Amino acid dipepetide frequency for Paracoccus aurantiacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.078AlaAla: 18.078 ± 0.192	0.935AlaCys: 0.935 ± 0.032	7.739AlaAsp: 7.739 ± 0.093	8.72AlaGlu: 8.72 ± 0.108	4.17AlaPhe: 4.17 ± 0.076	11.239AlaGly: 11.239 ± 0.124	2.184AlaHis: 2.184 ± 0.046	6.501AlaIle: 6.501 ± 0.088	3.673AlaLys: 3.673 ± 0.06	13.386AlaLeu: 13.386 ± 0.126	3.91AlaMet: 3.91 ± 0.067	2.828AlaAsn: 2.828 ± 0.048	5.984AlaPro: 5.984 ± 0.096	4.46AlaGln: 4.46 ± 0.073	9.08AlaArg: 9.08 ± 0.118	6.214AlaSer: 6.214 ± 0.088	6.285AlaThr: 6.285 ± 0.086	8.369AlaVal: 8.369 ± 0.101	1.509AlaTrp: 1.509 ± 0.037	2.376AlaTyr: 2.376 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.014CysAla: 1.014 ± 0.033	0.106CysCys: 0.106 ± 0.01	0.54CysAsp: 0.54 ± 0.022	0.377CysGlu: 0.377 ± 0.018	0.294CysPhe: 0.294 ± 0.016	0.842CysGly: 0.842 ± 0.026	0.255CysHis: 0.255 ± 0.017	0.387CysIle: 0.387 ± 0.018	0.155CysLys: 0.155 ± 0.011	0.731CysLeu: 0.731 ± 0.027	0.149CysMet: 0.149 ± 0.012	0.19CysAsn: 0.19 ± 0.012	0.469CysPro: 0.469 ± 0.022	0.232CysGln: 0.232 ± 0.014	0.563CysArg: 0.563 ± 0.026	0.408CysSer: 0.408 ± 0.02	0.348CysThr: 0.348 ± 0.018	0.523CysVal: 0.523 ± 0.021	0.126CysTrp: 0.126 ± 0.011	0.156CysTyr: 0.156 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.26AspAla: 8.26 ± 0.099	0.483AspCys: 0.483 ± 0.021	3.74AspAsp: 3.74 ± 0.075	3.919AspGlu: 3.919 ± 0.06	2.327AspPhe: 2.327 ± 0.045	5.858AspGly: 5.858 ± 0.09	1.413AspHis: 1.413 ± 0.036	3.076AspIle: 3.076 ± 0.054	1.64AspLys: 1.64 ± 0.041	6.496AspLeu: 6.496 ± 0.086	1.743AspMet: 1.743 ± 0.039	1.34AspAsn: 1.34 ± 0.038	3.917AspPro: 3.917 ± 0.068	2.182AspGln: 2.182 ± 0.039	4.711AspArg: 4.711 ± 0.065	2.428AspSer: 2.428 ± 0.049	2.735AspThr: 2.735 ± 0.059	3.741AspVal: 3.741 ± 0.066	1.299AspTrp: 1.299 ± 0.032	1.617AspTyr: 1.617 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.698GluAla: 7.698 ± 0.09	0.377GluCys: 0.377 ± 0.02	3.208GluAsp: 3.208 ± 0.057	2.944GluGlu: 2.944 ± 0.052	1.85GluPhe: 1.85 ± 0.04	4.764GluGly: 4.764 ± 0.071	1.067GluHis: 1.067 ± 0.031	3.686GluIle: 3.686 ± 0.068	2.081GluLys: 2.081 ± 0.05	5.141GluLeu: 5.141 ± 0.065	1.793GluMet: 1.793 ± 0.04	1.722GluAsn: 1.722 ± 0.042	2.502GluPro: 2.502 ± 0.046	1.944GluGln: 1.944 ± 0.046	4.328GluArg: 4.328 ± 0.066	2.411GluSer: 2.411 ± 0.042	3.432GluThr: 3.432 ± 0.059	3.894GluVal: 3.894 ± 0.059	0.817GluTrp: 0.817 ± 0.03	1.169GluTyr: 1.169 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.496PheAla: 4.496 ± 0.068	0.37PheCys: 0.37 ± 0.02	2.746PheAsp: 2.746 ± 0.044	1.896PheGlu: 1.896 ± 0.042	1.35PhePhe: 1.35 ± 0.039	3.624PheGly: 3.624 ± 0.062	0.73PheHis: 0.73 ± 0.025	1.732PheIle: 1.732 ± 0.04	0.77PheLys: 0.77 ± 0.026	3.32PheLeu: 3.32 ± 0.057	0.859PheMet: 0.859 ± 0.033	0.935PheAsn: 0.935 ± 0.029	1.564PhePro: 1.564 ± 0.04	1.001PheGln: 1.001 ± 0.031	2.258PheArg: 2.258 ± 0.049	2.07PheSer: 2.07 ± 0.052	1.966PheThr: 1.966 ± 0.051	2.51PheVal: 2.51 ± 0.054	0.6PheTrp: 0.6 ± 0.026	0.882PheTyr: 0.882 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.03GlyAla: 10.03 ± 0.109	0.801GlyCys: 0.801 ± 0.027	5.128GlyAsp: 5.128 ± 0.095	4.599GlyGlu: 4.599 ± 0.071	3.706GlyPhe: 3.706 ± 0.065	7.584GlyGly: 7.584 ± 0.103	1.877GlyHis: 1.877 ± 0.046	4.779GlyIle: 4.779 ± 0.072	3.136GlyLys: 3.136 ± 0.06	9.121GlyLeu: 9.121 ± 0.111	2.668GlyMet: 2.668 ± 0.051	2.305GlyAsn: 2.305 ± 0.066	3.763GlyPro: 3.763 ± 0.061	3.396GlyGln: 3.396 ± 0.065	6.203GlyArg: 6.203 ± 0.083	4.391GlySer: 4.391 ± 0.072	4.689GlyThr: 4.689 ± 0.09	6.105GlyVal: 6.105 ± 0.087	1.614GlyTrp: 1.614 ± 0.038	2.187GlyTyr: 2.187 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.275HisAla: 2.275 ± 0.052	0.198HisCys: 0.198 ± 0.014	1.377HisAsp: 1.377 ± 0.034	1.029HisGlu: 1.029 ± 0.031	0.794HisPhe: 0.794 ± 0.024	1.907HisGly: 1.907 ± 0.041	0.583HisHis: 0.583 ± 0.028	1.033HisIle: 1.033 ± 0.032	0.477HisLys: 0.477 ± 0.021	2.009HisLeu: 2.009 ± 0.043	0.497HisMet: 0.497 ± 0.023	0.445HisAsn: 0.445 ± 0.018	1.322HisPro: 1.322 ± 0.033	0.583HisGln: 0.583 ± 0.021	1.371HisArg: 1.371 ± 0.037	0.924HisSer: 0.924 ± 0.029	0.745HisThr: 0.745 ± 0.03	1.415HisVal: 1.415 ± 0.037	0.332HisTrp: 0.332 ± 0.015	0.519HisTyr: 0.519 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	7.804IleAla: 7.804 ± 0.094	0.557IleCys: 0.557 ± 0.023	3.604IleAsp: 3.604 ± 0.062	3.426IleGlu: 3.426 ± 0.062	1.867IlePhe: 1.867 ± 0.041	5.315IleGly: 5.315 ± 0.075	0.962IleHis: 0.962 ± 0.03	2.369IleIle: 2.369 ± 0.055	1.141IleLys: 1.141 ± 0.033	4.698IleLeu: 4.698 ± 0.077	1.201IleMet: 1.201 ± 0.038	1.322IleAsn: 1.322 ± 0.036	2.447IlePro: 2.447 ± 0.047	1.144IleGln: 1.144 ± 0.03	3.765IleArg: 3.765 ± 0.062	3.104IleSer: 3.104 ± 0.048	2.837IleThr: 2.837 ± 0.056	3.943IleVal: 3.943 ± 0.061	0.84IleTrp: 0.84 ± 0.033	1.179IleTyr: 1.179 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.735LysAla: 3.735 ± 0.063	0.146LysCys: 0.146 ± 0.012	1.697LysAsp: 1.697 ± 0.04	1.354LysGlu: 1.354 ± 0.04	0.868LysPhe: 0.868 ± 0.026	2.513LysGly: 2.513 ± 0.058	0.554LysHis: 0.554 ± 0.021	1.574LysIle: 1.574 ± 0.04	1.042LysLys: 1.042 ± 0.035	2.927LysLeu: 2.927 ± 0.053	0.755LysMet: 0.755 ± 0.028	0.759LysAsn: 0.759 ± 0.025	1.849LysPro: 1.849 ± 0.044	0.881LysGln: 0.881 ± 0.033	2.047LysArg: 2.047 ± 0.049	1.627LysSer: 1.627 ± 0.039	1.649LysThr: 1.649 ± 0.042	2.093LysVal: 2.093 ± 0.057	0.345LysTrp: 0.345 ± 0.018	0.59LysTyr: 0.59 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.833LeuAla: 12.833 ± 0.122	0.826LeuCys: 0.826 ± 0.027	6.186LeuAsp: 6.186 ± 0.076	4.603LeuGlu: 4.603 ± 0.068	3.358LeuPhe: 3.358 ± 0.054	8.425LeuGly: 8.425 ± 0.096	1.873LeuHis: 1.873 ± 0.04	5.651LeuIle: 5.651 ± 0.077	2.87LeuLys: 2.87 ± 0.052	9.111LeuLeu: 9.111 ± 0.111	2.696LeuMet: 2.696 ± 0.045	2.727LeuAsn: 2.727 ± 0.05	5.899LeuPro: 5.899 ± 0.074	2.7LeuGln: 2.7 ± 0.052	7.361LeuArg: 7.361 ± 0.103	6.774LeuSer: 6.774 ± 0.078	5.861LeuThr: 5.861 ± 0.079	6.481LeuVal: 6.481 ± 0.086	1.268LeuTrp: 1.268 ± 0.038	1.855LeuTyr: 1.855 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.451MetAla: 3.451 ± 0.053	0.157MetCys: 0.157 ± 0.013	1.433MetAsp: 1.433 ± 0.033	1.22MetGlu: 1.22 ± 0.035	0.823MetPhe: 0.823 ± 0.03	2.205MetGly: 2.205 ± 0.046	0.439MetHis: 0.439 ± 0.018	1.629MetIle: 1.629 ± 0.041	1.054MetLys: 1.054 ± 0.03	2.796MetLeu: 2.796 ± 0.058	0.787MetMet: 0.787 ± 0.026	0.955MetAsn: 0.955 ± 0.031	1.697MetPro: 1.697 ± 0.036	0.997MetGln: 0.997 ± 0.028	2.045MetArg: 2.045 ± 0.043	1.825MetSer: 1.825 ± 0.04	2.106MetThr: 2.106 ± 0.042	1.824MetVal: 1.824 ± 0.043	0.271MetTrp: 0.271 ± 0.016	0.298MetTyr: 0.298 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.274AsnAla: 3.274 ± 0.061	0.237AsnCys: 0.237 ± 0.014	1.547AsnAsp: 1.547 ± 0.059	1.223AsnGlu: 1.223 ± 0.036	0.92AsnPhe: 0.92 ± 0.028	2.304AsnGly: 2.304 ± 0.053	0.528AsnHis: 0.528 ± 0.022	1.402AsnIle: 1.402 ± 0.034	0.593AsnLys: 0.593 ± 0.024	2.52AsnLeu: 2.52 ± 0.047	0.702AsnMet: 0.702 ± 0.026	0.662AsnAsn: 0.662 ± 0.033	1.87AsnPro: 1.87 ± 0.039	0.724AsnGln: 0.724 ± 0.029	1.861AsnArg: 1.861 ± 0.038	1.219AsnSer: 1.219 ± 0.038	1.202AsnThr: 1.202 ± 0.031	1.779AsnVal: 1.779 ± 0.046	0.488AsnTrp: 0.488 ± 0.023	0.682AsnTyr: 0.682 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.734ProAla: 6.734 ± 0.113	0.321ProCys: 0.321 ± 0.017	4.37ProAsp: 4.37 ± 0.072	4.159ProGlu: 4.159 ± 0.067	1.869ProPhe: 1.869 ± 0.039	4.776ProGly: 4.776 ± 0.069	1.074ProHis: 1.074 ± 0.031	2.239ProIle: 2.239 ± 0.043	1.553ProLys: 1.553 ± 0.045	4.599ProLeu: 4.599 ± 0.068	1.337ProMet: 1.337 ± 0.036	1.262ProAsn: 1.262 ± 0.034	2.627ProPro: 2.627 ± 0.054	1.765ProGln: 1.765 ± 0.042	3.007ProArg: 3.007 ± 0.047	2.556ProSer: 2.556 ± 0.055	2.366ProThr: 2.366 ± 0.046	4.454ProVal: 4.454 ± 0.061	0.68ProTrp: 0.68 ± 0.022	1.105ProTyr: 1.105 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.092GlnAla: 4.092 ± 0.057	0.196GlnCys: 0.196 ± 0.013	1.75GlnAsp: 1.75 ± 0.039	1.395GlnGlu: 1.395 ± 0.037	0.995GlnPhe: 0.995 ± 0.029	2.703GlnGly: 2.703 ± 0.048	0.602GlnHis: 0.602 ± 0.025	2.197GlnIle: 2.197 ± 0.046	1.073GlnLys: 1.073 ± 0.033	2.945GlnLeu: 2.945 ± 0.055	1.11GlnMet: 1.11 ± 0.035	0.982GlnAsn: 0.982 ± 0.032	1.842GlnPro: 1.842 ± 0.045	1.235GlnGln: 1.235 ± 0.041	2.293GlnArg: 2.293 ± 0.051	1.845GlnSer: 1.845 ± 0.04	1.773GlnThr: 1.773 ± 0.042	2.369GlnVal: 2.369 ± 0.048	0.347GlnTrp: 0.347 ± 0.017	0.543GlnTyr: 0.543 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.487ArgAla: 8.487 ± 0.099	0.463ArgCys: 0.463 ± 0.021	4.81ArgAsp: 4.81 ± 0.077	4.043ArgGlu: 4.043 ± 0.064	2.707ArgPhe: 2.707 ± 0.053	4.887ArgGly: 4.887 ± 0.07	1.624ArgHis: 1.624 ± 0.043	4.21ArgIle: 4.21 ± 0.055	2.183ArgLys: 2.183 ± 0.046	7.781ArgLeu: 7.781 ± 0.108	2.231ArgMet: 2.231 ± 0.048	1.862ArgAsn: 1.862 ± 0.04	3.64ArgPro: 3.64 ± 0.062	2.511ArgGln: 2.511 ± 0.052	5.553ArgArg: 5.553 ± 0.092	3.427ArgSer: 3.427 ± 0.064	2.843ArgThr: 2.843 ± 0.053	4.735ArgVal: 4.735 ± 0.07	1.008ArgTrp: 1.008 ± 0.03	1.577ArgTyr: 1.577 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.361SerAla: 6.361 ± 0.09	0.412SerCys: 0.412 ± 0.018	3.452SerAsp: 3.452 ± 0.058	2.789SerGlu: 2.789 ± 0.053	2.148SerPhe: 2.148 ± 0.045	5.685SerGly: 5.685 ± 0.087	1.038SerHis: 1.038 ± 0.027	2.404SerIle: 2.404 ± 0.049	1.335SerLys: 1.335 ± 0.033	5.029SerLeu: 5.029 ± 0.064	1.326SerMet: 1.326 ± 0.035	1.291SerAsn: 1.291 ± 0.034	2.733SerPro: 2.733 ± 0.051	1.644SerGln: 1.644 ± 0.04	3.679SerArg: 3.679 ± 0.067	2.582SerSer: 2.582 ± 0.061	2.448SerThr: 2.448 ± 0.05	3.762SerVal: 3.762 ± 0.067	0.797SerTrp: 0.797 ± 0.029	1.245SerTyr: 1.245 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.285ThrAla: 6.285 ± 0.077	0.426ThrCys: 0.426 ± 0.021	3.255ThrAsp: 3.255 ± 0.058	3.174ThrGlu: 3.174 ± 0.057	1.658ThrPhe: 1.658 ± 0.038	5.323ThrGly: 5.323 ± 0.083	0.997ThrHis: 0.997 ± 0.031	2.758ThrIle: 2.758 ± 0.058	1.301ThrLys: 1.301 ± 0.032	5.535ThrLeu: 5.535 ± 0.073	1.183ThrMet: 1.183 ± 0.033	1.277ThrAsn: 1.277 ± 0.04	3.32ThrPro: 3.32 ± 0.05	1.503ThrGln: 1.503 ± 0.037	3.61ThrArg: 3.61 ± 0.06	2.488ThrSer: 2.488 ± 0.048	2.706ThrThr: 2.706 ± 0.054	3.932ThrVal: 3.932 ± 0.055	0.593ThrTrp: 0.593 ± 0.024	1.06ThrTyr: 1.06 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.893ValAla: 8.893 ± 0.107	0.516ValCys: 0.516 ± 0.02	3.901ValAsp: 3.901 ± 0.062	4.187ValGlu: 4.187 ± 0.066	2.548ValPhe: 2.548 ± 0.046	5.024ValGly: 5.024 ± 0.066	1.2ValHis: 1.2 ± 0.037	4.268ValIle: 4.268 ± 0.069	1.999ValLys: 1.999 ± 0.042	7.072ValLeu: 7.072 ± 0.083	2.204ValMet: 2.204 ± 0.044	1.905ValAsn: 1.905 ± 0.047	3.555ValPro: 3.555 ± 0.056	1.96ValGln: 1.96 ± 0.043	4.053ValArg: 4.053 ± 0.058	3.971ValSer: 3.971 ± 0.059	4.594ValThr: 4.594 ± 0.074	5.24ValVal: 5.24 ± 0.077	0.976ValTrp: 0.976 ± 0.028	1.376ValTyr: 1.376 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.371TrpAla: 1.371 ± 0.037	0.12TrpCys: 0.12 ± 0.01	0.807TrpAsp: 0.807 ± 0.031	0.593TrpGlu: 0.593 ± 0.022	0.573TrpPhe: 0.573 ± 0.024	1.031TrpGly: 1.031 ± 0.029	0.356TrpHis: 0.356 ± 0.016	0.736TrpIle: 0.736 ± 0.027	0.453TrpLys: 0.453 ± 0.021	1.894TrpLeu: 1.894 ± 0.043	0.411TrpMet: 0.411 ± 0.02	0.423TrpAsn: 0.423 ± 0.019	0.774TrpPro: 0.774 ± 0.027	0.746TrpGln: 0.746 ± 0.026	1.198TrpArg: 1.198 ± 0.03	0.799TrpSer: 0.799 ± 0.028	0.782TrpThr: 0.782 ± 0.029	0.889TrpVal: 0.889 ± 0.027	0.266TrpTrp: 0.266 ± 0.016	0.297TrpTyr: 0.297 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.465TyrAla: 2.465 ± 0.046	0.22TyrCys: 0.22 ± 0.014	1.634TyrAsp: 1.634 ± 0.04	1.18TyrGlu: 1.18 ± 0.037	0.854TyrPhe: 0.854 ± 0.032	2.071TyrGly: 2.071 ± 0.046	0.481TyrHis: 0.481 ± 0.023	0.895TyrIle: 0.895 ± 0.027	0.477TyrLys: 0.477 ± 0.021	2.248TyrLeu: 2.248 ± 0.052	0.45TyrMet: 0.45 ± 0.021	0.543TyrAsn: 0.543 ± 0.022	1.08TyrPro: 1.08 ± 0.032	0.679TyrGln: 0.679 ± 0.025	1.597TyrArg: 1.597 ± 0.041	1.095TyrSer: 1.095 ± 0.033	1.015TyrThr: 1.015 ± 0.027	1.385TyrVal: 1.385 ± 0.037	0.345TyrTrp: 0.345 ± 0.016	0.566TyrTyr: 0.566 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3639 proteins (1145814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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