Amino acid dipepetide frequency for Agathobacter ruminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.473AlaAla: 6.473 ± 0.125	1.153AlaCys: 1.153 ± 0.037	4.95AlaAsp: 4.95 ± 0.079	5.241AlaGlu: 5.241 ± 0.092	3.167AlaPhe: 3.167 ± 0.069	5.439AlaGly: 5.439 ± 0.1	1.337AlaHis: 1.337 ± 0.042	5.921AlaIle: 5.921 ± 0.092	5.464AlaLys: 5.464 ± 0.087	6.877AlaLeu: 6.877 ± 0.09	2.47AlaMet: 2.47 ± 0.066	3.329AlaAsn: 3.329 ± 0.063	2.01AlaPro: 2.01 ± 0.056	2.84AlaGln: 2.84 ± 0.066	2.996AlaArg: 2.996 ± 0.064	4.251AlaSer: 4.251 ± 0.078	3.992AlaThr: 3.992 ± 0.078	5.748AlaVal: 5.748 ± 0.075	0.593AlaTrp: 0.593 ± 0.03	3.103AlaTyr: 3.103 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.037	0.238CysCys: 0.238 ± 0.021	0.934CysAsp: 0.934 ± 0.037	1.014CysGlu: 1.014 ± 0.037	0.62CysPhe: 0.62 ± 0.027	1.428CysGly: 1.428 ± 0.049	0.324CysHis: 0.324 ± 0.017	1.066CysIle: 1.066 ± 0.04	0.871CysLys: 0.871 ± 0.034	1.091CysLeu: 1.091 ± 0.033	0.471CysMet: 0.471 ± 0.023	0.629CysAsn: 0.629 ± 0.026	0.643CysPro: 0.643 ± 0.029	0.351CysGln: 0.351 ± 0.019	0.614CysArg: 0.614 ± 0.026	0.813CysSer: 0.813 ± 0.033	0.711CysThr: 0.711 ± 0.032	0.986CysVal: 0.986 ± 0.041	0.113CysTrp: 0.113 ± 0.012	0.629CysTyr: 0.629 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	5.067AspAla: 5.067 ± 0.097	0.982AspCys: 0.982 ± 0.037	3.494AspAsp: 3.494 ± 0.082	5.406AspGlu: 5.406 ± 0.077	2.92AspPhe: 2.92 ± 0.061	4.382AspGly: 4.382 ± 0.088	1.189AspHis: 1.189 ± 0.044	4.352AspIle: 4.352 ± 0.08	3.381AspLys: 3.381 ± 0.067	5.102AspLeu: 5.102 ± 0.084	1.859AspMet: 1.859 ± 0.043	2.304AspAsn: 2.304 ± 0.051	1.879AspPro: 1.879 ± 0.054	1.588AspGln: 1.588 ± 0.047	2.581AspArg: 2.581 ± 0.059	3.266AspSer: 3.266 ± 0.064	3.003AspThr: 3.003 ± 0.069	4.068AspVal: 4.068 ± 0.074	0.641AspTrp: 0.641 ± 0.026	3.169AspTyr: 3.169 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.702GluAla: 5.702 ± 0.101	0.848GluCys: 0.848 ± 0.029	4.318GluAsp: 4.318 ± 0.085	6.549GluGlu: 6.549 ± 0.096	2.624GluPhe: 2.624 ± 0.059	3.961GluGly: 3.961 ± 0.072	1.497GluHis: 1.497 ± 0.041	5.847GluIle: 5.847 ± 0.089	5.918GluLys: 5.918 ± 0.095	6.626GluLeu: 6.626 ± 0.102	2.619GluMet: 2.619 ± 0.057	4.06GluAsn: 4.06 ± 0.077	1.866GluPro: 1.866 ± 0.055	3.213GluGln: 3.213 ± 0.068	3.251GluArg: 3.251 ± 0.072	3.789GluSer: 3.789 ± 0.068	3.917GluThr: 3.917 ± 0.074	4.357GluVal: 4.357 ± 0.078	0.625GluTrp: 0.625 ± 0.027	3.312GluTyr: 3.312 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.354PheAla: 3.354 ± 0.07	0.7PheCys: 0.7 ± 0.025	2.906PheAsp: 2.906 ± 0.062	2.976PheGlu: 2.976 ± 0.059	1.782PhePhe: 1.782 ± 0.052	2.995PheGly: 2.995 ± 0.071	0.885PheHis: 0.885 ± 0.03	2.673PheIle: 2.673 ± 0.068	1.936PheLys: 1.936 ± 0.052	3.648PheLeu: 3.648 ± 0.082	1.254PheMet: 1.254 ± 0.04	1.524PheAsn: 1.524 ± 0.047	1.306PhePro: 1.306 ± 0.044	1.167PheGln: 1.167 ± 0.038	1.763PheArg: 1.763 ± 0.051	2.677PheSer: 2.677 ± 0.058	2.282PheThr: 2.282 ± 0.059	3.215PheVal: 3.215 ± 0.054	0.448PheTrp: 0.448 ± 0.023	1.77PheTyr: 1.77 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.738GlyAla: 4.738 ± 0.081	1.16GlyCys: 1.16 ± 0.037	3.55GlyAsp: 3.55 ± 0.075	4.31GlyGlu: 4.31 ± 0.078	3.104GlyPhe: 3.104 ± 0.066	4.413GlyGly: 4.413 ± 0.097	1.236GlyHis: 1.236 ± 0.037	5.799GlyIle: 5.799 ± 0.081	5.162GlyLys: 5.162 ± 0.089	5.514GlyLeu: 5.514 ± 0.089	2.357GlyMet: 2.357 ± 0.059	3.134GlyAsn: 3.134 ± 0.073	1.383GlyPro: 1.383 ± 0.041	1.959GlyGln: 1.959 ± 0.054	2.845GlyArg: 2.845 ± 0.061	3.703GlySer: 3.703 ± 0.074	3.933GlyThr: 3.933 ± 0.076	4.577GlyVal: 4.577 ± 0.083	0.679GlyTrp: 0.679 ± 0.031	3.296GlyTyr: 3.296 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.378HisAla: 1.378 ± 0.044	0.356HisCys: 0.356 ± 0.022	1.05HisAsp: 1.05 ± 0.041	1.308HisGlu: 1.308 ± 0.041	0.98HisPhe: 0.98 ± 0.031	1.337HisGly: 1.337 ± 0.041	0.479HisHis: 0.479 ± 0.03	1.468HisIle: 1.468 ± 0.042	0.946HisLys: 0.946 ± 0.03	1.697HisLeu: 1.697 ± 0.048	0.65HisMet: 0.65 ± 0.028	0.814HisAsn: 0.814 ± 0.039	0.999HisPro: 0.999 ± 0.039	0.591HisGln: 0.591 ± 0.023	0.877HisArg: 0.877 ± 0.032	1.051HisSer: 1.051 ± 0.04	1.006HisThr: 1.006 ± 0.037	1.28HisVal: 1.28 ± 0.038	0.197HisTrp: 0.197 ± 0.015	0.897HisTyr: 0.897 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.335IleAla: 6.335 ± 0.101	1.361IleCys: 1.361 ± 0.044	4.563IleAsp: 4.563 ± 0.079	5.108IleGlu: 5.108 ± 0.089	2.798IlePhe: 2.798 ± 0.068	5.18IleGly: 5.18 ± 0.091	1.428IleHis: 1.428 ± 0.043	5.113IleIle: 5.113 ± 0.115	3.987IleLys: 3.987 ± 0.074	6.771IleLeu: 6.771 ± 0.101	2.047IleMet: 2.047 ± 0.052	3.11IleAsn: 3.11 ± 0.066	3.047IlePro: 3.047 ± 0.064	2.166IleGln: 2.166 ± 0.049	3.66IleArg: 3.66 ± 0.069	4.823IleSer: 4.823 ± 0.087	4.159IleThr: 4.159 ± 0.073	5.078IleVal: 5.078 ± 0.081	0.645IleTrp: 0.645 ± 0.027	3.001IleTyr: 3.001 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.031LysAla: 5.031 ± 0.082	0.709LysCys: 0.709 ± 0.029	4.037LysAsp: 4.037 ± 0.074	5.885LysGlu: 5.885 ± 0.09	1.973LysPhe: 1.973 ± 0.05	3.895LysGly: 3.895 ± 0.071	1.186LysHis: 1.186 ± 0.038	4.59LysIle: 4.59 ± 0.069	5.697LysLys: 5.697 ± 0.096	5.023LysLeu: 5.023 ± 0.079	2.097LysMet: 2.097 ± 0.049	3.609LysAsn: 3.609 ± 0.075	2.0LysPro: 2.0 ± 0.05	2.425LysGln: 2.425 ± 0.052	2.94LysArg: 2.94 ± 0.068	3.412LysSer: 3.412 ± 0.069	3.626LysThr: 3.626 ± 0.069	4.096LysVal: 4.096 ± 0.085	0.63LysTrp: 0.63 ± 0.027	2.947LysTyr: 2.947 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.8LeuAla: 6.8 ± 0.1	1.433LeuCys: 1.433 ± 0.047	5.256LeuAsp: 5.256 ± 0.083	5.907LeuGlu: 5.907 ± 0.101	3.759LeuPhe: 3.759 ± 0.086	5.366LeuGly: 5.366 ± 0.084	1.606LeuHis: 1.606 ± 0.039	6.261LeuIle: 6.261 ± 0.103	5.52LeuLys: 5.52 ± 0.085	8.023LeuLeu: 8.023 ± 0.125	2.521LeuMet: 2.521 ± 0.059	4.038LeuAsn: 4.038 ± 0.074	3.161LeuPro: 3.161 ± 0.061	2.991LeuGln: 2.991 ± 0.065	3.623LeuArg: 3.623 ± 0.062	6.136LeuSer: 6.136 ± 0.098	4.808LeuThr: 4.808 ± 0.079	5.388LeuVal: 5.388 ± 0.085	0.676LeuTrp: 0.676 ± 0.035	3.309LeuTyr: 3.309 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.444MetAla: 2.444 ± 0.062	0.342MetCys: 0.342 ± 0.018	2.024MetAsp: 2.024 ± 0.056	2.368MetGlu: 2.368 ± 0.061	1.107MetPhe: 1.107 ± 0.044	2.049MetGly: 2.049 ± 0.059	0.608MetHis: 0.608 ± 0.029	2.299MetIle: 2.299 ± 0.052	2.388MetLys: 2.388 ± 0.048	2.631MetLeu: 2.631 ± 0.056	1.014MetMet: 1.014 ± 0.033	1.69MetAsn: 1.69 ± 0.041	1.108MetPro: 1.108 ± 0.036	1.21MetGln: 1.21 ± 0.039	1.441MetArg: 1.441 ± 0.042	1.852MetSer: 1.852 ± 0.053	1.814MetThr: 1.814 ± 0.049	2.012MetVal: 2.012 ± 0.044	0.191MetTrp: 0.191 ± 0.014	0.93MetTyr: 0.93 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.538AsnAla: 3.538 ± 0.065	0.644AsnCys: 0.644 ± 0.028	2.428AsnAsp: 2.428 ± 0.055	3.262AsnGlu: 3.262 ± 0.066	1.652AsnPhe: 1.652 ± 0.046	3.618AsnGly: 3.618 ± 0.063	1.177AsnHis: 1.177 ± 0.04	3.351AsnIle: 3.351 ± 0.072	2.542AsnLys: 2.542 ± 0.063	4.052AsnLeu: 4.052 ± 0.069	1.399AsnMet: 1.399 ± 0.043	1.939AsnAsn: 1.939 ± 0.059	2.146AsnPro: 2.146 ± 0.049	1.825AsnGln: 1.825 ± 0.049	2.267AsnArg: 2.267 ± 0.052	2.361AsnSer: 2.361 ± 0.062	2.278AsnThr: 2.278 ± 0.052	2.997AsnVal: 2.997 ± 0.057	0.49AsnTrp: 0.49 ± 0.026	2.084AsnTyr: 2.084 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.275ProAla: 2.275 ± 0.06	0.411ProCys: 0.411 ± 0.023	2.326ProAsp: 2.326 ± 0.052	2.996ProGlu: 2.996 ± 0.064	1.415ProPhe: 1.415 ± 0.04	2.064ProGly: 2.064 ± 0.048	0.583ProHis: 0.583 ± 0.028	2.316ProIle: 2.316 ± 0.054	1.961ProLys: 1.961 ± 0.05	2.546ProLeu: 2.546 ± 0.06	0.975ProMet: 0.975 ± 0.032	1.443ProAsn: 1.443 ± 0.038	0.608ProPro: 0.608 ± 0.031	1.189ProGln: 1.189 ± 0.04	1.001ProArg: 1.001 ± 0.038	1.753ProSer: 1.753 ± 0.051	1.615ProThr: 1.615 ± 0.05	2.632ProVal: 2.632 ± 0.062	0.314ProTrp: 0.314 ± 0.02	1.444ProTyr: 1.444 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.421GlnAla: 2.421 ± 0.06	0.354GlnCys: 0.354 ± 0.019	1.619GlnAsp: 1.619 ± 0.042	2.573GlnGlu: 2.573 ± 0.061	1.305GlnPhe: 1.305 ± 0.037	1.757GlnGly: 1.757 ± 0.049	0.545GlnHis: 0.545 ± 0.028	2.833GlnIle: 2.833 ± 0.059	2.937GlnLys: 2.937 ± 0.062	3.031GlnLeu: 3.031 ± 0.057	1.397GlnMet: 1.397 ± 0.041	1.755GlnAsn: 1.755 ± 0.051	0.916GlnPro: 0.916 ± 0.034	1.282GlnGln: 1.282 ± 0.041	1.301GlnArg: 1.301 ± 0.04	1.905GlnSer: 1.905 ± 0.052	1.943GlnThr: 1.943 ± 0.048	2.054GlnVal: 2.054 ± 0.049	0.306GlnTrp: 0.306 ± 0.019	1.496GlnTyr: 1.496 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.981ArgAla: 2.981 ± 0.061	0.48ArgCys: 0.48 ± 0.027	2.475ArgAsp: 2.475 ± 0.058	3.627ArgGlu: 3.627 ± 0.076	1.875ArgPhe: 1.875 ± 0.045	2.434ArgGly: 2.434 ± 0.054	0.811ArgHis: 0.811 ± 0.031	3.559ArgIle: 3.559 ± 0.065	3.276ArgLys: 3.276 ± 0.07	3.776ArgLeu: 3.776 ± 0.072	1.656ArgMet: 1.656 ± 0.048	2.2ArgAsn: 2.2 ± 0.052	1.227ArgPro: 1.227 ± 0.04	1.462ArgGln: 1.462 ± 0.037	2.166ArgArg: 2.166 ± 0.054	2.028ArgSer: 2.028 ± 0.048	2.22ArgThr: 2.22 ± 0.05	2.869ArgVal: 2.869 ± 0.059	0.344ArgTrp: 0.344 ± 0.023	1.824ArgTyr: 1.824 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.485SerAla: 4.485 ± 0.078	0.782SerCys: 0.782 ± 0.033	3.631SerAsp: 3.631 ± 0.073	3.939SerGlu: 3.939 ± 0.082	2.614SerPhe: 2.614 ± 0.068	4.557SerGly: 4.557 ± 0.077	1.096SerHis: 1.096 ± 0.037	4.073SerIle: 4.073 ± 0.079	3.484SerLys: 3.484 ± 0.067	4.882SerLeu: 4.882 ± 0.079	1.852SerMet: 1.852 ± 0.043	2.614SerAsn: 2.614 ± 0.057	1.562SerPro: 1.562 ± 0.045	1.775SerGln: 1.775 ± 0.043	2.463SerArg: 2.463 ± 0.058	3.27SerSer: 3.27 ± 0.072	2.853SerThr: 2.853 ± 0.058	4.395SerVal: 4.395 ± 0.088	0.514SerTrp: 0.514 ± 0.025	2.506SerTyr: 2.506 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	4.218ThrAla: 4.218 ± 0.079	0.685ThrCys: 0.685 ± 0.025	3.282ThrAsp: 3.282 ± 0.069	3.793ThrGlu: 3.793 ± 0.091	2.202ThrPhe: 2.202 ± 0.056	4.3ThrGly: 4.3 ± 0.076	0.919ThrHis: 0.919 ± 0.033	4.356ThrIle: 4.356 ± 0.078	3.286ThrLys: 3.286 ± 0.064	4.393ThrLeu: 4.393 ± 0.081	1.482ThrMet: 1.482 ± 0.044	2.4ThrAsn: 2.4 ± 0.051	1.941ThrPro: 1.941 ± 0.053	1.699ThrGln: 1.699 ± 0.053	2.016ThrArg: 2.016 ± 0.051	2.802ThrSer: 2.802 ± 0.059	2.92ThrThr: 2.92 ± 0.067	4.402ThrVal: 4.402 ± 0.08	0.437ThrTrp: 0.437 ± 0.025	2.253ThrTyr: 2.253 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	5.356ValAla: 5.356 ± 0.084	1.178ValCys: 1.178 ± 0.042	4.236ValAsp: 4.236 ± 0.081	4.692ValGlu: 4.692 ± 0.076	2.952ValPhe: 2.952 ± 0.059	4.287ValGly: 4.287 ± 0.076	1.205ValHis: 1.205 ± 0.043	5.055ValIle: 5.055 ± 0.075	4.218ValLys: 4.218 ± 0.072	6.261ValLeu: 6.261 ± 0.087	1.959ValMet: 1.959 ± 0.049	3.034ValAsn: 3.034 ± 0.065	2.314ValPro: 2.314 ± 0.057	1.924ValGln: 1.924 ± 0.047	2.915ValArg: 2.915 ± 0.061	4.511ValSer: 4.511 ± 0.084	4.014ValThr: 4.014 ± 0.079	4.932ValVal: 4.932 ± 0.087	0.599ValTrp: 0.599 ± 0.025	2.792ValTyr: 2.792 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.563TrpAla: 0.563 ± 0.031	0.134TrpCys: 0.134 ± 0.012	0.541TrpAsp: 0.541 ± 0.024	0.628TrpGlu: 0.628 ± 0.025	0.422TrpPhe: 0.422 ± 0.024	0.563TrpGly: 0.563 ± 0.024	0.171TrpHis: 0.171 ± 0.015	0.666TrpIle: 0.666 ± 0.034	0.644TrpLys: 0.644 ± 0.031	0.764TrpLeu: 0.764 ± 0.029	0.358TrpMet: 0.358 ± 0.018	0.588TrpAsn: 0.588 ± 0.028	0.237TrpPro: 0.237 ± 0.018	0.334TrpGln: 0.334 ± 0.021	0.335TrpArg: 0.335 ± 0.023	0.513TrpSer: 0.513 ± 0.027	0.43TrpThr: 0.43 ± 0.022	0.525TrpVal: 0.525 ± 0.023	0.11TrpTrp: 0.11 ± 0.013	0.391TrpTyr: 0.391 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.124TyrAla: 3.124 ± 0.065	0.669TyrCys: 0.669 ± 0.028	3.013TyrAsp: 3.013 ± 0.06	3.316TyrGlu: 3.316 ± 0.069	1.99TyrPhe: 1.99 ± 0.043	2.825TyrGly: 2.825 ± 0.055	1.079TyrHis: 1.079 ± 0.036	2.783TyrIle: 2.783 ± 0.059	2.193TyrLys: 2.193 ± 0.059	3.874TyrLeu: 3.874 ± 0.073	1.084TyrMet: 1.084 ± 0.038	1.834TyrAsn: 1.834 ± 0.05	1.512TyrPro: 1.512 ± 0.044	1.742TyrGln: 1.742 ± 0.045	2.238TyrArg: 2.238 ± 0.059	2.431TyrSer: 2.431 ± 0.06	2.259TyrThr: 2.259 ± 0.058	2.822TyrVal: 2.822 ± 0.06	0.366TyrTrp: 0.366 ± 0.021	2.156TyrTyr: 2.156 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2568 proteins (859823 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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