368TyrAsn: 0.368 ± 0.022	0.969TyrPro: 0.969 ± 0.039	0.585TyrGln: 0.585 ± 0.028	1.56TyrArg: 1.56 ± 0.045	0.997TyrSer: 0.997 ± 0.033	1.138TyrThr: 1.138 ± 0.041	1.439TyrVal: 1.439 ± 0.045	0.301TyrTrp: 0.301 ± 0.019	0.425TyrTyr: 0.425 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2790 proteins (933859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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