Amino acid dipepetide frequency for Bdellovibrio sp. SKB1291214

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.761AlaAla: 7.761 ± 0.125	0.845AlaCys: 0.845 ± 0.032	4.209AlaAsp: 4.209 ± 0.062	5.227AlaGlu: 5.227 ± 0.068	3.501AlaPhe: 3.501 ± 0.067	5.826AlaGly: 5.826 ± 0.09	1.615AlaHis: 1.615 ± 0.036	4.698AlaIle: 4.698 ± 0.075	5.8AlaLys: 5.8 ± 0.093	8.345AlaLeu: 8.345 ± 0.11	2.391AlaMet: 2.391 ± 0.049	3.39AlaAsn: 3.39 ± 0.058	3.287AlaPro: 3.287 ± 0.053	3.79AlaGln: 3.79 ± 0.072	3.57AlaArg: 3.57 ± 0.064	5.43AlaSer: 5.43 ± 0.092	4.641AlaThr: 4.641 ± 0.083	5.588AlaVal: 5.588 ± 0.079	0.859AlaTrp: 0.859 ± 0.029	2.327AlaTyr: 2.327 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.818CysAla: 0.818 ± 0.029	0.069CysCys: 0.069 ± 0.008	0.544CysAsp: 0.544 ± 0.022	0.554CysGlu: 0.554 ± 0.022	0.411CysPhe: 0.411 ± 0.018	0.732CysGly: 0.732 ± 0.031	0.208CysHis: 0.208 ± 0.014	0.398CysIle: 0.398 ± 0.02	0.508CysLys: 0.508 ± 0.023	0.864CysLeu: 0.864 ± 0.027	0.217CysMet: 0.217 ± 0.013	0.319CysAsn: 0.319 ± 0.017	0.447CysPro: 0.447 ± 0.021	0.35CysGln: 0.35 ± 0.019	0.446CysArg: 0.446 ± 0.02	0.731CysSer: 0.731 ± 0.029	0.506CysThr: 0.506 ± 0.021	0.646CysVal: 0.646 ± 0.025	0.143CysTrp: 0.143 ± 0.021	0.269CysTyr: 0.269 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.813AspAla: 3.813 ± 0.061	0.459AspCys: 0.459 ± 0.021	2.422AspAsp: 2.422 ± 0.056	3.284AspGlu: 3.284 ± 0.061	2.766AspPhe: 2.766 ± 0.053	3.537AspGly: 3.537 ± 0.065	1.031AspHis: 1.031 ± 0.033	3.382AspIle: 3.382 ± 0.068	3.346AspLys: 3.346 ± 0.054	5.669AspLeu: 5.669 ± 0.077	1.309AspMet: 1.309 ± 0.039	1.886AspAsn: 1.886 ± 0.046	2.307AspPro: 2.307 ± 0.044	2.095AspGln: 2.095 ± 0.046	2.587AspArg: 2.587 ± 0.053	3.439AspSer: 3.439 ± 0.058	2.309AspThr: 2.309 ± 0.055	3.571AspVal: 3.571 ± 0.063	0.638AspTrp: 0.638 ± 0.029	1.832AspTyr: 1.832 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.196GluAla: 5.196 ± 0.072	0.482GluCys: 0.482 ± 0.024	2.948GluAsp: 2.948 ± 0.059	4.054GluGlu: 4.054 ± 0.077	2.783GluPhe: 2.783 ± 0.049	3.741GluGly: 3.741 ± 0.06	1.174GluHis: 1.174 ± 0.033	4.602GluIle: 4.602 ± 0.078	5.243GluLys: 5.243 ± 0.074	5.893GluLeu: 5.893 ± 0.089	1.994GluMet: 1.994 ± 0.045	2.942GluAsn: 2.942 ± 0.051	1.78GluPro: 1.78 ± 0.045	2.501GluGln: 2.501 ± 0.051	2.865GluArg: 2.865 ± 0.059	3.757GluSer: 3.757 ± 0.064	3.274GluThr: 3.274 ± 0.051	4.597GluVal: 4.597 ± 0.072	0.67GluTrp: 0.67 ± 0.027	1.842GluTyr: 1.842 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.893PheAla: 3.893 ± 0.064	0.531PheCys: 0.531 ± 0.023	2.692PheAsp: 2.692 ± 0.052	2.769PheGlu: 2.769 ± 0.052	2.297PhePhe: 2.297 ± 0.056	3.081PheGly: 3.081 ± 0.057	0.904PheHis: 0.904 ± 0.03	2.654PheIle: 2.654 ± 0.051	3.097PheLys: 3.097 ± 0.048	4.195PheLeu: 4.195 ± 0.079	1.289PheMet: 1.289 ± 0.033	2.06PheAsn: 2.06 ± 0.048	1.728PhePro: 1.728 ± 0.044	1.674PheGln: 1.674 ± 0.037	1.833PheArg: 1.833 ± 0.046	3.253PheSer: 3.253 ± 0.06	2.489PheThr: 2.489 ± 0.051	3.244PheVal: 3.244 ± 0.054	0.579PheTrp: 0.579 ± 0.027	1.472PheTyr: 1.472 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.47GlyAla: 5.47 ± 0.088	0.709GlyCys: 0.709 ± 0.032	3.497GlyAsp: 3.497 ± 0.074	3.881GlyGlu: 3.881 ± 0.06	3.424GlyPhe: 3.424 ± 0.063	5.36GlyGly: 5.36 ± 0.121	1.454GlyHis: 1.454 ± 0.039	4.356GlyIle: 4.356 ± 0.065	4.76GlyLys: 4.76 ± 0.07	6.426GlyLeu: 6.426 ± 0.086	1.998GlyMet: 1.998 ± 0.053	2.772GlyAsn: 2.772 ± 0.058	2.179GlyPro: 2.179 ± 0.048	2.624GlyGln: 2.624 ± 0.052	3.108GlyArg: 3.108 ± 0.06	4.79GlySer: 4.79 ± 0.083	4.304GlyThr: 4.304 ± 0.106	4.965GlyVal: 4.965 ± 0.069	0.835GlyTrp: 0.835 ± 0.026	2.468GlyTyr: 2.468 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.347HisAla: 1.347 ± 0.034	0.231HisCys: 0.231 ± 0.014	0.934HisAsp: 0.934 ± 0.032	1.149HisGlu: 1.149 ± 0.031	1.029HisPhe: 1.029 ± 0.029	1.392HisGly: 1.392 ± 0.037	0.522HisHis: 0.522 ± 0.023	1.038HisIle: 1.038 ± 0.035	1.069HisLys: 1.069 ± 0.032	2.027HisLeu: 2.027 ± 0.053	0.552HisMet: 0.552 ± 0.022	0.659HisAsn: 0.659 ± 0.023	1.101HisPro: 1.101 ± 0.032	0.747HisGln: 0.747 ± 0.026	0.98HisArg: 0.98 ± 0.027	1.323HisSer: 1.323 ± 0.033	0.838HisThr: 0.838 ± 0.028	1.232HisVal: 1.232 ± 0.033	0.27HisTrp: 0.27 ± 0.015	0.671HisTyr: 0.671 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.317IleAla: 5.317 ± 0.071	0.636IleCys: 0.636 ± 0.022	3.361IleAsp: 3.361 ± 0.063	4.129IleGlu: 4.129 ± 0.078	2.664IlePhe: 2.664 ± 0.057	3.983IleGly: 3.983 ± 0.07	1.214IleHis: 1.214 ± 0.031	3.178IleIle: 3.178 ± 0.057	3.912IleLys: 3.912 ± 0.07	5.868IleLeu: 5.868 ± 0.085	1.344IleMet: 1.344 ± 0.034	2.521IleAsn: 2.521 ± 0.046	2.905IlePro: 2.905 ± 0.048	2.398IleGln: 2.398 ± 0.05	2.901IleArg: 2.901 ± 0.056	4.543IleSer: 4.543 ± 0.083	3.4IleThr: 3.4 ± 0.057	4.064IleVal: 4.064 ± 0.073	0.614IleTrp: 0.614 ± 0.025	1.857IleTyr: 1.857 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	5.87LysAla: 5.87 ± 0.088	0.446LysCys: 0.446 ± 0.026	4.12LysAsp: 4.12 ± 0.072	4.595LysGlu: 4.595 ± 0.073	2.695LysPhe: 2.695 ± 0.049	4.277LysGly: 4.277 ± 0.073	1.174LysHis: 1.174 ± 0.034	4.796LysIle: 4.796 ± 0.069	5.87LysLys: 5.87 ± 0.109	5.599LysLeu: 5.599 ± 0.074	2.212LysMet: 2.212 ± 0.044	3.627LysAsn: 3.627 ± 0.052	2.618LysPro: 2.618 ± 0.055	2.264LysGln: 2.264 ± 0.043	2.673LysArg: 2.673 ± 0.048	4.636LysSer: 4.636 ± 0.067	4.175LysThr: 4.175 ± 0.066	4.956LysVal: 4.956 ± 0.07	0.758LysTrp: 0.758 ± 0.026	2.117LysTyr: 2.117 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	7.952LeuAla: 7.952 ± 0.085	0.847LeuCys: 0.847 ± 0.026	4.663LeuAsp: 4.663 ± 0.075	5.697LeuGlu: 5.697 ± 0.076	4.103LeuPhe: 4.103 ± 0.062	6.645LeuGly: 6.645 ± 0.077	1.693LeuHis: 1.693 ± 0.039	5.743LeuIle: 5.743 ± 0.077	7.263LeuLys: 7.263 ± 0.096	8.471LeuLeu: 8.471 ± 0.108	2.714LeuMet: 2.714 ± 0.048	4.44LeuAsn: 4.44 ± 0.067	3.943LeuPro: 3.943 ± 0.063	3.679LeuGln: 3.679 ± 0.06	4.715LeuArg: 4.715 ± 0.073	6.99LeuSer: 6.99 ± 0.083	5.319LeuThr: 5.319 ± 0.065	6.365LeuVal: 6.365 ± 0.075	1.009LeuTrp: 1.009 ± 0.035	2.377LeuTyr: 2.377 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.593MetAla: 2.593 ± 0.047	0.194MetCys: 0.194 ± 0.014	1.489MetAsp: 1.489 ± 0.039	1.564MetGlu: 1.564 ± 0.041	0.955MetPhe: 0.955 ± 0.03	2.129MetGly: 2.129 ± 0.05	0.418MetHis: 0.418 ± 0.018	1.798MetIle: 1.798 ± 0.037	2.564MetLys: 2.564 ± 0.049	2.129MetLeu: 2.129 ± 0.042	0.859MetMet: 0.859 ± 0.029	1.463MetAsn: 1.463 ± 0.037	1.091MetPro: 1.091 ± 0.033	1.008MetGln: 1.008 ± 0.032	1.217MetArg: 1.217 ± 0.036	2.14MetSer: 2.14 ± 0.044	1.803MetThr: 1.803 ± 0.04	1.732MetVal: 1.732 ± 0.038	0.24MetTrp: 0.24 ± 0.015	0.622MetTyr: 0.622 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.171AsnAla: 3.171 ± 0.065	0.433AsnCys: 0.433 ± 0.02	2.088AsnAsp: 2.088 ± 0.046	2.434AsnGlu: 2.434 ± 0.048	2.162AsnPhe: 2.162 ± 0.047	3.018AsnGly: 3.018 ± 0.066	0.827AsnHis: 0.827 ± 0.028	2.626AsnIle: 2.626 ± 0.05	2.776AsnLys: 2.776 ± 0.054	4.479AsnLeu: 4.479 ± 0.072	1.139AsnMet: 1.139 ± 0.032	1.855AsnAsn: 1.855 ± 0.044	2.4AsnPro: 2.4 ± 0.046	1.811AsnGln: 1.811 ± 0.045	1.983AsnArg: 1.983 ± 0.043	3.09AsnSer: 3.09 ± 0.062	2.262AsnThr: 2.262 ± 0.05	2.719AsnVal: 2.719 ± 0.046	0.597AsnTrp: 0.597 ± 0.025	1.557AsnTyr: 1.557 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.446ProAla: 3.446 ± 0.064	0.287ProCys: 0.287 ± 0.014	2.155ProAsp: 2.155 ± 0.041	3.15ProGlu: 3.15 ± 0.058	1.881ProPhe: 1.881 ± 0.044	2.736ProGly: 2.736 ± 0.052	0.816ProHis: 0.816 ± 0.029	2.112ProIle: 2.112 ± 0.053	2.518ProLys: 2.518 ± 0.053	3.65ProLeu: 3.65 ± 0.06	1.087ProMet: 1.087 ± 0.034	1.675ProAsn: 1.675 ± 0.041	1.5ProPro: 1.5 ± 0.052	1.751ProGln: 1.751 ± 0.044	1.619ProArg: 1.619 ± 0.039	2.649ProSer: 2.649 ± 0.052	2.459ProThr: 2.459 ± 0.053	3.137ProVal: 3.137 ± 0.054	0.539ProTrp: 0.539 ± 0.022	1.283ProTyr: 1.283 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.396GlnAla: 3.396 ± 0.058	0.267GlnCys: 0.267 ± 0.016	1.958GlnAsp: 1.958 ± 0.045	2.469GlnGlu: 2.469 ± 0.041	1.711GlnPhe: 1.711 ± 0.042	2.592GlnGly: 2.592 ± 0.051	0.633GlnHis: 0.633 ± 0.025	2.542GlnIle: 2.542 ± 0.047	3.069GlnLys: 3.069 ± 0.053	3.433GlnLeu: 3.433 ± 0.057	1.31GlnMet: 1.31 ± 0.038	1.94GlnAsn: 1.94 ± 0.051	1.295GlnPro: 1.295 ± 0.041	1.663GlnGln: 1.663 ± 0.056	1.861GlnArg: 1.861 ± 0.041	2.603GlnSer: 2.603 ± 0.047	2.219GlnThr: 2.219 ± 0.046	2.876GlnVal: 2.876 ± 0.052	0.531GlnTrp: 0.531 ± 0.021	1.174GlnTyr: 1.174 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.422ArgAla: 3.422 ± 0.063	0.361ArgCys: 0.361 ± 0.02	2.415ArgAsp: 2.415 ± 0.05	3.109ArgGlu: 3.109 ± 0.059	2.113ArgPhe: 2.113 ± 0.043	2.957ArgGly: 2.957 ± 0.06	0.848ArgHis: 0.848 ± 0.029	2.975ArgIle: 2.975 ± 0.058	3.052ArgLys: 3.052 ± 0.055	4.335ArgLeu: 4.335 ± 0.077	1.411ArgMet: 1.411 ± 0.037	1.944ArgAsn: 1.944 ± 0.047	1.755ArgPro: 1.755 ± 0.045	1.763ArgGln: 1.763 ± 0.045	2.267ArgArg: 2.267 ± 0.055	2.906ArgSer: 2.906 ± 0.06	2.3ArgThr: 2.3 ± 0.048	3.214ArgVal: 3.214 ± 0.054	0.606ArgTrp: 0.606 ± 0.027	1.541ArgTyr: 1.541 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.724SerAla: 5.724 ± 0.078	0.749SerCys: 0.749 ± 0.03	3.381SerAsp: 3.381 ± 0.059	4.194SerGlu: 4.194 ± 0.073	3.515SerPhe: 3.515 ± 0.058	5.188SerGly: 5.188 ± 0.091	1.353SerHis: 1.353 ± 0.036	3.992SerIle: 3.992 ± 0.063	4.341SerLys: 4.341 ± 0.062	7.075SerLeu: 7.075 ± 0.083	1.824SerMet: 1.824 ± 0.042	2.63SerAsn: 2.63 ± 0.052	2.815SerPro: 2.815 ± 0.056	2.906SerGln: 2.906 ± 0.062	2.993SerArg: 2.993 ± 0.06	5.38SerSer: 5.38 ± 0.103	3.706SerThr: 3.706 ± 0.083	4.736SerVal: 4.736 ± 0.065	0.929SerTrp: 0.929 ± 0.03	2.291SerTyr: 2.291 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.894ThrAla: 4.894 ± 0.097	0.531ThrCys: 0.531 ± 0.023	2.683ThrAsp: 2.683 ± 0.056	3.327ThrGlu: 3.327 ± 0.056	2.367ThrPhe: 2.367 ± 0.048	4.301ThrGly: 4.301 ± 0.088	1.082ThrHis: 1.082 ± 0.034	3.139ThrIle: 3.139 ± 0.059	3.146ThrLys: 3.146 ± 0.055	5.456ThrLeu: 5.456 ± 0.072	1.266ThrMet: 1.266 ± 0.032	2.26ThrAsn: 2.26 ± 0.055	2.896ThrPro: 2.896 ± 0.06	2.112ThrGln: 2.112 ± 0.045	2.336ThrArg: 2.336 ± 0.05	3.993ThrSer: 3.993 ± 0.095	3.385ThrThr: 3.385 ± 0.098	4.118ThrVal: 4.118 ± 0.077	0.723ThrTrp: 0.723 ± 0.031	1.799ThrTyr: 1.799 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.877ValAla: 5.877 ± 0.094	0.661ValCys: 0.661 ± 0.024	3.729ValAsp: 3.729 ± 0.068	4.36ValGlu: 4.36 ± 0.071	3.124ValPhe: 3.124 ± 0.063	4.855ValGly: 4.855 ± 0.065	1.263ValHis: 1.263 ± 0.039	4.405ValIle: 4.405 ± 0.067	4.443ValLys: 4.443 ± 0.072	6.64ValLeu: 6.64 ± 0.079	1.869ValMet: 1.869 ± 0.05	2.975ValAsn: 2.975 ± 0.056	2.749ValPro: 2.749 ± 0.051	2.638ValGln: 2.638 ± 0.049	3.217ValArg: 3.217 ± 0.057	4.925ValSer: 4.925 ± 0.076	4.167ValThr: 4.167 ± 0.084	5.107ValVal: 5.107 ± 0.083	0.654ValTrp: 0.654 ± 0.024	1.934ValTyr: 1.934 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.94TrpAla: 0.94 ± 0.034	0.102TrpCys: 0.102 ± 0.012	0.657TrpAsp: 0.657 ± 0.023	0.621TrpGlu: 0.621 ± 0.024	0.51TrpPhe: 0.51 ± 0.023	0.918TrpGly: 0.918 ± 0.04	0.223TrpHis: 0.223 ± 0.015	0.769TrpIle: 0.769 ± 0.031	0.801TrpLys: 0.801 ± 0.03	1.049TrpLeu: 1.049 ± 0.032	0.418TrpMet: 0.418 ± 0.021	0.646TrpAsn: 0.646 ± 0.027	0.398TrpPro: 0.398 ± 0.022	0.434TrpGln: 0.434 ± 0.02	0.515TrpArg: 0.515 ± 0.023	0.819TrpSer: 0.819 ± 0.03	0.682TrpThr: 0.682 ± 0.024	0.806TrpVal: 0.806 ± 0.029	0.172TrpTrp: 0.172 ± 0.013	0.329TrpTyr: 0.329 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.201TyrAla: 2.201 ± 0.045	0.34TyrCys: 0.34 ± 0.017	1.737TyrAsp: 1.737 ± 0.044	1.773TyrGlu: 1.773 ± 0.041	1.72TyrPhe: 1.72 ± 0.045	2.115TyrGly: 2.115 ± 0.045	0.659TyrHis: 0.659 ± 0.026	1.61TyrIle: 1.61 ± 0.039	1.902TyrLys: 1.902 ± 0.041	3.027TyrLeu: 3.027 ± 0.061	0.802TyrMet: 0.802 ± 0.027	1.42TyrAsn: 1.42 ± 0.045	1.258TyrPro: 1.258 ± 0.032	1.332TyrGln: 1.332 ± 0.036	1.607TyrArg: 1.607 ± 0.034	2.321TyrSer: 2.321 ± 0.049	1.578TyrThr: 1.578 ± 0.038	1.919TyrVal: 1.919 ± 0.042	0.441TyrTrp: 0.441 ± 0.022	1.147TyrTyr: 1.147 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3588 proteins (1113114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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