Amino acid dipepetide frequency for Lactobacillus lindneri DSM 20690 = JCM 11027

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.827AlaAla: 5.827 ± 0.165
0.335AlaCys: 0.335 ± 0.025
4.457AlaAsp: 4.457 ± 0.105
3.822AlaGlu: 3.822 ± 0.096
2.809AlaPhe: 2.809 ± 0.09
5.026AlaGly: 5.026 ± 0.131
1.28AlaHis: 1.28 ± 0.056
5.663AlaIle: 5.663 ± 0.136
5.675AlaLys: 5.675 ± 0.135
6.291AlaLeu: 6.291 ± 0.167
1.867AlaMet: 1.867 ± 0.065
3.656AlaAsn: 3.656 ± 0.116
1.917AlaPro: 1.917 ± 0.079
2.662AlaGln: 2.662 ± 0.087
2.207AlaArg: 2.207 ± 0.076
3.789AlaSer: 3.789 ± 0.115
4.055AlaThr: 4.055 ± 0.117
4.764AlaVal: 4.764 ± 0.123
0.488AlaTrp: 0.488 ± 0.035
2.333AlaTyr: 2.333 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.278CysAla: 0.278 ± 0.027
0.05CysCys: 0.05 ± 0.009
0.262CysAsp: 0.262 ± 0.028
0.285CysGlu: 0.285 ± 0.028
0.233CysPhe: 0.233 ± 0.025
0.521CysGly: 0.521 ± 0.037
0.105CysHis: 0.105 ± 0.015
0.321CysIle: 0.321 ± 0.029
0.254CysLys: 0.254 ± 0.026
0.49CysLeu: 0.49 ± 0.037
0.107CysMet: 0.107 ± 0.016
0.24CysAsn: 0.24 ± 0.023
0.212CysPro: 0.212 ± 0.028
0.181CysGln: 0.181 ± 0.02
0.176CysArg: 0.176 ± 0.021
0.269CysSer: 0.269 ± 0.027
0.219CysThr: 0.219 ± 0.024
0.281CysVal: 0.281 ± 0.026
0.045CysTrp: 0.045 ± 0.011
0.157CysTyr: 0.157 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.948AspAla: 3.948 ± 0.119
0.259AspCys: 0.259 ± 0.025
4.036AspAsp: 4.036 ± 0.121
4.483AspGlu: 4.483 ± 0.124
2.973AspPhe: 2.973 ± 0.093
3.92AspGly: 3.92 ± 0.107
1.349AspHis: 1.349 ± 0.059
4.329AspIle: 4.329 ± 0.125
4.607AspLys: 4.607 ± 0.123
5.734AspLeu: 5.734 ± 0.129
1.418AspMet: 1.418 ± 0.059
3.684AspAsn: 3.684 ± 0.112
2.329AspPro: 2.329 ± 0.074
2.752AspGln: 2.752 ± 0.075
1.912AspArg: 1.912 ± 0.072
3.439AspSer: 3.439 ± 0.109
2.88AspThr: 2.88 ± 0.085
4.288AspVal: 4.288 ± 0.111
0.585AspTrp: 0.585 ± 0.04
2.654AspTyr: 2.654 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
3.67GluAla: 3.67 ± 0.112
0.259GluCys: 0.259 ± 0.027
2.769GluAsp: 2.769 ± 0.097
2.818GluGlu: 2.818 ± 0.101
2.2GluPhe: 2.2 ± 0.073
2.471GluGly: 2.471 ± 0.083
1.111GluHis: 1.111 ± 0.051
5.04GluIle: 5.04 ± 0.125
5.223GluLys: 5.223 ± 0.129
5.627GluLeu: 5.627 ± 0.143
1.927GluMet: 1.927 ± 0.07
3.865GluAsn: 3.865 ± 0.106
1.57GluPro: 1.57 ± 0.07
2.528GluGln: 2.528 ± 0.089
2.238GluArg: 2.238 ± 0.08
2.733GluSer: 2.733 ± 0.084
3.335GluThr: 3.335 ± 0.099
3.679GluVal: 3.679 ± 0.108
0.488GluTrp: 0.488 ± 0.028
1.922GluTyr: 1.922 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
2.952PheAla: 2.952 ± 0.095
0.259PheCys: 0.259 ± 0.024
2.899PheAsp: 2.899 ± 0.083
2.312PheGlu: 2.312 ± 0.076
1.977PhePhe: 1.977 ± 0.077
3.318PheGly: 3.318 ± 0.105
0.759PheHis: 0.759 ± 0.038
3.228PheIle: 3.228 ± 0.091
3.209PheLys: 3.209 ± 0.108
3.703PheLeu: 3.703 ± 0.12
1.099PheMet: 1.099 ± 0.054
2.507PheAsn: 2.507 ± 0.082
1.546PhePro: 1.546 ± 0.064
1.406PheGln: 1.406 ± 0.053
1.175PheArg: 1.175 ± 0.058
2.994PheSer: 2.994 ± 0.087
2.264PheThr: 2.264 ± 0.068
3.118PheVal: 3.118 ± 0.092
0.514PheTrp: 0.514 ± 0.038
1.772PheTyr: 1.772 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
4.234GlyAla: 4.234 ± 0.136
0.357GlyCys: 0.357 ± 0.034
3.413GlyAsp: 3.413 ± 0.1
3.03GlyGlu: 3.03 ± 0.096
2.966GlyPhe: 2.966 ± 0.096
4.148GlyGly: 4.148 ± 0.14
1.377GlyHis: 1.377 ± 0.055
6.129GlyIle: 6.129 ± 0.143
5.542GlyLys: 5.542 ± 0.117
6.063GlyLeu: 6.063 ± 0.133
2.107GlyMet: 2.107 ± 0.072
3.449GlyAsn: 3.449 ± 0.097
1.551GlyPro: 1.551 ± 0.062
2.179GlyGln: 2.179 ± 0.065
2.269GlyArg: 2.269 ± 0.082
4.048GlySer: 4.048 ± 0.108
3.977GlyThr: 3.977 ± 0.104
4.598GlyVal: 4.598 ± 0.107
0.621GlyTrp: 0.621 ± 0.043
2.707GlyTyr: 2.707 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
1.234HisAla: 1.234 ± 0.055
0.095HisCys: 0.095 ± 0.015
1.365HisAsp: 1.365 ± 0.061
1.208HisGlu: 1.208 ± 0.056
1.023HisPhe: 1.023 ± 0.05
1.513HisGly: 1.513 ± 0.063
0.64HisHis: 0.64 ± 0.038
1.287HisIle: 1.287 ± 0.061
1.263HisLys: 1.263 ± 0.054
1.946HisLeu: 1.946 ± 0.071
0.454HisMet: 0.454 ± 0.033
1.08HisAsn: 1.08 ± 0.053
1.016HisPro: 1.016 ± 0.05
1.225HisGln: 1.225 ± 0.059
0.804HisArg: 0.804 ± 0.046
1.151HisSer: 1.151 ± 0.048
0.928HisThr: 0.928 ± 0.053
1.322HisVal: 1.322 ± 0.055
0.193HisTrp: 0.193 ± 0.022
0.923HisTyr: 0.923 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.627IleAla: 5.627 ± 0.106
0.557IleCys: 0.557 ± 0.04
5.073IleAsp: 5.073 ± 0.111
4.336IleGlu: 4.336 ± 0.118
3.427IlePhe: 3.427 ± 0.122
5.494IleGly: 5.494 ± 0.14
1.349IleHis: 1.349 ± 0.053
6.346IleIle: 6.346 ± 0.142
6.455IleLys: 6.455 ± 0.141
6.888IleLeu: 6.888 ± 0.162
1.962IleMet: 1.962 ± 0.073
4.997IleAsn: 4.997 ± 0.123
3.204IlePro: 3.204 ± 0.082
2.685IleGln: 2.685 ± 0.08
2.483IleArg: 2.483 ± 0.079
5.349IleSer: 5.349 ± 0.129
4.529IleThr: 4.529 ± 0.102
5.387IleVal: 5.387 ± 0.111
0.635IleTrp: 0.635 ± 0.042
2.438IleTyr: 2.438 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.795LysAla: 4.795 ± 0.109
0.228LysCys: 0.228 ± 0.026
4.776LysAsp: 4.776 ± 0.122
4.588LysGlu: 4.588 ± 0.133
2.676LysPhe: 2.676 ± 0.078
3.722LysGly: 3.722 ± 0.096
1.708LysHis: 1.708 ± 0.067
6.298LysIle: 6.298 ± 0.145
6.829LysLys: 6.829 ± 0.167
7.107LysLeu: 7.107 ± 0.152
2.785LysMet: 2.785 ± 0.079
5.587LysAsn: 5.587 ± 0.133
2.676LysPro: 2.676 ± 0.079
4.174LysGln: 4.174 ± 0.124
3.308LysArg: 3.308 ± 0.1
4.395LysSer: 4.395 ± 0.114
4.662LysThr: 4.662 ± 0.127
4.809LysVal: 4.809 ± 0.112
0.649LysTrp: 0.649 ± 0.045
3.071LysTyr: 3.071 ± 0.097
0.0LysXaa: 0.0 ± 0.0
Leu
6.836LeuAla: 6.836 ± 0.124
0.459LeuCys: 0.459 ± 0.033
5.485LeuAsp: 5.485 ± 0.128
4.322LeuGlu: 4.322 ± 0.115
3.963LeuPhe: 3.963 ± 0.105
6.096LeuGly: 6.096 ± 0.145
1.743LeuHis: 1.743 ± 0.063
7.468LeuIle: 7.468 ± 0.188
7.359LeuLys: 7.359 ± 0.154
8.12LeuLeu: 8.12 ± 0.181
2.3LeuMet: 2.3 ± 0.078
5.834LeuAsn: 5.834 ± 0.151
3.679LeuPro: 3.679 ± 0.092
3.672LeuGln: 3.672 ± 0.104
2.964LeuArg: 2.964 ± 0.09
6.034LeuSer: 6.034 ± 0.135
5.699LeuThr: 5.699 ± 0.137
6.372LeuVal: 6.372 ± 0.139
0.744LeuTrp: 0.744 ± 0.039
2.569LeuTyr: 2.569 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
2.067MetAla: 2.067 ± 0.076
0.133MetCys: 0.133 ± 0.015
1.508MetAsp: 1.508 ± 0.064
1.296MetGlu: 1.296 ± 0.054
0.961MetPhe: 0.961 ± 0.05
1.762MetGly: 1.762 ± 0.056
0.516MetHis: 0.516 ± 0.038
2.164MetIle: 2.164 ± 0.084
2.369MetLys: 2.369 ± 0.079
2.321MetLeu: 2.321 ± 0.078
0.821MetMet: 0.821 ± 0.055
1.72MetAsn: 1.72 ± 0.065
1.027MetPro: 1.027 ± 0.047
1.142MetGln: 1.142 ± 0.045
0.978MetArg: 0.978 ± 0.049
1.736MetSer: 1.736 ± 0.065
1.758MetThr: 1.758 ± 0.058
1.808MetVal: 1.808 ± 0.073
0.207MetTrp: 0.207 ± 0.022
0.664MetTyr: 0.664 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.853AsnAla: 3.853 ± 0.107
0.247AsnCys: 0.247 ± 0.026
3.913AsnAsp: 3.913 ± 0.103
3.718AsnGlu: 3.718 ± 0.101
2.531AsnPhe: 2.531 ± 0.082
4.053AsnGly: 4.053 ± 0.108
1.52AsnHis: 1.52 ± 0.071
4.079AsnIle: 4.079 ± 0.126
4.474AsnLys: 4.474 ± 0.127
5.285AsnLeu: 5.285 ± 0.112
1.394AsnMet: 1.394 ± 0.054
4.089AsnAsn: 4.089 ± 0.141
2.814AsnPro: 2.814 ± 0.083
3.508AsnGln: 3.508 ± 0.115
2.105AsnArg: 2.105 ± 0.066
3.558AsnSer: 3.558 ± 0.123
2.709AsnThr: 2.709 ± 0.083
4.089AsnVal: 4.089 ± 0.099
0.661AsnTrp: 0.661 ± 0.043
2.29AsnTyr: 2.29 ± 0.088
0.002AsnXaa: 0.002 ± 0.002
Pro
2.462ProAla: 2.462 ± 0.099
0.086ProCys: 0.086 ± 0.013
2.402ProAsp: 2.402 ± 0.077
2.692ProGlu: 2.692 ± 0.081
1.682ProPhe: 1.682 ± 0.061
2.236ProGly: 2.236 ± 0.081
0.656ProHis: 0.656 ± 0.035
2.807ProIle: 2.807 ± 0.074
2.797ProLys: 2.797 ± 0.092
3.033ProLeu: 3.033 ± 0.083
0.773ProMet: 0.773 ± 0.047
2.169ProAsn: 2.169 ± 0.075
0.559ProPro: 0.559 ± 0.037
1.475ProGln: 1.475 ± 0.062
1.02ProArg: 1.02 ± 0.052
2.038ProSer: 2.038 ± 0.075
2.217ProThr: 2.217 ± 0.087
2.754ProVal: 2.754 ± 0.083
0.297ProTrp: 0.297 ± 0.027
1.287ProTyr: 1.287 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
3.042GlnAla: 3.042 ± 0.101
0.126GlnCys: 0.126 ± 0.017
2.043GlnAsp: 2.043 ± 0.077
2.179GlnGlu: 2.179 ± 0.08
1.734GlnPhe: 1.734 ± 0.078
2.11GlnGly: 2.11 ± 0.076
0.963GlnHis: 0.963 ± 0.044
3.568GlnIle: 3.568 ± 0.105
3.599GlnLys: 3.599 ± 0.101
4.2GlnLeu: 4.2 ± 0.121
1.211GlnMet: 1.211 ± 0.055
2.733GlnAsn: 2.733 ± 0.085
1.489GlnPro: 1.489 ± 0.068
2.65GlnGln: 2.65 ± 0.097
1.715GlnArg: 1.715 ± 0.074
2.409GlnSer: 2.409 ± 0.091
2.621GlnThr: 2.621 ± 0.087
3.068GlnVal: 3.068 ± 0.093
0.373GlnTrp: 0.373 ± 0.029
1.465GlnTyr: 1.465 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
2.176ArgAla: 2.176 ± 0.067
0.131ArgCys: 0.131 ± 0.018
2.138ArgAsp: 2.138 ± 0.074
2.045ArgGlu: 2.045 ± 0.084
1.591ArgPhe: 1.591 ± 0.059
2.221ArgGly: 2.221 ± 0.082
0.79ArgHis: 0.79 ± 0.048
2.747ArgIle: 2.747 ± 0.088
2.719ArgLys: 2.719 ± 0.081
3.168ArgLeu: 3.168 ± 0.081
1.03ArgMet: 1.03 ± 0.047
2.112ArgAsn: 2.112 ± 0.082
1.237ArgPro: 1.237 ± 0.055
1.622ArgGln: 1.622 ± 0.079
1.624ArgArg: 1.624 ± 0.085
1.812ArgSer: 1.812 ± 0.074
1.739ArgThr: 1.739 ± 0.067
2.264ArgVal: 2.264 ± 0.088
0.254ArgTrp: 0.254 ± 0.024
1.346ArgTyr: 1.346 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.746SerAla: 3.746 ± 0.121
0.247SerCys: 0.247 ± 0.026
4.089SerAsp: 4.089 ± 0.12
3.477SerGlu: 3.477 ± 0.087
2.795SerPhe: 2.795 ± 0.083
4.146SerGly: 4.146 ± 0.097
1.289SerHis: 1.289 ± 0.053
4.507SerIle: 4.507 ± 0.107
4.674SerLys: 4.674 ± 0.12
5.863SerLeu: 5.863 ± 0.136
1.603SerMet: 1.603 ± 0.063
3.489SerAsn: 3.489 ± 0.1
1.95SerPro: 1.95 ± 0.062
2.607SerGln: 2.607 ± 0.094
2.074SerArg: 2.074 ± 0.071
3.746SerSer: 3.746 ± 0.133
3.247SerThr: 3.247 ± 0.101
3.917SerVal: 3.917 ± 0.092
0.557SerTrp: 0.557 ± 0.041
2.148SerTyr: 2.148 ± 0.081
0.0SerXaa: 0.0 ± 0.0
Thr
4.067ThrAla: 4.067 ± 0.105
0.243ThrCys: 0.243 ± 0.027
3.72ThrAsp: 3.72 ± 0.106
3.109ThrGlu: 3.109 ± 0.1
2.39ThrPhe: 2.39 ± 0.078
4.312ThrGly: 4.312 ± 0.113
1.123ThrHis: 1.123 ± 0.047
4.645ThrIle: 4.645 ± 0.1
4.246ThrLys: 4.246 ± 0.097
4.759ThrLeu: 4.759 ± 0.123
1.313ThrMet: 1.313 ± 0.056
3.435ThrAsn: 3.435 ± 0.105
2.583ThrPro: 2.583 ± 0.098
1.919ThrGln: 1.919 ± 0.066
1.627ThrArg: 1.627 ± 0.055
3.615ThrSer: 3.615 ± 0.103
3.53ThrThr: 3.53 ± 0.127
3.836ThrVal: 3.836 ± 0.116
0.476ThrTrp: 0.476 ± 0.034
1.967ThrTyr: 1.967 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
5.428ValAla: 5.428 ± 0.129
0.352ValCys: 0.352 ± 0.026
4.436ValAsp: 4.436 ± 0.116
3.508ValGlu: 3.508 ± 0.108
2.692ValPhe: 2.692 ± 0.094
4.738ValGly: 4.738 ± 0.132
1.213ValHis: 1.213 ± 0.054
5.725ValIle: 5.725 ± 0.128
5.009ValLys: 5.009 ± 0.124
6.082ValLeu: 6.082 ± 0.145
1.732ValMet: 1.732 ± 0.068
3.858ValAsn: 3.858 ± 0.1
2.488ValPro: 2.488 ± 0.082
2.293ValGln: 2.293 ± 0.082
2.193ValArg: 2.193 ± 0.079
4.431ValSer: 4.431 ± 0.086
4.345ValThr: 4.345 ± 0.121
5.08ValVal: 5.08 ± 0.12
0.495ValTrp: 0.495 ± 0.035
2.164ValTyr: 2.164 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.428TrpAla: 0.428 ± 0.031
0.05TrpCys: 0.05 ± 0.011
0.459TrpAsp: 0.459 ± 0.038
0.39TrpGlu: 0.39 ± 0.031
0.495TrpPhe: 0.495 ± 0.041
0.58TrpGly: 0.58 ± 0.037
0.214TrpHis: 0.214 ± 0.022
0.756TrpIle: 0.756 ± 0.039
0.604TrpLys: 0.604 ± 0.036
1.006TrpLeu: 1.006 ± 0.054
0.297TrpMet: 0.297 ± 0.026
0.583TrpAsn: 0.583 ± 0.052
0.224TrpPro: 0.224 ± 0.021
0.419TrpGln: 0.419 ± 0.032
0.342TrpArg: 0.342 ± 0.03
0.528TrpSer: 0.528 ± 0.035
0.404TrpThr: 0.404 ± 0.031
0.511TrpVal: 0.511 ± 0.037
0.095TrpTrp: 0.095 ± 0.016
0.362TrpTyr: 0.362 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.252TyrAla: 2.252 ± 0.081
0.212TyrCys: 0.212 ± 0.026
2.338TyrAsp: 2.338 ± 0.082
1.853TyrGlu: 1.853 ± 0.071
1.893TyrPhe: 1.893 ± 0.076
2.376TyrGly: 2.376 ± 0.064
0.966TyrHis: 0.966 ± 0.052
2.114TyrIle: 2.114 ± 0.073
1.941TyrLys: 1.941 ± 0.069
4.029TyrLeu: 4.029 ± 0.101
0.756TyrMet: 0.756 ± 0.045
1.805TyrAsn: 1.805 ± 0.067
1.372TyrPro: 1.372 ± 0.056
2.2TyrGln: 2.2 ± 0.081
1.553TyrArg: 1.553 ± 0.073
2.093TyrSer: 2.093 ± 0.074
1.798TyrThr: 1.798 ± 0.079
2.314TyrVal: 2.314 ± 0.074
0.371TyrTrp: 0.371 ± 0.03
1.337TyrTyr: 1.337 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.081XaaXaa: 0.081 ± 0.079
Statistics based on 1407 proteins (420439 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski