Amino acid dipepetide frequency for Candidatus Neoehrlichia lotoris str. RAC413

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.455AlaAla: 3.455 ± 0.141
0.963AlaCys: 0.963 ± 0.052
2.261AlaAsp: 2.261 ± 0.099
2.435AlaGlu: 2.435 ± 0.096
2.174AlaPhe: 2.174 ± 0.097
2.85AlaGly: 2.85 ± 0.116
1.175AlaHis: 1.175 ± 0.066
5.961AlaIle: 5.961 ± 0.157
3.871AlaLys: 3.871 ± 0.131
5.336AlaLeu: 5.336 ± 0.168
1.333AlaMet: 1.333 ± 0.064
2.963AlaAsn: 2.963 ± 0.132
1.175AlaPro: 1.175 ± 0.062
1.816AlaGln: 1.816 ± 0.091
1.852AlaArg: 1.852 ± 0.087
3.713AlaSer: 3.713 ± 0.129
2.57AlaThr: 2.57 ± 0.093
3.687AlaVal: 3.687 ± 0.138
0.345AlaTrp: 0.345 ± 0.037
2.19AlaTyr: 2.19 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.844CysAla: 0.844 ± 0.055
0.299CysCys: 0.299 ± 0.03
1.005CysAsp: 1.005 ± 0.059
0.667CysGlu: 0.667 ± 0.049
0.689CysPhe: 0.689 ± 0.048
1.101CysGly: 1.101 ± 0.073
0.361CysHis: 0.361 ± 0.041
1.819CysIle: 1.819 ± 0.083
1.32CysLys: 1.32 ± 0.08
1.076CysLeu: 1.076 ± 0.066
0.341CysMet: 0.341 ± 0.036
1.398CysAsn: 1.398 ± 0.088
0.419CysPro: 0.419 ± 0.041
0.409CysGln: 0.409 ± 0.038
0.47CysArg: 0.47 ± 0.04
1.253CysSer: 1.253 ± 0.072
0.757CysThr: 0.757 ± 0.05
0.944CysVal: 0.944 ± 0.054
0.106CysTrp: 0.106 ± 0.021
0.773CysTyr: 0.773 ± 0.048
0.0CysXaa: 0.0 ± 0.0
Asp
2.641AspAla: 2.641 ± 0.128
0.634AspCys: 0.634 ± 0.053
3.066AspAsp: 3.066 ± 0.311
2.927AspGlu: 2.927 ± 0.368
2.641AspPhe: 2.641 ± 0.101
2.515AspGly: 2.515 ± 0.246
1.037AspHis: 1.037 ± 0.087
6.257AspIle: 6.257 ± 0.217
4.415AspLys: 4.415 ± 0.2
4.505AspLeu: 4.505 ± 0.139
1.233AspMet: 1.233 ± 0.068
4.351AspAsn: 4.351 ± 0.211
1.214AspPro: 1.214 ± 0.062
1.353AspGln: 1.353 ± 0.078
1.346AspArg: 1.346 ± 0.08
3.42AspSer: 3.42 ± 0.158
2.344AspThr: 2.344 ± 0.099
3.961AspVal: 3.961 ± 0.271
0.357AspTrp: 0.357 ± 0.036
2.399AspTyr: 2.399 ± 0.14
0.0AspXaa: 0.0 ± 0.0
Glu
2.573GluAla: 2.573 ± 0.113
0.779GluCys: 0.779 ± 0.051
2.647GluAsp: 2.647 ± 0.179
3.092GluGlu: 3.092 ± 0.139
2.154GluPhe: 2.154 ± 0.089
2.264GluGly: 2.264 ± 0.102
1.404GluHis: 1.404 ± 0.175
4.876GluIle: 4.876 ± 0.161
4.402GluLys: 4.402 ± 0.118
4.895GluLeu: 4.895 ± 0.123
1.14GluMet: 1.14 ± 0.061
3.584GluAsn: 3.584 ± 0.142
0.973GluPro: 0.973 ± 0.07
1.791GluGln: 1.791 ± 0.136
1.845GluArg: 1.845 ± 0.158
3.459GluSer: 3.459 ± 0.129
1.797GluThr: 1.797 ± 0.086
3.616GluVal: 3.616 ± 0.175
0.332GluTrp: 0.332 ± 0.033
2.257GluTyr: 2.257 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.38PheAla: 2.38 ± 0.118
0.956PheCys: 0.956 ± 0.062
2.357PheAsp: 2.357 ± 0.105
1.646PheGlu: 1.646 ± 0.084
2.789PhePhe: 2.789 ± 0.11
2.299PheGly: 2.299 ± 0.108
0.998PheHis: 0.998 ± 0.062
5.233PheIle: 5.233 ± 0.163
2.502PheLys: 2.502 ± 0.084
4.386PheLeu: 4.386 ± 0.135
1.024PheMet: 1.024 ± 0.058
3.333PheAsn: 3.333 ± 0.105
1.459PhePro: 1.459 ± 0.08
1.169PheGln: 1.169 ± 0.056
1.175PheArg: 1.175 ± 0.07
4.08PheSer: 4.08 ± 0.123
2.596PheThr: 2.596 ± 0.114
2.505PheVal: 2.505 ± 0.109
0.332PheTrp: 0.332 ± 0.037
2.061PheTyr: 2.061 ± 0.092
0.0PheXaa: 0.0 ± 0.0
Gly
2.966GlyAla: 2.966 ± 0.153
0.886GlyCys: 0.886 ± 0.069
2.628GlyAsp: 2.628 ± 0.282
2.476GlyGlu: 2.476 ± 0.126
2.409GlyPhe: 2.409 ± 0.093
3.443GlyGly: 3.443 ± 0.151
0.989GlyHis: 0.989 ± 0.062
5.993GlyIle: 5.993 ± 0.211
4.318GlyLys: 4.318 ± 0.128
4.241GlyLeu: 4.241 ± 0.15
1.372GlyMet: 1.372 ± 0.069
3.198GlyAsn: 3.198 ± 0.139
1.069GlyPro: 1.069 ± 0.07
1.456GlyGln: 1.456 ± 0.07
1.89GlyArg: 1.89 ± 0.096
3.652GlySer: 3.652 ± 0.126
2.557GlyThr: 2.557 ± 0.147
3.475GlyVal: 3.475 ± 0.141
0.441GlyTrp: 0.441 ± 0.045
2.383GlyTyr: 2.383 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.143HisAla: 1.143 ± 0.073
0.396HisCys: 0.396 ± 0.038
1.385HisAsp: 1.385 ± 0.235
1.043HisGlu: 1.043 ± 0.076
0.873HisPhe: 0.873 ± 0.054
1.23HisGly: 1.23 ± 0.075
0.644HisHis: 0.644 ± 0.06
2.431HisIle: 2.431 ± 0.105
1.894HisLys: 1.894 ± 0.094
1.816HisLeu: 1.816 ± 0.066
0.512HisMet: 0.512 ± 0.045
2.174HisAsn: 2.174 ± 0.096
0.844HisPro: 0.844 ± 0.062
0.56HisGln: 0.56 ± 0.045
0.737HisArg: 0.737 ± 0.055
1.514HisSer: 1.514 ± 0.092
1.14HisThr: 1.14 ± 0.072
1.295HisVal: 1.295 ± 0.074
0.164HisTrp: 0.164 ± 0.022
1.069HisTyr: 1.069 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
6.553IleAla: 6.553 ± 0.185
1.765IleCys: 1.765 ± 0.097
5.78IleAsp: 5.78 ± 0.148
5.642IleGlu: 5.642 ± 0.156
4.612IlePhe: 4.612 ± 0.147
5.719IleGly: 5.719 ± 0.2
2.106IleHis: 2.106 ± 0.092
11.287IleIle: 11.287 ± 0.332
8.354IleLys: 8.354 ± 0.209
9.349IleLeu: 9.349 ± 0.24
2.57IleMet: 2.57 ± 0.102
8.006IleAsn: 8.006 ± 0.214
3.529IlePro: 3.529 ± 0.13
3.162IleGln: 3.162 ± 0.125
3.307IleArg: 3.307 ± 0.112
8.74IleSer: 8.74 ± 0.202
5.777IleThr: 5.777 ± 0.185
6.386IleVal: 6.386 ± 0.199
0.496IleTrp: 0.496 ± 0.039
3.926IleTyr: 3.926 ± 0.223
0.0IleXaa: 0.0 ± 0.0
Lys
3.671LysAla: 3.671 ± 0.13
1.031LysCys: 1.031 ± 0.069
4.457LysAsp: 4.457 ± 0.179
4.859LysGlu: 4.859 ± 0.242
3.472LysPhe: 3.472 ± 0.111
3.616LysGly: 3.616 ± 0.162
1.514LysHis: 1.514 ± 0.077
8.505LysIle: 8.505 ± 0.18
6.933LysLys: 6.933 ± 0.192
7.803LysLeu: 7.803 ± 0.161
1.694LysMet: 1.694 ± 0.08
6.331LysAsn: 6.331 ± 0.186
1.565LysPro: 1.565 ± 0.08
2.608LysGln: 2.608 ± 0.102
2.483LysArg: 2.483 ± 0.113
5.587LysSer: 5.587 ± 0.175
3.082LysThr: 3.082 ± 0.116
5.281LysVal: 5.281 ± 0.144
0.47LysTrp: 0.47 ± 0.044
3.652LysTyr: 3.652 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
4.505LeuAla: 4.505 ± 0.134
1.778LeuCys: 1.778 ± 0.08
4.521LeuAsp: 4.521 ± 0.196
4.479LeuGlu: 4.479 ± 0.141
4.048LeuPhe: 4.048 ± 0.13
4.431LeuGly: 4.431 ± 0.144
2.579LeuHis: 2.579 ± 0.096
8.505LeuIle: 8.505 ± 0.231
7.017LeuLys: 7.017 ± 0.177
10.27LeuLeu: 10.27 ± 0.294
2.325LeuMet: 2.325 ± 0.095
6.051LeuAsn: 6.051 ± 0.175
3.587LeuPro: 3.587 ± 0.124
3.903LeuGln: 3.903 ± 0.12
3.465LeuArg: 3.465 ± 0.131
8.843LeuSer: 8.843 ± 0.217
4.206LeuThr: 4.206 ± 0.137
4.76LeuVal: 4.76 ± 0.159
0.673LeuTrp: 0.673 ± 0.056
4.106LeuTyr: 4.106 ± 0.153
0.0LeuXaa: 0.0 ± 0.0
Met
1.163MetAla: 1.163 ± 0.063
0.386MetCys: 0.386 ± 0.036
0.982MetAsp: 0.982 ± 0.059
0.956MetGlu: 0.956 ± 0.059
1.124MetPhe: 1.124 ± 0.056
1.33MetGly: 1.33 ± 0.078
0.737MetHis: 0.737 ± 0.059
2.232MetIle: 2.232 ± 0.096
1.687MetLys: 1.687 ± 0.079
2.931MetLeu: 2.931 ± 0.115
0.618MetMet: 0.618 ± 0.041
1.24MetAsn: 1.24 ± 0.059
0.95MetPro: 0.95 ± 0.077
1.111MetGln: 1.111 ± 0.055
0.895MetArg: 0.895 ± 0.057
1.948MetSer: 1.948 ± 0.069
0.908MetThr: 0.908 ± 0.059
1.243MetVal: 1.243 ± 0.069
0.164MetTrp: 0.164 ± 0.023
1.005MetTyr: 1.005 ± 0.061
0.0MetXaa: 0.0 ± 0.0
Asn
3.626AsnAla: 3.626 ± 0.111
1.027AsnCys: 1.027 ± 0.059
3.797AsnAsp: 3.797 ± 0.176
2.969AsnGlu: 2.969 ± 0.118
3.352AsnPhe: 3.352 ± 0.119
2.85AsnGly: 2.85 ± 0.118
1.249AsnHis: 1.249 ± 0.072
9.423AsnIle: 9.423 ± 0.252
6.518AsnLys: 6.518 ± 0.226
6.328AsnLeu: 6.328 ± 0.167
1.62AsnMet: 1.62 ± 0.071
7.755AsnAsn: 7.755 ± 0.302
1.987AsnPro: 1.987 ± 0.089
1.855AsnGln: 1.855 ± 0.085
2.042AsnArg: 2.042 ± 0.097
5.03AsnSer: 5.03 ± 0.163
4.354AsnThr: 4.354 ± 0.176
4.876AsnVal: 4.876 ± 0.14
0.383AsnTrp: 0.383 ± 0.034
3.082AsnTyr: 3.082 ± 0.105
0.0AsnXaa: 0.0 ± 0.0
Pro
1.204ProAla: 1.204 ± 0.063
0.412ProCys: 0.412 ± 0.037
1.623ProAsp: 1.623 ± 0.224
1.565ProGlu: 1.565 ± 0.069
1.298ProPhe: 1.298 ± 0.066
1.53ProGly: 1.53 ± 0.083
0.763ProHis: 0.763 ± 0.051
3.117ProIle: 3.117 ± 0.122
1.819ProLys: 1.819 ± 0.084
2.702ProLeu: 2.702 ± 0.11
0.541ProMet: 0.541 ± 0.051
1.694ProAsn: 1.694 ± 0.071
0.837ProPro: 0.837 ± 0.063
1.085ProGln: 1.085 ± 0.083
0.699ProArg: 0.699 ± 0.048
2.077ProSer: 2.077 ± 0.095
1.507ProThr: 1.507 ± 0.083
1.868ProVal: 1.868 ± 0.086
0.206ProTrp: 0.206 ± 0.028
1.42ProTyr: 1.42 ± 0.067
0.0ProXaa: 0.0 ± 0.0
Gln
1.697GlnAla: 1.697 ± 0.102
0.564GlnCys: 0.564 ± 0.039
2.032GlnAsp: 2.032 ± 0.11
2.293GlnGlu: 2.293 ± 0.097
1.188GlnPhe: 1.188 ± 0.069
1.452GlnGly: 1.452 ± 0.075
1.021GlnHis: 1.021 ± 0.076
2.75GlnIle: 2.75 ± 0.103
2.956GlnLys: 2.956 ± 0.111
3.137GlnLeu: 3.137 ± 0.117
0.696GlnMet: 0.696 ± 0.055
2.38GlnAsn: 2.38 ± 0.114
0.699GlnPro: 0.699 ± 0.078
1.324GlnGln: 1.324 ± 0.076
1.13GlnArg: 1.13 ± 0.064
2.447GlnSer: 2.447 ± 0.134
1.04GlnThr: 1.04 ± 0.069
2.209GlnVal: 2.209 ± 0.131
0.2GlnTrp: 0.2 ± 0.023
1.591GlnTyr: 1.591 ± 0.07
0.0GlnXaa: 0.0 ± 0.0
Arg
1.807ArgAla: 1.807 ± 0.084
0.454ArgCys: 0.454 ± 0.042
1.675ArgAsp: 1.675 ± 0.104
1.887ArgGlu: 1.887 ± 0.092
1.52ArgPhe: 1.52 ± 0.084
1.739ArgGly: 1.739 ± 0.102
0.67ArgHis: 0.67 ± 0.05
3.265ArgIle: 3.265 ± 0.109
2.641ArgLys: 2.641 ± 0.11
3.104ArgLeu: 3.104 ± 0.112
0.802ArgMet: 0.802 ± 0.055
2.106ArgAsn: 2.106 ± 0.091
0.799ArgPro: 0.799 ± 0.06
1.082ArgGln: 1.082 ± 0.063
1.211ArgArg: 1.211 ± 0.067
2.29ArgSer: 2.29 ± 0.099
1.324ArgThr: 1.324 ± 0.069
1.836ArgVal: 1.836 ± 0.082
0.254ArgTrp: 0.254 ± 0.03
1.439ArgTyr: 1.439 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
3.761SerAla: 3.761 ± 0.117
1.246SerCys: 1.246 ± 0.075
4.048SerAsp: 4.048 ± 0.259
3.671SerGlu: 3.671 ± 0.149
3.404SerPhe: 3.404 ± 0.109
4.306SerGly: 4.306 ± 0.128
1.784SerHis: 1.784 ± 0.083
8.782SerIle: 8.782 ± 0.208
5.304SerLys: 5.304 ± 0.173
6.985SerLeu: 6.985 ± 0.178
1.993SerMet: 1.993 ± 0.095
5.549SerAsn: 5.549 ± 0.163
2.006SerPro: 2.006 ± 0.085
2.499SerGln: 2.499 ± 0.117
2.344SerArg: 2.344 ± 0.086
6.486SerSer: 6.486 ± 0.177
4.132SerThr: 4.132 ± 0.154
4.892SerVal: 4.892 ± 0.132
0.522SerTrp: 0.522 ± 0.044
3.565SerTyr: 3.565 ± 0.129
0.0SerXaa: 0.0 ± 0.0
Thr
2.489ThrAla: 2.489 ± 0.083
0.76ThrCys: 0.76 ± 0.055
2.27ThrAsp: 2.27 ± 0.109
2.199ThrGlu: 2.199 ± 0.101
2.203ThrPhe: 2.203 ± 0.077
2.728ThrGly: 2.728 ± 0.091
1.285ThrHis: 1.285 ± 0.07
5.024ThrIle: 5.024 ± 0.17
3.501ThrLys: 3.501 ± 0.143
5.008ThrLeu: 5.008 ± 0.144
0.973ThrMet: 0.973 ± 0.064
3.23ThrAsn: 3.23 ± 0.129
1.572ThrPro: 1.572 ± 0.078
1.926ThrGln: 1.926 ± 0.104
1.443ThrArg: 1.443 ± 0.078
3.926ThrSer: 3.926 ± 0.158
2.744ThrThr: 2.744 ± 0.119
3.017ThrVal: 3.017 ± 0.121
0.335ThrTrp: 0.335 ± 0.042
1.758ThrTyr: 1.758 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
3.275ValAla: 3.275 ± 0.116
0.898ValCys: 0.898 ± 0.054
3.188ValAsp: 3.188 ± 0.12
2.753ValGlu: 2.753 ± 0.112
2.869ValPhe: 2.869 ± 0.114
3.575ValGly: 3.575 ± 0.131
1.324ValHis: 1.324 ± 0.065
6.846ValIle: 6.846 ± 0.2
5.037ValLys: 5.037 ± 0.216
5.935ValLeu: 5.935 ± 0.188
1.665ValMet: 1.665 ± 0.086
4.537ValAsn: 4.537 ± 0.141
1.906ValPro: 1.906 ± 0.114
1.987ValGln: 1.987 ± 0.107
1.993ValArg: 1.993 ± 0.082
4.95ValSer: 4.95 ± 0.167
3.365ValThr: 3.365 ± 0.132
4.657ValVal: 4.657 ± 0.159
0.415ValTrp: 0.415 ± 0.048
2.328ValTyr: 2.328 ± 0.102
0.0ValXaa: 0.0 ± 0.0
Trp
0.312TrpAla: 0.312 ± 0.034
0.132TrpCys: 0.132 ± 0.02
0.28TrpAsp: 0.28 ± 0.031
0.316TrpGlu: 0.316 ± 0.034
0.312TrpPhe: 0.312 ± 0.034
0.357TrpGly: 0.357 ± 0.037
0.2TrpHis: 0.2 ± 0.028
0.625TrpIle: 0.625 ± 0.057
0.609TrpLys: 0.609 ± 0.044
0.708TrpLeu: 0.708 ± 0.059
0.184TrpMet: 0.184 ± 0.026
0.412TrpAsn: 0.412 ± 0.038
0.219TrpPro: 0.219 ± 0.028
0.299TrpGln: 0.299 ± 0.031
0.206TrpArg: 0.206 ± 0.027
0.412TrpSer: 0.412 ± 0.04
0.222TrpThr: 0.222 ± 0.029
0.37TrpVal: 0.37 ± 0.04
0.077TrpTrp: 0.077 ± 0.015
0.361TrpTyr: 0.361 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.058TyrAla: 2.058 ± 0.084
0.683TyrCys: 0.683 ± 0.046
2.615TyrAsp: 2.615 ± 0.118
2.003TyrGlu: 2.003 ± 0.117
2.151TyrPhe: 2.151 ± 0.1
2.505TyrGly: 2.505 ± 0.11
1.024TyrHis: 1.024 ± 0.057
4.135TyrIle: 4.135 ± 0.135
3.517TyrLys: 3.517 ± 0.134
3.542TyrLeu: 3.542 ± 0.12
0.973TyrMet: 0.973 ± 0.056
3.832TyrAsn: 3.832 ± 0.126
1.159TyrPro: 1.159 ± 0.062
1.411TyrGln: 1.411 ± 0.059
1.369TyrArg: 1.369 ± 0.069
3.452TyrSer: 3.452 ± 0.138
1.968TyrThr: 1.968 ± 0.085
2.628TyrVal: 2.628 ± 0.096
0.341TyrTrp: 0.341 ± 0.039
2.045TyrTyr: 2.045 ± 0.111
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1017 proteins (310528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski