Amino acid dipepetide frequency for Avian metapneumovirus type D

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.059AlaAla: 6.059 ± 2.316
1.398AlaCys: 1.398 ± 0.454
3.263AlaAsp: 3.263 ± 1.136
4.661AlaGlu: 4.661 ± 0.865
0.932AlaPhe: 0.932 ± 0.582
4.428AlaGly: 4.428 ± 1.708
0.932AlaHis: 0.932 ± 0.35
6.525AlaIle: 6.525 ± 1.511
3.962AlaLys: 3.962 ± 1.331
6.525AlaLeu: 6.525 ± 2.261
2.097AlaMet: 2.097 ± 0.503
1.864AlaAsn: 1.864 ± 0.65
3.729AlaPro: 3.729 ± 0.516
2.33AlaGln: 2.33 ± 0.645
1.864AlaArg: 1.864 ± 0.856
3.263AlaSer: 3.263 ± 1.35
5.127AlaThr: 5.127 ± 1.72
6.758AlaVal: 6.758 ± 0.714
0.0AlaTrp: 0.0 ± 0.0
1.864AlaTyr: 1.864 ± 0.559
0.0AlaXaa: 0.0 ± 0.0
Cys
0.932CysAla: 0.932 ± 0.35
1.398CysCys: 1.398 ± 0.72
1.398CysAsp: 1.398 ± 0.776
0.932CysGlu: 0.932 ± 0.278
1.165CysPhe: 1.165 ± 0.532
0.699CysGly: 0.699 ± 0.288
0.699CysHis: 0.699 ± 0.436
1.631CysIle: 1.631 ± 0.346
3.263CysLys: 3.263 ± 1.219
1.398CysLeu: 1.398 ± 0.485
0.932CysMet: 0.932 ± 0.742
1.631CysAsn: 1.631 ± 1.463
0.466CysPro: 0.466 ± 0.253
1.864CysGln: 1.864 ± 0.621
1.398CysArg: 1.398 ± 1.295
0.932CysSer: 0.932 ± 0.788
2.097CysThr: 2.097 ± 0.57
1.165CysVal: 1.165 ± 0.371
0.466CysTrp: 0.466 ± 0.242
1.398CysTyr: 1.398 ± 0.403
0.0CysXaa: 0.0 ± 0.0
Asp
3.496AspAla: 3.496 ± 0.826
0.699AspCys: 0.699 ± 0.324
1.864AspAsp: 1.864 ± 0.379
2.564AspGlu: 2.564 ± 0.961
2.097AspPhe: 2.097 ± 0.964
2.797AspGly: 2.797 ± 1.292
1.631AspHis: 1.631 ± 1.071
4.894AspIle: 4.894 ± 1.033
2.097AspLys: 2.097 ± 0.627
3.496AspLeu: 3.496 ± 1.286
0.932AspMet: 0.932 ± 0.514
2.33AspAsn: 2.33 ± 0.969
1.864AspPro: 1.864 ± 1.04
2.797AspGln: 2.797 ± 1.163
2.564AspArg: 2.564 ± 0.623
3.263AspSer: 3.263 ± 0.532
2.097AspThr: 2.097 ± 0.502
1.864AspVal: 1.864 ± 0.531
0.233AspTrp: 0.233 ± 0.145
1.398AspTyr: 1.398 ± 0.351
0.0AspXaa: 0.0 ± 0.0
Glu
4.661GluAla: 4.661 ± 1.335
0.466GluCys: 0.466 ± 0.406
2.797GluAsp: 2.797 ± 0.879
3.263GluGlu: 3.263 ± 1.901
1.864GluPhe: 1.864 ± 0.422
3.263GluGly: 3.263 ± 0.553
1.864GluHis: 1.864 ± 0.942
2.797GluIle: 2.797 ± 0.852
4.195GluLys: 4.195 ± 0.728
7.691GluLeu: 7.691 ± 1.143
0.932GluMet: 0.932 ± 0.406
2.564GluAsn: 2.564 ± 0.709
2.564GluPro: 2.564 ± 0.898
1.398GluGln: 1.398 ± 0.46
2.564GluArg: 2.564 ± 0.792
4.661GluSer: 4.661 ± 1.506
4.661GluThr: 4.661 ± 0.767
4.661GluVal: 4.661 ± 1.379
0.699GluTrp: 0.699 ± 0.436
2.097GluTyr: 2.097 ± 0.506
0.0GluXaa: 0.0 ± 0.0
Phe
0.932PheAla: 0.932 ± 0.507
1.631PheCys: 1.631 ± 0.694
1.165PheAsp: 1.165 ± 0.571
1.631PheGlu: 1.631 ± 0.732
1.864PhePhe: 1.864 ± 0.917
2.097PheGly: 2.097 ± 0.775
0.699PheHis: 0.699 ± 0.436
1.864PheIle: 1.864 ± 0.423
1.165PheLys: 1.165 ± 0.57
2.097PheLeu: 2.097 ± 0.759
0.699PheMet: 0.699 ± 0.296
2.097PheAsn: 2.097 ± 0.744
1.864PhePro: 1.864 ± 0.327
1.165PheGln: 1.165 ± 0.57
1.398PheArg: 1.398 ± 0.873
1.398PheSer: 1.398 ± 0.571
1.398PheThr: 1.398 ± 0.586
3.03PheVal: 3.03 ± 0.897
0.233PheTrp: 0.233 ± 0.145
0.699PheTyr: 0.699 ± 0.435
0.0PheXaa: 0.0 ± 0.0
Gly
3.496GlyAla: 3.496 ± 1.223
1.398GlyCys: 1.398 ± 0.544
2.797GlyAsp: 2.797 ± 0.967
3.263GlyGlu: 3.263 ± 0.958
0.932GlyPhe: 0.932 ± 0.328
2.097GlyGly: 2.097 ± 0.722
1.631GlyHis: 1.631 ± 0.598
3.263GlyIle: 3.263 ± 1.1
3.729GlyLys: 3.729 ± 0.859
5.36GlyLeu: 5.36 ± 1.478
1.864GlyMet: 1.864 ± 0.856
2.797GlyAsn: 2.797 ± 0.513
3.263GlyPro: 3.263 ± 1.045
1.631GlyGln: 1.631 ± 0.807
2.797GlyArg: 2.797 ± 0.474
5.36GlySer: 5.36 ± 0.772
2.564GlyThr: 2.564 ± 0.739
5.826GlyVal: 5.826 ± 1.872
0.932GlyTrp: 0.932 ± 0.584
1.864GlyTyr: 1.864 ± 0.958
0.0GlyXaa: 0.0 ± 0.0
His
1.398HisAla: 1.398 ± 0.642
0.233HisCys: 0.233 ± 0.145
0.466HisAsp: 0.466 ± 0.389
0.233HisGlu: 0.233 ± 0.145
0.932HisPhe: 0.932 ± 0.582
0.932HisGly: 0.932 ± 0.392
0.699HisHis: 0.699 ± 0.436
0.932HisIle: 0.932 ± 0.463
0.699HisLys: 0.699 ± 0.343
0.466HisLeu: 0.466 ± 0.253
0.699HisMet: 0.699 ± 0.436
0.466HisAsn: 0.466 ± 0.594
1.631HisPro: 1.631 ± 0.488
1.165HisGln: 1.165 ± 0.455
0.466HisArg: 0.466 ± 0.291
1.398HisSer: 1.398 ± 0.442
0.932HisThr: 0.932 ± 0.35
1.864HisVal: 1.864 ± 0.721
0.932HisTrp: 0.932 ± 0.582
0.233HisTyr: 0.233 ± 0.145
0.0HisXaa: 0.0 ± 0.0
Ile
3.496IleAla: 3.496 ± 0.768
1.864IleCys: 1.864 ± 0.718
3.263IleAsp: 3.263 ± 0.749
2.564IleGlu: 2.564 ± 0.715
2.097IlePhe: 2.097 ± 0.562
4.195IleGly: 4.195 ± 0.657
0.699IleHis: 0.699 ± 0.296
3.729IleIle: 3.729 ± 1.288
4.661IleLys: 4.661 ± 0.823
7.224IleLeu: 7.224 ± 0.981
2.564IleMet: 2.564 ± 0.763
3.962IleAsn: 3.962 ± 1.341
2.097IlePro: 2.097 ± 0.701
1.864IleGln: 1.864 ± 0.633
3.263IleArg: 3.263 ± 0.611
6.991IleSer: 6.991 ± 0.897
4.428IleThr: 4.428 ± 1.733
3.729IleVal: 3.729 ± 1.014
0.233IleTrp: 0.233 ± 0.145
1.398IleTyr: 1.398 ± 0.674
0.0IleXaa: 0.0 ± 0.0
Lys
3.496LysAla: 3.496 ± 0.956
1.631LysCys: 1.631 ± 1.381
3.496LysAsp: 3.496 ± 1.173
3.962LysGlu: 3.962 ± 0.718
1.631LysPhe: 1.631 ± 0.511
3.03LysGly: 3.03 ± 0.737
0.932LysHis: 0.932 ± 0.604
4.428LysIle: 4.428 ± 1.43
4.661LysLys: 4.661 ± 1.182
8.157LysLeu: 8.157 ± 1.81
1.165LysMet: 1.165 ± 0.268
3.729LysAsn: 3.729 ± 1.233
2.097LysPro: 2.097 ± 0.626
1.864LysGln: 1.864 ± 0.379
2.33LysArg: 2.33 ± 0.565
5.127LysSer: 5.127 ± 0.555
5.127LysThr: 5.127 ± 1.609
4.428LysVal: 4.428 ± 0.791
0.466LysTrp: 0.466 ± 0.291
0.932LysTyr: 0.932 ± 0.368
0.0LysXaa: 0.0 ± 0.0
Leu
6.525LeuAla: 6.525 ± 0.991
3.263LeuCys: 3.263 ± 0.742
4.195LeuAsp: 4.195 ± 0.744
7.224LeuGlu: 7.224 ± 1.38
2.33LeuPhe: 2.33 ± 1.31
7.691LeuGly: 7.691 ± 1.82
1.398LeuHis: 1.398 ± 0.413
5.593LeuIle: 5.593 ± 2.08
7.224LeuLys: 7.224 ± 1.259
9.089LeuLeu: 9.089 ± 3.085
2.564LeuMet: 2.564 ± 0.636
4.661LeuAsn: 4.661 ± 1.616
3.496LeuPro: 3.496 ± 0.711
3.03LeuGln: 3.03 ± 0.535
5.826LeuArg: 5.826 ± 1.463
10.021LeuSer: 10.021 ± 1.794
7.224LeuThr: 7.224 ± 1.472
3.03LeuVal: 3.03 ± 0.792
0.0LeuTrp: 0.0 ± 0.0
2.097LeuTyr: 2.097 ± 0.679
0.0LeuXaa: 0.0 ± 0.0
Met
1.631MetAla: 1.631 ± 0.481
0.699MetCys: 0.699 ± 0.36
0.932MetAsp: 0.932 ± 0.392
2.797MetGlu: 2.797 ± 0.583
0.466MetPhe: 0.466 ± 0.291
1.398MetGly: 1.398 ± 0.538
0.233MetHis: 0.233 ± 0.145
2.097MetIle: 2.097 ± 0.946
0.466MetLys: 0.466 ± 0.245
2.564MetLeu: 2.564 ± 0.658
1.165MetMet: 1.165 ± 0.571
0.699MetAsn: 0.699 ± 0.352
0.932MetPro: 0.932 ± 0.727
1.631MetGln: 1.631 ± 0.6
1.398MetArg: 1.398 ± 0.651
3.496MetSer: 3.496 ± 0.967
2.564MetThr: 2.564 ± 0.62
2.564MetVal: 2.564 ± 0.966
0.233MetTrp: 0.233 ± 0.145
0.932MetTyr: 0.932 ± 0.392
0.0MetXaa: 0.0 ± 0.0
Asn
3.962AsnAla: 3.962 ± 0.858
0.932AsnCys: 0.932 ± 0.357
1.864AsnAsp: 1.864 ± 0.564
3.03AsnGlu: 3.03 ± 1.178
2.33AsnPhe: 2.33 ± 1.199
1.398AsnGly: 1.398 ± 0.538
0.699AsnHis: 0.699 ± 0.358
3.03AsnIle: 3.03 ± 0.687
1.398AsnLys: 1.398 ± 0.895
4.195AsnLeu: 4.195 ± 0.9
2.33AsnMet: 2.33 ± 0.725
3.03AsnAsn: 3.03 ± 1.058
3.263AsnPro: 3.263 ± 1.032
2.33AsnGln: 2.33 ± 0.484
3.496AsnArg: 3.496 ± 0.867
3.263AsnSer: 3.263 ± 0.633
3.496AsnThr: 3.496 ± 0.692
3.263AsnVal: 3.263 ± 1.19
0.233AsnTrp: 0.233 ± 0.145
1.864AsnTyr: 1.864 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
2.33ProAla: 2.33 ± 0.897
1.165ProCys: 1.165 ± 0.85
2.097ProAsp: 2.097 ± 0.922
3.03ProGlu: 3.03 ± 0.699
0.699ProPhe: 0.699 ± 0.304
1.864ProGly: 1.864 ± 0.733
0.699ProHis: 0.699 ± 0.304
3.263ProIle: 3.263 ± 1.277
5.127ProLys: 5.127 ± 1.231
2.097ProLeu: 2.097 ± 0.399
0.932ProMet: 0.932 ± 0.442
2.564ProAsn: 2.564 ± 0.503
2.33ProPro: 2.33 ± 1.746
1.165ProGln: 1.165 ± 0.654
1.864ProArg: 1.864 ± 0.937
3.263ProSer: 3.263 ± 0.554
4.195ProThr: 4.195 ± 2.052
3.496ProVal: 3.496 ± 0.717
1.165ProTrp: 1.165 ± 0.532
1.631ProTyr: 1.631 ± 1.162
0.0ProXaa: 0.0 ± 0.0
Gln
2.564GlnAla: 2.564 ± 0.988
0.699GlnCys: 0.699 ± 0.324
1.398GlnAsp: 1.398 ± 0.349
2.097GlnGlu: 2.097 ± 0.613
0.932GlnPhe: 0.932 ± 0.484
2.097GlnGly: 2.097 ± 0.541
0.699GlnHis: 0.699 ± 0.304
1.631GlnIle: 1.631 ± 0.638
2.564GlnLys: 2.564 ± 0.841
4.428GlnLeu: 4.428 ± 0.991
0.0GlnMet: 0.0 ± 0.0
2.097GlnAsn: 2.097 ± 0.941
1.398GlnPro: 1.398 ± 0.707
0.699GlnGln: 0.699 ± 0.362
2.564GlnArg: 2.564 ± 0.61
2.564GlnSer: 2.564 ± 0.744
2.097GlnThr: 2.097 ± 0.76
3.263GlnVal: 3.263 ± 0.815
0.466GlnTrp: 0.466 ± 0.297
0.932GlnTyr: 0.932 ± 0.622
0.0GlnXaa: 0.0 ± 0.0
Arg
3.263ArgAla: 3.263 ± 0.648
0.932ArgCys: 0.932 ± 0.49
3.263ArgAsp: 3.263 ± 0.569
3.962ArgGlu: 3.962 ± 0.844
2.564ArgPhe: 2.564 ± 0.611
3.03ArgGly: 3.03 ± 0.834
0.466ArgHis: 0.466 ± 0.242
3.03ArgIle: 3.03 ± 0.852
2.33ArgLys: 2.33 ± 0.758
4.195ArgLeu: 4.195 ± 1.081
2.797ArgMet: 2.797 ± 0.757
2.797ArgAsn: 2.797 ± 0.984
0.466ArgPro: 0.466 ± 0.245
1.631ArgGln: 1.631 ± 0.458
4.195ArgArg: 4.195 ± 1.038
4.661ArgSer: 4.661 ± 0.764
3.729ArgThr: 3.729 ± 0.787
3.496ArgVal: 3.496 ± 1.171
1.165ArgTrp: 1.165 ± 0.512
1.398ArgTyr: 1.398 ± 0.532
0.0ArgXaa: 0.0 ± 0.0
Ser
5.36SerAla: 5.36 ± 1.678
3.496SerCys: 3.496 ± 1.103
3.496SerAsp: 3.496 ± 0.844
5.593SerGlu: 5.593 ± 1.494
2.564SerPhe: 2.564 ± 0.511
4.661SerGly: 4.661 ± 1.084
0.466SerHis: 0.466 ± 0.291
5.593SerIle: 5.593 ± 1.317
5.593SerLys: 5.593 ± 1.38
9.788SerLeu: 9.788 ± 1.391
1.864SerMet: 1.864 ± 0.478
4.195SerAsn: 4.195 ± 1.596
3.496SerPro: 3.496 ± 1.038
1.631SerGln: 1.631 ± 1.005
3.962SerArg: 3.962 ± 0.798
5.593SerSer: 5.593 ± 1.188
6.991SerThr: 6.991 ± 2.133
4.661SerVal: 4.661 ± 0.763
0.699SerTrp: 0.699 ± 0.343
2.33SerTyr: 2.33 ± 0.67
0.0SerXaa: 0.0 ± 0.0
Thr
7.924ThrAla: 7.924 ± 2.383
1.165ThrCys: 1.165 ± 0.371
2.564ThrAsp: 2.564 ± 0.772
3.962ThrGlu: 3.962 ± 0.95
1.165ThrPhe: 1.165 ± 0.423
4.428ThrGly: 4.428 ± 0.944
0.699ThrHis: 0.699 ± 0.325
3.729ThrIle: 3.729 ± 0.858
3.729ThrLys: 3.729 ± 1.531
5.593ThrLeu: 5.593 ± 0.964
1.631ThrMet: 1.631 ± 0.658
2.097ThrAsn: 2.097 ± 0.747
4.428ThrPro: 4.428 ± 1.516
2.797ThrGln: 2.797 ± 0.813
3.962ThrArg: 3.962 ± 1.01
7.224ThrSer: 7.224 ± 1.508
6.292ThrThr: 6.292 ± 3.428
4.661ThrVal: 4.661 ± 1.728
0.466ThrTrp: 0.466 ± 0.295
2.564ThrTyr: 2.564 ± 0.558
0.0ThrXaa: 0.0 ± 0.0
Val
4.661ValAla: 4.661 ± 2.024
1.631ValCys: 1.631 ± 0.596
2.097ValAsp: 2.097 ± 0.441
4.195ValGlu: 4.195 ± 0.997
1.165ValPhe: 1.165 ± 0.775
4.195ValGly: 4.195 ± 1.027
0.932ValHis: 0.932 ± 0.408
3.263ValIle: 3.263 ± 0.858
3.496ValLys: 3.496 ± 0.918
7.691ValLeu: 7.691 ± 1.066
2.097ValMet: 2.097 ± 0.753
3.263ValAsn: 3.263 ± 0.9
2.33ValPro: 2.33 ± 0.675
3.263ValGln: 3.263 ± 1.07
4.195ValArg: 4.195 ± 1.673
7.224ValSer: 7.224 ± 1.217
4.195ValThr: 4.195 ± 0.835
5.593ValVal: 5.593 ± 0.929
0.466ValTrp: 0.466 ± 0.295
3.962ValTyr: 3.962 ± 0.84
0.0ValXaa: 0.0 ± 0.0
Trp
0.466TrpAla: 0.466 ± 0.253
0.466TrpCys: 0.466 ± 0.291
0.466TrpAsp: 0.466 ± 0.291
0.0TrpGlu: 0.0 ± 0.0
0.932TrpPhe: 0.932 ± 0.451
0.699TrpGly: 0.699 ± 0.362
0.233TrpHis: 0.233 ± 0.145
0.466TrpIle: 0.466 ± 0.291
0.466TrpLys: 0.466 ± 0.242
1.398TrpLeu: 1.398 ± 0.873
0.233TrpMet: 0.233 ± 0.145
0.233TrpAsn: 0.233 ± 0.304
0.466TrpPro: 0.466 ± 0.286
0.0TrpGln: 0.0 ± 0.0
0.699TrpArg: 0.699 ± 0.436
0.699TrpSer: 0.699 ± 0.343
0.466TrpThr: 0.466 ± 0.297
0.699TrpVal: 0.699 ± 0.436
0.0TrpTrp: 0.0 ± 0.0
0.466TrpTyr: 0.466 ± 0.624
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.932TyrAla: 0.932 ± 0.613
0.699TyrCys: 0.699 ± 0.539
2.097TyrAsp: 2.097 ± 0.585
0.932TyrGlu: 0.932 ± 0.369
0.466TyrPhe: 0.466 ± 0.291
1.864TyrGly: 1.864 ± 0.613
0.466TyrHis: 0.466 ± 0.291
2.564TyrIle: 2.564 ± 0.875
1.864TyrLys: 1.864 ± 0.516
3.03TyrLeu: 3.03 ± 1.194
1.165TyrMet: 1.165 ± 0.443
2.33TyrAsn: 2.33 ± 0.634
2.797TyrPro: 2.797 ± 0.71
0.932TyrGln: 0.932 ± 0.657
2.564TyrArg: 2.564 ± 1.12
1.631TyrSer: 1.631 ± 0.561
1.398TyrThr: 1.398 ± 0.793
1.864TyrVal: 1.864 ± 0.643
0.466TyrTrp: 0.466 ± 0.286
1.165TyrTyr: 1.165 ± 0.651
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (4292 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski