Amino acid dipepetide frequency for Tenacibaculum maritimum NCIMB 2154

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.849AlaAla: 3.849 ± 0.09	0.529AlaCys: 0.529 ± 0.022	2.995AlaAsp: 2.995 ± 0.142	3.257AlaGlu: 3.257 ± 0.061	3.136AlaPhe: 3.136 ± 0.058	3.701AlaGly: 3.701 ± 0.105	1.103AlaHis: 1.103 ± 0.04	5.942AlaIle: 5.942 ± 0.117	5.087AlaLys: 5.087 ± 0.08	5.809AlaLeu: 5.809 ± 0.083	1.386AlaMet: 1.386 ± 0.04	3.474AlaAsn: 3.474 ± 0.084	2.013AlaPro: 2.013 ± 0.055	2.018AlaGln: 2.018 ± 0.048	1.875AlaArg: 1.875 ± 0.054	4.151AlaSer: 4.151 ± 0.071	4.095AlaThr: 4.095 ± 0.125	3.66AlaVal: 3.66 ± 0.073	0.49AlaTrp: 0.49 ± 0.025	2.496AlaTyr: 2.496 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.383CysAla: 0.383 ± 0.019	0.085CysCys: 0.085 ± 0.011	0.449CysAsp: 0.449 ± 0.039	0.457CysGlu: 0.457 ± 0.033	0.439CysPhe: 0.439 ± 0.023	0.543CysGly: 0.543 ± 0.028	0.201CysHis: 0.201 ± 0.018	0.625CysIle: 0.625 ± 0.028	0.625CysLys: 0.625 ± 0.026	0.595CysLeu: 0.595 ± 0.025	0.152CysMet: 0.152 ± 0.013	0.511CysAsn: 0.511 ± 0.023	0.286CysPro: 0.286 ± 0.019	0.196CysGln: 0.196 ± 0.015	0.181CysArg: 0.181 ± 0.012	0.599CysSer: 0.599 ± 0.027	0.478CysThr: 0.478 ± 0.038	0.405CysVal: 0.405 ± 0.02	0.074CysTrp: 0.074 ± 0.01	0.283CysTyr: 0.283 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.46AspAla: 3.46 ± 0.104	0.423AspCys: 0.423 ± 0.023	2.526AspAsp: 2.526 ± 0.085	3.127AspGlu: 3.127 ± 0.069	3.512AspPhe: 3.512 ± 0.068	3.247AspGly: 3.247 ± 0.138	0.825AspHis: 0.825 ± 0.024	4.36AspIle: 4.36 ± 0.069	4.227AspLys: 4.227 ± 0.08	4.718AspLeu: 4.718 ± 0.077	0.915AspMet: 0.915 ± 0.033	2.853AspAsn: 2.853 ± 0.077	1.474AspPro: 1.474 ± 0.063	1.155AspGln: 1.155 ± 0.04	1.726AspArg: 1.726 ± 0.043	2.765AspSer: 2.765 ± 0.061	2.952AspThr: 2.952 ± 0.073	3.194AspVal: 3.194 ± 0.076	0.647AspTrp: 0.647 ± 0.026	2.527AspTyr: 2.527 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.265GluAla: 4.265 ± 0.077	0.342GluCys: 0.342 ± 0.018	3.137GluAsp: 3.137 ± 0.06	5.442GluGlu: 5.442 ± 0.104	2.857GluPhe: 2.857 ± 0.054	3.925GluGly: 3.925 ± 0.087	1.098GluHis: 1.098 ± 0.038	5.85GluIle: 5.85 ± 0.085	6.757GluLys: 6.757 ± 0.11	5.923GluLeu: 5.923 ± 0.083	1.413GluMet: 1.413 ± 0.035	4.752GluAsn: 4.752 ± 0.092	1.24GluPro: 1.24 ± 0.039	2.083GluGln: 2.083 ± 0.045	2.481GluArg: 2.481 ± 0.057	2.961GluSer: 2.961 ± 0.05	3.365GluThr: 3.365 ± 0.079	4.554GluVal: 4.554 ± 0.089	0.575GluTrp: 0.575 ± 0.024	2.571GluTyr: 2.571 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.633PheAla: 2.633 ± 0.056	0.422PheCys: 0.422 ± 0.021	2.999PheAsp: 2.999 ± 0.065	3.218PheGlu: 3.218 ± 0.075	2.896PhePhe: 2.896 ± 0.07	3.229PheGly: 3.229 ± 0.062	0.86PheHis: 0.86 ± 0.03	4.448PheIle: 4.448 ± 0.1	4.266PheLys: 4.266 ± 0.075	4.916PheLeu: 4.916 ± 0.097	1.045PheMet: 1.045 ± 0.033	3.329PheAsn: 3.329 ± 0.067	1.664PhePro: 1.664 ± 0.046	1.465PheGln: 1.465 ± 0.041	1.533PheArg: 1.533 ± 0.043	4.223PheSer: 4.223 ± 0.082	3.113PheThr: 3.113 ± 0.059	2.774PheVal: 2.774 ± 0.05	0.548PheTrp: 0.548 ± 0.027	2.332PheTyr: 2.332 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.314GlyAla: 4.314 ± 0.1	0.564GlyCys: 0.564 ± 0.038	3.102GlyAsp: 3.102 ± 0.09	3.471GlyGlu: 3.471 ± 0.076	3.525GlyPhe: 3.525 ± 0.063	4.618GlyGly: 4.618 ± 0.101	1.092GlyHis: 1.092 ± 0.041	5.497GlyIle: 5.497 ± 0.076	5.503GlyLys: 5.503 ± 0.079	5.198GlyLeu: 5.198 ± 0.088	1.407GlyMet: 1.407 ± 0.041	3.816GlyAsn: 3.816 ± 0.086	1.018GlyPro: 1.018 ± 0.039	1.563GlyGln: 1.563 ± 0.046	2.103GlyArg: 2.103 ± 0.055	3.615GlySer: 3.615 ± 0.106	4.079GlyThr: 4.079 ± 0.127	4.411GlyVal: 4.411 ± 0.106	0.725GlyTrp: 0.725 ± 0.029	2.732GlyTyr: 2.732 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.926HisAla: 0.926 ± 0.034	0.149HisCys: 0.149 ± 0.013	0.792HisAsp: 0.792 ± 0.036	1.027HisGlu: 1.027 ± 0.035	1.151HisPhe: 1.151 ± 0.036	1.034HisGly: 1.034 ± 0.039	0.545HisHis: 0.545 ± 0.032	1.586HisIle: 1.586 ± 0.041	1.606HisLys: 1.606 ± 0.046	1.833HisLeu: 1.833 ± 0.042	0.322HisMet: 0.322 ± 0.019	0.988HisAsn: 0.988 ± 0.037	0.921HisPro: 0.921 ± 0.038	0.855HisGln: 0.855 ± 0.032	0.67HisArg: 0.67 ± 0.029	1.054HisSer: 1.054 ± 0.035	1.11HisThr: 1.11 ± 0.038	0.845HisVal: 0.845 ± 0.026	0.213HisTrp: 0.213 ± 0.016	0.841HisTyr: 0.841 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.918IleAla: 5.918 ± 0.089	0.665IleCys: 0.665 ± 0.033	4.954IleAsp: 4.954 ± 0.081	5.568IleGlu: 5.568 ± 0.078	3.681IlePhe: 3.681 ± 0.084	5.346IleGly: 5.346 ± 0.081	1.614IleHis: 1.614 ± 0.046	6.446IleIle: 6.446 ± 0.117	6.853IleLys: 6.853 ± 0.091	7.233IleLeu: 7.233 ± 0.1	1.316IleMet: 1.316 ± 0.037	5.208IleAsn: 5.208 ± 0.093	3.448IlePro: 3.448 ± 0.064	2.872IleGln: 2.872 ± 0.054	2.728IleArg: 2.728 ± 0.048	5.964IleSer: 5.964 ± 0.093	5.484IleThr: 5.484 ± 0.117	4.716IleVal: 4.716 ± 0.078	0.672IleTrp: 0.672 ± 0.03	3.097IleTyr: 3.097 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.118LysAla: 5.118 ± 0.085	0.408LysCys: 0.408 ± 0.021	4.538LysAsp: 4.538 ± 0.067	8.406LysGlu: 8.406 ± 0.134	3.01LysPhe: 3.01 ± 0.065	5.53LysGly: 5.53 ± 0.088	1.695LysHis: 1.695 ± 0.044	7.395LysIle: 7.395 ± 0.108	9.496LysLys: 9.496 ± 0.143	7.25LysLeu: 7.25 ± 0.097	2.16LysMet: 2.16 ± 0.053	6.376LysAsn: 6.376 ± 0.106	2.443LysPro: 2.443 ± 0.049	3.056LysGln: 3.056 ± 0.06	3.445LysArg: 3.445 ± 0.077	4.812LysSer: 4.812 ± 0.082	5.076LysThr: 5.076 ± 0.083	5.163LysVal: 5.163 ± 0.079	0.878LysTrp: 0.878 ± 0.034	3.635LysTyr: 3.635 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.522LeuAla: 5.522 ± 0.093	0.602LeuCys: 0.602 ± 0.026	4.476LeuAsp: 4.476 ± 0.097	6.003LeuGlu: 6.003 ± 0.091	4.953LeuPhe: 4.953 ± 0.093	5.718LeuGly: 5.718 ± 0.092	1.753LeuHis: 1.753 ± 0.062	7.032LeuIle: 7.032 ± 0.101	8.727LeuLys: 8.727 ± 0.106	8.822LeuLeu: 8.822 ± 0.146	1.766LeuMet: 1.766 ± 0.05	5.489LeuAsn: 5.489 ± 0.088	3.436LeuPro: 3.436 ± 0.065	3.111LeuGln: 3.111 ± 0.068	3.099LeuArg: 3.099 ± 0.065	6.532LeuSer: 6.532 ± 0.084	5.028LeuThr: 5.028 ± 0.079	4.988LeuVal: 4.988 ± 0.083	0.749LeuTrp: 0.749 ± 0.03	3.383LeuTyr: 3.383 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.356MetAla: 1.356 ± 0.041	0.134MetCys: 0.134 ± 0.011	0.953MetAsp: 0.953 ± 0.031	1.279MetGlu: 1.279 ± 0.041	0.783MetPhe: 0.783 ± 0.032	1.199MetGly: 1.199 ± 0.037	0.4MetHis: 0.4 ± 0.021	1.488MetIle: 1.488 ± 0.044	2.106MetLys: 2.106 ± 0.047	1.846MetLeu: 1.846 ± 0.045	0.504MetMet: 0.504 ± 0.027	1.322MetAsn: 1.322 ± 0.038	0.726MetPro: 0.726 ± 0.027	0.665MetGln: 0.665 ± 0.026	0.802MetArg: 0.802 ± 0.029	1.322MetSer: 1.322 ± 0.036	1.013MetThr: 1.013 ± 0.033	1.278MetVal: 1.278 ± 0.034	0.147MetTrp: 0.147 ± 0.011	0.677MetTyr: 0.677 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.776AsnAla: 3.776 ± 0.066	0.551AsnCys: 0.551 ± 0.04	3.221AsnAsp: 3.221 ± 0.086	3.744AsnGlu: 3.744 ± 0.071	3.218AsnPhe: 3.218 ± 0.071	4.103AsnGly: 4.103 ± 0.104	1.237AsnHis: 1.237 ± 0.045	5.26AsnIle: 5.26 ± 0.098	5.284AsnLys: 5.284 ± 0.086	5.557AsnLeu: 5.557 ± 0.094	1.202AsnMet: 1.202 ± 0.04	4.367AsnAsn: 4.367 ± 0.086	2.591AsnPro: 2.591 ± 0.067	2.098AsnGln: 2.098 ± 0.042	2.195AsnArg: 2.195 ± 0.045	3.962AsnSer: 3.962 ± 0.067	4.293AsnThr: 4.293 ± 0.095	3.32AsnVal: 3.32 ± 0.076	0.786AsnTrp: 0.786 ± 0.03	3.131AsnTyr: 3.131 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.788ProAla: 1.788 ± 0.076	0.242ProCys: 0.242 ± 0.017	1.629ProAsp: 1.629 ± 0.054	2.282ProGlu: 2.282 ± 0.06	1.865ProPhe: 1.865 ± 0.04	1.475ProGly: 1.475 ± 0.039	0.602ProHis: 0.602 ± 0.024	2.99ProIle: 2.99 ± 0.058	2.991ProLys: 2.991 ± 0.063	2.817ProLeu: 2.817 ± 0.056	0.659ProMet: 0.659 ± 0.03	2.444ProAsn: 2.444 ± 0.06	0.845ProPro: 0.845 ± 0.034	0.933ProGln: 0.933 ± 0.032	0.889ProArg: 0.889 ± 0.031	2.262ProSer: 2.262 ± 0.054	1.991ProThr: 1.991 ± 0.054	2.034ProVal: 2.034 ± 0.066	0.341ProTrp: 0.341 ± 0.019	1.42ProTyr: 1.42 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.647GlnAla: 1.647 ± 0.043	0.187GlnCys: 0.187 ± 0.014	1.325GlnAsp: 1.325 ± 0.046	2.293GlnGlu: 2.293 ± 0.054	1.558GlnPhe: 1.558 ± 0.044	1.713GlnGly: 1.713 ± 0.052	0.637GlnHis: 0.637 ± 0.025	2.603GlnIle: 2.603 ± 0.048	3.348GlnLys: 3.348 ± 0.066	3.323GlnLeu: 3.323 ± 0.066	0.692GlnMet: 0.692 ± 0.029	1.938GlnAsn: 1.938 ± 0.056	0.964GlnPro: 0.964 ± 0.034	1.503GlnGln: 1.503 ± 0.048	1.213GlnArg: 1.213 ± 0.036	1.739GlnSer: 1.739 ± 0.044	1.687GlnThr: 1.687 ± 0.039	1.776GlnVal: 1.776 ± 0.043	0.321GlnTrp: 0.321 ± 0.02	1.348GlnTyr: 1.348 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.041ArgAla: 2.041 ± 0.048	0.195ArgCys: 0.195 ± 0.014	1.542ArgAsp: 1.542 ± 0.045	2.22ArgGlu: 2.22 ± 0.047	1.918ArgPhe: 1.918 ± 0.046	1.999ArgGly: 1.999 ± 0.049	0.554ArgHis: 0.554 ± 0.023	2.994ArgIle: 2.994 ± 0.059	3.31ArgLys: 3.31 ± 0.065	3.186ArgLeu: 3.186 ± 0.059	0.816ArgMet: 0.816 ± 0.03	2.24ArgAsn: 2.24 ± 0.049	0.936ArgPro: 0.936 ± 0.031	0.931ArgGln: 0.931 ± 0.039	1.32ArgArg: 1.32 ± 0.043	1.827ArgSer: 1.827 ± 0.051	1.709ArgThr: 1.709 ± 0.048	2.094ArgVal: 2.094 ± 0.045	0.342ArgTrp: 0.342 ± 0.019	1.574ArgTyr: 1.574 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.276SerAla: 3.276 ± 0.058	0.75SerCys: 0.75 ± 0.031	3.052SerAsp: 3.052 ± 0.056	3.817SerGlu: 3.817 ± 0.067	4.222SerPhe: 4.222 ± 0.083	4.127SerGly: 4.127 ± 0.111	0.989SerHis: 0.989 ± 0.032	5.451SerIle: 5.451 ± 0.094	5.637SerLys: 5.637 ± 0.082	6.251SerLeu: 6.251 ± 0.099	1.154SerMet: 1.154 ± 0.034	4.151SerAsn: 4.151 ± 0.077	2.044SerPro: 2.044 ± 0.05	1.88SerGln: 1.88 ± 0.047	1.944SerArg: 1.944 ± 0.04	4.513SerSer: 4.513 ± 0.095	3.455SerThr: 3.455 ± 0.077	3.535SerVal: 3.535 ± 0.066	0.679SerTrp: 0.679 ± 0.025	3.013SerTyr: 3.013 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	3.699ThrAla: 3.699 ± 0.099	0.384ThrCys: 0.384 ± 0.025	3.08ThrAsp: 3.08 ± 0.092	3.334ThrGlu: 3.334 ± 0.055	2.922ThrPhe: 2.922 ± 0.046	3.951ThrGly: 3.951 ± 0.134	1.085ThrHis: 1.085 ± 0.033	5.426ThrIle: 5.426 ± 0.097	4.616ThrLys: 4.616 ± 0.083	5.293ThrLeu: 5.293 ± 0.094	0.929ThrMet: 0.929 ± 0.031	3.636ThrAsn: 3.636 ± 0.083	2.868ThrPro: 2.868 ± 0.127	1.804ThrGln: 1.804 ± 0.045	1.631ThrArg: 1.631 ± 0.045	4.236ThrSer: 4.236 ± 0.081	3.867ThrThr: 3.867 ± 0.1	3.836ThrVal: 3.836 ± 0.119	0.59ThrTrp: 0.59 ± 0.028	2.591ThrTyr: 2.591 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	4.195ValAla: 4.195 ± 0.084	0.487ValCys: 0.487 ± 0.023	3.053ValAsp: 3.053 ± 0.069	3.482ValGlu: 3.482 ± 0.081	3.227ValPhe: 3.227 ± 0.07	3.608ValGly: 3.608 ± 0.075	1.041ValHis: 1.041 ± 0.036	4.585ValIle: 4.585 ± 0.073	4.682ValLys: 4.682 ± 0.084	5.75ValLeu: 5.75 ± 0.082	1.104ValMet: 1.104 ± 0.037	3.601ValAsn: 3.601 ± 0.076	1.977ValPro: 1.977 ± 0.057	1.654ValGln: 1.654 ± 0.037	1.917ValArg: 1.917 ± 0.047	4.254ValSer: 4.254 ± 0.099	3.772ValThr: 3.772 ± 0.168	4.02ValVal: 4.02 ± 0.124	0.616ValTrp: 0.616 ± 0.025	2.352ValTyr: 2.352 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.534TrpAla: 0.534 ± 0.028	0.092TrpCys: 0.092 ± 0.01	0.486TrpAsp: 0.486 ± 0.021	0.655TrpGlu: 0.655 ± 0.027	0.576TrpPhe: 0.576 ± 0.026	0.627TrpGly: 0.627 ± 0.026	0.201TrpHis: 0.201 ± 0.015	0.715TrpIle: 0.715 ± 0.031	0.914TrpLys: 0.914 ± 0.037	1.006TrpLeu: 1.006 ± 0.037	0.339TrpMet: 0.339 ± 0.019	0.727TrpAsn: 0.727 ± 0.032	0.158TrpPro: 0.158 ± 0.015	0.338TrpGln: 0.338 ± 0.02	0.363TrpArg: 0.363 ± 0.022	0.584TrpSer: 0.584 ± 0.027	0.463TrpThr: 0.463 ± 0.025	0.608TrpVal: 0.608 ± 0.029	0.127TrpTrp: 0.127 ± 0.011	0.464TrpTyr: 0.464 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.367TyrAla: 2.367 ± 0.056	0.356TyrCys: 0.356 ± 0.019	2.325TyrAsp: 2.325 ± 0.059	2.508TyrGlu: 2.508 ± 0.058	2.462TyrPhe: 2.462 ± 0.064	2.661TyrGly: 2.661 ± 0.055	0.939TyrHis: 0.939 ± 0.031	3.091TyrIle: 3.091 ± 0.054	3.855TyrLys: 3.855 ± 0.069	3.863TyrLeu: 3.863 ± 0.077	0.717TyrMet: 0.717 ± 0.028	2.673TyrAsn: 2.673 ± 0.063	1.446TyrPro: 1.446 ± 0.04	1.636TyrGln: 1.636 ± 0.048	1.63TyrArg: 1.63 ± 0.044	2.569TyrSer: 2.569 ± 0.058	2.749TyrThr: 2.749 ± 0.074	2.167TyrVal: 2.167 ± 0.044	0.455TyrTrp: 0.455 ± 0.023	2.048TyrTyr: 2.048 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2844 proteins (983416 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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